Best TWAS P=1.17e-11 · Best GWAS P=1.18e-10 conditioned to 0.72
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Gastroesophageal Junction | FYCO1 | 0.15 | 0.13 | lasso | 5 | 0.13 | 2.8e-05 | 6.2 | 6.8 | 1.2e-11 | 0.93 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Esophagus Muscularis | FYCO1 | 0.17 | 0.06 | lasso | 8 | 0.08 | 1.7e-05 | 4.7 | 5.8 | 5.8e-09 | 0.75 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Lung | FYCO1 | 0.20 | 0.16 | enet | 17 | 0.16 | 4.4e-12 | 4.7 | 6.0 | 2.6e-09 | 0.82 | 0.12 | 0.88 | FALSE |
| 4 | GTEx | Nerve Tibial | FYCO1 | 0.26 | 0.24 | enet | 25 | 0.27 | 2.8e-19 | 6.2 | 6.2 | 6.6e-10 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Whole Blood | CCR1 | 0.12 | 0.10 | lasso | 4 | 0.09 | 4.8e-09 | 5.3 | 5.8 | 7.2e-09 | 0.60 | 0.18 | 0.82 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | FYCO1 | 0.07 | 0.02 | blup | 79 | 0.04 | 1.5e-03 | -3.2 | 5.1 | 3.0e-07 | 0.71 | 0.02 | 0.70 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FYCO1 | 0.08 | 0.03 | enet | 12 | 0.04 | 8.1e-04 | 6.2 | 6.3 | 2.5e-10 | 0.83 | 0.01 | 0.95 | FALSE |