TWAS
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Traits
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Traits
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Impedance of leg (left)
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chr10:71,736,472-73,345,380
Best TWAS P=5.08e-13 · Best GWAS P=1.37e-19 conditioned to 0.0335
71.8M
72M
72.2M
72.4M
72.6M
72.8M
73M
73.2M
73.4M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
ADAMTS14
0.38
0.35
bslmm
710
0.47
3.9e-67
8.8
7.2
5.1e-13
0.79
0.03
0.97
TRUE
2
GTEx
Artery Tibial
PCBD1
0.19
0.01
lasso
6
0.01
3.0e-02
-5.1
5.7
1.5e-08
0.43
0.12
0.14
TRUE
1
CommonMind
Brain Pre-frontal Cortex
ADAMTS14
0.28
0.24
bslmm
733
0.35
7.9e-44
-2.9
6.5
8.6e-11
0.74
0.01
0.99
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
ADAMTS14
0.05
0.03
enet
17
0.03
3.4e-07
-2.7
5.5
3.6e-08
0.67
0.40
0.60
FALSE