Best TWAS P=7.7e-09 · Best GWAS P=9.66e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HSD17B12 | 0.44 | 0.51 | lasso | 11 | 0.53 | 6.0e-76 | -5.3 | 5.1 | 2.8e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP11-613D13.5 | 0.10 | 0.11 | lasso | 2 | 0.10 | 8.1e-09 | -5.3 | 5.2 | 2.4e-07 | -1.00 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | RP11-613D13.5 | 0.18 | 0.01 | lasso | 3 | 0.05 | 8.9e-04 | -5.3 | 5.6 | 1.9e-08 | -0.81 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Adrenal Gland | HSD17B12 | 0.20 | 0.19 | lasso | 7 | 0.18 | 5.2e-07 | -5.3 | 5.4 | 8.3e-08 | -1.00 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Artery Aorta | RP11-613D13.5 | 0.31 | 0.27 | lasso | 3 | 0.27 | 3.0e-15 | -5.3 | 5.2 | 2.5e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Artery Tibial | RP11-613D13.5 | 0.17 | 0.18 | lasso | 6 | 0.18 | 2.4e-14 | -5.3 | 5.4 | 7.3e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Frontal Cortex BA9 | HSD17B12 | 0.45 | 0.38 | lasso | 7 | 0.36 | 2.8e-10 | -5.3 | 5.1 | 2.6e-07 | -0.99 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Brain Hippocampus | HSD17B12 | 0.49 | 0.43 | lasso | 6 | 0.41 | 8.9e-11 | -5.3 | 5.2 | 2.3e-07 | -1.00 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | HSD17B12 | 0.21 | 0.17 | lasso | 1 | 0.12 | 6.0e-07 | -5.3 | 5.3 | 9.7e-08 | -1.00 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Colon Transverse | RP11-613D13.5 | 0.21 | 0.24 | lasso | 3 | 0.23 | 3.4e-11 | -5.3 | 5.2 | 2.1e-07 | -1.00 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Esophagus Muscularis | RP11-613D13.5 | 0.21 | 0.20 | lasso | 2 | 0.19 | 9.6e-12 | -5.3 | 5.2 | 1.9e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Heart Left Ventricle | HSD17B12 | 0.25 | 0.28 | lasso | 4 | 0.25 | 8.2e-14 | -5.3 | 5.4 | 8.3e-08 | -1.00 | 0.00 | 0.99 | FALSE |
| 13 | GTEx | Lung | RP11-613D13.5 | 0.18 | 0.20 | lasso | 2 | 0.17 | 6.0e-13 | -5.3 | 5.3 | 1.1e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Pancreas | HSD17B12 | 0.43 | 0.40 | lasso | 2 | 0.40 | 7.6e-18 | -5.3 | 5.3 | 1.1e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Skin Not Sun Exposed Suprapubic | HSD17B12 | 0.45 | 0.59 | lasso | 1 | 0.59 | 1.9e-39 | -5.3 | 5.3 | 9.7e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | HSD17B12 | 0.46 | 0.60 | lasso | 7 | 0.61 | 9.2e-63 | -5.3 | 5.1 | 2.6e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | RP11-613D13.5 | 0.17 | 0.22 | lasso | 3 | 0.21 | 2.2e-17 | -5.3 | 5.4 | 8.7e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Stomach | HSD17B12 | 0.37 | 0.51 | lasso | 2 | 0.51 | 9.5e-28 | -5.3 | 5.3 | 1.0e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Stomach | RP11-613D13.5 | 0.18 | 0.21 | lasso | 3 | 0.21 | 1.6e-10 | -5.3 | 5.3 | 9.5e-08 | -1.00 | 0.00 | 0.99 | FALSE |
| 20 | GTEx | Thyroid | HSD17B12 | 0.52 | 0.59 | lasso | 4 | 0.59 | 1.1e-55 | -5.3 | 5.3 | 1.2e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 21 | GTEx | Thyroid | RP11-613D13.5 | 0.24 | 0.18 | lasso | 2 | 0.15 | 7.3e-12 | -5.3 | 5.3 | 1.4e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Whole Blood | HSD17B12 | 0.29 | 0.36 | lasso | 3 | 0.36 | 4.5e-34 | -5.3 | 5.2 | 2.0e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HSD17B12 | 0.10 | 0.20 | lasso | 4 | 0.20 | 7.5e-39 | -5.3 | 5.3 | 1.1e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | HSD17B12 | 0.18 | 0.22 | lasso | 2 | 0.20 | 2.2e-10 | -5.3 | 5.8 | 7.7e-09 | -0.99 | 0.00 | 1.00 | TRUE |
| 25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSD17B12 | 0.32 | 0.48 | lasso | 4 | 0.47 | 1.5e-60 | -5.3 | 5.3 | 1.2e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 26 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | HSD17B12 | 0.22 | 0.25 | lasso | 1 | 0.24 | 9.8e-12 | -5.3 | 5.3 | 9.7e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 27 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | HSD17B12 | 0.20 | 0.26 | lasso | 2 | 0.26 | 1.3e-29 | -5.3 | 5.2 | 2.2e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HSD17B12 | 0.28 | 0.30 | lasso | 4 | 0.29 | 8.1e-13 | -5.3 | 5.3 | 1.0e-07 | -1.00 | 0.01 | 0.99 | FALSE |
| 29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HSD17B12 | 0.36 | 0.52 | lasso | 6 | 0.52 | 3.8e-63 | -5.3 | 5.2 | 2.4e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 30 | The Cancer Genome Atlas | Soft Tissue Sarcoma | HSD17B12 | 0.13 | 0.20 | lasso | 3 | 0.18 | 3.9e-11 | -5.3 | 5.3 | 1.0e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Stomach Adenocarcinoma | HSD17B12 | 0.17 | 0.27 | lasso | 1 | 0.26 | 6.0e-19 | -5.3 | 5.3 | 9.7e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 32 | The Cancer Genome Atlas | Thyroid Carcinoma | HSD17B12 | 0.60 | 0.66 | lasso | 2 | 0.65 | 4.5e-84 | -5.3 | 5.3 | 1.5e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | HSD17B12 | 0.21 | 0.20 | lasso | 1 | 0.16 | 4.3e-05 | -5.3 | 5.3 | 9.7e-08 | -1.00 | 0.01 | 0.98 | FALSE |