Best TWAS P=1.06e-12 · Best GWAS P=1.36e-15 conditioned to 2.71e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | ROSMAP | Brain Pre-frontal Cortex | FAM73A | 0.09 | 0.04 | enet | 19 | 0.06 | 9.6e-09 | 5.0 | -7.1 | 1.1e-12 | 0.33 | 0.99 | 0.01 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NEXN | 0.03 | 0.01 | blup | 44 | 0.01 | 1.3e-02 | 5.0 | -6.0 | 1.6e-09 | 0.23 | 0.02 | 0.11 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NEXN | 0.03 | 0.02 | blup | 44 | 0.03 | 6.6e-04 | 5.0 | -6.0 | 1.9e-09 | 0.24 | 0.20 | 0.17 | FALSE |
| 1 | GTEx | Cells Transformed fibroblasts | PTGFR | 0.12 | 0.04 | enet | 17 | 0.04 | 4.7e-04 | -4.3 | 5.8 | 6.2e-09 | -0.26 | 0.97 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJB4 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.2e-05 | -5.8 | 5.8 | 6.7e-09 | -0.45 | 0.00 | 1.00 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | NEXN | 0.11 | 0.07 | blup | 365 | 0.10 | 2.2e-13 | 5.0 | -5.5 | 5.1e-08 | 0.22 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | NEXN | 0.11 | 0.06 | lasso | 5 | 0.07 | 9.6e-06 | 5.4 | -5.2 | 2.5e-07 | 0.16 | 0.85 | 0.01 | FALSE |