Best TWAS P=6.46e-15 · Best GWAS P=1.82e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | SUPT3H | 0.22 | 0.12 | lasso | 6 | 0.10 | 8.1e-04 | 7.2 | 6.9 | 3.8e-12 | 0.87 | 0.05 | 0.84 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | SUPT3H | 0.38 | 0.40 | lasso | 2 | 0.34 | 1.3e-09 | 7.2 | 7.2 | 4.3e-13 | 0.84 | 0.09 | 0.90 | FALSE |
3 | GTEx | Brain Cortex | SUPT3H | 0.28 | 0.01 | lasso | 7 | 0.01 | 2.1e-01 | 7.9 | 7.8 | 6.5e-15 | 0.98 | 0.03 | 0.90 | TRUE |
4 | GTEx | Brain Frontal Cortex BA9 | SUPT3H | 0.37 | 0.14 | lasso | 11 | 0.18 | 1.3e-05 | 7.2 | 5.2 | 2.5e-07 | 0.77 | 0.08 | 0.87 | FALSE |
5 | GTEx | Brain Hypothalamus | SUPT3H | 0.33 | 0.03 | lasso | 8 | 0.03 | 5.9e-02 | 7.1 | 6.9 | 6.6e-12 | 0.79 | 0.05 | 0.66 | FALSE |
6 | GTEx | Brain Nucleus accumbens basal ganglia | SUPT3H | 0.16 | 0.11 | lasso | 4 | 0.08 | 3.6e-03 | 7.1 | 7.3 | 2.1e-13 | 0.94 | 0.04 | 0.82 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SUPT3H | 0.15 | 0.10 | lasso | 4 | 0.13 | 8.8e-10 | -3.4 | 6.2 | 6.0e-10 | 0.70 | 0.86 | 0.14 | FALSE |
8 | GTEx | Pituitary | SUPT3H | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.8e-02 | 6.6 | 6.0 | 1.8e-09 | 0.80 | 0.06 | 0.45 | FALSE |
9 | GTEx | Testis | SUPT3H | 0.30 | 0.16 | lasso | 7 | 0.17 | 6.7e-08 | 7.1 | 6.6 | 3.6e-11 | 0.93 | 0.02 | 0.98 | FALSE |
10 | NTR | Blood | SUPT3H | 0.03 | 0.02 | lasso | 7 | 0.02 | 1.9e-07 | 6.8 | 6.4 | 1.9e-10 | 0.70 | 0.95 | 0.05 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | SUPT3H | 0.15 | 0.13 | blup | 643 | 0.17 | 3.4e-21 | 7.2 | 5.8 | 5.2e-09 | 0.82 | 0.08 | 0.92 | FALSE |
12 | YFS | Blood | SUPT3H | 0.06 | 0.09 | lasso | 13 | 0.12 | 2.2e-36 | -4.2 | 6.3 | 2.3e-10 | 0.77 | 0.99 | 0.01 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUPT3H | 0.04 | 0.01 | blup | 191 | 0.02 | 6.5e-03 | 7.8 | 6.3 | 2.4e-10 | 0.85 | 0.08 | 0.88 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT3H | 0.07 | 0.05 | enet | 12 | 0.08 | 1.1e-09 | 7.1 | 6.3 | 2.3e-10 | 0.83 | 0.25 | 0.75 | FALSE |
15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SUPT3H | 0.06 | 0.05 | lasso | 3 | 0.05 | 3.9e-06 | 7.8 | 7.8 | 8.1e-15 | 0.99 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SUPT3H | 0.05 | 0.01 | blup | 191 | 0.00 | 1.4e-01 | 7.2 | 6.9 | 5.1e-12 | 0.93 | 0.04 | 0.71 | FALSE |