Best TWAS P=1.64e-27 · Best GWAS P=3.07e-29 conditioned to 0.000257
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CYBRD1 | 0.33 | 0.18 | lasso | 7 | 0.27 | 5.2e-33 | -4.5 | -8.3 | 1.3e-16 | -0.69 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CYBRD1 | 0.35 | 0.19 | lasso | 6 | 0.24 | 7.3e-20 | 9.4 | -9.7 | 5.2e-22 | -0.77 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | CYBRD1 | 0.33 | 0.10 | lasso | 10 | 0.26 | 4.6e-14 | 6.4 | -9.2 | 5.0e-20 | -0.71 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Artery Aorta | CYBRD1 | 0.52 | 0.30 | lasso | 10 | 0.41 | 6.0e-24 | -4.5 | -8.2 | 3.7e-16 | -0.66 | 0.96 | 0.04 | FALSE |
| 5 | GTEx | Artery Coronary | CYBRD1 | 0.29 | 0.01 | enet | 44 | 0.11 | 2.0e-04 | 6.4 | -7.5 | 6.2e-14 | -0.68 | 0.04 | 0.61 | FALSE |
| 6 | GTEx | Artery Tibial | CYBRD1 | 0.37 | 0.08 | lasso | 9 | 0.21 | 3.0e-16 | 7.9 | -9.4 | 4.9e-21 | -0.75 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | CYBRD1 | 0.32 | 0.21 | enet | 16 | 0.27 | 2.0e-14 | 9.4 | -9.9 | 2.6e-23 | -0.74 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | CYBRD1 | 0.35 | 0.24 | lasso | 6 | 0.20 | 2.4e-05 | 9.4 | -9.7 | 2.1e-22 | -0.72 | 0.00 | 0.98 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | CYBRD1 | 0.20 | 0.07 | lasso | 2 | 0.14 | 4.5e-05 | 9.4 | -9.7 | 2.4e-22 | -0.78 | 0.00 | 0.98 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CYBRD1 | 0.34 | 0.16 | enet | 27 | 0.26 | 6.3e-20 | 6.4 | -7.8 | 6.2e-15 | -0.57 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Esophagus Muscularis | CYBRD1 | 0.33 | 0.07 | lasso | 9 | 0.22 | 1.3e-13 | 7.9 | -9.8 | 1.7e-22 | -0.75 | 0.06 | 0.94 | FALSE |
| 12 | GTEx | Lung | CYBRD1 | 0.14 | 0.05 | enet | 8 | 0.10 | 5.6e-08 | -4.5 | -7.6 | 3.2e-14 | -0.45 | 0.98 | 0.01 | FALSE |
| 13 | GTEx | Muscle Skeletal | CYBRD1 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-02 | 9.4 | -9.2 | 2.7e-20 | -0.71 | 0.00 | 0.99 | FALSE |
| 14 | GTEx | Nerve Tibial | CYBRD1 | 0.36 | 0.07 | lasso | 10 | 0.20 | 2.3e-14 | 9.4 | -9.6 | 8.6e-22 | -0.73 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Thyroid | CYBRD1 | 0.26 | 0.08 | enet | 26 | 0.12 | 1.4e-09 | 9.4 | -8.8 | 1.3e-18 | -0.72 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Uterus | CYBRD1 | 0.54 | 0.04 | lasso | 6 | 0.19 | 1.1e-04 | -5.3 | -6.2 | 7.3e-10 | -0.49 | 0.05 | 0.44 | FALSE |
| 17 | GTEx | Whole Blood | CYBRD1 | 0.25 | 0.14 | enet | 19 | 0.15 | 1.4e-13 | -4.7 | -6.6 | 4.9e-11 | -0.52 | 1.00 | 0.00 | FALSE |
| 18 | METSIM | Adipose | CYBRD1 | 0.08 | 0.06 | lasso | 6 | 0.06 | 8.0e-09 | -4.1 | -6.3 | 3.5e-10 | -0.48 | 0.92 | 0.08 | FALSE |
| 19 | NTR | Blood | METTL8 | 0.03 | 0.02 | lasso | 7 | 0.02 | 1.7e-08 | -4.1 | 5.5 | 4.5e-08 | 0.37 | 1.00 | 0.00 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | CYBRD1 | 0.37 | 0.16 | lasso | 9 | 0.30 | 3.0e-39 | 6.8 | -9.3 | 8.8e-21 | -0.77 | 0.30 | 0.70 | FALSE |
| 21 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CYBRD1 | 0.14 | 0.04 | enet | 12 | 0.09 | 2.2e-05 | 11.2 | 9.3 | 1.3e-20 | 0.78 | 0.00 | 0.96 | FALSE |
| 22 | The Cancer Genome Atlas | Colon Adenocarcinoma | CYBRD1 | 0.14 | 0.06 | blup | 69 | 0.05 | 6.4e-04 | -5.7 | 6.7 | 1.8e-11 | 0.52 | 0.16 | 0.48 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CYBRD1 | 0.03 | 0.02 | lasso | 3 | 0.03 | 4.5e-04 | -4.5 | -5.6 | 2.5e-08 | -0.46 | 0.18 | 0.21 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CYBRD1 | 0.08 | 0.06 | blup | 68 | 0.08 | 1.5e-08 | 6.8 | -5.7 | 1.3e-08 | -0.51 | 0.94 | 0.06 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | CYBRD1 | 0.10 | 0.06 | lasso | 4 | 0.06 | 6.2e-07 | 9.4 | -10.9 | 1.6e-27 | -0.86 | 0.00 | 1.00 | TRUE |