TWAS hub - PCBP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0149	0.0088	0.0220	0.017	0.000	0.008	0.009	0.013	2.0e-06	0.5000	0.00087	0.00039	2.2e-05
2	TCGA	Rectum Adenocarcinoma	0.2540	0.1310	0.0047	0.040	0.101	0.062	NA	0.074	4.1e-02	0.0023	0.01500	NA	8.4e-03
3	TCGA	Thyroid Carcinoma	0.0420	0.0270	0.0047	0.009	0.011	0.019	NA	0.008	4.0e-02	0.0290	0.00480	NA	4.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ever had stillbirth, spontaneous miscarriage or termination	7.8	8.4	12.9	-0.5	3.5	3.6
Ever had prostate specific antigen (PSA) test	6.1	7.1	10.9	-1.8	2.7	3.3
Impedance of leg (right)	5.8	28.0	41.3	3.1	5.7	6.4
Impedance of leg (left)	5.8	28.3	39.7	2.8	6.1	6.3
Leg predicted mass (right)	5.8	30.9	43.4	-3.2	-6.2	-6.6
Leg fat-free mass (left)	5.7	30.1	40.7	-3.2	-6.3	-6.4
Leg predicted mass (left)	5.7	30.3	41.2	-3.2	-6.3	-6.4
Leg fat-free mass (right)	5.6	29.9	41.9	-3.2	-6.2	-6.5
Intelligence (Savage-Jansen 2018)	5.2	16.0	24.1	-1.1	-4.9	-4.8
LDL Cholesterol	4.7	7.4	12.8	0.4	-3.0	-3.6
BMI	4.7	27.5	36.6	-3.3	-5.9	-6.0
Schizophrenia (2018)	4.4	9.2	15.0	-0.9	3.9	3.4
Maternal smoking around birth	4.1	6.0	6.9	-2.1	2.6	2.6
Basal metabolic rate	4.1	22.5	30.3	-2.9	-5.4	-5.5
Hair/balding pattern: Pattern 4	4.0	9.8	12.5	-3.4	-2.2	-3.5
Whole body water mass	4.0	22.7	30.7	-2.9	-5.4	-5.5
Weight	3.9	19.3	25.0	-2.9	-4.9	-5.0
Whole body fat-free mass	3.8	22.0	29.5	-2.9	-5.3	-5.4
Arm fat mass (right)	3.6	15.0	21.1	-2.3	-4.3	-4.6
Schizophrenia (2014)	3.5	7.8	12.7	-0.5	3.6	3.2
Birth weight	3.5	7.5	12.1	1.0	-3.1	-3.5
Arm fat mass (left)	3.5	14.5	20.9	-2.2	-4.2	-4.6
Shortness of breath walking on level ground	3.4	4.0	7.3	0.2	-2.2	-2.7
Hip circumference	3.3	14.4	18.5	-2.5	-4.3	-4.3
Arm predicted mass (right)	3.3	16.7	21.9	-2.7	-4.6	-4.7
Arm fat-free mass (left)	3.3	16.5	21.6	-2.8	-4.5	-4.7
Body mass index (BMI)	3.2	13.6	19.2	-2.3	-4.0	-4.4
Arm predicted mass (left)	3.2	16.2	21.5	-2.7	-4.5	-4.6
Arm fat-free mass (right)	3.1	15.8	20.6	-2.7	-4.4	-4.5
Trunk fat-free mass	3.0	17.4	22.7	-2.6	-4.7	-4.8
Trunk predicted mass	3.0	17.0	22.1	-2.6	-4.7	-4.7
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.6	6.5	1.3	-2.4	-2.6
Impedance of whole body	2.8	14.1	18.6	2.4	4.3	4.3
Verbal and Numeric Reasoning (VNR)	2.7	6.6	9.4	-1.0	-3.0	-3.1
Blood Red Count	2.7	25.6	48.4	-1.7	-7.0	-5.1
Trunk fat mass	2.7	11.6	15.9	-2.3	-3.7	-4.0
Fluid intelligence score	2.6	5.5	8.2	0.3	-2.9	-2.9
Heart attack/myocardial infarction (self-reported)	2.6	3.4	5.1	0.3	-2.2	-2.3
Stomach or abdominal pain in last month	2.5	3.2	5.5	-1.5	2.3	1.3
Sitting height	2.5	17.4	26.4	-0.5	-5.1	-5.0
Heart attack	2.5	3.2	5.0	-0.1	-2.1	-2.2
Arm fat percentage (right)	2.5	9.7	14.4	-1.9	-3.3	-3.8
High cholesterol (Self-reported)	2.5	4.4	7.5	0.9	-2.2	-2.7
Medication: Lisinopril	2.5	3.3	5.1	-1.0	2.3	1.9
Alzheimer’s Disease (including proxy)	2.4	3.5	5.4	-0.4	-2.3	-2.2
Leg pain on walking	2.4	3.0	5.2	-0.0	-1.9	-2.3
Arm fat percentage (left)	2.4	9.7	14.7	-1.7	-3.4	-3.8
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	5.2	0.8	2.3	1.2
Exposure to tobacco smoke outside home	2.3	3.1	4.4	2.1	-1.0	-2.0
Health satisfaction	2.3	3.1	5.5	-0.4	-1.9	-2.4
Eye problems/disorders: None of the above	2.3	2.6	5.9	0.9	1.1	2.4
Whole body fat mass	2.3	9.7	12.5	-2.3	-3.4	-3.5
Cholesterol lowering medication	2.3	3.3	5.4	-1.8	-1.1	-2.3
Waist Hip Ratio (WHR)	2.2	9.9	14.9	2.6	3.9	2.9
Relative age of first facial hair	2.2	4.4	4.9	2.0	2.2	2.0
Leg fat mass (left)	2.2	8.4	9.9	-2.4	-3.1	-3.1
Hand grip strength (left)	2.1	5.6	11.4	-3.4	2.1	0.9
Gout (self-reported)	2.1	2.9	4.5	-1.8	2.1	0.9
Lung FEV1/FVC ratio	2.0	10.2	26.9	-5.2	-0.2	-1.9
Vitamin and mineral supplements	2.0	2.7	5.8	2.4	-0.9	-1.2
Leg fat mass (right)	2.0	7.7	9.5	-2.2	-3.1	-3.0
Bipolar Disorder or Schizophrenia	1.9	4.7	8.0	-0.4	2.8	2.4
Alzheimer’s Disease (in father)	1.9	2.0	4.5	0.1	-2.1	-1.3
Average weekly spirits intake	1.9	2.3	6.9	2.6	0.1	0.2
Had menopause	1.9	2.4	6.3	-2.5	-0.3	-0.9
Illnesses of father: High blood pressure	1.9	2.3	4.1	-0.9	2.0	1.4
Risk taking	1.9	2.8	5.2	-2.3	1.6	0.8
Schizophrenia vs Biploar Disorder	1.8	2.4	3.2	-1.8	1.5	1.3
Hand grip strength (right)	1.8	4.9	10.3	-3.2	1.9	0.8
Overall health rating	1.8	3.8	7.1	0.2	-2.1	-2.7
Waist circumference	1.7	6.0	9.9	-1.3	-2.6	-3.1
Medication: Allopurinol	1.7	2.3	3.4	-1.8	1.6	1.0
Pulse rate, automated reading	1.7	5.5	16.4	-4.1	-0.0	0.1
Body Mass Index (BMI) (2010)	1.6	2.2	3.4	-1.0	-1.5	-1.8
Systolic Blood Pressure	1.6	8.1	12.5	1.4	3.5	3.1
Trunk fat percentage	1.6	6.4	9.5	-1.7	-2.6	-3.1
Depression (self-reported)	1.6	2.0	4.5	-0.2	-1.2	-2.1
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	6.1	-2.5	1.2	0.6
Comparative body size at age 10	1.6	4.5	6.8	1.4	-2.6	-2.1
Mother’s age at death	1.6	2.0	3.3	0.1	-1.6	-1.8
Eye problems/disorders: Glaucoma	1.6	1.8	2.6	-1.5	-0.8	-1.6
Alcohol drinker status: Never	1.6	1.9	2.7	0.8	-1.6	-1.6
Sensitivity / hurt feelings	1.5	2.7	3.5	1.4	1.9	1.6
Time employed in main current job	1.5	1.8	2.3	1.4	-1.0	-1.5
Falls in the last year	1.5	2.0	3.0	1.2	1.7	1.3
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.2	0.7	-1.4	-1.8
Worry too long after embarrassment	1.5	2.5	3.4	1.3	1.8	1.6
Reaction Time	1.4	2.8	4.0	-2.0	1.6	1.2
Primary Biliary Cirrhosis	1.4	1.9	5.7	2.4	0.0	0.3
Triglycerides	1.4	2.3	3.4	-1.5	-1.0	-1.8
Hearing difficulty/problems: Yes	1.4	2.2	3.4	1.0	-1.8	-1.5
Multivitamins +/- minerals	1.4	1.8	3.0	-1.7	0.9	1.2
Number of incorrect matches in round	1.4	2.2	3.3	-0.8	1.8	1.6
Irritable Bowel Disease (IBD)	1.3	3.0	5.6	1.7	-2.4	-0.9
Bipolar Disorder (2011)	1.3	1.2	3.7	1.9	0.1	0.2
Smoking Status	1.3	3.1	5.5	-2.3	1.8	0.6
Systolic blood pressure, automated reading	1.3	3.8	5.5	1.0	2.3	2.2
Chronic bronchitis/emphysema (mother)	1.3	1.6	2.6	1.6	1.0	1.1
Body fat percentage	1.3	5.0	7.1	-1.7	-2.3	-2.7
Eye problems/disorders: Cataract	1.3	1.5	3.1	-0.3	-1.1	-1.8
Qualifications: CSEs or equivalent	1.2	1.6	2.5	1.6	0.3	1.5
Tense / ‘highly strung’	1.2	1.9	2.4	1.2	1.5	1.4
Peak expiratory flow (PEF)	1.2	2.9	6.5	-2.6	-1.3	-0.8
Qualifications: College or University degree	1.2	3.9	5.3	-1.5	2.3	2.0
Long-standing illness, disability or infirmity	1.2	1.8	2.4	1.1	-1.3	-1.6
Smoking status: Current	1.2	1.9	2.8	-1.4	1.7	0.9
Blood Eosinophil Count	1.1	8.1	22.0	4.7	-1.1	1.1
Diabetes (father)	1.1	1.3	3.9	2.0	-0.2	0.0
Severe depression (siblings)	1.1	1.3	1.9	0.9	1.1	1.4
Nervous feelings	1.1	2.0	4.7	2.2	1.0	0.6
Heart disease (mother)	1.1	1.4	2.8	-0.2	1.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	0.0	-1.2	-1.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.6	-1.9	0.5	-0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.1	-0.8	-0.7	-1.8
Myopia	1.1	1.6	3.9	-2.0	-0.4	-0.8
Ever had hysterectomy (womb removed)	1.0	1.2	1.4	0.9	-1.2	-1.2
Current tobacco smoking	1.0	1.6	2.7	-1.1	1.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	3.5	0.4	1.8	1.9
Number of live births	1.0	1.4	2.0	1.4	0.9	1.2
Medication: Cholesterol lowering	1.0	1.6	3.9	2.0	-0.9	-0.3
Mean time to correctly identify matches	1.0	1.9	2.6	-1.3	1.6	1.2
Alcohol intake frequency.	1.0	2.4	3.5	0.4	-1.8	-1.9
Age at last live birth	1.0	1.5	3.6	0.7	-0.7	-1.9
Ever had bowel cancer screening	1.0	1.2	3.5	-1.9	-0.2	-0.1
Medication: Aspirin	1.0	1.3	1.8	1.0	-1.1	-1.3
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.9	1.7	0.5	0.7
Diastolic blood pressure, automated reading	1.0	3.1	3.8	-1.8	1.9	1.5
Commuting to job workplace: Cycle	1.0	1.2	1.8	-1.0	1.3	0.9
Ulcerative Colitis (UC)	0.9	1.8	3.7	1.1	-1.9	-0.5
Coronary Artery Disease (CAD)	0.9	1.1	1.9	-1.4	-0.3	-1.2
Ulcerative Colitis	0.9	1.3	3.2	0.6	-1.8	-0.6
Cardiovascular Disease	0.9	3.0	7.5	-0.6	-1.1	-2.7
Relative age voice broke	0.9	1.4	3.4	1.8	0.2	0.9
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.2	1.8	0.2	0.1
High blood pressure (mother)	0.9	1.3	2.0	-0.5	1.3	1.4
Hair/balding pattern: Pattern 2	0.9	1.2	3.2	1.8	-0.5	-0.1
Medication: Simvastatin	0.9	1.4	3.1	0.6	-0.8	-1.8
Lung cancer (father)	0.9	1.1	2.7	-0.7	1.6	0.3
Impedance of arm (left)	0.9	4.2	5.0	1.7	2.2	2.1
Length of working week for main job	0.9	1.0	2.4	0.0	-1.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.5	-0.2	1.6	0.9
Suffer from ‘nerves’	0.9	1.4	3.7	1.9	-0.5	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.1	0.7	0.8	1.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	-0.7	-0.8	-1.3
Medication for hormone replacement therapy	0.8	0.9	1.7	-0.0	1.1	1.3
Supplements: Zinc	0.8	0.9	1.5	1.2	0.5	1.0
Medication: Atenolol	0.8	1.0	2.3	-1.5	0.7	-0.5
Impedance of arm (right)	0.8	3.8	5.0	1.5	2.2	2.0
Number of full brothers	0.8	1.0	1.9	0.5	0.9	1.4
Number of full sisters	0.8	0.9	1.7	0.5	1.3	0.9
Number of operations (self-reported)	0.8	1.1	1.6	0.7	-1.2	-1.3
Worry (Nagel 2018)	0.7	1.4	2.1	1.2	1.4	0.8
Crohns Disease (2017)	0.7	1.4	2.5	1.1	-1.6	-0.8
Crohns Disease (2012)	0.7	1.2	2.1	0.9	-1.4	-0.8
Lupus	0.7	1.0	2.9	1.7	-0.1	-0.4
Hypothyroidism (self reported)	0.7	1.7	2.4	0.8	1.6	1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.9	-1.7	0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	2.2	1.0	1.4	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.6	-1.3	1.2	-0.3
Medication: Ramipril	0.7	0.9	1.2	0.9	0.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.2	-2.1	-1.3	-0.7
Emphysema/chronic bronchitis	0.7	0.8	1.2	0.7	0.9	1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.7	1.0	1.0	-0.9	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.0	-1.7	0.4	0.1
Breast cancer (self-reported)	0.7	0.8	1.0	-0.8	1.0	0.9
Average weekly champagne plus white wine intake	0.7	1.0	2.6	-1.6	0.4	-0.4
Leg fat percentage (left)	0.7	2.4	2.6	-1.5	-1.5	-1.6
Fractured/broken bones in last 5 years	0.7	0.9	1.6	-0.5	0.9	1.3
Unable to work because of sickness or disability	0.7	0.8	1.7	-0.9	1.3	0.0
Respiratory disease	0.6	1.3	1.7	1.3	0.9	1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	-0.7	-0.2	-1.4
Townsend deprivation index at recruitment	0.6	0.8	1.9	-0.2	1.4	0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.2	-0.7	0.5	1.1
Pain all over the body in last month	0.6	0.6	1.4	1.2	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.3	-2.1	-1.3	-0.5
Exposure to tobacco smoke at home	0.6	0.7	1.2	0.3	0.9	1.1
Loud music exposure frequency	0.6	0.7	1.2	-1.1	0.7	0.6
Medication: Paracetamol	0.6	1.0	1.5	-0.9	-0.7	-1.2
Medication: Seretide 50 evohaler	0.6	0.7	2.0	1.4	0.2	0.0
Mood swings	0.6	1.1	2.1	0.0	-1.1	-1.5
Osteoarthritis (self-reported)	0.6	0.7	1.3	-0.5	-0.8	-1.1
Financial situation satisfaction	0.6	0.7	1.5	-0.5	-0.6	-1.2
Medication: Blood pressure	0.6	1.1	3.0	-1.7	-0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.0	1.0	0.6	0.9
Average weekly beer plus cider intake	0.6	0.8	1.8	-0.2	0.8	1.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	-0.1	-1.0	-1.1
Height	0.5	10.4	12.1	-2.8	-3.4	-3.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	-1.3	0.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.4	0.6	0.2	-1.2
Angina	0.5	0.6	1.4	-0.3	1.2	0.7
Age when periods started (menarche)	0.5	1.1	1.5	-1.0	0.9	1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-0.4	1.1	0.6
Medication: Levothyroxine sodium	0.5	0.8	1.0	0.7	0.9	1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	0.2	-0.3	-1.3
Diabetes (self-reported)	0.5	0.8	2.2	-0.1	1.5	0.4
Noisy workplace	0.5	0.6	0.7	-0.6	0.8	0.8
Prospective memory result	0.5	0.6	1.4	1.2	0.4	0.6
Headache pain in last month	0.5	0.8	1.4	-1.2	0.9	0.6
Leg fat percentage (right)	0.5	1.8	2.4	-1.1	-1.5	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	-1.1	0.9	0.3
Number of children fathered	0.5	0.5	0.8	0.2	0.8	0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	0.6	-0.8	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	1.3	1.1	0.1	1.1
Chest pain or discomfort	0.5	0.7	1.4	-0.7	-0.4	-1.2
Family relationship satisfaction	0.5	0.6	0.9	0.9	0.7	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.7	-1.6	-0.4	0.2
Wears glasses or contact lenses	0.5	0.6	1.3	-1.2	-0.5	-0.4
Hearing aid user	0.5	0.6	0.9	0.4	-0.9	-0.9
Medication: Atorvastatin	0.5	0.6	0.9	-0.7	-1.0	-0.5
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	-0.5	-0.9	-1.2
Major Depression (MDD)	0.4	0.5	0.6	0.7	-0.8	-0.6
Ovarian Cancer	0.4	0.5	0.8	0.6	-0.9	-0.5
HbA1C	0.4	0.5	1.2	1.1	-0.3	-0.3
Average weekly fortified wine intake	0.4	0.5	1.2	-0.5	-0.2	-1.1
Past tobacco smoking	0.4	0.8	2.0	1.4	-0.6	-0.0
Financial difficulties in last 2 years	0.4	0.6	1.5	1.2	0.3	0.2
Father’s age at death	0.4	0.5	1.3	0.4	-1.1	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	1.1	0.0	0.5	1.0
Standing height	0.4	4.3	5.8	-1.7	-2.4	-2.0
Birth weight of first child	0.4	0.8	2.0	-1.4	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.2	1.1	0.4	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.3	2.6	-0.9	-1.6	-0.8
Age at first live birth	0.4	0.7	1.1	1.0	-0.2	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.7	-0.3	-0.9	-0.7
Average weekly red wine intake	0.4	0.7	1.0	0.2	1.0	1.0
Diabetes diagnosed by doctor	0.4	0.7	1.7	-0.7	1.3	0.3
Medication for cholesterol	0.4	0.7	1.8	1.3	-0.1	0.4
Back pain experienced in last month	0.4	0.6	1.5	1.2	-0.2	0.3
Medication: Paracetamol	0.4	0.6	1.3	-1.1	-0.2	-0.6
Age started oral contraceptive pill	0.4	0.5	1.3	-1.1	0.1	-0.6
Depression (Nagel 2018)	0.3	0.4	0.9	-0.5	-0.1	-0.9
HDL Cholesterol	0.3	0.5	1.2	0.2	0.5	1.1
Rheumatoid Arthritis	0.3	0.4	0.6	0.7	0.3	0.8
Blood Platelet Count	0.3	3.7	4.3	2.1	-2.0	-1.7
Neuroticism	0.3	0.8	1.6	0.4	1.3	0.8
Hair Pigment	0.3	7.6	12.0	0.2	3.3	3.5
Medication: Metformin	0.3	0.4	0.7	-0.3	-0.7	-0.8
Diabetes (mother)	0.3	0.4	0.9	-0.9	0.1	0.7
Taking other prescription medications	0.3	0.5	1.0	-0.5	-1.0	-0.5
High blood pressure	0.3	0.9	2.1	-1.4	0.4	-0.7
Supplements: Glucosamine	0.3	0.4	1.2	-1.1	-0.2	-0.3
Alcohol usually taken with meals	0.3	0.4	0.7	-0.8	0.7	-0.1
Hearing difficulty/problems with background noise	0.3	0.4	0.7	-0.4	-0.9	-0.6
Had other major operations	0.3	0.4	0.6	0.4	0.5	0.8
Medication: Lansoprazole	0.3	0.4	0.9	-0.4	-0.4	-1.0
Pulse wave reflection index	0.3	0.4	0.9	0.9	-0.6	-0.2
Blood clot in the leg (DVT)	0.3	0.3	0.4	-0.6	-0.6	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	0.2	0.9	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	0.3	0.5	1.0
High blood pressure (siblings)	0.3	0.4	1.0	-1.0	0.3	0.2
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	1.1	0.2	-0.3
Neck or shoulder pain in last month	0.3	0.4	0.7	0.3	0.8	0.6
Medication: Blood pressure	0.3	0.5	1.4	1.2	-0.1	-0.1
Angina (self-reported)	0.3	0.4	0.8	-0.4	0.9	0.3
Medication: Ibuprofen	0.3	0.3	0.7	-0.2	0.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	-0.1	0.9	0.3
Medication: Aspirin	0.3	0.5	0.7	0.6	-0.6	-0.8
Supplements: Vitamin C	0.3	0.4	0.6	-0.6	0.5	0.8
Smoking status: Previous	0.3	0.4	1.0	-1.0	0.5	0.1
Loneliness, isolation	0.3	0.4	0.8	-0.7	-0.1	-0.9
Friendships satisfaction	0.3	0.3	0.5	0.7	0.6	0.2
Medication: Bendroflumethiazide	0.3	0.4	0.9	-0.9	0.2	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	1.4	-0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.8	-0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	-0.8	-0.3	-0.6
Alcohol drinker status: Previous	0.3	0.4	1.1	1.0	0.0	0.0
Neuroticism (Nagel 2018)	0.2	0.4	0.6	0.8	0.7	-0.2
Fasting Glucose	0.2	0.2	0.4	0.4	-0.3	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	-0.1	-0.6	-0.3
Blood White Count	0.2	1.1	3.2	-1.8	0.1	0.5
Heel T-Score	0.2	1.5	3.2	0.7	1.8	0.9
Allergy or Eczema	0.2	0.5	1.3	-1.1	-0.2	-0.2
Chronotype (morning person)	0.2	0.4	1.2	-1.1	0.0	-0.3
Number of treatments/medications taken	0.2	0.3	0.6	-0.8	-0.2	-0.4
Medication: Co-codamol	0.2	0.2	0.3	0.2	0.5	0.5
Fed-up feelings	0.2	0.3	0.4	-0.5	-0.6	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	0.6	-0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.1	-0.7	0.2
Forced vital capacity (FVC)	0.2	0.7	1.1	-1.1	-1.0	0.0
Mouth/teeth dental problems	0.2	0.2	0.4	-0.7	0.1	0.5
Hair/balding pattern: Pattern 3	0.2	0.4	0.8	-0.4	-0.9	-0.3
Pulse rate	0.2	0.4	0.8	-0.9	-0.6	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.1	0.4	0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	0.9	0.4	0.5
Asthma	0.2	0.5	1.3	1.2	0.2	0.1
Illnesses of mother	0.2	0.2	0.5	-0.7	-0.4	0.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.3	-0.6	0.6	0.4
Breastfed as a baby	0.2	0.3	0.6	0.3	0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.9	-0.1	-0.5
Glaucoma (self-reported)	0.2	0.2	0.3	-0.6	0.1	-0.5
Pulse wave peak to peak time	0.2	0.2	0.4	0.3	-0.6	-0.4
Migraine (self-reported)	0.2	0.2	0.5	0.7	-0.1	0.3
Comparative height size at age 10	0.2	1.0	1.2	-1.0	-0.8	-1.1
Hypertension (Self-reported)	0.2	0.7	1.4	-1.2	0.3	-0.7
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.8	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.5	0.7	-0.6	0.5
Mineral and other dietary supplements	0.2	0.3	0.4	-0.5	-0.4	-0.6
Asthma (self-reported)	0.2	0.4	1.1	1.1	0.3	0.2
Ever smoked	0.2	0.4	0.9	-1.0	0.5	0.0
Pain experienced in last month	0.2	0.4	0.5	0.7	0.2	0.7
Supplements: Calcium	0.2	0.2	0.3	-0.5	0.6	0.4
Bipolar Disorder (2018)	0.1	0.1	0.3	0.5	-0.1	-0.4
Age at First Birth	0.1	0.1	0.2	0.4	-0.5	-0.2
Lung FVC	0.1	0.4	1.0	0.4	0.2	1.0
Qualifications: None of the above	0.1	0.3	0.9	0.9	0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.1	0.3	0.5
Neuroticism score	0.1	0.3	0.5	0.7	0.5	0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.3	0.3	0.7
Worrier / anxious feelings	0.1	0.2	0.6	0.1	-0.2	-0.8
Happiness	0.1	0.1	0.2	0.2	0.2	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.1	-0.4	-0.6
Medication: Amlodipine	0.1	0.2	0.5	-0.7	0.2	0.2
Medication: Omeprazole	0.1	0.1	0.2	0.4	0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.5	0.2	0.1
Knee pain experienced in last month	0.1	0.2	0.6	-0.8	0.3	-0.0
Qualifications: nursing, teaching	0.1	0.1	0.3	0.5	0.1	0.1
Commuting to job workplace: Walk	0.1	0.2	0.2	-0.4	0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.4	0.3	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	0.1	0.5
Medication: Gliclazide	0.1	0.1	0.1	0.1	-0.4	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.4	0.2	0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.1	0.3	-0.4
Guilty feelings	0.1	0.1	0.2	0.5	-0.0	-0.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.1	0.5	0.2
Commuting to job workplace: Public transport	0.1	0.2	0.4	-0.6	-0.3	0.0
Irritability	0.1	0.1	0.4	-0.1	0.3	-0.6
Ever depressed for a whole week	0.1	0.2	0.4	-0.3	0.2	-0.6
Heart disease (siblings)	0.1	0.1	0.1	-0.4	-0.0	0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	-0.2	0.1	0.1
Neuroticism (2016)	0.0	0.1	0.2	-0.1	0.2	-0.4
Tanning	0.0	0.4	1.2	-0.1	0.0	-1.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	-0.0	0.1
Pack years adult smoking proportion	0.0	0.1	0.1	0.2	0.4	0.0
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	-0.3	-0.0	0.2
Allergy	0.0	0.0	0.0	-0.1	-0.1	-0.1
Illnesses of siblings	0.0	0.1	0.1	0.3	-0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.1	-0.3	-0.1
Had major operations	0.0	0.1	0.1	0.0	-0.2	-0.3
Miserableness	0.0	0.1	0.2	0.0	0.0	-0.4
Pack years of smoking	0.0	0.0	0.1	-0.3	0.2	-0.0

Hub : Genes

PCBP2

Models

Trait associations