Best TWAS P=9.87e-12 · Best GWAS P=1.21e-15 conditioned to 0.144
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cortex | WARS2 | 0.40 | 0.16 | enet | 31 | 0.34 | 3.6e-10 | 4.3 | -5.1 | 2.9e-07 | 0.79 | 0.01 | 0.99 | FALSE |
2 | GTEx | Brain Hypothalamus | WARS2 | 0.28 | 0.15 | enet | 13 | 0.25 | 1.1e-06 | 2.4 | -5.5 | 3.9e-08 | 0.84 | 0.02 | 0.96 | FALSE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | WARS2 | 0.40 | 0.18 | enet | 10 | 0.23 | 9.2e-07 | 4.3 | -5.7 | 1.5e-08 | 0.79 | 0.01 | 0.96 | FALSE |
4 | GTEx | Brain Putamen basal ganglia | RP11-418J17.1 | 0.49 | 0.26 | lasso | 10 | 0.37 | 1.3e-09 | 2.0 | -5.3 | 1.3e-07 | 0.63 | 0.52 | 0.36 | FALSE |
5 | GTEx | Pancreas | WARS2 | 0.33 | 0.14 | lasso | 8 | 0.28 | 3.8e-12 | 2.4 | -5.2 | 1.6e-07 | 0.78 | 0.08 | 0.92 | FALSE |
6 | GTEx | Testis | WARS2 | 0.25 | 0.17 | lasso | 3 | 0.17 | 4.3e-08 | 4.8 | 5.7 | 1.6e-08 | -0.46 | 0.83 | 0.08 | TRUE |
7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBX15 | 0.07 | 0.02 | blup | 92 | 0.05 | 2.2e-06 | 6.9 | 6.8 | 9.9e-12 | -0.67 | 0.10 | 0.89 | TRUE |
8 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | WARS2 | 0.30 | 0.12 | blup | 73 | 0.29 | 2.3e-08 | 4.3 | -5.3 | 9.7e-08 | 0.82 | 0.02 | 0.96 | FALSE |