Best TWAS P=5.08e-13 · Best GWAS P=1.37e-19 conditioned to 0.0335
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADAMTS14 | 0.28 | 0.24 | bslmm | 733 | 0.35 | 7.9e-44 | -2.9 | 6.5 | 8.6e-11 | 0.74 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | PCBD1 | 0.19 | 0.01 | lasso | 6 | 0.01 | 3.0e-02 | -5.1 | 5.7 | 1.5e-08 | 0.43 | 0.12 | 0.14 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | ADAMTS14 | 0.38 | 0.35 | bslmm | 710 | 0.47 | 3.9e-67 | 8.8 | 7.2 | 5.1e-13 | 0.79 | 0.03 | 0.97 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADAMTS14 | 0.05 | 0.03 | enet | 17 | 0.03 | 3.4e-07 | -2.7 | 5.5 | 3.6e-08 | 0.67 | 0.40 | 0.60 | FALSE |