Best TWAS P=5.32e-11 · Best GWAS P=7.76e-12 conditioned to 0.000641
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | WDR70 | 0.06 | 0.03 | lasso | 8 | 0.03 | 0.00346 | 5.9 | -6.6 | 5.3e-11 | -0.65 | 0.18 | 0.73 | TRUE |
| 2 | GTEx | Nerve Tibial | WDR70 | 0.17 | 0.07 | lasso | 3 | 0.05 | 0.00014 | -6.0 | -5.9 | 3.0e-09 | -0.25 | 0.23 | 0.43 | FALSE |
| 3 | GTEx | Whole Blood | NUP155 | 0.05 | 0.01 | enet | 14 | 0.04 | 0.00011 | 6.4 | -5.4 | 7.2e-08 | -0.38 | 0.08 | 0.29 | FALSE |
| 4 | GTEx | Whole Blood | C5orf42 | 0.07 | 0.00 | enet | 16 | 0.01 | 0.01830 | 6.4 | -5.9 | 3.3e-09 | -0.45 | 0.07 | 0.30 | FALSE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C5orf42 | 0.04 | 0.05 | lasso | 3 | 0.04 | 0.00108 | 6.5 | -6.4 | 1.7e-10 | -0.57 | 0.03 | 0.42 | FALSE |