Hub : Genes

PTGFR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0910	0.0330	1.7e-03	0.007	0.016	0.012	0.015	0.003	0.03700	0.00390	0.01000	0.0056	0.1200
2	GTEx	Cells Transformed fibroblasts	0.1170	0.0360	1.7e-05	0.040	NA	0.041	NA	0.027	0.00056	NA	0.00047	NA	0.0036
3	TCGA	Breast Invasive Carcinoma	0.0185	0.0101	7.0e-04	0.007	0.016	0.011	NA	0.011	0.01300	0.00022	0.00200	NA	0.0023
4	TCGA	Testicular Germ Cell Tumors	0.1240	0.0700	5.1e-03	0.051	0.069	-0.007	NA	0.037	0.00680	0.00190	0.65000	NA	0.0190

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.9	1.5	2.3	1.4	1.1	1.5	0.4
Bipolar Disorder or Schizophrenia	0.9	2.2	5.4	2.3	1.6	1.0	-0.0
Depressed Affect (Nagel 2018)	0.9	1.8	4.1	0.5	-0.4	2.0	1.6
Depression (Nagel 2018)	0.1	0.1	0.3	0.0	-0.6	-0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	0.0	1.0	-0.5	-0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.3	0.4	0.9	0.2
Schizophrenia (2018)	0.6	1.2	3.5	1.9	1.1	0.2	-0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	-0.2	-0.1	0.3	-0.6
Worry (Nagel 2018)	0.9	1.9	4.3	-1.3	2.1	-0.5	-1.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.3	1.2	0.8	-0.8	-0.7
Alzheimer’s Disease (in father)	0.4	0.5	1.0	-0.0	0.7	0.6	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	1.3	1.1	1.1	-1.1	-0.7
Crohns Disease (2017)	2.4	5.3	11.1	-1.3	1.1	-3.3	-2.7
Irritable Bowel Disease (IBD)	2.0	4.7	8.9	-2.6	-0.1	-3.0	-1.8
Ulcerative Colitis (UC)	1.5	2.8	5.3	-2.3	-1.5	-1.8	-0.7
Major Depression (MDD)	0.5	0.7	2.1	1.5	0.5	0.2	-0.4
Reaction Time	0.1	0.2	0.6	0.3	0.8	-0.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1
Breast Cancer	0.5	1.1	2.4	-1.2	-1.6	-0.5	0.4
Ovarian Cancer	1.0	1.3	2.6	-1.6	-1.6	-0.3	-0.2
Prostate Cancer	0.6	0.9	3.1	-0.5	-1.8	-0.1	-0.3
Age at First Birth	0.3	0.5	1.3	-0.6	1.1	0.2	-0.4
Bipolar Disorder (2011)	0.9	0.9	1.8	1.3	1.0	0.2	-0.8
Body Mass Index (BMI) (2010)	2.6	3.6	4.8	1.3	-2.2	1.8	2.1
Coronary Artery Disease (CAD)	2.1	2.5	4.2	-1.4	0.5	-2.0	-1.9
Crohns Disease (2012)	0.8	1.2	2.6	-0.3	0.9	-1.6	-1.1
Mean Putamen Volume	0.9	1.0	2.4	-1.5	-1.1	0.4	0.4
Fasting Glucose	1.3	1.6	4.1	2.0	1.3	-0.3	-0.7
HbA1C	1.8	2.0	5.0	-0.3	-1.4	2.2	1.1
HDL Cholesterol	0.1	0.1	0.2	-0.3	-0.4	-0.0	-0.2
LDL Cholesterol	0.7	1.1	1.9	-1.4	-0.7	-1.1	-0.8
Lupus	0.5	0.7	1.7	-0.1	-0.5	0.9	1.3
Neuroticism (2016)	0.0	0.0	0.0	0.1	-0.0	0.0	-0.0
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.6	-0.1	-0.8	-0.5
Rheumatoid Arthritis	1.5	2.1	4.6	-0.0	-2.1	1.3	1.5
Schizophrenia (2014)	0.3	0.7	2.5	1.6	0.4	0.2	-0.5
Triglycerides	0.4	0.7	2.2	-0.1	1.5	-0.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.9	-0.3	-1.4	-0.1	0.3
Ulcerative Colitis	1.1	1.6	3.8	-2.0	-1.2	-1.0	0.1
Blood Eosinophil Count	0.5	3.6	6.6	2.6	2.4	1.0	1.0
Blood Platelet Count	0.1	1.2	2.0	-0.5	-0.8	1.3	1.4
Blood Red Count	0.1	0.8	1.9	-1.4	0.4	0.7	0.8
Blood White Count	0.2	1.4	3.3	0.9	-1.1	0.2	1.8
Heel T-Score	0.1	0.5	1.9	0.2	1.4	-0.3	0.1
BMI	2.9	17.1	40.3	0.2	-6.3	3.4	4.1
Height	1.2	23.6	31.7	2.8	-5.2	5.3	5.6
Waist Hip Ratio (WHR)	1.0	4.5	13.3	1.1	3.6	0.9	1.6
Systolic Blood Pressure	0.4	2.1	5.8	-0.9	2.4	-1.0	-0.8
Smoking Status	0.6	1.4	4.4	-0.3	-0.1	1.1	2.1
Allergy or Eczema	0.5	1.2	4.2	0.4	2.0	-0.5	-0.5
Cardiovascular Disease	0.1	0.5	0.6	-0.8	0.6	-0.8	-0.6
Hypothyroidism (self reported)	0.8	1.9	3.3	1.6	-0.8	1.1	1.8
Respiratory disease	0.1	0.1	0.5	-0.7	0.1	0.3	0.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	1.2	0.3	-0.8	-0.6
Lung FEV1/FVC ratio	0.1	0.5	1.1	-0.0	-1.1	0.0	0.8
Lung FVC	0.3	1.7	5.5	2.3	-1.0	0.1	0.7
Neuroticism	0.2	0.6	1.1	-0.0	1.1	1.0	0.4
Chronotype (morning person)	0.3	0.7	1.7	-0.4	-0.7	-0.7	-1.3
Hair Pigment	0.1	2.8	3.5	1.9	-1.6	1.6	1.6
Tanning	0.0	0.2	0.5	0.1	0.7	0.2	0.3
Hand grip strength (left)	0.4	1.0	2.9	0.9	1.7	0.1	0.2
Number of treatments/medications taken	0.3	0.5	1.0	0.3	-1.0	0.9	0.3
Average weekly spirits intake	1.2	1.5	2.6	-1.1	0.3	-1.4	-1.6
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.3	1.0	0.3	-0.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.2	-0.2	0.0	-0.1
Hearing difficulty/problems: Yes	0.3	0.4	1.3	0.2	-1.1	0.1	-0.6
Relative age of first facial hair	0.3	0.6	0.9	-0.2	0.8	-0.9	-1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	1.1	0.5	0.0	-0.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.3	-2.3	-0.1	-1.0	-1.1
Ever had hysterectomy (womb removed)	3.4	3.8	7.8	-1.1	-1.1	2.8	2.3
Systolic blood pressure, automated reading	0.4	1.0	1.8	-1.3	-1.4	0.7	0.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.1	-1.8	-1.5	0.5	0.9
Angina	0.4	0.5	1.0	0.5	-0.6	0.7	1.0
Medication for hormone replacement therapy	0.5	0.6	1.8	-1.4	0.7	0.1	-0.1
Vitamin and mineral supplements	0.2	0.3	0.7	-0.3	0.9	0.3	0.3
Supplements: Zinc	0.3	0.4	0.7	-0.2	-0.8	-0.3	-0.9
Medication: Co-codamol	4.8	5.5	14.1	1.1	-3.8	2.0	1.7
Medication: Metformin	1.8	2.5	3.5	-1.7	-0.8	-1.7	-1.9
Diabetes (father)	0.8	1.0	1.9	-0.3	-1.0	1.4	1.0
Diabetes (mother)	0.4	0.5	1.8	-0.1	0.2	-0.6	-1.3
Severe depression (siblings)	0.7	0.8	2.3	0.8	1.5	0.4	0.3
Pack years adult smoking proportion	0.8	1.2	3.0	0.5	-1.7	0.9	0.9
Impedance of leg (right)	2.4	11.4	33.8	-0.9	5.8	-2.6	-2.1
Leg fat-free mass (left)	4.4	23.5	46.5	1.4	-6.8	4.3	5.2
Trunk fat percentage	1.8	7.2	11.7	-0.7	-3.4	2.9	2.9
Hand grip strength (right)	0.4	1.1	3.2	0.8	1.8	-0.3	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.4	-0.8	-0.4	0.1
Current tobacco smoking	0.8	1.2	2.9	0.6	-0.4	1.2	1.7
Average weekly fortified wine intake	0.4	0.5	1.8	-1.3	0.0	-0.2	0.3
Maternal smoking around birth	1.0	1.5	2.7	0.6	-1.6	0.8	1.5
Fed-up feelings	0.5	0.9	1.8	0.9	-0.4	1.4	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.3	-0.4	-0.9	-0.4
Relative age voice broke	0.3	0.4	1.0	0.3	0.5	-1.0	-0.6
Taking other prescription medications	0.5	0.8	1.5	-0.4	-1.1	1.2	0.5
Age when periods started (menarche)	0.9	2.2	3.8	0.9	0.7	-1.9	-1.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.4	2.9	-1.7	0.1	1.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.0	-0.3	0.7	0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.4	-1.5	1.2	-0.6	-0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.7	-0.6	0.8	1.4
Serious illness, injury or assault to yourself	0.6	0.8	1.2	-0.5	-0.9	0.8	1.1
High blood pressure	0.1	0.4	0.9	-0.4	-0.6	0.9	0.4
Hayfever, allergic rhinitis or eczema	0.9	1.9	7.1	0.5	2.7	-0.2	-0.0
Multivitamins +/- minerals	0.9	1.2	1.7	-0.5	-1.0	-1.3	-1.3
Stomach or abdominal pain in last month	0.3	0.4	0.9	-0.1	-0.4	1.0	0.7
Supplements: Glucosamine	0.5	0.6	1.2	0.4	0.6	-1.1	-0.9
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.6	0.6	1.6	-0.4	-1.2
Medication: Atenolol	1.4	1.8	3.7	-0.1	-0.9	1.6	1.9
Medication: Levothyroxine sodium	1.6	2.7	4.0	0.6	-1.6	2.0	2.0
Sitting height	1.7	12.0	16.0	3.5	-3.0	3.2	4.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.6	-0.6	-1.1	-0.9
High blood pressure (mother)	0.8	1.1	2.3	-1.1	1.5	-0.9	-0.3
Body mass index (BMI)	2.6	11.3	29.6	-0.7	-5.4	2.7	2.8
Impedance of leg (left)	2.9	14.1	41.7	-1.2	6.5	-2.6	-2.5
Leg predicted mass (left)	4.4	23.2	46.5	1.3	-6.8	4.3	5.1
Trunk fat mass	3.0	12.9	22.2	-0.2	-4.7	3.7	4.0
Waist circumference	4.0	14.5	24.8	0.1	-5.0	3.7	4.4
Number of incorrect matches in round	0.3	0.6	1.7	-0.3	-0.1	-0.7	-1.3
Past tobacco smoking	0.2	0.4	0.6	0.8	-0.6	0.2	-0.8
Alcohol usually taken with meals	1.9	3.1	5.2	2.0	-0.1	2.3	1.9
Nervous feelings	1.8	3.3	5.8	-1.0	1.9	-1.7	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	0.6	0.3	-0.2	-0.4
Hearing difficulty/problems with background noise	0.3	0.5	2.0	0.0	-1.4	-0.3	-0.1
Hair/balding pattern: Pattern 2	1.0	1.3	3.0	-0.4	0.5	-1.7	-1.4
Had menopause	1.2	1.5	2.6	0.1	-1.4	1.2	1.6
Had other major operations	0.4	0.5	1.0	-1.0	-0.6	0.5	0.7
Forced vital capacity (FVC)	1.7	6.7	12.1	2.9	-0.8	2.4	3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.4	-0.4	0.7	0.1	0.7
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	4.8	-1.2	2.2	-1.4	-2.2
Qualifications: None of the above	0.9	1.9	4.7	-1.6	-2.2	0.3	0.2
Financial difficulties in last 2 years	1.4	1.9	3.1	1.2	-1.8	1.0	1.5
Mouth/teeth dental problems	0.9	1.3	3.7	1.1	1.9	-0.4	0.4
Heart attack	0.4	0.5	1.2	0.4	-0.7	0.2	1.1
Allergy	1.4	3.3	5.4	-2.3	-2.2	-0.9	-1.4
Pain all over the body in last month	5.9	6.3	11.7	1.9	-1.1	3.0	3.4
Diabetes (self-reported)	0.3	0.5	1.6	0.3	-1.3	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.9	1.0	0.6	1.1	2.0
Medication: Ramipril	0.2	0.3	0.5	-0.7	0.3	0.6	0.4
Medication: Simvastatin	1.4	2.0	3.8	-0.7	1.1	-2.0	-1.6
Fluid intelligence score	0.0	0.1	0.2	-0.2	-0.1	0.5	-0.3
Illnesses of siblings	1.3	1.9	2.4	1.6	-1.2	1.4	1.3
Neuroticism score	0.2	0.4	0.8	0.1	0.7	0.9	0.6
Weight	4.5	22.2	43.6	0.2	-6.6	4.4	5.0
Impedance of arm (right)	0.8	3.9	13.8	-0.3	3.7	-0.7	-1.1
Arm fat percentage (right)	2.4	9.5	20.5	-0.8	-4.5	3.0	2.8
Trunk fat-free mass	3.4	19.6	41.1	1.3	-6.4	3.8	4.6
Hip circumference	3.4	14.8	39.3	-0.8	-6.3	3.1	3.1
Time employed in main current job	0.0	0.0	0.1	0.3	0.0	-0.0	-0.1
Alcohol intake versus 10 years previously	2.0	3.0	5.2	-1.3	-2.3	1.6	1.6
Father’s age at death	0.1	0.2	0.5	-0.4	0.3	0.2	-0.7
Worrier / anxious feelings	0.3	0.5	1.1	-0.6	1.0	-0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	-0.8	-0.4	-0.4	-0.8
Falls in the last year	1.2	1.6	2.9	0.9	-0.7	1.5	1.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.7	0.0	0.7	-0.2
Number of live births	1.5	2.1	4.2	1.0	-0.3	1.8	2.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	8.6	2.0	-0.8	1.8	2.9
Pulse rate	0.6	1.1	4.0	-2.0	0.1	-0.5	-0.1
Happiness	0.2	0.3	0.7	0.0	0.8	0.1	-0.6
Noisy workplace	0.6	0.7	1.6	0.2	-0.3	-1.3	-1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.4	1.3	1.1	-1.1	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.1	1.4	1.4	-0.5	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.1	2.7	-1.0	-1.6	0.8	0.6
Asthma	0.7	1.4	3.2	1.3	1.8	0.6	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	-0.4	-1.3	1.1	0.4
Medication: Cholesterol lowering	0.3	0.4	0.8	0.1	0.6	-0.9	-0.7
Depression (self-reported)	0.1	0.1	0.3	0.3	0.6	0.3	0.3
Medication: Lansoprazole	0.7	0.8	2.2	-1.5	-0.2	-0.7	-0.5
Prospective memory result	0.6	0.7	2.1	-0.1	-0.8	0.1	1.5
Lung cancer (father)	3.6	4.2	7.8	-0.8	-2.0	2.0	2.8
Illnesses of mother	1.3	1.6	2.9	1.4	-1.7	0.9	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	9.9	2.5	-0.3	2.0	3.1
Pulse wave Arterial Stiffness index	2.7	3.1	7.0	1.1	0.1	2.1	2.6
Impedance of arm (left)	1.1	4.9	17.1	0.2	4.1	-0.8	-1.3
Arm fat mass (right)	3.9	15.9	34.0	-0.5	-5.8	3.8	3.9
Trunk predicted mass	3.5	19.8	41.0	1.3	-6.4	3.9	4.6
Standing height	1.4	13.8	25.2	2.2	-2.9	4.1	5.0
Length of working week for main job	1.0	1.1	2.3	1.5	0.2	0.7	1.2
Exposure to tobacco smoke at home	1.6	1.8	3.2	1.8	-1.5	0.9	1.0
Breastfed as a baby	0.2	0.2	0.4	0.2	0.6	-0.5	0.3
Tense / ‘highly strung’	0.4	0.7	1.2	-0.7	1.1	0.4	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	5.3	0.1	2.3	-1.4	-2.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	0.3	1.2	-1.2	-0.3
Birth weight of first child	2.8	5.2	7.5	-1.8	-2.7	2.5	1.9
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.8	0.3	0.2	0.7
Pulse wave reflection index	0.9	1.1	1.3	1.1	0.9	1.1	1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.4	-1.5	0.6	-1.4	-0.5
Loud music exposure frequency	1.0	1.1	2.8	-0.7	-0.5	-1.7	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.5	2.1	0.2	0.6	0.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.9	-0.6	-0.8	-1.4	-1.3
Blood clot in the leg (DVT)	2.1	2.7	4.3	2.1	-0.4	1.7	1.9
Medication: Paracetamol	0.9	1.6	3.5	0.4	0.1	1.9	1.6
Headache pain in last month	0.0	0.1	0.1	0.3	-0.3	0.2	-0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.1	0.6	-0.8	1.4	1.3
Glaucoma (self-reported)	0.3	0.4	1.4	-0.2	1.2	0.1	0.3
Gout (self-reported)	1.1	1.4	2.4	-0.3	-1.5	1.4	1.2
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	5.6	1.7	-1.8	1.7	2.4
Medication: Amlodipine	0.2	0.3	1.2	0.2	-1.1	0.2	0.1
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.8	1.9	-0.0	1.5	1.1
Birth weight	1.4	3.0	3.9	1.8	-1.4	2.0	1.8
Chronic bronchitis/emphysema (mother)	2.4	2.8	5.8	-1.2	-0.4	1.9	2.4
High blood pressure (siblings)	1.9	2.8	5.4	-2.3	0.9	-1.3	-1.8
Forced vital capacity (FVC), Best measure	1.7	6.2	11.4	2.8	-0.5	2.2	3.4
Body fat percentage	1.5	6.0	10.0	-0.9	-3.2	2.5	2.6
Leg fat percentage (right)	1.4	4.9	10.1	-1.0	-3.2	1.8	2.3
Arm fat-free mass (right)	3.4	17.5	36.4	0.8	-6.0	3.6	4.5
Exposure to tobacco smoke outside home	0.3	0.4	1.2	-1.1	-0.3	-0.3	-0.2
Comparative body size at age 10	1.3	3.7	8.2	0.1	-2.9	2.0	1.6
Number of full brothers	0.4	0.5	0.9	-0.6	0.6	0.7	0.9
Worry too long after embarrassment	0.6	1.0	1.6	-0.2	-1.3	1.2	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	5.0	-1.7	2.2	1.2	0.4
Wheeze or whistling in the chest in last year	0.1	0.3	0.6	0.2	-0.8	0.5	0.4
Number of children fathered	0.6	0.6	2.2	1.5	0.2	0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-0.3	-0.1	-1.1	-1.2
Age at first live birth	1.7	3.0	5.5	-0.1	1.6	-2.0	-2.3
Pulse wave peak to peak time	1.6	1.8	4.3	-0.8	-0.2	-1.5	-2.1
Health satisfaction	0.7	0.9	2.4	0.5	1.6	0.6	0.7
Shortness of breath walking on level ground	2.3	2.8	4.0	-1.3	-1.9	1.4	2.0
Qualifications: College or University degree	0.5	1.5	4.3	-0.3	2.1	0.1	-1.3
Eye problems/disorders: None of the above	0.2	0.3	0.4	0.5	-0.2	0.7	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.1	1.5	-0.9	-0.1	-0.1
Emphysema/chronic bronchitis	0.4	0.5	1.3	-0.1	-0.2	-1.1	-0.7
Medication for pain relief, constipation, heartburn	1.3	2.2	4.1	-0.1	2.0	-1.6	-1.4
Neck or shoulder pain in last month	0.9	1.3	2.3	-1.5	-1.5	0.4	0.8
Medication: Blood pressure	0.5	0.9	2.4	-1.6	-0.1	-0.8	-0.6
Angina (self-reported)	0.2	0.3	0.4	0.6	-0.5	0.2	0.6
Migraine (self-reported)	1.4	1.7	3.3	-0.2	1.5	-1.2	-1.8
Medication: Ibuprofen	1.1	1.4	3.6	0.5	-0.7	1.9	1.1
Medication: Allopurinol	0.1	0.1	0.3	-0.5	-0.4	0.0	0.1
Medication: Omeprazole	1.2	1.4	2.2	-0.6	-1.3	1.1	1.5
Medication: Seretide 50 evohaler	0.5	0.6	0.8	-0.5	-0.9	0.8	0.8
Mean time to correctly identify matches	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.2
Heart disease (mother)	0.4	0.4	0.8	-0.0	0.9	-0.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.5	-1.4	1.9	-0.0	-0.2
Whole body fat mass	2.8	11.8	23.2	-0.7	-4.8	3.3	3.5
Leg fat mass (right)	2.7	10.4	22.2	-0.5	-4.7	2.8	3.3
Arm predicted mass (right)	3.3	16.8	35.4	0.7	-6.0	3.5	4.4
Pulse rate, automated reading	0.7	2.3	4.5	-2.1	0.6	-1.7	-1.2
Alcohol intake frequency.	0.4	1.0	2.1	-0.9	-1.1	1.4	0.3
Comparative height size at age 10	1.8	9.8	14.4	0.5	-3.5	3.5	3.8
Number of full sisters	0.9	1.0	3.1	0.5	-1.8	-0.2	0.9
Suffer from ‘nerves’	1.7	2.7	7.2	0.0	2.7	-1.5	-1.2
Overall health rating	1.2	2.6	6.1	0.1	-2.5	1.5	1.5
Chest pain or discomfort	0.1	0.1	0.2	-0.2	0.4	0.4	0.0
Had major operations	3.5	4.1	6.6	-1.5	-2.6	1.3	2.4
Age at last live birth	0.5	0.7	1.6	0.6	1.3	-0.6	-0.8
Family relationship satisfaction	1.2	1.4	4.7	-0.4	-0.1	-1.0	-2.2
Leg pain on walking	0.1	0.2	0.4	-0.4	-0.0	0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	5.5	-0.6	-2.4	-0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.0	1.0	-0.8	1.0	0.8
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.8	-0.9	2.2	-0.3	-1.1
Medication: Aspirin	0.6	0.9	1.6	0.2	-0.8	-1.0	-1.3
Supplements: Vitamin C	1.1	1.2	2.9	1.7	-0.6	1.3	0.1
Knee pain experienced in last month	1.8	2.8	4.7	-0.7	-1.7	2.2	1.8
Hypertension (Self-reported)	0.1	0.3	0.7	-0.6	-0.6	0.8	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.1	-1.4	-0.6	0.8	0.5
Illnesses of father: Heart disease	2.6	3.6	5.9	-0.5	1.8	-2.2	-2.4
Illnesses of siblings: Diabetes	1.0	1.3	2.9	-0.1	1.7	-1.3	-0.7
Smoking status: Previous	0.6	0.8	2.0	-1.4	0.9	-0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.4	2.1	0.3	0.9	1.1
Whole body fat-free mass	3.8	21.5	44.5	1.2	-6.7	4.0	4.9
Leg fat-free mass (right)	3.9	20.7	40.8	1.2	-6.4	4.2	4.8
Arm fat percentage (left)	2.3	9.3	18.2	-0.4	-4.3	3.1	3.0
Average weekly red wine intake	0.6	0.9	2.4	1.5	1.1	0.1	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.1	-0.4	-0.4	0.5
Mood swings	0.5	0.8	2.6	-0.6	1.6	-0.1	-0.6
Loneliness, isolation	1.3	1.8	3.2	0.4	-0.9	1.8	1.8
Long-standing illness, disability or infirmity	1.6	2.4	4.1	-0.0	-2.0	1.7	1.6
Ever had bowel cancer screening	0.1	0.2	0.4	-0.6	-0.4	-0.2	0.1
Diabetes diagnosed by doctor	0.3	0.4	0.7	-0.3	-0.7	-0.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	0.8	0.1	-0.7	-0.4
Friendships satisfaction	0.2	0.3	0.5	-0.2	0.7	0.1	-0.7
Qualifications: nursing, teaching	1.6	2.5	4.6	1.8	0.9	-1.1	-2.1
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	0.1	0.0	0.2
Eye problems/disorders: Cataract	0.9	1.0	3.1	-1.8	0.4	-0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	7.8	0.1	-1.8	2.8	1.9
Medication for cholesterol	0.2	0.4	0.7	0.7	-0.9	-0.4	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	0.8	1.2	0.2	0.8
Back pain experienced in last month	0.3	0.4	0.9	-0.9	-0.4	0.0	0.8
Mineral and other dietary supplements	1.1	1.5	3.3	0.6	-0.5	1.8	1.4
Breast cancer (self-reported)	2.0	2.4	5.4	-1.1	-0.5	-2.3	-1.7
Asthma (self-reported)	0.6	1.1	2.4	1.2	1.5	0.6	0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.5	-0.3	-0.1	0.3
Osteoarthritis (self-reported)	1.4	1.8	5.6	-0.8	-2.4	1.0	0.4
Medication: Aspirin	0.3	0.4	0.8	0.0	-0.9	-0.4	-0.7
Medication: Gliclazide	0.8	0.9	1.5	-1.1	-0.2	-0.9	-1.2
Illnesses of father: None of the above (group 1)	2.7	3.4	6.3	0.5	-1.1	2.4	2.5
Smoking status: Current	0.7	1.2	2.4	0.7	-0.5	1.2	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.8	1.1	0.3	1.2	1.7
Whole body water mass	3.8	21.6	44.8	1.2	-6.7	4.1	4.9
Leg predicted mass (right)	3.8	20.4	40.3	1.2	-6.3	4.2	4.7
Arm fat mass (left)	3.9	15.9	33.6	-0.3	-5.8	3.8	3.9
Number of self-reported non-cancer illnesses	0.7	1.2	2.4	0.6	-0.6	1.4	1.6
Average weekly champagne plus white wine intake	0.7	1.0	1.6	0.1	0.9	1.2	1.3
Miserableness	0.4	0.6	1.3	1.1	1.1	0.2	0.2
Guilty feelings	0.3	0.5	0.8	0.9	-0.5	0.8	0.5
Wears glasses or contact lenses	1.0	1.2	3.7	-0.3	1.9	-0.6	-0.9
Ever taken oral contraceptive pill	0.9	1.0	2.0	1.3	1.4	0.0	0.3
Hearing aid user	0.0	0.0	0.1	0.1	0.2	-0.1	-0.2
Mother’s age at death	0.4	0.4	1.4	0.2	-0.6	0.0	-1.2
Financial situation satisfaction	0.4	0.6	1.2	1.1	-0.5	0.2	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	-0.4	-0.6	1.2	0.3
Commuting to job workplace: Public transport	2.1	2.5	3.6	-0.3	1.9	-1.9	-1.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.1	0.9	-0.5	-0.4
Medication: Blood pressure	0.2	0.4	0.8	-0.5	0.8	0.9	0.2
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.7	0.1	-0.8	1.6	1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.5	-0.0	0.4	-1.6	-0.9
High cholesterol (Self-reported)	0.3	0.5	1.7	-1.3	0.6	-0.3	-0.2
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.0	-0.6	0.5	0.7
Medication: Paracetamol	0.8	1.3	3.0	0.7	0.6	1.7	1.2
Medication: Lisinopril	0.2	0.3	0.5	0.4	-0.4	0.7	0.6
Medication: Atorvastatin	1.5	1.9	2.5	1.6	-0.8	1.5	1.4
Illnesses of father: High blood pressure	1.4	1.7	4.1	-0.2	0.6	-2.0	-1.5
Alcohol drinker status: Never	0.2	0.2	0.4	-0.2	0.3	0.5	-0.6
Ever smoked	0.2	0.3	0.7	-0.4	0.8	-0.1	0.6
Basal metabolic rate	4.0	22.1	45.2	1.0	-6.7	4.2	5.0
Leg fat percentage (left)	1.1	4.0	7.6	-1.1	-2.8	1.7	2.1
Arm fat-free mass (left)	3.5	17.6	39.9	0.3	-6.3	3.5	4.2
Number of operations (self-reported)	1.0	1.5	2.8	-1.6	-1.7	-0.2	0.7
Average weekly beer plus cider intake	0.3	0.4	1.4	1.2	0.3	-0.3	-0.2
Irritability	0.3	0.4	1.3	-0.2	0.0	-0.6	-1.1
Risk taking	1.1	1.7	3.1	1.6	1.8	0.3	1.0
Ever had prostate specific antigen (PSA) test	1.2	1.3	3.3	0.5	0.5	-1.2	-1.8
Fractured/broken bones in last 5 years	0.7	0.9	1.8	0.1	-1.2	-1.3	-0.6
Age started oral contraceptive pill	1.6	2.0	4.1	-0.6	-0.2	-1.9	-2.0
Diastolic blood pressure, automated reading	0.3	1.1	3.8	-2.0	-0.6	0.2	0.0
Ever depressed for a whole week	1.0	1.2	4.2	0.8	2.0	0.1	-0.1
Unable to work because of sickness or disability	0.5	0.6	1.6	-0.0	-0.5	0.9	1.3
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.8	0.8	-0.3	-0.0
Myopia	0.4	0.6	1.3	0.8	1.1	0.6	0.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	0.4	1.0	-0.8	-0.7
Cholesterol lowering medication	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.5	3.5	-0.8	-1.9	0.7	1.2
Pain experienced in last month	1.9	3.2	4.9	-0.4	2.0	-2.2	-2.0
Supplements: Calcium	0.1	0.2	0.2	-0.5	-0.3	-0.4	-0.4
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	0.2	-0.8	0.9	0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.7	0.4	-1.0	0.5	1.3
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.0	2.0	-0.6	1.3	1.7
Heart disease (siblings)	0.9	1.1	1.8	-1.0	0.6	-1.1	-1.4
Alcohol drinker status: Previous	1.2	1.4	2.3	0.0	1.0	-1.5	-1.5
Pack years of smoking	0.9	1.3	3.1	0.1	-1.8	1.0	1.1
Impedance of whole body	2.1	10.8	33.2	-0.7	5.8	-2.2	-2.2
Leg fat mass (left)	2.5	9.9	20.1	-0.6	-4.5	2.8	3.4
Arm predicted mass (left)	3.4	17.1	37.9	0.3	-6.2	3.5	4.3