[Hub]/) : Traits : Impedance of leg (left) : ← →

chr11:42,881,882-44,596,817

Best TWAS P=7.7e-09 · Best GWAS P=9.66e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
24	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HSD17B12	0.18	0.22	lasso	2	0.20	2.2e-10	-5.3	5.8	7.7e-09	-0.99	0.00	1.00	TRUE
3	GTEx	Adipose Visceral Omentum	RP11-613D13.5	0.18	0.01	lasso	3	0.05	8.9e-04	-5.3	5.6	1.9e-08	-0.81	0.00	0.99	FALSE
6	GTEx	Artery Tibial	RP11-613D13.5	0.17	0.18	lasso	6	0.18	2.4e-14	-5.3	5.4	7.3e-08	-0.98	0.00	1.00	FALSE
4	GTEx	Adrenal Gland	HSD17B12	0.20	0.19	lasso	7	0.18	5.2e-07	-5.3	5.4	8.3e-08	-1.00	0.01	0.98	FALSE
12	GTEx	Heart Left Ventricle	HSD17B12	0.25	0.28	lasso	4	0.25	8.2e-14	-5.3	5.4	8.3e-08	-1.00	0.00	0.99	FALSE
17	GTEx	Skin Sun Exposed Lower leg	RP11-613D13.5	0.17	0.22	lasso	3	0.21	2.2e-17	-5.3	5.4	8.7e-08	-1.00	0.00	1.00	FALSE
19	GTEx	Stomach	RP11-613D13.5	0.18	0.21	lasso	3	0.21	1.6e-10	-5.3	5.3	9.5e-08	-1.00	0.00	0.99	FALSE
9	GTEx	Breast Mammary Tissue	HSD17B12	0.21	0.17	lasso	1	0.12	6.0e-07	-5.3	5.3	9.7e-08	-1.00	0.01	0.99	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	HSD17B12	0.45	0.59	lasso	1	0.59	1.9e-39	-5.3	5.3	9.7e-08	-1.00	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD17B12	0.22	0.25	lasso	1	0.24	9.8e-12	-5.3	5.3	9.7e-08	-1.00	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	HSD17B12	0.17	0.27	lasso	1	0.26	6.0e-19	-5.3	5.3	9.7e-08	-1.00	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	HSD17B12	0.21	0.20	lasso	1	0.16	4.3e-05	-5.3	5.3	9.7e-08	-1.00	0.01	0.98	FALSE
18	GTEx	Stomach	HSD17B12	0.37	0.51	lasso	2	0.51	9.5e-28	-5.3	5.3	1.0e-07	-1.00	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HSD17B12	0.28	0.30	lasso	4	0.29	8.1e-13	-5.3	5.3	1.0e-07	-1.00	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	HSD17B12	0.13	0.20	lasso	3	0.18	3.9e-11	-5.3	5.3	1.0e-07	-1.00	0.00	1.00	FALSE
13	GTEx	Lung	RP11-613D13.5	0.18	0.20	lasso	2	0.17	6.0e-13	-5.3	5.3	1.1e-07	-1.00	0.00	1.00	FALSE
14	GTEx	Pancreas	HSD17B12	0.43	0.40	lasso	2	0.40	7.6e-18	-5.3	5.3	1.1e-07	-0.99	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD17B12	0.10	0.20	lasso	4	0.20	7.5e-39	-5.3	5.3	1.1e-07	-1.00	0.00	1.00	FALSE
20	GTEx	Thyroid	HSD17B12	0.52	0.59	lasso	4	0.59	1.1e-55	-5.3	5.3	1.2e-07	-1.00	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B12	0.32	0.48	lasso	4	0.47	1.5e-60	-5.3	5.3	1.2e-07	-1.00	0.00	1.00	FALSE
21	GTEx	Thyroid	RP11-613D13.5	0.24	0.18	lasso	2	0.15	7.3e-12	-5.3	5.3	1.4e-07	-1.00	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B12	0.60	0.66	lasso	2	0.65	4.5e-84	-5.3	5.3	1.5e-07	-1.00	0.00	1.00	FALSE
11	GTEx	Esophagus Muscularis	RP11-613D13.5	0.21	0.20	lasso	2	0.19	9.6e-12	-5.3	5.2	1.9e-07	-0.96	0.01	0.99	FALSE
22	GTEx	Whole Blood	HSD17B12	0.29	0.36	lasso	3	0.36	4.5e-34	-5.3	5.2	2.0e-07	-1.00	0.00	1.00	FALSE
10	GTEx	Colon Transverse	RP11-613D13.5	0.21	0.24	lasso	3	0.23	3.4e-11	-5.3	5.2	2.1e-07	-1.00	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HSD17B12	0.20	0.26	lasso	2	0.26	1.3e-29	-5.3	5.2	2.2e-07	-1.00	0.00	1.00	FALSE
8	GTEx	Brain Hippocampus	HSD17B12	0.49	0.43	lasso	6	0.41	8.9e-11	-5.3	5.2	2.3e-07	-1.00	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	RP11-613D13.5	0.10	0.11	lasso	2	0.10	8.1e-09	-5.3	5.2	2.4e-07	-1.00	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD17B12	0.36	0.52	lasso	6	0.52	3.8e-63	-5.3	5.2	2.4e-07	-1.00	0.00	1.00	FALSE
5	GTEx	Artery Aorta	RP11-613D13.5	0.31	0.27	lasso	3	0.27	3.0e-15	-5.3	5.2	2.5e-07	-0.99	0.00	1.00	FALSE
7	GTEx	Brain Frontal Cortex BA9	HSD17B12	0.45	0.38	lasso	7	0.36	2.8e-10	-5.3	5.1	2.6e-07	-0.99	0.01	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	HSD17B12	0.46	0.60	lasso	7	0.61	9.2e-63	-5.3	5.1	2.6e-07	-0.99	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HSD17B12	0.44	0.51	lasso	11	0.53	6.0e-76	-5.3	5.1	2.8e-07	-0.99	0.00	1.00	FALSE