Best TWAS P=2.82e-09 · Best GWAS P=1.17e-09 conditioned to 0.00233
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | -5.4 | 5.7 | 9.6e-09 | 0.06 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | -5.4 | 5.9 | 3.0e-09 | 0.06 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | -5.4 | 5.5 | 5.0e-08 | 0.07 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Aorta | VCL | 0.17 | 0.06 | lasso | 9 | 0.09 | 7.9e-06 | -3.8 | 5.6 | 1.7e-08 | -0.57 | 0.20 | 0.76 | FALSE |
5 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | -5.4 | 5.8 | 7.7e-09 | 0.05 | 0.02 | 0.98 | FALSE |
6 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | -5.4 | 5.7 | 1.5e-08 | 0.06 | 0.02 | 0.98 | FALSE |
7 | GTEx | Testis | ZNF503-AS2 | 0.16 | 0.02 | lasso | 4 | 0.06 | 1.3e-03 | -5.7 | -5.3 | 8.8e-08 | -0.07 | 0.01 | 0.95 | FALSE |
8 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | -5.0 | 5.9 | 2.8e-09 | 0.08 | 0.03 | 0.97 | TRUE |
9 | YFS | Blood | ADK | 0.42 | 0.38 | enet | 45 | 0.44 | 1.4e-163 | -3.9 | -5.2 | 2.1e-07 | 0.65 | 0.99 | 0.00 | FALSE |
10 | YFS | Blood | AP3M1 | 0.27 | 0.11 | lasso | 5 | 0.15 | 1.5e-45 | -3.9 | -5.4 | 5.8e-08 | 0.58 | 0.99 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | VCL | 0.02 | 0.00 | blup | 57 | 0.01 | 5.7e-04 | -6.1 | 5.9 | 4.1e-09 | -0.82 | 0.00 | 0.91 | TRUE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | VCL | 0.04 | 0.03 | lasso | 1 | 0.02 | 5.8e-04 | -5.7 | 5.7 | 1.0e-08 | -0.94 | 0.01 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VCL | 0.08 | 0.06 | blup | 56 | 0.07 | 1.5e-07 | -6.1 | 5.9 | 4.8e-09 | -0.93 | 0.00 | 1.00 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | VCL | 0.08 | 0.02 | blup | 57 | 0.05 | 7.6e-06 | -3.9 | 5.8 | 5.5e-09 | -0.71 | 0.10 | 0.78 | FALSE |