TWAS
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Usage
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Genes
Traits
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Traits
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Impedance of leg (left)
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chr7:45,255,940-46,658,015
Best TWAS P=2.1e-09 · Best GWAS P=1.17e-25 conditioned to 1.06e-21
45.2M
45.4M
45.6M
45.8M
46M
46.2M
46.4M
46.6M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Skin Sun Exposed Lower leg
IGFBP3
0.09
0
lasso
6
0
0.27
4.9
6
2.1e-09
-0.17
0.14
0.06
TRUE