Best TWAS P=3e-10 · Best GWAS P=7.65e-10 conditioned to 0.00239
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PRR13 | 0.13 | 0.10 | lasso | 7 | 0.09 | 9.2e-08 | -5.3 | 5.5 | 4.7e-08 | -0.60 | 0.14 | 0.86 | FALSE |
2 | GTEx | Adipose Visceral Omentum | PRR13 | 0.09 | 0.09 | lasso | 2 | 0.06 | 4.2e-04 | -5.2 | 5.3 | 1.3e-07 | -0.60 | 0.03 | 0.90 | FALSE |
3 | GTEx | Artery Aorta | PRR13 | 0.23 | 0.28 | enet | 39 | 0.30 | 4.3e-17 | -5.3 | 5.3 | 9.4e-08 | -0.49 | 0.06 | 0.94 | FALSE |
4 | GTEx | Artery Tibial | PRR13 | 0.15 | 0.18 | enet | 21 | 0.22 | 5.4e-17 | -5.3 | 5.2 | 1.7e-07 | -0.49 | 0.05 | 0.95 | FALSE |
5 | GTEx | Brain Cerebellum | PRR13 | 0.19 | 0.02 | enet | 5 | 0.03 | 4.6e-02 | -5.6 | -5.5 | 2.9e-08 | 0.62 | 0.04 | 0.67 | FALSE |
6 | GTEx | Brain Putamen basal ganglia | ATP5G2 | 0.26 | 0.26 | lasso | 6 | 0.21 | 1.0e-05 | -5.9 | -5.9 | 3.6e-09 | 0.98 | 0.01 | 0.98 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | PRR13 | 0.22 | 0.16 | lasso | 4 | 0.18 | 3.2e-07 | -5.3 | 5.6 | 2.5e-08 | -0.46 | 0.03 | 0.89 | FALSE |
8 | GTEx | Esophagus Muscularis | PRR13 | 0.13 | 0.15 | lasso | 2 | 0.14 | 9.2e-09 | -5.3 | 5.5 | 4.2e-08 | -0.55 | 0.05 | 0.95 | FALSE |
9 | GTEx | Nerve Tibial | PRR13 | 0.17 | 0.21 | lasso | 3 | 0.20 | 2.7e-14 | -5.3 | 5.2 | 2.0e-07 | -0.56 | 0.05 | 0.95 | FALSE |
10 | GTEx | Ovary | ATP5G2 | 0.41 | 0.29 | lasso | 12 | 0.28 | 1.7e-07 | -4.6 | -5.2 | 2.2e-07 | 0.93 | 0.01 | 0.98 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | PRR13 | 0.17 | 0.09 | lasso | 4 | 0.09 | 1.6e-05 | -5.2 | 5.4 | 8.2e-08 | -0.60 | 0.04 | 0.96 | FALSE |
12 | GTEx | Thyroid | SP1 | 0.11 | 0.05 | lasso | 7 | 0.04 | 8.2e-04 | -5.5 | -5.4 | 6.9e-08 | 0.63 | 0.05 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRR13 | 0.13 | 0.04 | blup | 28 | 0.07 | 3.3e-06 | -4.1 | 5.3 | 9.3e-08 | -0.44 | 0.03 | 0.72 | FALSE |
14 | The Cancer Genome Atlas | Colon Adenocarcinoma | ATP5G2 | 0.07 | 0.06 | lasso | 2 | 0.06 | 4.0e-04 | -5.9 | -6.1 | 1.3e-09 | 0.94 | 0.00 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRR13 | 0.05 | 0.03 | blup | 28 | 0.04 | 4.1e-03 | -5.3 | 5.8 | 8.6e-09 | -0.65 | 0.01 | 0.67 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRR13 | 0.07 | 0.04 | blup | 28 | 0.05 | 4.7e-06 | -5.3 | 5.9 | 4.0e-09 | -0.61 | 0.01 | 0.97 | FALSE |
17 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PCBP2 | 0.25 | 0.04 | blup | 36 | 0.10 | 2.3e-03 | 4.6 | 6.1 | 8.6e-10 | -0.69 | 0.01 | 0.25 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | PCBP2 | 0.04 | 0.01 | enet | 6 | 0.02 | 4.8e-03 | -4.6 | 6.3 | 3.0e-10 | -0.59 | 0.01 | 0.22 | TRUE |