Best TWAS P=2.37e-12 · Best GWAS P=9.96e-13 conditioned to 0.00488
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HINT1 | 0.10 | 0.07 | enet | 16 | 0.06 | 8.8e-06 | 5.6 | 6.8 | 7.7e-12 | 0.49 | 0.70 | 0.14 | FALSE |
| 2 | GTEx | Artery Aorta | HINT1 | 0.07 | 0.07 | enet | 8 | 0.06 | 4.7e-04 | 6.4 | 7.0 | 2.4e-12 | 0.75 | 0.06 | 0.69 | TRUE |
| 3 | GTEx | Artery Tibial | HINT1 | 0.11 | 0.04 | enet | 18 | 0.06 | 1.0e-05 | 6.0 | 6.1 | 1.1e-09 | 0.55 | 0.15 | 0.74 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | HINT1 | 0.10 | 0.06 | lasso | 2 | 0.05 | 2.1e-04 | 6.0 | 6.2 | 4.5e-10 | 0.57 | 0.51 | 0.35 | FALSE |
| 5 | GTEx | Testis | RAPGEF6 | 0.50 | 0.35 | lasso | 4 | 0.32 | 6.5e-15 | 5.6 | 6.2 | 6.2e-10 | 0.89 | 0.05 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HINT1 | 0.06 | 0.03 | enet | 5 | 0.03 | 5.2e-04 | 4.5 | 5.4 | 8.1e-08 | 0.74 | 0.06 | 0.57 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | LYRM7 | 0.03 | 0.01 | enet | 10 | 0.02 | 7.5e-04 | 4.7 | -5.7 | 1.6e-08 | -0.74 | 0.01 | 0.83 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | HINT1 | 0.07 | 0.04 | lasso | 2 | 0.01 | 1.8e-02 | 5.8 | 5.8 | 5.9e-09 | 0.57 | 0.00 | 0.98 | FALSE |