Hub : Genes

RAPGEF6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.164	0.0710	1.1e-10	0.090	0.093	0.108	0.098	0.106	4.1e-11	2.1e-11	4.4e-13	5.5e-12	7.9e-13
2	GTEx	Testis	0.503	0.0820	1.3e-10	0.352	NA	0.312	NA	0.322	2.0e-16	NA	2.2e-14	NA	6.5e-15
3	ROSMAP	Brain Pre-frontal Cortex	0.157	0.0622	0.0e+00	0.199	0.206	0.201	0.203	0.204	5.6e-25	6.1e-26	2.8e-25	1.5e-25	1.1e-25
4	TCGA	Skin Cutaneous Melanoma	0.133	0.0800	3.4e-03	0.073	0.064	0.020	NA	0.039	5.2e-03	8.8e-03	9.3e-02	NA	3.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.7	0.8	-0.4	0.5	-0.1
Bipolar Disorder or Schizophrenia	0.3	0.8	1.3	1.0	-0.2	1.1	-1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	-1.0	-0.1	-0.7	0.8
Depression (Nagel 2018)	0.2	0.3	0.8	-0.3	-0.9	-0.1	0.5
Intelligence (Savage-Jansen 2018)	1.7	5.3	6.7	-2.5	1.9	-2.1	2.6
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.2	-0.1	0.4	-0.1
Schizophrenia (2018)	0.4	0.8	1.6	0.6	0.1	1.1	-1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	-0.8	0.1	-0.4	0.4
Worry (Nagel 2018)	0.1	0.1	0.2	-0.1	-0.4	0.4	-0.4
Alzheimer’s Disease (in mother)	0.0	0.1	0.1	0.3	-0.2	0.3	-0.1
Alzheimer’s Disease (in father)	0.4	0.4	0.5	0.6	0.7	0.7	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.2	0.8	0.1	0.1
Crohns Disease (2017)	7.7	16.8	24.8	-5.0	-4.4	-3.3	3.4
Irritable Bowel Disease (IBD)	4.8	11.5	25.0	-3.5	-5.0	-2.0	2.1
Ulcerative Colitis (UC)	1.6	2.9	11.0	-0.8	-3.3	0.0	-0.1
Major Depression (MDD)	0.8	1.0	2.1	0.7	-1.4	0.9	-0.8
Reaction Time	0.0	0.1	0.1	-0.1	-0.4	0.3	-0.0
Verbal and Numeric Reasoning (VNR)	1.3	3.0	4.9	-1.8	2.2	-1.4	1.4
Breast Cancer	3.0	7.3	13.2	2.3	-0.0	3.6	-3.3
Ovarian Cancer	0.4	0.5	1.1	0.7	-1.0	0.4	-0.3
Prostate Cancer	0.4	0.5	0.9	0.8	0.1	0.8	-0.9
Age at First Birth	0.4	0.6	1.1	0.2	-1.0	0.7	-0.9
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	0.4	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.5	-0.1	-0.9	-1.1	1.2
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.0	0.3	-0.8	0.7
Crohns Disease (2012)	10.0	16.1	28.5	-5.3	-3.5	-3.4	3.5
Mean Putamen Volume	1.2	1.3	3.6	-1.0	-1.9	-0.5	0.7
Fasting Glucose	1.8	2.1	7.5	-0.1	-2.7	0.6	-0.8
HbA1C	0.2	0.2	0.3	0.6	-0.5	0.4	-0.3
HDL Cholesterol	1.2	2.0	3.7	0.7	-1.9	1.6	-1.2
LDL Cholesterol	1.0	1.6	3.0	-1.7	1.0	-0.8	1.4
Lupus	1.2	1.7	6.9	0.3	-2.6	-0.0	0.1
Neuroticism (2016)	0.5	0.8	2.0	0.2	-0.7	1.4	-0.7
Primary Biliary Cirrhosis	0.9	1.3	3.3	1.1	-1.8	0.6	-0.5
Rheumatoid Arthritis	0.4	0.6	1.6	1.3	-0.1	0.1	-0.8
Schizophrenia (2014)	0.8	1.8	2.7	1.4	-0.7	1.5	-1.6
Triglycerides	0.4	0.7	1.2	1.0	1.1	0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	0.9	-0.8	-0.0	-0.0
Ulcerative Colitis	1.2	1.7	6.0	-0.8	-2.4	0.5	-0.2
Blood Eosinophil Count	39.6	304.7	412.1	19.9	5.9	19.4	-20.3
Blood Platelet Count	1.3	15.6	21.5	4.6	4.4	2.7	-3.7
Blood Red Count	0.3	2.7	9.5	1.1	-3.1	-0.1	-0.3
Blood White Count	1.4	10.7	21.6	3.6	4.7	0.9	-2.7
Heel T-Score	1.1	8.6	13.5	-1.3	3.3	-3.7	2.9
BMI	1.1	6.1	8.6	-1.1	-2.9	-2.5	2.8
Height	3.1	60.0	142.0	-6.6	-11.9	-4.1	6.2
Waist Hip Ratio (WHR)	0.2	1.0	3.0	1.1	-1.7	0.1	0.0
Systolic Blood Pressure	0.0	0.2	0.3	0.2	-0.4	-0.6	0.5
Smoking Status	0.2	0.4	1.1	-0.6	-0.1	-0.5	1.1
Allergy or Eczema	0.8	2.0	2.2	1.4	1.4	1.5	-1.4
Cardiovascular Disease	0.7	2.3	3.8	1.9	1.0	1.7	-1.3
Hypothyroidism (self reported)	0.1	0.1	0.3	0.2	0.2	0.2	-0.6
Respiratory disease	1.9	4.2	6.1	2.1	2.5	1.7	-1.8
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	-0.0	0.3	0.1	0.1
Lung FEV1/FVC ratio	0.7	3.5	7.1	-2.7	-2.0	-1.2	1.2
Lung FVC	4.8	24.3	42.5	6.5	2.4	4.4	-5.4
Neuroticism	0.0	0.1	0.2	-0.4	-0.4	-0.0	0.1
Chronotype (morning person)	0.7	1.7	6.5	0.1	2.5	-0.5	0.4
Hair Pigment	0.2	5.1	15.2	1.2	-3.9	1.3	-1.5
Tanning	0.1	1.1	2.7	-0.1	1.6	-1.0	0.9
Hand grip strength (left)	3.9	10.2	40.6	-0.2	-6.4	0.5	-0.1
Number of treatments/medications taken	0.8	1.4	2.6	1.6	0.6	1.2	-1.2
Average weekly spirits intake	0.6	0.8	1.2	-0.6	1.1	-0.9	0.9
Sensitivity / hurt feelings	0.9	1.6	2.2	-1.5	1.3	-0.7	1.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.7	0.0	-1.6	-0.1	0.6
Hearing difficulty/problems: Yes	0.6	0.9	1.4	1.2	1.0	0.8	-0.7
Relative age of first facial hair	0.1	0.2	0.4	0.6	0.3	0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	-0.6	-0.4	-0.4	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	-0.3	0.1	-1.0	0.6
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.2	-0.9	0.5	-0.5
Systolic blood pressure, automated reading	1.9	5.5	9.0	-2.0	-0.8	-3.0	2.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	-0.5	-1.3	-0.3	0.7
Angina	0.9	1.2	1.9	-1.0	-0.4	-1.3	1.4
Medication for hormone replacement therapy	0.9	1.0	2.8	0.8	-1.7	-0.6	0.4
Vitamin and mineral supplements	0.2	0.3	1.0	1.0	-0.4	0.4	-0.0
Supplements: Zinc	1.5	1.6	5.2	0.7	-2.3	-0.4	0.7
Medication: Co-codamol	0.8	0.9	1.9	-1.4	0.4	-0.9	0.9
Medication: Metformin	0.1	0.1	0.2	-0.4	0.2	-0.1	0.4
Diabetes (father)	1.0	1.3	1.8	-1.0	1.2	-1.3	1.0
Diabetes (mother)	2.2	2.8	4.1	2.0	-0.8	1.7	-1.8
Severe depression (siblings)	0.1	0.1	0.3	0.2	-0.5	0.1	-0.2
Pack years adult smoking proportion	1.5	2.3	3.5	-1.2	-1.3	-1.9	1.7
Impedance of leg (right)	2.0	9.7	38.3	0.1	6.2	0.3	-0.7
Leg fat-free mass (left)	4.5	23.7	70.2	-2.6	-8.4	-2.1	3.6
Trunk fat percentage	1.1	4.3	7.9	-1.5	-1.1	-2.4	2.8
Hand grip strength (right)	4.0	11.0	43.7	0.1	-6.6	0.5	-0.1
Townsend deprivation index at recruitment	1.6	2.3	2.8	1.7	-1.4	1.4	-1.5
Current tobacco smoking	0.6	1.0	1.5	-1.0	-0.7	-1.1	1.2
Average weekly fortified wine intake	0.7	0.8	1.5	-0.9	-0.5	-0.8	1.2
Maternal smoking around birth	1.2	1.8	2.6	-1.2	0.7	-1.6	1.6
Fed-up feelings	0.1	0.1	0.3	-0.5	-0.1	-0.2	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.0	0.1	-1.0	0.0	0.0
Relative age voice broke	2.1	3.3	4.3	1.8	1.2	2.1	-2.0
Taking other prescription medications	0.3	0.4	1.1	1.1	-0.7	0.1	-0.2
Age when periods started (menarche)	1.5	3.6	9.2	-1.0	-3.0	-1.5	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	0.7	-1.0	0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	-0.5	0.6	-0.6	0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	-0.5	-0.8	-0.5	1.1
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.1	-0.7	-0.2	0.3
Serious illness, injury or assault to yourself	0.6	0.7	1.2	-1.0	0.4	-0.7	1.1
High blood pressure	0.2	0.5	0.9	-0.2	0.9	-0.8	0.7
Hayfever, allergic rhinitis or eczema	2.2	4.9	6.1	2.5	1.9	2.2	-2.2
Multivitamins +/- minerals	0.3	0.4	0.8	-0.9	0.9	-0.2	-0.1
Stomach or abdominal pain in last month	1.0	1.3	1.9	-1.1	-1.4	-1.2	0.9
Supplements: Glucosamine	0.2	0.3	0.7	0.3	-0.2	0.5	-0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.0	0.5	-1.7	-0.0	-0.2
Medication: Atenolol	1.0	1.2	1.8	1.2	0.1	1.4	-1.2
Medication: Levothyroxine sodium	0.2	0.4	0.8	0.1	0.6	0.6	-0.9
Sitting height	1.2	8.8	28.8	-2.1	-5.4	-0.2	1.3
Chronic bronchitis/emphysema (father)	3.0	3.5	5.3	1.8	-1.1	2.1	-2.3
High blood pressure (mother)	1.9	2.7	5.5	2.3	-0.6	1.6	-1.5
Body mass index (BMI)	0.9	4.0	6.1	-0.9	-2.5	-2.0	2.3
Impedance of leg (left)	2.4	11.5	42.1	0.8	6.5	0.8	-1.6
Leg predicted mass (left)	4.6	24.2	71.9	-2.6	-8.5	-2.1	3.7
Trunk fat mass	2.0	8.5	11.6	-2.1	-3.4	-2.6	3.4
Waist circumference	2.1	7.6	14.4	-1.2	-3.8	-2.5	2.9
Number of incorrect matches in round	1.6	2.6	3.2	1.5	-1.8	1.3	-1.7
Past tobacco smoking	0.8	1.4	3.4	0.5	-1.8	0.8	-1.2
Alcohol usually taken with meals	0.0	0.0	0.1	-0.3	-0.0	0.1	0.0
Nervous feelings	0.3	0.5	0.8	0.7	0.9	0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.4	-1.6	-0.6	-0.7	1.2
Hearing difficulty/problems with background noise	0.7	1.1	1.8	1.1	0.3	1.3	-1.2
Hair/balding pattern: Pattern 2	0.8	1.0	1.4	-1.2	-0.5	-1.1	1.0
Had menopause	0.8	1.0	1.3	-1.0	-0.7	-1.1	1.0
Had other major operations	0.5	0.6	2.2	-0.3	-1.5	-0.4	0.2
Forced vital capacity (FVC)	1.3	5.1	7.6	2.4	-2.8	2.1	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.3	-0.6	1.2	-1.1	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	0.8	0.7	0.4	-0.3
Qualifications: None of the above	0.9	1.9	3.1	0.8	-1.2	1.6	-1.8
Financial difficulties in last 2 years	1.6	2.2	3.2	-1.6	0.4	-1.6	1.8
Mouth/teeth dental problems	0.1	0.2	0.4	-0.3	0.4	-0.3	0.7
Heart attack	0.1	0.1	0.3	0.5	0.5	0.0	-0.3
Allergy	2.5	5.9	8.1	-2.3	-2.8	-2.1	2.4
Pain all over the body in last month	1.2	1.3	2.3	0.3	-1.5	1.1	-1.1
Diabetes (self-reported)	0.0	0.0	0.1	0.1	0.1	0.0	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.0	1.0	0.2	1.0	-0.8
Medication: Ramipril	0.2	0.3	0.8	0.9	-0.5	0.1	-0.3
Medication: Simvastatin	1.6	2.3	4.2	1.2	-0.6	2.0	-1.8
Fluid intelligence score	1.4	2.9	6.2	-1.5	2.5	-1.1	1.4
Illnesses of siblings	0.9	1.2	1.9	-1.3	0.5	-1.0	1.4
Neuroticism score	0.1	0.2	0.5	0.1	-0.7	0.4	-0.3
Weight	3.5	17.1	36.6	-2.8	-6.0	-2.9	3.9
Impedance of arm (right)	0.6	3.0	11.8	-0.0	3.4	-0.3	0.2
Arm fat percentage (right)	0.7	2.7	5.9	-0.6	-1.0	-1.9	2.4
Trunk fat-free mass	4.0	22.7	70.7	-2.6	-8.4	-1.8	3.2
Hip circumference	1.0	4.1	9.3	-1.0	-3.0	-1.4	2.0
Time employed in main current job	0.5	0.5	1.0	0.7	-0.6	0.5	-1.0
Alcohol intake versus 10 years previously	4.3	6.4	10.0	2.2	1.0	3.1	-3.2
Father’s age at death	2.3	3.1	5.3	-2.0	-0.5	-1.7	2.3
Worrier / anxious feelings	0.2	0.3	1.0	-0.4	-1.0	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	6.6	1.8	-2.2	2.6	-1.8
Falls in the last year	0.5	0.7	1.6	0.3	-1.3	-0.9	0.4
Hair/balding pattern: Pattern 3	0.4	0.5	1.5	0.5	1.2	0.5	-0.4
Number of live births	2.3	3.2	4.3	-1.6	-1.8	-2.1	1.7
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	11.3	1.6	-3.4	1.3	-1.0
Pulse rate	0.6	1.0	2.1	-0.6	-0.3	-1.3	1.4
Happiness	0.7	0.8	2.4	-0.5	-1.5	0.7	-0.4
Noisy workplace	0.5	0.6	1.0	-0.3	0.9	-0.8	1.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.1	-0.1	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	-1.0	-0.7	0.3	0.7
Mouth/teeth dental problems: Dentures	2.0	3.5	5.7	-2.1	0.5	-2.4	1.9
Asthma	2.9	5.8	12.3	2.2	3.5	1.6	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.1	0.2	-0.6	0.5
Medication: Cholesterol lowering	0.5	0.8	1.0	0.8	-0.9	1.0	-0.8
Depression (self-reported)	0.9	1.1	2.6	1.6	-0.2	0.7	-1.1
Medication: Lansoprazole	0.5	0.5	1.1	-1.0	-0.1	-0.5	0.9
Prospective memory result	1.0	1.3	2.1	0.6	1.1	1.4	-1.2
Lung cancer (father)	1.1	1.3	2.1	-1.0	-1.4	-1.0	1.0
Illnesses of mother	1.0	1.3	1.9	-1.4	1.1	-0.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	10.2	1.6	-3.2	1.9	-1.6
Pulse wave Arterial Stiffness index	2.4	2.8	3.9	-1.5	-2.0	-1.2	1.9
Impedance of arm (left)	0.7	3.3	13.2	-0.0	3.6	0.2	-0.4
Arm fat mass (right)	1.8	7.5	12.3	-1.6	-3.5	-2.3	3.1
Trunk predicted mass	3.9	22.3	69.4	-2.6	-8.3	-1.7	3.1
Standing height	2.5	24.6	65.5	-4.2	-8.1	-1.7	3.6
Length of working week for main job	0.0	0.1	0.1	-0.2	0.3	-0.2	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.1
Breastfed as a baby	0.3	0.4	0.8	-0.7	-0.9	-0.6	0.3
Tense / ‘highly strung’	0.7	1.2	2.0	-1.1	1.4	-1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.9	-0.4	-2.0	-1.5	1.6
Hair/balding pattern: Pattern 4	0.4	1.0	3.3	1.8	-0.0	0.4	-0.7
Birth weight of first child	0.8	1.4	2.0	-0.9	-1.1	-1.1	1.4
Peak expiratory flow (PEF)	0.7	1.7	6.6	-0.1	-2.6	-0.4	0.3
Pulse wave reflection index	0.8	1.0	2.0	0.9	0.6	1.4	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.0	-0.6	-0.8	0.7
Loud music exposure frequency	0.3	0.4	0.7	0.5	-0.8	0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	-0.8	0.2	-0.9	1.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	1.1	0.6	1.3	-1.4
Blood clot in the leg (DVT)	2.2	2.8	3.7	-1.7	-0.9	-1.9	1.9
Medication: Paracetamol	1.9	3.1	4.6	-1.9	1.4	-1.5	2.1
Headache pain in last month	0.2	0.3	1.2	1.1	0.0	0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.3	-1.5	0.6	-1.4	1.3
Glaucoma (self-reported)	0.6	0.7	1.3	-0.8	1.2	-0.6	0.5
Gout (self-reported)	0.8	1.2	3.0	0.4	-1.7	1.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	0.3	-0.2	0.6	-0.9
Medication: Amlodipine	0.4	0.5	0.9	0.8	-0.9	0.4	-0.6
Medication: Ventolin 100micrograms inhaler	2.8	3.7	5.8	1.7	2.4	1.8	-1.7
Birth weight	1.2	2.6	7.2	-0.9	-2.7	-1.1	1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.8	0.9	-1.7	1.0	-0.9
High blood pressure (siblings)	0.3	0.4	0.7	0.9	0.8	0.0	-0.3
Forced vital capacity (FVC), Best measure	1.3	4.7	5.7	2.1	-2.4	2.2	-2.0
Body fat percentage	0.9	3.5	7.1	-1.2	-0.4	-2.3	2.7
Leg fat percentage (right)	0.9	3.4	6.5	-0.9	0.9	-2.4	2.5
Arm fat-free mass (right)	3.8	19.3	55.2	-2.8	-7.4	-2.0	3.2
Exposure to tobacco smoke outside home	0.8	1.1	2.3	-1.0	-0.8	-0.6	1.5
Comparative body size at age 10	0.6	1.6	3.2	1.7	-1.8	-0.2	-0.1
Number of full brothers	2.0	2.5	3.1	1.4	-1.5	1.7	-1.8
Worry too long after embarrassment	0.2	0.3	0.8	-0.0	0.9	-0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	1.6	-0.9	-1.2	-1.3	1.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.4	0.6	-0.1	1.5	-1.4
Number of children fathered	0.3	0.3	0.8	-0.4	0.0	-0.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.4	1.4	0.8	1.8	-1.6
Age at first live birth	0.1	0.2	0.2	0.4	-0.5	-0.3	0.4
Pulse wave peak to peak time	1.9	2.2	3.5	1.3	1.4	1.3	-1.9
Health satisfaction	1.2	1.6	5.3	-0.7	-2.3	-0.6	0.6
Shortness of breath walking on level ground	0.1	0.1	0.2	0.2	0.3	-0.4	0.3
Qualifications: College or University degree	0.5	1.6	2.3	-0.7	1.5	-1.4	1.3
Eye problems/disorders: None of the above	1.0	1.2	2.0	1.1	-0.3	1.4	-1.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.6	0.1	0.2	-0.3
Emphysema/chronic bronchitis	1.8	2.0	3.3	-1.8	-1.3	-1.4	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	2.0	0.6	-0.4	1.1	-1.4
Neck or shoulder pain in last month	0.8	1.1	4.4	-0.0	-2.1	0.2	-0.2
Medication: Blood pressure	0.7	1.3	2.6	1.6	-0.0	1.2	-1.1
Angina (self-reported)	1.0	1.3	2.1	-1.1	-0.1	-1.4	1.5
Migraine (self-reported)	0.2	0.3	0.7	-0.2	0.8	-0.2	0.6
Medication: Ibuprofen	0.1	0.1	0.2	0.0	0.2	-0.5	0.3
Medication: Allopurinol	0.4	0.5	1.0	-0.5	-0.8	-0.4	1.0
Medication: Omeprazole	0.4	0.5	1.9	-0.1	-1.4	-0.3	0.3
Medication: Seretide 50 evohaler	2.4	2.7	4.7	2.2	1.5	1.3	-1.6
Mean time to correctly identify matches	0.1	0.1	0.2	-0.3	0.2	0.4	-0.3
Heart disease (mother)	1.3	1.6	3.0	-1.1	0.7	-1.7	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-0.8	0.0	-1.1	1.3
Whole body fat mass	1.8	7.5	11.4	-1.8	-3.4	-2.4	3.2
Leg fat mass (right)	1.6	6.1	9.7	-1.5	-2.5	-2.5	3.1
Arm predicted mass (right)	3.8	19.6	54.7	-3.0	-7.4	-2.1	3.3
Pulse rate, automated reading	0.1	0.4	0.7	0.4	0.0	-0.8	0.8
Alcohol intake frequency.	0.3	0.6	0.9	0.6	-1.0	0.8	-0.8
Comparative height size at age 10	3.1	16.9	25.6	-4.0	-5.1	-3.0	4.2
Number of full sisters	0.4	0.5	1.3	-1.1	-0.2	-0.6	0.7
Suffer from ‘nerves’	0.0	0.0	0.0	0.1	0.1	0.2	0.2
Overall health rating	0.8	1.6	6.4	-0.1	-2.5	-0.2	0.3
Chest pain or discomfort	0.5	0.8	2.5	-0.5	-1.6	0.6	-0.2
Had major operations	3.4	4.0	4.6	-2.1	1.8	-2.1	2.0
Age at last live birth	1.2	1.8	3.2	-0.7	-1.8	-1.4	1.2
Family relationship satisfaction	0.8	1.0	1.8	0.4	-1.0	1.4	-0.9
Leg pain on walking	1.4	1.7	2.9	-1.4	0.2	-1.4	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	-1.2	0.7	-1.1	1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.1	-0.2	-0.8	0.6
Illness, injury, bereavement, stress in last 2 years	3.9	4.8	8.9	2.2	1.1	2.1	-3.0
Medication: Aspirin	0.1	0.1	0.2	0.2	-0.3	-0.4	0.4
Supplements: Vitamin C	0.1	0.1	0.2	0.1	-0.1	-0.5	0.2
Knee pain experienced in last month	1.3	2.0	4.1	0.9	0.4	2.0	-1.7
Hypertension (Self-reported)	0.1	0.4	0.7	0.2	0.9	-0.7	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	0.4	-1.5	0.5	-0.7
Illnesses of father: Heart disease	1.8	2.5	3.6	-1.9	-0.1	-1.8	1.8
Illnesses of siblings: Diabetes	6.5	8.0	13.1	2.5	-1.4	3.3	-3.6
Smoking status: Previous	0.2	0.4	1.4	-0.1	1.2	0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	8.7	-0.7	-3.0	0.5	0.6
Whole body fat-free mass	4.3	24.9	75.0	-2.8	-8.7	-2.0	3.5
Leg fat-free mass (right)	4.3	23.1	73.4	-2.4	-8.6	-1.8	3.2
Arm fat percentage (left)	0.6	2.4	4.9	-0.6	-0.9	-1.8	2.2
Average weekly red wine intake	1.6	2.3	4.1	2.0	1.0	1.1	-1.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.9	-0.6	1.4	-0.2	0.4
Mood swings	0.2	0.4	0.7	0.9	0.2	0.6	-0.6
Loneliness, isolation	0.0	0.1	0.2	-0.1	-0.1	0.4	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.0	-1.0	-0.5	-0.5	0.6
Ever had bowel cancer screening	0.3	0.4	1.2	-1.1	-0.2	-0.5	0.2
Diabetes diagnosed by doctor	0.1	0.1	0.5	-0.3	0.0	0.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.8	2.9	5.1	-1.1	0.6	-2.2	2.3
Friendships satisfaction	0.3	0.4	0.7	0.4	-0.9	0.7	-0.5
Qualifications: nursing, teaching	0.9	1.4	2.1	-1.3	0.6	-1.2	1.4
Commuting to job workplace: Walk	0.7	0.8	2.2	-0.3	1.5	0.7	-0.6
Eye problems/disorders: Cataract	0.7	0.9	1.7	-1.0	-0.0	-1.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	0.1	-1.5	0.5	-0.7
Medication for cholesterol	0.2	0.3	0.5	-0.7	0.6	-0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.2	-0.6	-0.6	-1.1	1.1
Back pain experienced in last month	0.5	0.8	3.1	-0.2	-1.7	-0.2	-0.2
Mineral and other dietary supplements	0.4	0.6	2.2	0.1	1.5	0.1	0.0
Breast cancer (self-reported)	0.4	0.5	1.1	-0.3	-1.1	-0.7	0.5
Asthma (self-reported)	3.4	6.7	11.5	2.6	3.4	1.9	-2.2
Osteoporosis (self-reported)	0.7	0.8	2.9	0.4	-1.7	0.4	-0.2
Osteoarthritis (self-reported)	1.1	1.4	2.4	1.2	-0.3	1.3	-1.5
Medication: Aspirin	0.1	0.2	0.3	0.1	-0.5	-0.4	0.5
Medication: Gliclazide	1.0	1.2	2.2	-1.2	0.6	-0.9	1.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.2	-0.0	0.6	-0.2
Smoking status: Current	0.5	0.8	1.5	-0.7	-0.4	-1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.4	1.6	-0.8	1.1	-1.2
Whole body water mass	4.4	25.3	73.6	-3.0	-8.6	-2.2	3.7
Leg predicted mass (right)	4.4	23.3	74.1	-2.3	-8.6	-1.8	3.2
Arm fat mass (left)	1.7	6.8	10.8	-1.5	-3.3	-2.3	3.0
Number of self-reported non-cancer illnesses	0.4	0.7	1.0	0.6	1.0	0.6	-1.0
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.2	0.6	-0.0	-0.0
Miserableness	0.3	0.5	2.0	-0.3	-1.4	-0.0	0.2
Guilty feelings	0.1	0.1	0.2	0.4	-0.4	0.4	-0.3
Wears glasses or contact lenses	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.2
Ever taken oral contraceptive pill	1.1	1.3	2.3	1.1	1.5	0.9	-0.9
Hearing aid user	1.4	1.5	5.7	-0.0	2.4	-0.7	0.1
Mother’s age at death	0.2	0.3	1.2	-0.1	-1.1	-0.0	0.1
Financial situation satisfaction	0.1	0.1	0.3	0.1	-0.5	0.4	-0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.7	0.3	0.1	-0.6
Commuting to job workplace: Public transport	2.4	2.8	5.3	-2.3	0.5	-1.4	1.9
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	0.4	0.5	0.9	-0.9
Medication: Blood pressure	0.6	1.2	2.6	1.2	1.6	0.2	-0.7
Pain type(s) experienced in last month: Hip pain	1.5	1.8	2.9	-1.2	-0.7	-1.6	1.7
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.4	-1.6	-0.5	-2.1	1.7
High cholesterol (Self-reported)	0.3	0.6	1.4	-0.2	-0.5	1.2	-0.8
Medication: Bendroflumethiazide	2.3	3.6	5.3	2.0	0.4	2.2	-2.3
Medication: Paracetamol	1.2	1.9	4.0	-0.9	2.0	-0.8	1.4
Medication: Lisinopril	0.2	0.3	0.5	0.3	-0.6	0.7	-0.3
Medication: Atorvastatin	0.3	0.4	1.3	0.2	-1.1	-0.2	0.3
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.1	1.0	-0.8	0.3
Alcohol drinker status: Never	1.4	1.7	3.5	-0.9	0.4	-1.9	1.6
Ever smoked	0.4	0.7	1.3	-0.4	1.1	-0.6	1.1
Basal metabolic rate	4.3	23.7	67.9	-2.8	-8.2	-2.2	3.7
Leg fat percentage (left)	0.7	2.5	4.3	-0.6	1.0	-2.1	2.1
Arm fat-free mass (left)	4.3	21.8	56.9	-3.0	-7.5	-2.6	3.8
Number of operations (self-reported)	3.0	4.5	6.7	-2.6	-0.0	-2.3	2.4
Average weekly beer plus cider intake	3.0	4.3	9.8	-1.5	-3.1	-1.5	1.7
Irritability	0.1	0.2	0.6	0.3	-0.3	0.4	-0.8
Risk taking	1.5	2.2	4.2	-0.7	0.2	-2.1	2.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.5	1.1	-0.5	1.1	-1.2
Fractured/broken bones in last 5 years	2.1	2.7	8.8	-0.9	-3.0	-0.6	0.8
Age started oral contraceptive pill	0.8	1.0	1.5	-1.2	-0.6	-1.2	0.8
Diastolic blood pressure, automated reading	0.1	0.3	0.5	0.4	0.6	-0.7	0.3
Ever depressed for a whole week	0.2	0.3	1.0	-0.3	-1.0	-0.3	0.2
Unable to work because of sickness or disability	3.1	4.1	6.5	-1.7	-1.1	-2.4	2.6
Commuting to job workplace: Cycle	1.9	2.3	4.4	-2.1	-1.0	-1.2	1.5
Myopia	0.7	1.0	1.8	-0.7	0.6	-1.1	1.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	-0.5	-0.5	0.5	-0.1
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	-0.4	-1.4	-0.1	0.2
Pain experienced in last month	0.3	0.6	1.2	-0.8	0.3	-0.5	1.1
Supplements: Calcium	0.8	0.9	2.8	-0.0	-1.7	-0.7	0.5
Basal cell carcinoma (self-reported)	0.2	0.3	0.9	-0.6	-0.9	0.1	0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.8	0.3	0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	3.8	-1.6	-0.3	-1.9	1.9
Heart disease (siblings)	1.0	1.2	2.2	-1.5	-0.2	-1.1	1.2
Alcohol drinker status: Previous	2.7	3.0	4.4	-1.9	-0.6	-2.0	2.1
Pack years of smoking	1.1	1.7	2.8	-0.8	-1.1	-1.7	1.4
Impedance of whole body	1.3	6.8	26.1	0.2	5.1	0.4	-1.0
Leg fat mass (left)	1.2	4.9	7.5	-1.2	-2.4	-2.1	2.7
Arm predicted mass (left)	4.3	21.9	61.0	-2.9	-7.8	-2.4	3.6