Hub : Genes

HINT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0960	0.0420	3.3e-04	0.069	NA	0.062	NA	0.059	2.7e-06	NA	8.8e-06	NA	1.5e-05
2	GTEx	Artery Aorta	0.0660	0.0380	8.5e-03	0.066	NA	0.056	NA	0.056	1.6e-04	NA	4.7e-04	NA	4.9e-04
3	GTEx	Artery Tibial	0.1074	0.0483	6.6e-05	0.042	NA	0.063	NA	0.035	2.8e-04	NA	1.0e-05	NA	8.4e-04
4	GTEx	Cells Transformed fibroblasts	0.0960	0.0430	1.3e-04	0.056	NA	0.044	NA	0.046	5.2e-05	NA	3.0e-04	NA	2.1e-04
5	GTEx	Testis	0.6940	0.0700	8.5e-08	0.292	NA	0.252	NA	0.266	1.9e-13	NA	1.5e-11	NA	3.3e-12
6	NTR	Blood	0.0174	0.0111	3.1e-03	0.009	0.007	0.002	0.008	0.005	5.5e-04	0.00170	5.5e-02	0.00073	7.2e-03
7	ROSMAP	Brain Pre-frontal Cortex	0.0247	0.0145	2.0e-03	0.033	0.012	0.017	0.014	0.020	4.2e-05	0.00920	2.8e-03	0.00540	1.1e-03
8	TCGA	Brain Lower Grade Glioma	0.0580	0.0405	6.8e-04	0.033	0.024	0.026	NA	0.023	1.2e-04	0.00079	5.2e-04	NA	1.1e-03
9	TCGA	Prostate Adenocarcinoma	0.2473	0.1246	1.1e-03	0.017	0.022	0.015	NA	0.010	5.7e-03	0.00190	9.3e-03	NA	2.8e-02
10	TCGA	Thyroid Carcinoma	0.0680	0.0510	1.6e-03	0.038	0.006	0.002	NA	0.013	1.2e-04	0.08200	2.1e-01	NA	1.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.9	1.7	-1.3	-0.7	-0.9	-0.9	-0.9	-0.8	0.6	-1.2	1.1	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	1.4	-0.1	0.0	0.2	0.0	-0.3	-1.2	-0.3	-0.9	0.3	0.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.0	-1.0	-1.3	-1.4	-1.2	-1.1	0.9	1.3	-0.2	1.1	-1.4
Depression (Nagel 2018)	0.4	0.6	2.1	-1.0	-0.8	-1.4	-0.7	-0.8	-0.2	0.3	-0.0	0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.2	-2.3	-0.7	-1.6	-1.4	0.5	-0.9	-0.6	-0.6	-0.0	-1.2
Neuroticism (Nagel 2018)	0.4	1.0	2.2	-1.5	-1.3	-1.4	-1.1	-0.5	-0.3	0.3	-0.5	1.0	-1.2
Schizophrenia (2018)	0.2	0.5	0.9	0.8	0.6	0.9	0.8	0.5	-1.0	-0.9	-0.1	-0.3	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	1.0	0.6	-0.0	0.2	0.1	1.0	0.6	0.2	-0.1	-0.6	-0.0
Worry (Nagel 2018)	0.7	1.5	3.6	-1.9	-1.4	-1.5	-1.5	0.8	-0.2	0.4	-1.0	0.9	-1.6
Alzheimer’s Disease (in mother)	0.2	0.3	0.9	1.0	-0.4	-0.2	0.3	0.6	0.5	0.1	-0.9	-0.2	0.2
Alzheimer’s Disease (in father)	1.8	1.9	4.1	2.0	1.6	1.3	1.8	-0.9	-0.2	-1.6	1.4	-0.7	1.2
Alzheimer’s Disease (including proxy)	1.1	1.6	4.7	2.2	1.1	0.6	1.8	-0.0	0.0	-1.6	0.5	-1.2	1.5
Crohns Disease (2017)	11.0	24.2	48.7	-4.6	-6.0	-7.0	-5.7	2.3	1.7	5.5	-4.7	3.1	-5.7
Irritable Bowel Disease (IBD)	6.7	15.8	33.4	-3.3	-4.9	-5.8	-4.4	2.8	1.2	4.5	-4.3	1.6	-4.5
Ulcerative Colitis (UC)	1.4	2.7	6.2	-0.9	-2.0	-2.5	-1.4	1.6	-0.1	1.7	-2.2	0.1	-1.7
Major Depression (MDD)	0.3	0.3	1.1	-1.1	-0.6	-0.6	-0.3	-0.3	-0.6	0.4	-0.7	0.0	0.1
Reaction Time	0.2	0.3	1.4	-0.5	-0.2	-1.0	-0.1	-0.5	-1.2	-0.2	-0.4	-0.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.6	4.9	-2.2	-1.1	-1.3	-1.7	0.9	-0.8	-0.1	-0.7	0.6	-1.6
Breast Cancer	0.6	1.5	10.8	-0.1	-0.3	0.9	0.4	0.6	-3.3	-1.3	-0.4	-1.0	0.4
Ovarian Cancer	0.5	0.7	1.4	0.6	-1.0	-0.5	-0.3	0.0	0.2	1.1	-1.2	1.0	-1.1
Prostate Cancer	0.2	0.3	1.8	0.2	-0.2	0.3	-0.5	0.1	0.1	0.4	0.2	1.3	-0.5
Age at First Birth	0.6	0.9	5.4	-2.3	-0.9	-1.0	-1.0	-0.1	-0.6	0.1	-0.7	0.1	-0.2
Bipolar Disorder (2011)	1.0	1.0	2.1	0.5	1.5	0.8	1.2	-0.1	-0.1	-0.6	0.9	-1.4	1.4
Body Mass Index (BMI) (2010)	1.5	2.0	4.7	-2.2	-1.8	-1.6	-1.9	0.0	-0.0	0.6	-1.1	1.2	-1.9
Coronary Artery Disease (CAD)	0.3	0.4	1.3	0.5	-0.3	0.7	-0.3	0.1	0.9	1.1	0.1	1.0	-0.3
Crohns Disease (2012)	10.0	16.0	38.1	-3.8	-4.7	-6.2	-4.6	0.6	1.4	4.6	-3.5	2.6	-4.7
Mean Putamen Volume	3.0	3.5	9.0	-2.0	-2.3	-3.0	-1.8	-1.2	-0.6	0.9	-2.2	1.5	-1.8
Fasting Glucose	4.7	5.6	10.2	-3.2	-2.6	-2.6	-2.7	0.6	-1.5	1.9	-3.0	2.3	-2.0
HbA1C	0.2	0.2	0.8	0.2	-0.6	0.0	-0.4	-0.1	0.6	0.9	-0.4	0.7	-0.3
HDL Cholesterol	0.5	0.8	3.5	0.0	-0.7	-1.2	0.2	-0.1	-1.9	-0.9	-1.2	-0.3	-0.7
LDL Cholesterol	0.3	0.5	1.7	-1.0	-0.3	-1.3	-0.3	-0.4	-0.9	-0.8	0.1	-0.1	0.1
Lupus	1.9	2.9	5.4	-1.8	-2.3	-1.5	-2.2	-0.5	0.4	1.6	-1.8	1.5	-2.1
Neuroticism (2016)	0.9	1.4	2.8	-1.7	-1.4	-1.6	-1.0	0.9	-1.6	-0.5	-0.6	0.2	-1.2
Primary Biliary Cirrhosis	0.4	0.6	2.8	-0.2	-0.6	-0.9	-0.6	1.7	-0.3	0.5	-0.3	0.5	-0.7
Rheumatoid Arthritis	0.9	1.2	3.7	-0.0	-0.8	0.6	-0.6	-1.0	1.8	1.5	-0.2	1.9	-0.5
Schizophrenia (2014)	0.1	0.3	1.4	0.3	-0.2	0.6	0.0	-0.0	-1.2	0.1	-1.0	0.3	0.3
Triglycerides	0.5	0.8	3.0	1.2	0.9	1.7	0.7	0.4	0.7	0.4	0.8	0.4	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	-1.2	-1.0	-0.0	-1.0	-0.1	-0.0	1.0	-1.1	0.8	-0.7
Ulcerative Colitis	1.4	2.0	4.5	-0.5	-1.9	-2.1	-1.2	1.2	-0.3	1.2	-2.1	0.3	-1.6
Blood Eosinophil Count	8.0	61.9	204.5	6.8	5.9	14.3	8.0	-0.5	-10.0	-10.5	2.5	-1.7	7.1
Blood Platelet Count	0.7	8.0	34.5	3.1	3.1	5.9	2.5	1.2	-0.0	-2.1	3.0	0.5	2.2
Blood Red Count	1.1	10.8	19.6	-2.9	-4.4	-2.1	-4.0	-0.9	0.5	4.2	-4.1	3.4	-3.6
Blood White Count	2.2	16.2	57.6	5.3	4.3	7.6	3.5	0.8	4.3	-0.6	3.9	0.3	3.4
Heel T-Score	0.6	4.8	14.8	2.2	2.4	3.2	1.5	1.1	3.9	0.6	2.2	-1.4	1.4
BMI	2.8	16.2	33.4	-5.8	-5.1	-4.9	-5.4	-0.6	0.7	2.7	-2.1	2.8	-5.4
Height	5.3	101.5	237.4	-13.4	-12.5	-15.4	-11.5	2.3	-3.6	7.4	-11.5	2.1	-9.9
Waist Hip Ratio (WHR)	0.5	2.4	9.1	-0.7	-1.8	-0.6	-2.0	0.9	0.8	3.0	-1.0	1.5	-1.4
Systolic Blood Pressure	0.3	1.6	7.6	-1.7	-0.8	-0.5	-1.6	2.8	1.0	0.2	-0.2	0.5	-1.0
Smoking Status	0.4	1.0	3.3	-1.8	-0.8	-1.3	-1.2	0.8	-1.3	0.3	-0.3	-0.1	-0.6
Allergy or Eczema	0.7	1.8	3.4	1.4	1.6	1.9	1.6	-0.1	-1.1	-1.7	0.8	-0.7	1.5
Cardiovascular Disease	0.2	0.8	2.7	-0.8	0.2	0.7	-0.0	1.7	-1.5	-1.0	0.3	-0.8	-0.2
Hypothyroidism (self reported)	0.2	0.4	2.1	0.0	-0.3	-0.2	-0.4	-1.1	-0.2	-0.3	0.2	1.5	-0.4
Respiratory disease	1.7	3.7	7.2	1.5	1.9	2.7	1.8	2.2	-0.2	-2.1	1.6	-2.0	2.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	0.3	-0.1	0.5	-0.1	-0.1	0.3	0.6	-0.3	0.5	-0.3
Lung FEV1/FVC ratio	1.2	6.2	13.8	-3.5	-2.7	-3.7	-3.0	0.1	-0.8	1.3	-2.1	1.2	-3.3
Lung FVC	2.9	14.7	54.1	4.9	4.2	7.4	4.4	-0.6	-0.2	-2.0	2.4	-1.4	4.4
Neuroticism	0.8	1.9	3.2	-1.8	-1.8	-1.7	-1.7	-0.6	0.2	1.0	-0.7	1.5	-1.7
Chronotype (morning person)	0.8	2.0	3.6	1.2	1.9	1.9	1.6	-0.0	1.0	-0.6	1.7	-1.1	1.7
Hair Pigment	0.1	3.2	8.5	-0.2	-2.5	-2.3	-1.1	-0.5	-0.1	2.3	-2.9	1.8	-1.3
Tanning	0.1	0.9	2.6	-0.0	1.4	1.6	0.7	0.1	0.6	-0.1	0.7	-1.2	1.2
Hand grip strength (left)	4.5	11.8	22.2	-4.0	-4.7	-4.4	-3.7	1.5	-0.9	3.3	-4.5	0.6	-3.5
Number of treatments/medications taken	0.3	0.6	1.7	-0.1	0.4	1.3	0.5	-1.1	-0.4	-1.1	0.2	-0.0	1.0
Average weekly spirits intake	0.7	0.9	3.0	-0.9	-0.3	-0.4	-0.8	-1.7	0.5	-0.6	0.8	1.7	-0.7
Sensitivity / hurt feelings	0.2	0.3	1.0	-0.1	0.4	-0.8	0.2	-0.6	-0.3	-0.5	1.0	-0.1	0.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.1	-0.9	-1.3	-1.4	-1.1	0.4	0.6	1.0	-0.8	1.1	-1.4
Hearing difficulty/problems: Yes	1.3	2.0	3.7	1.9	1.7	1.8	1.8	0.2	0.1	-0.9	1.9	-1.0	1.3
Relative age of first facial hair	0.9	1.8	4.7	-0.6	-1.4	-0.0	-1.3	1.2	-0.1	2.2	-2.1	1.3	-1.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.7	-0.6	-0.8	-0.5	-1.1	0.4	0.8	1.2	-0.6	1.3	-1.0
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.8	-0.2	-0.5	-0.3	-1.0	-1.7	1.4	1.3	-0.3	1.6	-0.9
Ever had hysterectomy (womb removed)	0.8	0.9	2.7	-0.2	-1.0	-0.9	-0.6	-0.7	-0.5	1.6	-0.9	1.3	-1.0
Systolic blood pressure, automated reading	1.3	3.7	7.2	-2.2	-1.7	-2.1	-2.7	1.3	2.4	1.6	-0.4	1.5	-2.3
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	6.3	-2.3	-2.4	-2.4	-2.5	-0.2	-0.8	0.9	-1.6	1.4	-2.5
Angina	0.6	0.8	4.2	-0.0	-0.1	-0.6	-0.5	-0.9	2.0	1.0	0.6	0.9	-0.8
Medication for hormone replacement therapy	0.7	0.8	3.3	-1.2	-0.6	-0.0	-0.8	-0.5	0.9	1.8	-0.8	0.6	0.1
Vitamin and mineral supplements	0.4	0.5	2.9	-0.5	-0.5	0.4	-0.7	1.7	0.0	0.7	-0.3	-0.2	-0.9
Supplements: Zinc	1.8	2.0	4.8	-2.2	-1.9	-1.9	-1.7	-0.7	-0.2	0.9	-1.2	0.6	-1.3
Medication: Co-codamol	0.8	0.9	1.7	-0.8	-1.0	-0.7	-1.0	1.3	-0.2	1.2	-1.3	-0.3	-1.0
Medication: Metformin	0.1	0.2	0.5	-0.2	-0.3	-0.3	-0.3	-0.6	-0.6	-0.1	-0.7	0.3	-0.5
Diabetes (father)	0.4	0.5	1.5	-0.3	0.2	-0.0	-0.8	-0.4	1.2	0.1	1.0	1.2	-0.5
Diabetes (mother)	0.2	0.3	1.8	-0.2	-0.4	0.5	-0.1	-0.3	-1.4	-0.4	-0.6	0.3	-0.1
Severe depression (siblings)	0.1	0.2	0.7	0.0	0.1	0.0	-0.0	0.6	0.5	0.8	-0.1	0.4	0.2
Pack years adult smoking proportion	2.3	3.5	6.3	-1.2	-1.9	-1.9	-2.0	-1.7	2.2	2.1	-0.5	2.5	-1.9
Impedance of leg (right)	5.4	26.2	49.1	6.8	7.0	6.1	6.2	-0.9	1.0	-4.0	5.4	-3.0	5.8
Leg fat-free mass (left)	10.3	54.6	116.6	-10.8	-9.6	-10.4	-9.0	1.7	-2.8	4.6	-7.1	2.0	-7.9
Trunk fat percentage	0.9	3.8	10.4	-3.2	-2.0	-3.0	-2.6	-0.7	0.5	0.4	-0.0	1.2	-2.4
Hand grip strength (right)	5.2	14.1	28.5	-4.2	-5.3	-4.6	-4.1	1.0	-0.7	3.8	-4.8	1.4	-4.0
Townsend deprivation index at recruitment	0.7	1.0	5.3	0.0	-0.8	0.2	-0.3	-2.3	-0.1	0.1	-0.4	2.0	-0.1
Current tobacco smoking	1.1	1.9	4.8	-2.2	-1.5	-1.9	-1.7	-0.1	-0.2	1.0	-0.7	1.2	-1.4
Average weekly fortified wine intake	1.0	1.2	4.4	-1.2	-1.1	-2.1	-1.2	0.2	-0.3	0.2	-0.6	0.4	-1.7
Maternal smoking around birth	0.4	0.6	3.8	0.2	0.4	0.2	-0.1	0.2	1.9	0.5	1.1	0.0	-0.2
Fed-up feelings	0.5	0.9	1.9	1.4	0.8	0.6	1.1	-1.0	1.3	-0.0	1.1	-0.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	-0.5	-0.6	-0.9	-0.3	-0.1	0.2	0.3	-0.4	0.3	-0.6
Relative age voice broke	0.8	1.1	2.8	1.4	0.8	1.7	1.2	1.1	-1.4	-0.4	-0.5	-0.7	0.7
Taking other prescription medications	0.3	0.4	2.1	0.3	0.0	0.5	-0.0	-0.9	1.4	0.6	0.1	0.8	0.4
Age when periods started (menarche)	2.0	4.8	8.6	-2.0	-2.3	-2.8	-2.5	1.7	2.0	2.9	-1.4	0.7	-2.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	-0.2	-0.9	-0.5	-0.7	-0.6	0.2	1.5	-1.2	0.8	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	1.2	1.4	0.6	1.4	-0.9	0.0	-1.3	1.2	-1.2	1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.9	-1.1	-1.2	-1.4	-1.2	1.4	-0.6	0.7	-0.4	-0.0	-1.3
Qualifications: CSEs or equivalent	0.5	0.6	2.0	1.0	0.2	0.0	0.7	-1.4	1.2	0.2	1.0	-0.1	0.8
Serious illness, injury or assault to yourself	1.0	1.2	3.2	-1.4	-1.1	-1.4	-1.5	0.8	-0.7	0.1	-0.2	0.9	-1.8
High blood pressure	0.1	0.2	1.3	-0.6	0.1	0.0	-0.4	1.1	0.6	0.2	0.0	-0.0	-0.3
Hayfever, allergic rhinitis or eczema	2.7	5.8	12.7	3.4	2.7	3.6	3.1	-0.0	-0.3	-2.3	1.6	-1.2	2.7
Multivitamins +/- minerals	0.7	0.9	3.7	-0.1	0.5	-0.3	0.6	-1.9	-1.0	-1.5	0.6	0.1	0.8
Stomach or abdominal pain in last month	1.7	2.2	3.6	-1.9	-1.6	-1.6	-1.9	0.1	1.0	1.2	-1.5	1.4	-1.6
Supplements: Glucosamine	0.7	1.0	6.3	-0.3	-0.1	-0.1	-0.0	-2.5	-1.0	-1.3	-0.2	0.7	0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	0.9	-0.3	-0.2	0.4	1.3	0.9	1.2	-0.8	-0.4	-0.2
Medication: Atenolol	1.4	1.8	4.4	-2.1	-1.3	-0.6	-1.4	-1.3	-1.5	-0.2	-0.8	1.6	-1.3
Medication: Levothyroxine sodium	0.5	0.9	4.4	0.2	0.5	0.0	0.3	-2.1	-0.9	-1.0	1.1	0.7	0.5
Sitting height	1.8	12.5	29.6	-4.8	-3.6	-5.4	-3.1	2.6	-3.9	1.3	-4.3	-1.4	-2.3
Chronic bronchitis/emphysema (father)	0.8	1.0	4.6	0.7	-0.7	0.7	-0.2	-0.9	-0.1	1.5	-0.6	2.1	-0.5
High blood pressure (mother)	1.1	1.5	3.7	0.9	1.2	1.9	1.7	-0.5	-0.2	-1.0	0.4	-1.1	1.9
Body mass index (BMI)	2.4	10.4	24.5	-5.0	-4.0	-4.1	-4.4	-0.3	0.2	1.8	-1.7	2.1	-4.1
Impedance of leg (left)	6.5	31.7	60.7	7.8	7.5	7.0	6.9	-0.9	1.5	-4.3	5.8	-2.7	6.4
Leg predicted mass (left)	10.6	56.4	121.0	-11.0	-9.8	-10.5	-9.2	1.6	-2.8	4.7	-7.2	2.1	-8.0
Trunk fat mass	3.0	13.1	32.6	-5.7	-4.4	-5.6	-4.7	-0.3	-0.5	1.5	-2.1	1.5	-4.1
Waist circumference	4.2	15.2	32.2	-5.7	-4.8	-5.0	-5.3	-0.6	0.5	3.2	-2.5	2.7	-4.5
Number of incorrect matches in round	1.9	3.2	7.5	-0.1	-2.1	-0.3	-1.6	-0.2	0.6	2.7	-2.2	2.7	-2.1
Past tobacco smoking	0.4	0.7	1.7	-0.4	-1.0	-0.6	-0.7	-1.0	0.9	0.6	-0.9	1.3	-0.7
Alcohol usually taken with meals	0.9	1.5	7.2	-2.7	-0.6	-0.8	-1.2	1.1	-1.7	-0.3	-1.0	-0.5	-0.4
Nervous feelings	0.3	0.5	1.1	-0.3	0.6	0.8	0.0	-0.9	1.0	-0.8	0.9	0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.9	2.6	-0.9	-0.6	-1.6	-0.7	1.4	-0.5	0.5	-0.8	-0.4	-1.0
Hearing difficulty/problems with background noise	0.6	0.9	1.9	1.2	1.0	1.3	1.1	-0.3	-0.7	-0.5	0.8	-0.5	1.4
Hair/balding pattern: Pattern 2	1.3	1.6	5.0	-1.1	-1.1	-1.2	-1.2	2.2	0.7	1.0	-1.3	-0.6	-1.5
Had menopause	0.4	0.6	1.5	-0.8	-0.5	-0.5	-0.9	-0.4	-0.3	1.2	-1.2	0.4	-0.6
Had other major operations	1.6	1.9	3.4	-0.9	-1.8	-1.6	-1.6	0.9	0.4	1.7	-1.8	1.1	-1.4
Forced vital capacity (FVC)	0.3	1.1	3.4	-0.8	-1.1	-0.1	-0.3	0.9	-1.7	0.7	-1.8	-1.3	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.9	1.4	1.7	1.1	1.5	-0.7	1.3	-1.1	1.7	-0.9	1.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.5	1.4	1.5	1.4	1.6	-0.6	0.3	-1.0	1.4	-0.7	1.3
Qualifications: None of the above	1.0	2.1	6.0	2.4	1.2	1.0	1.9	-2.5	0.6	-0.1	0.3	0.4	1.5
Financial difficulties in last 2 years	2.2	2.9	6.0	-2.4	-1.8	-2.3	-2.2	0.0	1.3	0.9	0.0	1.6	-2.1
Mouth/teeth dental problems	0.5	0.7	2.5	0.2	-0.1	-0.8	-0.1	1.3	-1.6	-0.8	-0.3	-1.1	-0.7
Heart attack	0.4	0.5	1.3	-0.1	-0.4	0.3	-0.6	-1.0	0.9	0.3	-0.2	1.1	-0.9
Allergy	4.1	9.5	19.2	-4.3	-3.5	-4.4	-3.9	-1.4	0.4	2.7	-1.9	2.1	-3.5
Pain all over the body in last month	1.4	1.5	3.9	-1.2	-1.2	-0.5	-0.9	2.0	-0.7	1.5	-1.9	0.4	-0.8
Diabetes (self-reported)	0.0	0.0	0.2	0.3	-0.0	0.4	0.1	-0.3	-0.1	0.0	-0.1	0.1	-0.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.6	1.6	1.0	1.0	1.3	0.3	-0.9	-0.9	0.7	-1.1	0.5
Medication: Ramipril	1.0	1.3	2.8	0.7	1.1	1.3	1.0	0.3	1.7	-0.8	1.2	-1.2	1.5
Medication: Simvastatin	0.5	0.7	2.0	-0.6	-0.9	0.0	-0.7	-0.6	-1.4	0.2	-1.2	1.0	-0.9
Fluid intelligence score	0.4	0.7	2.3	-1.5	-0.1	-0.7	-0.4	0.8	-1.0	-1.1	0.0	-1.3	-0.1
Illnesses of siblings	0.9	1.2	3.9	-2.0	-0.6	-1.1	-1.0	1.8	-0.5	0.6	-1.1	-0.8	-0.6
Neuroticism score	0.8	1.6	3.1	-1.3	-1.5	-1.4	-1.4	-0.8	0.0	0.9	-1.1	1.8	-1.7
Weight	7.1	34.9	75.9	-8.7	-7.5	-8.6	-7.5	0.6	-1.4	3.5	-5.0	2.3	-6.6
Impedance of arm (right)	2.3	10.7	20.1	4.3	4.5	3.8	4.2	-1.0	0.8	-2.3	3.5	-1.7	3.8
Arm fat percentage (right)	0.9	3.6	10.2	-3.2	-2.1	-2.4	-2.6	-0.7	0.2	0.6	-0.1	1.2	-2.5
Trunk fat-free mass	8.9	51.1	103.5	-10.1	-9.3	-10.2	-8.6	1.4	-2.9	4.7	-7.2	1.9	-7.5
Hip circumference	2.7	11.7	30.7	-5.5	-4.3	-4.8	-4.4	-0.3	-1.1	1.3	-2.2	1.8	-3.8
Time employed in main current job	0.3	0.3	1.0	0.5	-0.0	0.8	-0.0	0.8	1.0	0.8	-0.3	0.1	-0.0
Alcohol intake versus 10 years previously	2.5	3.7	10.2	1.1	1.7	2.1	1.9	0.9	-3.2	-2.7	1.1	-1.4	1.8
Father’s age at death	0.3	0.4	2.5	0.2	0.1	-1.1	0.3	0.2	0.2	-0.2	0.5	-1.6	0.1
Worrier / anxious feelings	0.6	1.1	3.2	-0.7	-1.3	-1.8	-1.0	-0.1	-0.2	0.9	-0.8	1.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.2	-1.7	-1.8	-1.1	-0.8	-0.1	-1.5	-0.1	-1.3	0.7	-1.1
Falls in the last year	1.1	1.5	6.9	-0.7	-0.9	-0.7	-1.1	-0.7	2.6	1.8	-0.1	1.1	-0.8
Hair/balding pattern: Pattern 3	0.6	0.9	1.3	1.1	1.1	1.1	1.1	-1.1	-0.5	-0.8	0.7	0.6	1.0
Number of live births	0.8	1.1	3.0	-0.5	-0.9	-1.4	-1.0	0.2	1.7	1.5	-0.8	0.5	-1.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.7	-1.6	-1.6	-0.9	-0.9	0.9	-1.4	1.1	-2.2	-1.1	-0.5
Pulse rate	0.2	0.4	1.7	-0.9	-0.1	-0.4	-0.5	0.2	1.3	0.0	0.9	-0.1	0.1
Happiness	1.1	1.4	3.7	-0.8	-1.4	-1.1	-1.2	1.9	-0.6	0.6	-1.5	0.6	-1.2
Noisy workplace	0.2	0.2	1.0	-0.1	0.2	-0.1	0.0	0.7	0.4	-0.2	1.0	-0.8	-0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.7	0.4	-0.4	0.1	0.2	-0.8	-0.7	0.5	-0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.5	-0.4	-0.2	-1.1	0.1	0.1	-1.9	-0.8	-0.0	-1.5	-0.1
Mouth/teeth dental problems: Dentures	0.7	1.2	5.7	1.2	1.1	0.5	0.6	-0.3	2.4	1.2	0.9	0.1	0.8
Asthma	3.8	7.5	16.4	2.9	3.1	4.0	2.9	2.2	0.3	-2.7	2.3	-2.0	3.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.2	0.7	0.5	0.7	0.4	-1.7	1.8	0.2	1.1	0.5	1.1
Medication: Cholesterol lowering	0.8	1.2	2.3	-1.5	-1.3	-1.2	-1.3	0.1	-0.9	0.3	-1.2	0.7	-1.4
Depression (self-reported)	0.4	0.5	1.9	0.5	0.6	1.4	0.5	0.5	0.9	-0.1	0.4	-0.3	0.8
Medication: Lansoprazole	0.2	0.2	0.7	-0.4	0.2	-0.6	0.2	0.0	-0.6	-0.4	-0.1	-0.8	0.1
Prospective memory result	1.1	1.3	2.0	1.2	1.4	1.1	1.4	0.7	-1.3	-1.3	1.3	-0.5	0.8
Lung cancer (father)	3.9	4.5	7.7	-2.0	-2.5	-2.8	-2.5	-0.2	0.3	2.3	-2.0	2.2	-2.7
Illnesses of mother	0.1	0.1	0.4	-0.1	0.3	-0.4	0.1	0.5	0.1	-0.3	0.6	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	7.0	-2.0	-1.9	-1.2	-1.2	1.0	-2.2	1.1	-2.6	-0.9	-0.7
Pulse wave Arterial Stiffness index	1.3	1.5	6.1	-1.6	-1.5	-2.5	-1.2	0.1	-0.1	0.5	-0.2	-0.3	-1.4
Impedance of arm (left)	2.3	10.8	20.5	4.5	4.4	3.8	4.2	-0.8	0.8	-2.5	3.4	-1.6	3.8
Arm fat mass (right)	3.7	15.3	36.4	-6.0	-4.8	-5.6	-5.2	-0.1	-0.6	2.1	-2.4	1.9	-4.6
Trunk predicted mass	8.9	50.6	102.0	-10.0	-9.3	-10.1	-8.6	1.6	-2.9	4.7	-7.3	1.9	-7.5
Standing height	4.3	43.1	105.9	-8.9	-8.1	-10.3	-7.3	2.1	-4.0	3.8	-7.4	0.7	-6.0
Length of working week for main job	0.2	0.2	0.4	-0.6	0.1	0.2	-0.5	0.5	0.4	0.2	0.5	0.6	0.1
Exposure to tobacco smoke at home	0.3	0.4	1.5	1.0	-0.3	-0.4	0.1	-1.2	0.6	-0.2	0.3	0.8	-0.1
Breastfed as a baby	0.7	0.9	5.8	-0.9	-0.3	-1.0	-0.4	-2.4	-0.1	0.3	-0.5	0.5	-0.1
Tense / ‘highly strung’	0.2	0.3	1.1	-1.1	-0.1	-0.4	-0.7	0.7	-0.2	-0.5	-0.1	0.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.8	-0.5	-0.9	-1.6	-0.8	-1.9	1.9	2.0	-0.4	0.8	-1.2
Hair/balding pattern: Pattern 4	1.7	4.2	9.2	2.0	2.4	3.0	2.3	-0.2	1.2	-1.0	2.3	-1.6	2.8
Birth weight of first child	0.3	0.6	1.8	-1.0	-0.8	-1.3	-0.4	-0.2	0.2	0.7	-0.9	-1.0	-0.3
Peak expiratory flow (PEF)	0.6	1.4	3.2	-1.7	-1.4	-1.0	-1.2	0.9	0.2	1.4	-1.8	-0.5	-0.7
Pulse wave reflection index	1.4	1.7	3.0	1.5	1.0	1.2	1.7	-0.4	-1.5	-1.6	0.9	-1.5	1.0
Ever highly irritable/argumentative for 2 days	2.0	2.4	7.8	-2.8	-1.7	-1.5	-2.3	0.4	0.7	1.3	-0.8	1.2	-1.4
Loud music exposure frequency	0.5	0.5	2.2	-0.7	-0.6	-0.4	-0.5	0.8	-0.3	1.5	-0.9	-0.6	-0.3
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	5.3	-2.3	-0.5	-1.7	-0.7	1.2	-1.2	-1.5	0.7	-1.6	-0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.8	0.2	0.3	1.3	0.5	0.2	0.2	-0.2	0.4	0.2	0.9
Blood clot in the leg (DVT)	0.4	0.6	1.9	-0.7	-0.4	-1.4	-0.3	0.7	0.5	1.1	-0.8	-0.7	0.1
Medication: Paracetamol	0.5	0.8	2.3	-0.1	0.8	-0.6	0.4	1.3	-0.9	-1.2	1.1	-1.5	0.3
Headache pain in last month	0.5	0.8	2.1	1.0	0.8	0.6	1.1	-0.6	0.7	-1.1	1.4	-0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.4	0.2	-0.2	-0.5	-0.2	0.1	0.6	0.4	0.2	0.0	-0.3
Glaucoma (self-reported)	0.9	1.1	3.3	-1.8	-0.4	-0.3	-1.2	1.8	-1.3	-0.8	0.1	-0.2	-0.5
Gout (self-reported)	0.6	0.8	3.5	-0.3	-0.5	-0.9	0.2	-1.1	-1.9	0.0	-1.1	-1.0	0.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	5.2	-0.2	-0.3	-0.4	-0.4	-2.3	-0.7	-0.7	0.3	1.4	-0.5
Medication: Amlodipine	0.1	0.2	0.4	-0.1	0.1	0.4	0.3	0.4	0.6	0.2	-0.5	-0.5	0.6
Medication: Ventolin 100micrograms inhaler	2.5	3.2	7.0	2.3	1.9	2.6	1.9	0.8	-0.7	-2.1	1.7	-0.8	1.9
Birth weight	1.9	4.1	7.8	-2.4	-2.4	-2.8	-2.5	-0.4	0.5	2.2	-1.7	1.6	-2.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.5	-0.5	-1.6	-1.2	-1.3	-0.5	0.6	1.2	-1.1	1.5	-1.4
High blood pressure (siblings)	2.0	2.8	6.6	2.6	1.6	1.9	1.8	-1.8	1.4	-0.7	2.2	0.2	1.5
Forced vital capacity (FVC), Best measure	0.4	1.4	4.3	-0.9	-1.2	-0.2	-0.5	1.2	-2.0	0.8	-2.1	-1.2	-0.1
Body fat percentage	0.6	2.4	7.1	-2.7	-1.3	-2.3	-2.1	-1.0	0.5	-0.1	0.5	1.0	-1.9
Leg fat percentage (right)	0.3	1.1	3.3	-1.8	-0.3	-1.1	-1.3	-0.8	0.8	-0.2	1.2	0.4	-1.2
Arm fat-free mass (right)	8.6	44.3	91.8	-9.5	-8.6	-9.6	-8.2	1.7	-2.3	4.2	-6.5	1.9	-7.0
Exposure to tobacco smoke outside home	2.1	2.8	7.9	-2.8	-1.8	-2.6	-1.8	0.2	-1.9	-1.0	-0.4	0.1	-1.5
Comparative body size at age 10	1.1	3.1	6.4	-1.1	-2.2	-0.3	-1.7	-0.1	2.4	2.5	-1.9	1.6	-1.8
Number of full brothers	0.2	0.2	0.5	0.6	0.2	0.7	0.5	0.4	0.2	0.4	0.2	0.2	0.7
Worry too long after embarrassment	0.1	0.2	0.7	-0.4	-0.1	-0.8	-0.2	-0.5	-0.3	-0.3	0.2	0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	6.0	-0.5	-0.5	-1.1	-0.6	0.1	2.4	1.6	0.1	0.4	-0.8
Wheeze or whistling in the chest in last year	0.3	0.4	2.5	-0.3	-0.0	-0.2	0.2	0.5	-0.9	-1.6	0.4	-0.8	0.1
Number of children fathered	0.7	0.8	1.9	-1.3	-0.6	-0.8	-1.2	0.1	0.8	1.4	0.4	0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.7	1.4	1.9	1.9	1.8	-1.4	-1.1	-1.1	1.6	-0.4	1.7
Age at first live birth	0.3	0.6	3.2	0.5	-0.6	-0.6	-0.3	-0.6	1.8	0.5	0.3	0.6	-0.7
Pulse wave peak to peak time	0.6	0.7	3.2	1.0	0.8	1.8	0.6	0.0	-0.2	-0.1	-0.6	0.6	0.9
Health satisfaction	2.2	2.8	4.5	-1.8	-2.1	-1.6	-2.1	1.8	0.8	1.5	-1.3	1.3	-2.0
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.4	-0.4	-0.2	-0.5	0.5	0.5	-0.2	0.1	0.2	-0.6
Qualifications: College or University degree	0.3	0.8	3.3	-1.8	-0.6	-0.7	-1.5	0.2	0.3	0.1	-0.1	1.0	-0.9
Eye problems/disorders: None of the above	1.9	2.2	4.1	1.5	1.6	1.0	2.0	0.1	-0.5	-2.0	1.3	-1.9	1.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.2	-1.1	-1.1	-0.9	-1.1	-0.1	-0.5	1.0	-0.8	1.0	-0.8
Emphysema/chronic bronchitis	2.7	3.0	8.0	-0.6	-1.7	-1.7	-1.7	0.8	2.1	2.8	-2.0	1.4	-1.6
Medication for pain relief, constipation, heartburn	0.8	1.3	3.5	1.3	1.3	0.9	1.7	-0.0	-0.7	-0.6	0.4	-1.4	1.9
Neck or shoulder pain in last month	0.4	0.5	2.9	-0.8	-0.7	-1.7	-0.1	0.2	-0.4	-0.5	-0.6	-0.7	-0.2
Medication: Blood pressure	0.3	0.5	1.4	0.1	0.6	1.2	0.7	-0.2	-0.4	-0.9	0.4	-0.6	1.0
Angina (self-reported)	0.9	1.1	4.6	-0.1	-0.2	-0.7	-0.8	-1.0	2.1	1.2	0.5	1.3	-1.0
Migraine (self-reported)	0.6	0.7	3.3	-0.5	0.4	-0.3	0.2	-0.2	-1.3	-1.8	0.8	-0.6	0.4
Medication: Ibuprofen	0.5	0.6	1.9	0.2	0.2	0.6	0.0	-1.3	1.4	0.2	0.8	0.7	0.8
Medication: Allopurinol	0.5	0.6	3.3	-0.2	-0.6	-1.0	-0.2	-1.8	-1.0	-0.0	-0.8	-0.3	-0.1
Medication: Omeprazole	2.1	2.5	5.6	-2.4	-2.0	-1.7	-2.2	0.2	-0.1	1.0	-1.2	1.2	-1.9
Medication: Seretide 50 evohaler	2.6	3.0	8.8	2.6	1.7	3.0	1.9	-0.9	0.5	-1.1	1.2	0.5	2.0
Mean time to correctly identify matches	0.3	0.6	1.1	0.6	1.0	0.0	1.0	-0.4	-1.1	-0.6	0.1	-0.9	0.9
Heart disease (mother)	0.7	0.8	2.9	-0.0	-0.0	-0.1	-0.7	1.1	1.7	1.2	0.2	0.6	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.2	1.3	1.1	0.7	1.2	-1.5	1.0	-0.6	1.1	-1.0	0.9
Whole body fat mass	3.3	14.0	34.3	-5.9	-4.5	-5.5	-4.9	-0.4	-0.6	1.7	-2.2	1.8	-4.3
Leg fat mass (right)	2.6	10.2	26.5	-5.2	-3.8	-4.6	-4.3	-0.3	-0.2	1.6	-1.7	1.3	-3.9
Arm predicted mass (right)	8.8	45.0	92.8	-9.5	-8.7	-9.6	-8.2	1.7	-2.2	4.3	-6.7	1.9	-7.1
Pulse rate, automated reading	0.1	0.5	1.9	-1.4	0.0	0.3	-0.8	0.7	1.1	0.3	0.4	0.5	0.1
Alcohol intake frequency.	0.1	0.3	0.9	0.3	0.2	-0.3	0.6	-0.5	-0.6	-1.0	0.4	-0.3	0.7
Comparative height size at age 10	3.1	16.9	48.4	-5.5	-4.9	-7.0	-4.5	1.1	-2.0	2.6	-4.3	-0.6	-3.9
Number of full sisters	1.1	1.3	2.8	-1.0	-1.1	-1.6	-1.3	-0.8	-0.1	1.1	-0.3	1.7	-1.4
Suffer from ‘nerves’	0.7	1.1	3.7	-1.9	-1.2	-0.9	-1.2	0.3	-0.8	-0.2	-0.9	0.4	-1.2
Overall health rating	0.9	2.0	4.1	-1.6	-1.5	-1.7	-1.5	2.0	1.1	1.2	-1.0	0.7	-1.5
Chest pain or discomfort	0.4	0.6	1.8	-0.8	-1.0	-1.3	-0.7	0.5	-0.7	0.5	-0.9	0.3	-0.7
Had major operations	0.4	0.5	1.3	0.6	1.1	0.7	0.5	-1.1	0.5	-0.1	0.5	-0.2	0.6
Age at last live birth	2.0	2.8	5.1	-1.1	-1.6	-1.8	-1.9	1.5	2.3	1.9	-0.9	1.4	-2.0
Family relationship satisfaction	0.9	1.1	2.8	-1.4	-0.6	-0.6	-0.6	1.7	-1.5	0.2	-1.4	-0.8	-0.1
Leg pain on walking	0.3	0.3	1.1	-0.5	-0.5	-1.1	-0.6	0.5	0.2	0.3	-0.0	-0.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	-0.9	-0.4	-0.5	-0.5	0.1	-0.5	-0.9	0.6	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.4	-0.6	-0.6	0.2	-0.7	-0.4	1.4	1.5	-0.2	0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	9.0	1.9	1.5	3.0	1.6	-0.6	-0.2	-0.7	0.3	-0.1	2.2
Medication: Aspirin	1.9	2.5	7.2	-1.0	-1.6	-0.4	-1.8	-0.8	0.3	1.5	-1.7	2.2	-2.7
Supplements: Vitamin C	0.1	0.2	0.7	0.3	0.4	-0.2	0.5	-0.8	-0.2	-0.3	-0.4	0.0	0.5
Knee pain experienced in last month	1.5	2.4	5.7	0.6	1.2	0.8	1.5	-2.4	-2.3	-2.3	0.9	-0.3	1.3
Hypertension (Self-reported)	0.1	0.2	0.9	-0.5	0.1	0.3	-0.4	0.8	0.9	0.3	0.0	0.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	7.3	-0.9	-1.6	-1.0	-1.6	-0.6	-0.1	1.1	-1.8	2.7	-1.9
Illnesses of father: Heart disease	0.2	0.3	1.3	0.1	0.3	-0.8	-0.1	1.2	0.4	-0.0	-0.3	-0.8	0.1
Illnesses of siblings: Diabetes	0.7	0.8	3.5	1.9	0.2	0.7	1.0	-0.4	-1.0	-1.2	0.2	0.6	0.3
Smoking status: Previous	0.7	1.0	1.8	1.0	1.1	0.8	1.2	0.6	-1.3	-0.9	0.4	-1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.7	11.8	-3.2	-2.5	-3.4	-1.8	2.3	-3.1	0.2	-2.5	-1.4	-1.3
Whole body fat-free mass	9.8	56.0	114.5	-10.7	-9.7	-10.6	-9.1	1.6	-2.8	4.9	-7.4	2.1	-7.9
Leg fat-free mass (right)	10.3	55.1	112.4	-10.6	-9.8	-10.3	-9.1	1.7	-2.5	4.8	-7.3	2.4	-8.0
Arm fat percentage (left)	0.9	3.8	10.3	-3.2	-2.2	-2.5	-2.7	-0.5	0.2	0.6	-0.2	1.3	-2.6
Average weekly red wine intake	0.7	1.0	3.8	0.1	1.0	1.9	0.7	-0.7	0.1	-1.7	0.9	-0.3	0.7
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	0.7	1.1	1.1	1.0	0.2	-0.4	-1.1	1.6	-1.1	0.9
Mood swings	0.2	0.3	0.9	-0.6	-0.7	-0.1	-0.5	-0.9	0.4	0.3	0.2	0.9	-0.7
Loneliness, isolation	0.4	0.6	1.9	0.4	0.6	-0.2	1.0	-1.4	-0.4	-0.7	0.4	-1.0	0.8
Long-standing illness, disability or infirmity	0.6	0.8	1.6	-0.2	-1.1	-1.3	-0.7	0.9	0.7	1.2	-1.1	0.7	-0.8
Ever had bowel cancer screening	0.9	1.0	2.8	-0.4	-0.9	-1.1	-0.9	-0.6	0.1	1.2	-1.5	1.7	-1.0
Diabetes diagnosed by doctor	0.0	0.0	0.1	0.3	-0.0	-0.0	0.2	-0.4	-0.4	-0.2	-0.1	-0.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	4.9	-0.2	0.3	-0.2	-0.3	0.7	2.2	0.8	1.4	-0.3	0.2
Friendships satisfaction	0.9	1.1	2.0	-1.4	-1.3	-0.6	-1.4	0.5	-0.8	1.0	-1.3	0.8	-1.2
Qualifications: nursing, teaching	0.7	1.1	5.8	-1.3	-0.1	-1.1	-0.8	2.4	-0.5	0.0	-0.2	-0.8	-0.7
Commuting to job workplace: Walk	0.9	1.0	2.9	0.6	0.9	0.9	1.0	0.7	-1.3	-1.7	0.2	-1.0	1.0
Eye problems/disorders: Cataract	1.6	1.9	4.5	-0.7	-1.2	-1.0	-1.4	-1.3	0.7	2.0	-1.4	2.1	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.8	-1.7	-1.5	-1.4	-1.5	-2.0	1.0	0.8	-0.9	2.2	-1.2
Medication for cholesterol	0.3	0.5	1.8	1.3	0.6	-0.3	0.8	0.5	0.1	-0.6	1.1	-0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.4	-0.7	-0.6	-0.9	-1.1	1.1	0.9	1.0	-0.0	0.3	-1.6
Back pain experienced in last month	1.4	2.1	3.5	-0.8	-1.6	-1.5	-1.3	0.7	0.8	1.9	-1.5	1.7	-1.9
Mineral and other dietary supplements	0.9	1.2	7.7	0.1	0.8	1.2	0.4	2.8	0.3	-0.0	0.7	-1.1	0.5
Breast cancer (self-reported)	2.5	2.9	5.0	-1.3	-1.8	-1.5	-2.0	2.1	0.6	2.0	-1.7	1.1	-2.2
Asthma (self-reported)	4.0	7.9	17.8	3.1	3.2	4.2	3.1	1.9	0.4	-2.7	2.4	-1.9	3.3
Osteoporosis (self-reported)	0.8	1.0	2.9	-0.3	-1.1	-1.1	-0.4	-1.7	-0.3	1.0	-1.6	0.5	-0.5
Osteoarthritis (self-reported)	0.5	0.6	2.6	-0.6	-0.8	0.1	-0.6	-0.0	-0.5	-0.0	-1.0	1.6	-1.0
Medication: Aspirin	3.2	4.1	11.2	-1.9	-2.2	-1.1	-2.6	-0.0	-0.0	1.9	-2.1	2.3	-3.3
Medication: Gliclazide	0.3	0.4	1.7	-1.3	-0.3	-0.8	-0.6	0.0	-0.6	-0.1	-0.2	-0.4	-0.7
Illnesses of father: None of the above (group 1)	0.6	0.7	2.4	-0.6	0.3	-0.1	0.4	1.3	-1.3	-0.4	0.0	-1.6	0.7
Smoking status: Current	0.8	1.3	3.5	-1.9	-1.2	-1.5	-1.5	-0.0	-0.1	0.9	-0.4	1.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.5	0.4	0.4	1.3	0.4	1.9	-0.4	-0.2	-0.2	-1.2	0.2
Whole body water mass	9.8	55.9	114.5	-10.7	-9.7	-10.6	-9.1	1.7	-2.7	5.0	-7.4	2.1	-7.9
Leg predicted mass (right)	10.4	55.6	114.5	-10.7	-9.8	-10.3	-9.1	1.8	-2.6	4.8	-7.3	2.3	-8.0
Arm fat mass (left)	3.6	14.6	34.9	-5.9	-4.8	-5.3	-5.1	0.0	-0.5	2.0	-2.4	1.9	-4.5
Number of self-reported non-cancer illnesses	0.6	1.1	3.0	1.7	1.3	1.4	1.3	-0.1	0.7	-0.4	0.6	-0.0	1.1
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.6	0.3	0.6	-0.1	0.6	-0.2	-0.8	0.1	-0.6	0.4
Miserableness	0.6	1.0	2.3	-0.4	-1.2	-1.1	-0.8	0.1	0.6	1.5	-1.4	1.1	-1.0
Guilty feelings	1.3	2.0	7.1	-0.5	-1.2	-1.2	-1.0	-2.7	0.1	-0.2	-0.0	2.5	-1.4
Wears glasses or contact lenses	0.3	0.3	1.2	0.8	0.1	0.5	0.1	-1.1	0.2	0.5	-0.2	0.8	-0.1
Ever taken oral contraceptive pill	3.2	3.5	7.7	2.3	2.0	2.8	2.2	0.2	-0.2	-2.0	1.7	-1.4	2.2
Hearing aid user	3.3	3.7	5.7	2.1	2.4	2.3	2.2	0.2	2.3	-1.0	2.1	-1.1	2.4
Mother’s age at death	1.2	1.5	9.3	-0.4	-0.4	-0.9	-0.5	-3.0	-0.0	0.2	-0.1	2.1	-0.4
Financial situation satisfaction	0.3	0.4	1.0	-1.0	-0.7	-0.4	-0.8	0.2	0.2	0.0	-0.1	0.7	-0.8
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.8	1.4	1.5	1.4	1.3	-0.1	1.7	-0.3	0.9	-0.6	1.4
Commuting to job workplace: Public transport	1.3	1.6	5.7	-2.1	-0.6	-2.4	-1.2	1.0	-1.1	-0.7	-0.2	-0.4	-1.0
Eye problems/disorders: Glaucoma	0.5	0.6	2.7	-0.4	-0.2	0.7	-0.3	1.6	-1.3	-0.6	-0.3	0.0	-0.1
Medication: Blood pressure	0.2	0.4	2.6	-0.0	0.7	1.6	0.0	-0.7	0.5	-0.1	0.6	0.6	0.1
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.5	-1.9	-1.5	-1.8	-1.8	-0.3	0.5	1.1	-1.1	1.1	-1.8
Supplements: Fish oil (including cod liver oil)	1.8	2.4	10.9	-0.3	-0.9	-1.6	-0.9	-3.3	1.6	0.8	-0.3	2.0	-1.1
High cholesterol (Self-reported)	0.6	1.0	4.4	-1.0	-0.8	-0.8	-0.7	0.3	-2.1	-0.2	-1.3	0.1	-1.0
Medication: Bendroflumethiazide	0.7	1.1	3.1	0.5	0.9	1.7	1.1	0.2	-1.5	-1.2	-0.1	-0.6	1.2
Medication: Paracetamol	1.4	2.2	5.4	0.3	1.7	0.6	1.3	1.2	-1.1	-2.1	1.8	-2.3	1.3
Medication: Lisinopril	0.3	0.4	1.7	-0.5	-0.1	0.1	-0.0	0.3	-1.3	-0.4	-0.9	-0.9	-0.1
Medication: Atorvastatin	1.6	2.0	3.7	-1.7	-1.5	-1.2	-1.7	0.9	-0.7	1.3	-1.9	0.7	-1.9
Illnesses of father: High blood pressure	0.9	1.1	5.3	1.0	0.7	1.3	0.8	-0.5	2.3	-0.1	1.0	-0.0	0.9
Alcohol drinker status: Never	0.8	0.9	7.5	0.4	0.3	-0.6	0.0	-0.1	2.7	0.7	0.9	-0.2	-0.1
Ever smoked	0.2	0.3	0.9	-0.2	0.3	0.0	0.0	0.6	-1.0	-0.3	0.9	-0.6	-0.0
Basal metabolic rate	9.5	52.7	110.2	-10.5	-9.4	-10.4	-8.9	1.5	-2.5	4.6	-6.9	2.1	-7.7
Leg fat percentage (left)	0.3	0.9	2.0	-1.4	-0.2	-0.7	-1.1	-0.8	1.1	-0.3	1.3	0.8	-1.1
Arm fat-free mass (left)	8.9	45.2	95.5	-9.8	-8.5	-9.6	-8.3	1.7	-2.0	4.5	-6.4	1.9	-7.1
Number of operations (self-reported)	1.1	1.7	2.9	-1.0	-1.2	-1.7	-1.6	-1.2	0.2	1.4	-1.4	1.2	-1.4
Average weekly beer plus cider intake	1.9	2.7	9.5	-0.8	-1.9	-3.1	-1.0	-0.7	2.0	2.2	-1.2	0.2	-1.3
Irritability	0.4	0.6	1.6	-1.2	-0.9	-0.0	-0.9	-0.3	-0.0	0.7	-1.0	0.9	-0.6
Risk taking	0.6	0.9	2.3	-1.3	-0.5	-0.6	-1.3	0.4	1.5	0.8	1.0	0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	1.0	0.6	0.9	0.5	-0.0	-0.6	0.0	0.1	0.4	0.2
Fractured/broken bones in last 5 years	4.5	5.8	11.4	-2.0	-3.0	-2.8	-2.6	-0.2	0.8	3.4	-3.2	1.9	-2.0
Age started oral contraceptive pill	0.2	0.3	0.8	0.5	0.0	-0.1	-0.1	0.9	0.7	0.9	-0.3	-0.4	-0.4
Diastolic blood pressure, automated reading	0.2	0.8	2.0	-1.0	-0.1	0.3	-1.0	1.2	1.4	-0.6	1.1	0.3	-0.6
Ever depressed for a whole week	0.1	0.1	0.3	0.0	-0.1	-0.2	-0.2	0.1	0.5	0.5	-0.4	0.5	-0.1
Unable to work because of sickness or disability	2.2	2.8	6.0	-1.2	-1.7	-2.4	-1.8	-0.9	1.9	2.5	-0.2	1.4	-1.6
Commuting to job workplace: Cycle	2.2	2.6	7.2	-1.4	-1.6	-2.7	-1.9	1.1	-0.5	1.3	-1.6	0.8	-2.1
Myopia	0.7	1.0	2.4	0.5	1.2	0.2	1.0	-1.2	0.1	-1.2	1.5	-1.2	0.7
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.5	0.2	-0.1	-0.5	0.4	-0.7	-1.2	-0.7	0.0	-0.5	0.6
Cholesterol lowering medication	0.4	0.6	1.8	-0.8	-0.7	-0.1	-0.8	-0.1	-0.4	0.9	-1.3	0.9	-0.8
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	6.4	-2.5	-2.0	-1.9	-2.1	0.7	-0.6	0.7	-1.4	0.9	-1.8
Pain experienced in last month	0.3	0.5	1.1	-0.9	-0.4	-0.7	-0.7	0.9	-1.0	0.0	-0.0	-0.8	-0.3
Supplements: Calcium	1.6	1.7	3.9	-1.5	-1.5	-1.3	-1.5	-1.0	0.8	2.0	-1.0	1.2	-0.8
Basal cell carcinoma (self-reported)	1.6	1.9	4.3	-1.3	-1.4	-0.9	-1.3	2.0	-0.3	1.4	-2.1	-0.3	-1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	-0.2	-0.5	0.4	-0.7	-0.9	0.7	0.4	-0.4	1.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.3	0.2	-0.9	0.1	1.0	0.4	0.7	-0.4	-0.9	0.3
Heart disease (siblings)	1.3	1.6	3.3	-1.2	-1.2	-1.5	-1.5	-1.3	0.0	0.6	-0.4	1.8	-1.5
Alcohol drinker status: Previous	1.0	1.1	3.3	-1.6	-1.0	-1.8	-1.5	0.2	0.7	0.1	-0.0	0.7	-1.2
Pack years of smoking	1.7	2.5	5.0	-0.6	-1.5	-1.3	-1.5	-1.6	2.2	2.0	-0.4	2.1	-1.4
Impedance of whole body	4.2	21.2	41.3	6.4	6.2	5.5	5.8	-0.9	1.4	-3.5	4.6	-2.1	5.4
Leg fat mass (left)	2.4	9.4	24.5	-5.0	-3.7	-4.3	-4.1	-0.3	-0.2	1.4	-1.6	1.4	-3.7
Arm predicted mass (left)	9.3	47.4	97.6	-9.9	-8.8	-9.8	-8.5	1.6	-2.0	4.6	-6.7	2.2	-7.3