TWAS hub - SP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0880	0.0270	4.0e-06	0.128	NA	0.098	NA	0.108	1.3e-10	NA	2.0e-08	NA	4.1e-09
2	GTEx	Adrenal Gland	0.2704	0.0714	3.7e-07	0.350	NA	0.305	NA	0.343	2.4e-13	NA	1.5e-11	NA	4.4e-13
3	GTEx	Artery Aorta	0.1350	0.0380	7.5e-07	0.143	NA	0.127	NA	0.145	2.9e-08	NA	1.7e-07	NA	2.2e-08
4	GTEx	Artery Coronary	0.1670	0.0710	3.4e-03	0.124	NA	0.068	NA	0.118	5.8e-05	NA	2.7e-03	NA	8.6e-05
5	GTEx	Breast Mammary Tissue	0.1210	0.0420	1.2e-04	0.129	NA	0.062	NA	0.076	3.8e-07	NA	4.3e-04	NA	9.5e-05
6	GTEx	Cells Transformed fibroblasts	0.0680	0.0310	6.9e-03	0.040	NA	0.021	NA	0.035	5.6e-04	NA	9.3e-03	NA	1.2e-03
7	GTEx	Colon Transverse	0.0980	0.0440	4.0e-03	0.089	NA	0.028	NA	0.060	5.3e-05	NA	1.7e-02	NA	7.7e-04
8	GTEx	Esophagus Mucosa	0.3520	0.0540	0.0e+00	0.462	NA	0.430	NA	0.454	4.1e-34	NA	4.1e-31	NA	2.6e-33
9	GTEx	Esophagus Muscularis	0.1530	0.0420	1.9e-07	0.217	NA	0.196	NA	0.211	2.5e-13	NA	5.0e-12	NA	5.9e-13
10	GTEx	Lung	0.1716	0.0424	8.5e-08	0.043	NA	0.079	NA	0.055	3.2e-04	NA	1.3e-06	NA	4.5e-05
11	GTEx	Nerve Tibial	0.2692	0.0542	3.7e-15	0.312	NA	0.311	NA	0.308	1.5e-22	NA	1.7e-22	NA	3.0e-22
12	GTEx	Skin Not Sun Exposed Suprapubic	0.0760	0.0320	1.3e-03	0.021	NA	0.045	NA	0.032	2.4e-02	NA	1.6e-03	NA	7.2e-03
13	GTEx	Skin Sun Exposed Lower leg	0.1330	0.0410	1.6e-06	0.099	NA	0.123	NA	0.127	1.6e-08	NA	2.2e-10	NA	1.1e-10
14	GTEx	Thyroid	0.1100	0.0380	2.3e-04	0.048	NA	0.031	NA	0.036	1.5e-04	NA	2.0e-03	NA	8.2e-04
15	GTEx	Vagina	0.3580	0.1180	2.5e-03	0.123	NA	0.095	NA	0.165	9.6e-04	NA	3.5e-03	NA	1.3e-04
16	METSIM	Adipose	0.0932	0.0247	4.8e-10	0.088	0.072	0.073	0.08	0.079	3.9e-13	5.7e-11	4.0e-11	5.0e-12	7.1e-12
17	YFS	Blood	0.2181	0.0372	0.0e+00	0.168	0.178	0.171	0.18	0.174	1.4e-52	6.3e-56	1.8e-53	1.4e-56	1.4e-54
18	TCGA	Brain Lower Grade Glioma	0.0347	0.0260	6.5e-03	0.014	0.006	0.009	NA	0.023	8.8e-03	5.6e-02	3.1e-02	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Blood Red Count	15.1	145.5	183.3	12.6	12.8	12.6	12.8	12.9	12.9	12.6	12.4	13.5	8.6	11.1	10.1	11.2	10.6	12.4	12.0	13.5	11.5
Heart attack/myocardial infarction (self-reported)	7.8	10.0	14.2	3.3	3.3	3.4	3.3	3.8	3.2	3.3	3.3	3.4	2.5	3.2	3.0	3.1	3.5	2.3	2.8	3.3	2.8
Ever had stillbirth, spontaneous miscarriage or termination	7.6	8.1	10.3	-3.2	-3.2	-3.2	-2.0	-2.9	-3.1	-3.2	-3.1	-2.9	-2.0	-3.1	-2.4	-2.9	-2.9	-2.7	-2.7	-2.6	-2.8
Heart attack	6.9	8.8	12.8	3.1	3.1	3.1	3.0	3.6	2.9	3.0	3.1	3.2	2.5	3.0	2.8	3.0	3.1	2.2	2.7	3.1	2.5
Frequency of tiredness / lethargy in last 2 weeks	5.7	9.2	12.6	3.3	3.3	3.2	2.8	3.6	3.3	3.3	3.3	3.2	2.3	2.5	2.7	3.3	2.8	3.0	2.8	3.2	2.5
High cholesterol (Self-reported)	5.6	9.9	12.8	3.6	3.6	3.5	2.5	2.8	3.5	3.6	3.4	3.6	3.3	3.2	1.6	2.8	3.0	3.2	2.5	3.2	3.4
Alzheimer’s Disease (including proxy)	5.5	7.9	9.7	3.1	3.0	3.0	2.2	2.9	3.0	3.1	3.1	3.1	1.6	3.0	2.3	2.7	2.8	3.1	2.5	2.8	2.9
Maternal smoking around birth	5.1	7.4	12.9	-2.9	-3.0	-3.2	-2.0	-2.6	-3.1	-2.9	-2.8	-2.8	-3.6	-2.9	-2.0	-2.3	-3.2	-1.2	-2.2	-2.5	-2.6
Shortness of breath walking on level ground	4.9	5.8	9.1	2.5	2.5	2.5	2.6	3.0	2.5	2.5	2.6	2.6	1.5	2.2	2.6	2.7	2.0	1.6	2.2	2.4	2.3
Medication: Simvastatin	4.7	6.9	8.9	3.0	3.0	2.8	2.0	2.5	2.9	3.0	2.9	2.9	3.0	2.2	1.5	2.4	2.5	2.2	2.3	3.0	2.9
Average weekly beer plus cider intake	4.7	6.8	13.3	-2.9	-2.9	-2.7	-1.5	-2.4	-2.7	-2.9	-2.8	-2.3	-3.2	-2.3	-1.5	-2.3	-2.8	-2.0	-3.7	-2.8	-2.1
Medication: Cholesterol lowering	4.5	6.9	10.4	3.2	3.2	2.9	1.9	2.9	2.9	3.2	3.1	3.0	2.1	2.6	0.7	1.7	2.8	2.1	2.3	2.8	2.6
Leg predicted mass (right)	4.4	23.7	40.2	4.9	5.1	5.3	6.3	5.9	5.1	5.0	5.0	5.1	1.4	4.6	3.0	4.6	5.1	4.7	4.9	5.4	4.2
Leg predicted mass (left)	4.3	23.0	36.7	5.0	5.0	5.2	6.1	5.8	5.0	5.0	5.0	4.9	1.5	4.7	3.0	4.5	5.2	4.6	4.9	5.2	3.9
Leg fat-free mass (right)	4.3	23.0	39.1	4.9	5.0	5.2	6.2	5.8	5.0	4.9	4.9	5.0	1.4	4.6	2.9	4.5	5.0	4.6	4.8	5.3	4.2
Relative age of first facial hair	4.2	8.6	14.0	-3.3	-3.2	-3.0	-2.0	-3.1	-2.9	-3.3	-3.3	-2.7	-1.3	-3.7	-3.3	-3.6	-2.8	-2.8	-2.3	-2.6	-2.3
Leg fat-free mass (left)	4.2	22.2	36.1	4.8	4.9	5.1	6.0	5.8	4.9	4.9	4.9	4.9	1.4	4.6	2.9	4.4	5.1	4.5	4.7	5.1	3.8
Hair/balding pattern: Pattern 4	4.2	10.1	17.3	3.1	3.2	3.4	3.0	3.0	3.1	3.1	3.3	2.7	1.7	4.0	4.2	4.1	3.6	3.5	2.4	2.3	2.4
Cholesterol lowering medication	4.1	6.1	8.8	2.6	2.6	2.7	1.8	2.2	2.6	2.5	2.5	2.6	2.4	3.0	2.1	2.6	2.6	1.8	2.5	2.7	2.1
Sensitivity / hurt feelings	4.0	6.8	10.4	-2.8	-2.9	-2.7	-1.9	-2.5	-2.7	-2.8	-2.8	-2.5	-2.6	-3.2	-2.4	-3.1	-2.9	-1.9	-2.7	-2.3	-1.8
Number of full sisters	3.9	4.7	6.8	-2.4	-2.4	-2.2	-1.2	-2.4	-2.3	-2.4	-2.4	-2.0	-2.5	-2.6	-2.3	-2.2	-1.8	-2.1	-2.2	-1.8	-1.3
HDL Cholesterol	3.8	6.4	9.8	-2.6	-2.5	-2.3	-2.3	-2.2	-2.4	-2.6	-2.7	-2.7	-3.1	-2.5	-2.5	-2.7	-2.2	-2.8	-2.4	-2.1	-2.7
Impedance of leg (left)	3.8	18.5	29.1	-4.3	-4.4	-4.7	-5.0	-4.8	-4.5	-4.3	-4.5	-4.1	-1.7	-3.9	-4.1	-4.8	-5.4	-4.3	-4.5	-4.1	-2.8
Arm fat mass (right)	3.8	15.6	20.3	4.5	4.4	4.3	4.0	4.5	4.3	4.5	4.5	4.0	1.3	3.9	2.6	4.0	4.0	2.8	4.2	4.3	3.5
Impedance of leg (right)	3.7	17.9	27.2	-4.2	-4.3	-4.6	-5.2	-4.7	-4.4	-4.2	-4.4	-4.1	-1.5	-3.8	-3.8	-4.8	-5.0	-4.1	-4.4	-4.2	-3.3
Taking other prescription medications	3.7	5.7	7.8	2.8	2.7	2.5	1.8	2.8	2.6	2.8	2.8	2.4	1.0	2.5	2.7	2.4	2.5	2.2	1.7	2.3	1.8
Weight	3.7	18.3	27.4	4.7	4.6	4.6	5.0	5.2	4.6	4.7	4.6	4.4	1.2	4.4	2.3	4.0	4.4	3.3	4.5	4.8	3.7
Medication for cholesterol, blood pressure or diabetes	3.6	5.9	9.0	-3.0	-2.9	-2.7	-1.2	-2.4	-2.7	-3.0	-2.9	-2.4	-3.0	-2.4	-1.2	-1.7	-2.8	-1.7	-2.0	-2.1	-2.4
Medication: Aspirin	3.6	4.6	6.9	2.6	2.5	2.4	1.3	2.3	2.3	2.6	2.5	2.2	1.6	2.4	1.5	1.6	2.4	2.0	1.7	2.0	1.9
Major Depression (MDD)	3.5	4.2	10.7	2.1	2.1	2.1	1.8	2.2	1.9	2.2	2.3	1.6	1.3	1.6	3.3	2.5	2.3	1.8	1.7	1.8	1.4
Arm fat mass (left)	3.5	14.5	19.3	4.3	4.3	4.1	3.8	4.4	4.1	4.3	4.3	3.9	1.1	3.8	2.5	3.9	3.9	2.6	4.1	4.1	3.3
BMI	3.4	19.5	28.1	4.8	4.8	4.6	4.9	5.3	4.7	4.8	4.9	4.3	1.7	4.3	3.8	5.2	4.4	3.1	4.8	4.6	3.1
Medication: Atorvastatin	3.4	4.2	6.8	2.4	2.4	2.4	1.4	2.4	2.2	2.4	2.3	2.2	0.3	2.6	1.8	1.9	2.2	1.7	1.9	2.0	1.2
Trunk fat mass	3.3	14.1	19.7	4.3	4.2	4.0	3.9	4.4	4.0	4.3	4.2	3.8	1.2	3.8	2.0	3.6	3.7	2.5	4.1	4.3	3.4
Falls in the last year	3.2	4.3	5.9	-2.4	-2.3	-2.1	-2.0	-2.2	-2.1	-2.4	-2.3	-2.1	-0.9	-2.4	-2.4	-2.4	-1.5	-1.8	-2.2	-1.9	-1.8
Depression (self-reported)	3.2	3.8	5.1	2.0	2.1	2.0	1.7	2.2	1.9	2.0	2.1	1.9	1.9	2.1	1.3	2.2	2.3	2.0	2.0	1.9	1.6
Overall health rating	3.2	7.0	9.8	2.9	2.8	2.8	1.7	2.7	2.8	2.9	3.0	2.6	1.1	2.6	2.5	3.0	3.1	2.3	2.6	2.4	3.0
Basal metabolic rate	3.2	17.6	30.6	4.3	4.4	4.5	5.5	5.3	4.4	4.3	4.3	4.4	0.9	4.2	2.2	3.7	4.3	4.1	4.2	4.7	3.6
Intelligence (Savage-Jansen 2018)	3.0	9.3	14.6	3.3	3.3	3.3	3.1	3.0	3.3	3.3	3.2	3.0	2.5	3.4	3.1	3.8	2.6	3.3	2.5	2.1	2.0
Smoking Status	3.0	7.2	10.3	-3.1	-3.1	-2.6	-1.8	-3.2	-2.9	-3.1	-3.0	-2.7	-3.2	-1.9	-2.0	-2.7	-2.1	-2.8	-3.0	-2.4	-2.2
Severe depression (siblings)	3.0	3.3	5.9	-2.1	-2.0	-1.6	-1.4	-1.6	-1.9	-2.1	-2.2	-1.7	-2.4	-1.6	-0.8	-1.9	-2.0	-2.1	-1.9	-1.6	-1.4
Arm predicted mass (left)	3.0	15.1	25.2	4.1	4.1	4.1	5.0	5.0	4.0	4.1	4.1	4.1	0.9	4.0	2.1	3.5	3.7	3.7	3.7	4.3	3.5
Verbal and Numeric Reasoning (VNR)	2.9	6.9	9.9	2.9	2.9	2.7	2.1	2.6	2.7	2.9	2.9	2.5	2.8	3.0	2.6	2.9	2.0	3.2	2.5	2.0	1.7
Cardiovascular Disease	2.9	9.5	12.7	3.5	3.5	3.3	2.7	2.7	3.3	3.6	3.5	3.4	3.2	3.5	1.9	3.1	2.7	1.9	2.2	3.1	3.4
Body mass index (BMI)	2.9	12.5	18.6	4.0	3.9	3.7	3.3	4.0	3.7	4.0	4.1	3.4	1.4	3.5	3.2	4.3	3.7	2.1	3.9	3.6	2.7
Arm fat percentage (right)	2.9	11.4	15.4	3.9	3.9	3.7	3.0	3.6	3.7	3.9	3.9	3.3	1.4	3.2	2.4	3.6	3.7	1.9	3.7	3.6	3.0
Hip circumference	2.9	12.5	19.3	3.8	3.8	3.8	4.2	4.4	3.8	3.8	3.8	3.6	0.6	3.6	1.8	3.3	3.6	2.6	4.0	4.0	3.0
Whole body fat mass	2.9	12.0	16.7	4.0	4.0	3.6	3.4	4.1	3.7	4.0	4.0	3.5	1.1	3.5	1.9	3.4	3.4	2.3	3.8	4.0	3.1
Osteoporosis (self-reported)	2.9	3.5	5.3	2.1	2.0	1.9	1.5	2.3	2.0	2.1	2.1	1.7	1.7	1.4	2.2	1.5	1.6	1.8	2.0	2.3	1.3
Arm fat-free mass (left)	2.9	14.7	26.1	4.0	4.0	4.0	5.1	4.9	3.9	4.0	3.9	4.1	0.8	4.0	2.1	3.4	3.7	3.7	3.6	4.3	3.5
Waist circumference	2.8	10.3	14.7	3.8	3.7	3.3	2.7	3.7	3.5	3.8	3.8	3.2	1.2	3.3	1.7	3.3	3.2	1.8	3.3	3.4	3.4
Whole body fat-free mass	2.8	15.8	29.6	4.1	4.1	4.3	5.4	5.1	4.1	4.1	4.0	4.2	0.7	4.0	2.0	3.4	4.2	4.0	3.8	4.4	3.3
Long-standing illness, disability or infirmity	2.8	4.3	7.5	2.1	2.2	2.3	1.2	1.8	2.4	2.1	2.0	2.4	1.4	1.5	1.2	1.9	2.1	2.2	2.0	2.7	2.7
Whole body water mass	2.8	16.2	30.5	4.1	4.2	4.3	5.5	5.2	4.1	4.1	4.1	4.2	0.7	4.1	2.0	3.5	4.2	4.0	3.9	4.4	3.4
Ever had prostate specific antigen (PSA) test	2.7	3.1	4.8	-1.6	-1.7	-1.9	-2.2	-1.5	-2.0	-1.6	-1.7	-2.2	-1.9	-1.0	-1.6	-2.2	-1.6	-1.9	-1.5	-1.1	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.9	9.1	-2.9	-2.8	-2.6	-2.4	-3.0	-2.7	-2.9	-3.0	-2.5	0.2	-2.2	-3.0	-2.9	-1.7	-1.3	-2.2	-2.3	-1.1
Gout (self-reported)	2.6	3.6	9.4	-1.6	-1.8	-1.9	-3.1	-2.2	-2.2	-1.6	-1.5	-2.5	-1.1	-0.5	-0.3	-1.0	-1.5	-2.4	-1.0	-2.6	-2.6
Leg fat mass (left)	2.6	10.0	14.0	3.7	3.6	3.2	3.1	3.7	3.3	3.7	3.7	3.1	0.8	3.3	2.1	3.4	2.8	2.0	3.3	3.4	2.8
Trunk fat percentage	2.5	10.1	14.4	3.8	3.7	3.3	2.8	3.6	3.5	3.8	3.7	3.2	1.4	3.1	1.8	3.3	3.0	1.7	3.5	3.6	3.0
Medication: Paracetamol	2.5	4.1	8.0	1.8	1.9	2.0	1.8	2.2	1.9	1.8	1.9	1.8	1.8	1.7	2.5	2.8	2.0	2.0	1.8	2.4	1.9
Arm fat percentage (left)	2.5	10.0	13.7	3.7	3.6	3.4	2.7	3.4	3.4	3.7	3.7	3.0	1.1	3.0	2.3	3.4	3.4	1.7	3.6	3.4	2.7
Crohns Disease (2012)	2.4	3.9	5.7	2.1	2.2	2.3	1.8	1.8	2.2	2.1	2.0	2.2	1.0	1.9	2.1	1.8	2.4	2.4	1.8	1.8	0.0
LDL Cholesterol	2.4	3.9	6.8	2.0	2.1	2.3	2.3	2.4	2.0	2.0	2.0	1.6	0.9	1.8	1.9	2.3	2.6	1.8	1.8	1.6	1.2
Lung FVC	2.4	12.4	18.7	-3.8	-3.7	-3.5	-2.6	-3.1	-3.5	-3.7	-3.8	-3.4	-3.2	-3.3	-3.7	-3.6	-3.6	-2.8	-4.3	-3.8	-3.7
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	4.9	-1.7	-1.7	-2.0	-1.8	-1.5	-1.8	-1.6	-1.5	-1.8	-1.2	-1.5	-0.1	-0.7	-1.8	-2.2	-1.5	-1.7	-1.8
Medication: Aspirin	2.4	3.1	4.8	2.2	2.2	2.0	1.1	1.8	2.0	2.2	2.1	1.9	1.1	2.0	0.9	1.1	1.8	1.8	1.3	1.8	1.6
Trunk fat-free mass	2.3	13.2	26.9	3.7	3.7	3.9	5.2	4.7	3.7	3.7	3.6	3.8	0.5	3.8	1.5	2.7	3.8	3.7	3.4	4.0	3.1
Father’s age at death	2.3	3.1	4.3	2.0	2.0	2.0	1.4	2.1	2.0	2.0	1.8	1.7	1.0	1.7	1.9	1.5	1.9	1.4	1.6	2.1	1.2
Trunk predicted mass	2.3	13.0	26.6	3.6	3.7	3.8	5.2	4.7	3.7	3.6	3.6	3.8	0.5	3.8	1.5	2.7	3.8	3.7	3.4	4.0	3.1
Arm fat-free mass (right)	2.3	11.9	22.8	3.6	3.6	3.5	4.8	4.5	3.5	3.6	3.5	3.7	0.2	3.6	1.6	3.0	3.2	3.5	3.2	3.9	3.0
Medication: Omeprazole	2.3	2.7	4.0	1.7	1.8	1.6	1.3	1.6	1.8	1.7	1.7	1.7	1.6	1.3	1.5	1.5	1.9	1.8	1.5	1.6	2.0
Leg fat mass (right)	2.3	8.9	12.7	3.6	3.4	3.1	2.9	3.5	3.2	3.6	3.5	2.9	0.7	3.1	2.0	3.2	2.8	2.0	3.1	3.2	2.5
Arm predicted mass (right)	2.3	11.7	22.1	3.5	3.5	3.5	4.7	4.5	3.5	3.5	3.5	3.6	0.2	3.5	1.8	3.2	3.2	3.4	3.2	3.8	2.9
Medication: Bendroflumethiazide	2.3	3.5	5.2	2.2	2.2	2.0	1.7	1.7	2.2	2.2	2.2	2.1	1.0	1.9	1.2	1.6	1.2	1.8	1.7	2.0	2.3
Sitting height	2.2	15.5	41.2	3.6	3.8	4.0	6.4	5.1	4.1	3.6	3.5	4.9	1.8	2.6	1.1	3.0	3.1	4.6	3.5	5.0	3.9
Had menopause	2.2	2.8	6.6	2.0	1.9	1.9	0.4	1.5	1.7	2.0	2.0	1.5	0.9	2.6	1.4	1.4	2.1	0.8	2.2	1.5	0.9
Health satisfaction	2.2	2.8	6.3	1.7	1.8	1.8	1.6	1.2	2.0	1.7	1.7	2.1	1.0	1.2	1.1	1.7	1.4	2.5	0.9	1.7	2.2
Medication for pain relief, constipation, heartburn	2.2	3.7	6.1	-1.9	-1.9	-1.8	-1.2	-2.0	-1.8	-1.9	-2.0	-1.8	-2.3	-1.7	-1.9	-2.5	-1.8	-1.7	-1.6	-2.1	-2.3
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	4.4	1.7	1.7	1.6	1.2	1.4	1.8	1.7	1.7	1.7	1.6	1.1	1.4	1.5	1.7	1.9	1.4	1.5	2.1
Worry (Nagel 2018)	2.0	4.2	5.2	-2.2	-2.2	-2.0	-2.0	-2.0	-2.2	-2.2	-2.1	-2.2	-1.6	-2.3	-1.6	-2.2	-1.6	-2.2	-2.2	-1.9	-2.0
Medication: Metformin	2.0	2.8	4.5	1.8	1.8	1.9	0.5	1.0	1.9	1.8	1.7	2.0	2.0	2.1	1.3	1.5	2.1	1.2	1.3	1.7	1.6
Number of incorrect matches in round	2.0	3.2	5.9	-1.6	-1.7	-2.0	-2.1	-1.8	-1.8	-1.7	-1.8	-1.8	-1.0	-1.3	-2.4	-1.8	-2.0	-1.6	-2.3	-1.6	-1.6
Body fat percentage	2.0	7.9	11.7	3.4	3.3	2.9	2.3	3.1	3.1	3.4	3.4	2.8	1.0	2.8	1.6	3.0	2.6	1.4	3.2	3.2	2.6
Medication: Blood pressure	2.0	3.5	11.2	2.3	2.1	1.9	-0.2	1.4	1.7	2.3	2.3	1.3	3.3	2.1	1.9	1.7	2.3	0.6	1.2	1.0	1.6
Mean time to correctly identify matches	2.0	3.9	7.0	2.2	2.2	2.0	0.5	1.8	2.3	2.2	2.2	2.1	0.9	2.6	1.5	1.6	1.9	1.2	2.0	2.1	2.5
Had major operations	2.0	2.3	3.7	1.7	1.6	1.5	1.1	1.6	1.3	1.7	1.7	1.1	1.1	1.6	1.9	1.6	1.7	1.8	1.5	1.1	1.1
Medication: Blood pressure	2.0	3.9	6.5	1.9	2.0	1.9	2.5	2.0	2.1	1.9	1.9	2.4	1.2	2.3	0.7	1.4	1.5	1.9	1.9	2.5	2.3
Reaction Time	1.9	3.6	6.5	2.0	2.0	1.8	0.8	1.8	2.3	2.0	1.9	2.1	0.7	2.4	1.6	1.7	1.4	1.6	2.0	2.3	2.6
Lung FEV1/FVC ratio	1.9	9.7	17.1	3.1	3.1	3.0	1.7	3.9	2.8	3.1	3.3	2.2	2.1	4.1	3.6	3.9	4.0	0.6	4.0	3.0	1.7
Number of treatments/medications taken	1.9	3.4	5.0	2.0	2.0	1.8	0.7	1.7	1.8	2.0	2.0	1.6	1.9	2.2	2.2	2.0	2.0	1.6	1.7	1.7	1.5
Number of children fathered	1.9	2.1	5.1	-1.3	-1.3	-1.5	-1.1	-1.2	-1.4	-1.2	-1.3	-1.2	-1.6	-1.5	-2.0	-1.5	-2.3	-1.1	-1.5	-1.4	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	4.3	-1.9	-1.7	-1.4	-1.3	-2.1	-1.4	-1.9	-1.8	-1.3	0.3	-1.4	-1.3	-1.6	-0.6	-0.9	-2.1	-1.5	-0.1
Alcohol intake frequency.	1.9	4.3	7.5	2.1	2.1	2.3	1.6	2.6	2.1	2.1	2.2	1.9	1.3	1.8	2.2	1.9	2.6	1.1	2.7	2.6	1.5
Vascular/heart problems diagnosed by doctor	1.9	5.1	11.4	-2.9	-2.7	-2.3	-0.9	-2.2	-2.3	-2.9	-2.9	-2.1	-1.8	-3.4	-1.6	-2.3	-2.1	-0.5	-1.8	-1.7	-2.0
Impedance of whole body	1.9	9.5	14.5	-3.1	-3.1	-3.2	-3.5	-3.5	-3.1	-3.0	-3.3	-2.9	-0.9	-2.8	-3.5	-3.8	-3.5	-3.0	-3.2	-2.9	-2.0
Alzheimer’s Disease (in mother)	1.8	2.1	4.6	1.5	1.5	1.6	1.2	1.2	1.7	1.5	1.4	1.8	0.5	1.6	0.9	1.4	1.4	2.1	0.9	1.6	1.6
Primary Biliary Cirrhosis	1.8	2.5	6.2	-2.0	-1.9	-1.6	-0.9	-1.4	-1.8	-2.0	-1.8	-1.5	-1.3	-2.5	-0.7	-1.5	-1.5	-1.6	-1.0	-1.2	-1.5
Birth weight	1.8	3.8	6.2	1.9	2.0	2.3	1.9	2.2	2.2	1.9	2.0	2.0	1.7	1.6	1.7	2.2	2.5	1.1	2.2	1.7	1.6
Leg pain on walking	1.8	2.3	3.5	1.8	1.7	1.7	1.5	1.8	1.7	1.8	1.9	1.8	0.6	1.4	1.0	1.6	1.4	1.4	1.2	1.4	0.9
Number of self-reported non-cancer illnesses	1.8	3.2	4.8	2.0	2.0	1.9	0.5	1.6	1.9	2.0	2.1	1.7	1.4	1.9	1.6	1.9	2.2	1.2	1.6	1.6	2.1
Body Mass Index (BMI) (2010)	1.7	2.3	4.6	1.6	1.6	1.5	2.1	1.4	1.5	1.6	1.6	1.4	1.0	1.4	1.6	2.1	1.3	1.7	1.2	0.9	0.7
Hearing difficulty/problems: Yes	1.7	2.5	3.5	1.8	1.7	1.7	1.7	1.6	1.6	1.8	1.8	1.5	1.3	1.4	1.6	1.9	1.8	1.0	1.3	1.4	1.7
Tense / ‘highly strung’	1.7	2.8	6.2	-1.7	-1.7	-1.4	-0.9	-1.9	-1.4	-1.7	-1.8	-1.1	-1.7	-1.8	-2.1	-2.1	-1.6	-1.4	-2.5	-1.2	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	3.5	-1.4	-1.5	-1.4	-1.4	-1.6	-1.6	-1.4	-1.3	-1.6	-1.5	-1.4	-1.4	-1.5	-1.2	-1.9	-1.3	-1.3	-0.8
Illnesses of father: Heart disease	1.7	2.3	4.2	1.6	1.5	1.4	0.5	1.7	1.3	1.6	1.7	1.3	1.6	2.0	1.7	1.9	1.4	0.7	1.9	1.6	1.1
Ovarian Cancer	1.6	2.2	4.3	1.9	1.7	1.6	1.1	1.8	1.5	1.9	1.8	1.5	0.5	1.4	2.1	1.5	1.4	-0.5	1.5	0.9	0.7
Ulcerative Colitis	1.6	2.4	3.8	1.6	1.7	1.9	1.5	1.5	1.7	1.6	1.5	1.6	1.4	1.6	1.3	1.3	1.9	1.7	1.6	1.4	0.0
Average weekly fortified wine intake	1.6	1.9	3.8	1.5	1.5	1.5	1.0	1.1	1.5	1.5	1.4	1.3	1.8	1.3	0.5	1.0	1.9	1.2	1.5	1.4	1.4
Hearing difficulty/problems with background noise	1.6	2.6	4.5	1.7	1.6	1.4	1.6	1.8	1.3	1.7	1.9	1.1	1.4	1.9	2.1	2.1	1.6	0.4	1.7	1.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	7.5	-2.3	-2.3	-2.1	-1.9	-2.1	-2.0	-2.3	-2.3	-1.8	0.4	-1.9	-2.7	-2.4	-1.8	-1.1	-1.4	-1.1	-0.5
Hypertension (Self-reported)	1.6	4.4	10.1	2.7	2.5	2.2	0.9	1.9	2.2	2.7	2.6	2.0	1.9	3.2	1.4	2.0	2.0	0.5	1.7	1.8	2.1
Pack years of smoking	1.6	2.4	5.0	1.5	1.6	1.4	1.1	1.8	1.5	1.5	1.5	1.8	0.5	0.9	1.1	1.9	0.9	1.7	2.2	2.2	1.8
Alzheimer’s Disease (in father)	1.5	1.6	2.8	1.6	1.5	1.2	0.4	1.6	1.2	1.6	1.7	1.0	1.0	1.6	1.5	1.4	1.1	0.8	1.2	0.7	1.2
Schizophrenia (2014)	1.5	3.4	5.4	-2.2	-2.2	-2.0	-1.7	-2.3	-1.9	-2.2	-2.1	-1.7	-1.4	-2.2	-1.0	-1.8	-1.7	-1.7	-1.9	-0.8	-1.3
Triglycerides	1.5	2.5	4.3	1.4	1.5	1.6	2.0	1.6	1.5	1.4	1.5	1.6	2.1	1.8	1.5	1.7	1.8	1.1	1.5	1.7	1.1
Leg fat percentage (left)	1.5	5.4	8.4	2.9	2.7	2.2	1.7	2.6	2.4	2.9	2.9	2.2	0.9	2.5	1.6	2.7	1.9	1.1	2.5	2.5	2.2
Schizophrenia (2018)	1.4	2.8	4.4	-1.9	-1.8	-1.8	-1.8	-2.1	-1.7	-1.9	-1.8	-1.7	-1.4	-1.8	-1.0	-1.6	-1.5	-2.0	-1.7	-0.7	-1.3
Qualifications: CSEs or equivalent	1.4	1.9	3.7	-1.3	-1.3	-1.4	-0.7	-0.8	-1.5	-1.2	-1.2	-1.3	-1.9	-1.7	-0.3	-1.1	-1.8	-1.3	-1.2	-1.8	-1.7
Leg fat percentage (right)	1.4	4.9	7.9	2.8	2.6	2.2	1.4	2.4	2.4	2.8	2.8	2.1	0.9	2.4	1.7	2.5	1.9	1.1	2.4	2.3	1.9
Smoking status: Current	1.4	2.2	5.8	-1.6	-1.7	-1.4	-1.1	-1.6	-1.7	-1.7	-1.6	-1.3	-2.4	-0.9	-1.5	-1.4	-1.0	-1.4	-1.5	-1.3	-1.1
Alcohol drinker status: Never	1.4	1.7	2.8	1.4	1.6	1.5	0.6	1.2	1.6	1.4	1.3	1.5	0.8	1.2	1.3	1.7	1.0	0.6	1.4	1.4	1.2
Number of operations (self-reported)	1.4	2.1	5.4	1.5	1.5	1.6	0.9	1.5	1.4	1.5	1.5	1.1	0.4	1.7	2.3	1.5	1.9	1.4	0.8	0.5	1.3
Pain experienced in last month	1.4	2.3	4.1	-1.4	-1.4	-1.6	-0.9	-1.3	-1.4	-1.4	-1.6	-1.6	-1.7	-1.6	-1.4	-1.5	-2.0	-1.2	-1.4	-1.5	-1.9
Mean Putamen Volume	1.3	1.5	5.6	1.1	1.2	1.0	0.7	0.6	1.3	1.1	1.1	1.2	2.4	0.8	0.1	1.0	1.0	2.0	0.9	1.2	1.6
High blood pressure	1.3	3.5	9.0	2.5	2.3	1.9	0.8	1.6	2.0	2.5	2.4	1.8	1.6	3.0	1.2	1.9	1.6	0.2	1.3	1.5	1.8
Hair/balding pattern: Pattern 3	1.3	1.9	4.9	1.8	1.7	1.4	0.7	1.4	1.5	1.8	1.6	1.4	0.0	2.2	0.5	1.2	1.3	0.9	1.5	0.9	1.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.7	1.0	1.1	1.4	0.9	1.0	1.4	1.0	0.9	1.6	0.6	0.8	1.0	0.8	1.6	1.2	1.6	2.2	1.5
Fluid intelligence score	1.2	2.5	3.9	1.7	1.7	1.8	1.4	1.5	1.6	1.7	1.7	1.5	1.7	1.5	2.0	1.9	1.4	1.8	1.3	1.3	0.7
Headache pain in last month	1.2	2.0	4.8	1.0	1.1	1.2	1.5	1.3	1.2	1.0	1.0	1.5	1.8	1.1	1.2	1.4	0.9	2.2	1.6	1.9	1.8
Suffer from ‘nerves’	1.2	1.9	3.6	-1.4	-1.4	-1.2	-1.2	-1.6	-1.4	-1.3	-1.4	-1.4	-1.1	-1.6	-1.0	-1.1	-1.2	-1.4	-1.6	-1.9	-1.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.0	1.0	1.1	1.3	1.4	0.8	1.2	1.0	1.0	1.2	1.2	1.4	0.7	0.9	0.8	1.7	0.8	1.2	2.0
Ever taken oral contraceptive pill	1.2	1.3	2.9	-0.9	-1.0	-1.0	-0.2	-0.5	-1.2	-0.9	-0.9	-1.0	-1.6	-1.1	-1.5	-1.3	-1.7	-1.3	-1.3	-1.0	-1.4
Supplements: Calcium	1.2	1.4	2.8	1.2	1.2	1.2	1.0	1.4	1.2	1.2	1.2	0.9	1.1	1.2	1.7	1.1	1.4	1.1	0.8	1.0	0.8
Neuroticism	1.1	2.7	5.7	-1.7	-1.8	-1.6	-1.1	-1.6	-1.9	-1.7	-1.6	-1.6	-0.6	-1.4	-2.1	-2.4	-1.5	-1.5	-1.8	-1.3	-1.3
Hand grip strength (left)	1.1	2.9	6.5	-2.1	-2.0	-1.9	-0.6	-1.2	-1.9	-2.1	-2.0	-1.7	-1.4	-1.2	-2.5	-2.1	-1.4	-1.2	-1.6	-1.1	-1.1
Financial difficulties in last 2 years	1.1	1.5	4.4	-1.1	-1.2	-1.0	-0.5	-0.8	-1.3	-1.1	-0.9	-1.4	-1.9	-2.1	-1.0	-1.1	-0.4	-1.0	-0.6	-0.9	-2.0
Medication: Allopurinol	1.1	1.4	5.5	-0.8	-1.0	-0.9	-2.4	-1.3	-1.3	-0.8	-0.8	-1.6	-1.0	0.2	0.2	-0.5	-0.1	-1.8	-0.6	-1.5	-1.8
Height	1.0	18.6	48.5	4.0	4.2	4.2	7.0	6.1	4.5	4.0	3.5	4.8	-0.8	4.5	-2.8	0.4	3.5	5.0	3.4	5.3	4.6
Neuroticism score	1.0	2.1	3.9	-1.6	-1.6	-1.3	-0.7	-1.6	-1.5	-1.6	-1.5	-1.4	-1.2	-1.2	-1.6	-2.0	-1.2	-0.9	-1.8	-1.4	-1.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.1	-0.9	-1.0	-1.2	-1.5	-1.3	-1.2	-0.9	-0.9	-1.0	-0.9	-1.4	-0.6	-1.0	-1.2	-1.0	-0.9	-1.1	-0.3
Age at first live birth	1.0	1.8	4.5	-1.2	-1.3	-1.2	-1.3	-1.3	-1.3	-1.3	-1.3	-1.2	-0.4	-1.6	-2.1	-1.5	-1.2	-1.9	-0.6	-1.1	-1.2
Emphysema/chronic bronchitis	1.0	1.1	2.2	-1.2	-1.1	-1.1	-1.0	-1.2	-1.0	-1.2	-1.1	-1.0	-0.7	-1.2	-1.0	-0.8	-0.5	-0.7	-1.5	-1.3	-1.2
Friendships satisfaction	1.0	1.3	2.7	1.1	1.2	1.2	1.3	1.3	1.2	1.1	1.1	1.4	0.6	0.6	1.3	1.1	0.4	1.0	0.3	1.6	1.4
Qualifications: nursing, teaching	1.0	1.6	6.1	1.1	1.2	1.1	1.2	1.2	1.3	1.1	1.1	1.5	1.4	0.1	0.2	0.6	0.4	1.5	1.7	2.5	1.3
Risk taking	1.0	1.4	3.8	-1.2	-1.3	-1.3	-0.1	-0.8	-1.4	-1.2	-1.2	-1.0	-1.9	-1.1	-0.3	-0.7	-1.5	-1.0	-1.7	-0.9	-1.5
Irritable Bowel Disease (IBD)	0.9	2.1	4.3	1.5	1.5	1.8	1.2	1.5	1.5	1.5	1.4	1.5	0.6	1.2	2.0	1.3	1.7	2.1	1.5	1.0	0.5
Blood Platelet Count	0.9	10.5	15.7	2.9	3.0	3.3	4.0	3.2	3.4	2.9	3.0	3.5	3.7	2.3	2.8	2.7	3.8	2.7	2.8	3.8	3.8
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.5	0.9	1.0	1.1	0.9	0.8	1.1	0.9	1.0	1.3	0.7	1.4	0.8	0.6	0.8	2.1	1.0	1.2	1.0
Ever had hysterectomy (womb removed)	0.9	1.0	2.7	0.8	1.0	1.0	1.1	1.1	1.1	0.9	0.8	1.1	-0.3	0.9	-0.4	0.3	1.0	1.6	0.7	1.1	1.6
Townsend deprivation index at recruitment	0.9	1.3	2.3	-1.3	-1.3	-1.3	-0.6	-0.8	-1.2	-1.3	-1.2	-1.4	-1.0	-1.1	-1.4	-1.5	-0.4	-1.2	-0.5	-0.9	-1.1
Peak expiratory flow (PEF)	0.9	2.1	5.1	1.5	1.5	1.3	2.1	2.3	1.4	1.5	1.3	1.4	-0.2	1.5	0.8	1.5	0.4	1.1	1.7	1.8	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.0	1.2	1.1	1.0	0.3	0.6	0.9	1.2	1.2	0.9	1.4	0.9	1.3	1.4	1.1	1.0	0.3	0.3	0.8
Mother’s age at death	0.9	1.1	3.8	1.0	0.9	1.1	0.1	0.7	0.9	1.0	1.0	0.5	2.0	1.7	0.4	0.3	1.8	0.9	0.8	0.3	0.9
Crohns Disease (2017)	0.8	1.8	4.3	1.4	1.4	1.6	0.7	1.4	1.3	1.4	1.4	1.2	0.3	1.2	2.1	1.2	1.6	1.8	1.3	0.8	0.7
Heel T-Score	0.8	6.7	20.1	-2.7	-2.7	-2.9	-2.3	-2.8	-2.7	-2.7	-2.8	-2.1	-0.1	-2.4	-4.5	-3.2	-2.8	-1.4	-2.4	-2.3	-0.6
Pack years adult smoking proportion	0.8	1.3	3.3	1.0	1.1	1.0	0.8	1.3	1.0	1.0	1.0	1.4	-0.0	0.4	0.7	1.5	0.5	1.3	1.8	1.7	1.4
Hand grip strength (right)	0.8	2.1	4.4	-1.8	-1.8	-1.6	-0.7	-1.1	-1.7	-1.8	-1.8	-1.6	-1.1	-1.0	-2.1	-1.7	-1.1	-1.1	-1.3	-0.9	-0.7
Current tobacco smoking	0.8	1.3	3.3	-1.3	-1.3	-1.1	-0.8	-1.3	-1.3	-1.3	-1.3	-1.0	-1.8	-0.7	-1.3	-1.1	-0.8	-1.1	-1.1	-1.0	-0.6
Past tobacco smoking	0.8	1.5	5.7	1.2	1.4	1.2	0.8	1.2	1.4	1.2	1.2	1.4	1.1	0.4	0.8	1.3	0.6	2.4	1.3	1.2	1.0
Nervous feelings	0.8	1.5	3.5	-1.1	-1.2	-1.2	-1.1	-1.1	-1.3	-1.1	-1.1	-1.1	-0.6	-1.6	-1.9	-1.5	-1.6	-1.2	-1.0	-1.0	-1.3
Pain all over the body in last month	0.8	0.8	4.5	0.6	0.6	0.8	-0.2	0.5	0.8	0.6	0.8	0.8	2.1	0.4	0.6	0.7	1.2	0.4	1.1	0.8	1.2
Alcohol intake versus 10 years previously	0.8	1.2	2.3	0.8	0.9	1.1	1.5	1.1	1.0	0.9	0.9	1.2	0.1	1.0	1.4	1.1	0.8	1.5	0.7	1.3	1.3
Breastfed as a baby	0.8	1.0	3.5	0.9	0.9	0.8	-0.1	0.9	0.7	0.9	1.0	0.1	1.3	1.0	1.8	1.1	1.9	0.2	1.0	0.6	0.0
Birth weight of first child	0.8	1.4	4.4	1.0	1.0	0.9	1.6	1.8	1.1	1.0	1.0	1.0	0.4	1.4	0.9	1.2	0.9	0.7	2.1	1.5	0.7
Medication: Ibuprofen	0.8	0.9	2.0	-1.4	-1.3	-1.0	0.5	-1.0	-1.3	-1.4	-1.3	-0.7	-0.5	-1.3	0.1	-0.3	-1.1	-0.6	-1.1	-0.5	-0.6
Back pain experienced in last month	0.8	1.1	1.8	1.2	1.2	1.2	0.6	1.1	1.2	1.1	1.2	1.2	0.7	1.1	1.4	1.0	1.0	0.4	0.5	1.2	1.3
Systolic Blood Pressure	0.7	3.7	12.3	-1.6	-1.6	-1.8	-2.2	-2.9	-1.5	-1.6	-1.7	-1.3	-0.0	-1.8	-1.7	-2.2	-1.9	-2.1	-3.5	-1.8	-0.8
Chronotype (morning person)	0.7	1.5	5.0	1.5	1.5	1.3	0.7	1.4	1.2	1.5	1.4	1.2	0.0	2.2	1.1	1.3	0.7	0.9	1.2	0.9	0.7
Medication: Atenolol	0.7	0.8	2.5	1.2	1.0	0.8	-0.6	0.9	0.7	1.2	1.2	0.5	0.7	1.6	0.7	0.9	0.9	1.0	1.0	0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.9	1.2	1.2	1.1	1.4	1.0	1.1	1.2	1.3	1.1	0.2	1.1	0.5	0.9	0.6	0.6	0.9	0.8	1.3
Noisy workplace	0.7	0.8	1.5	-1.1	-1.0	-0.9	-0.6	-1.0	-0.9	-1.1	-1.0	-1.0	-1.2	-0.4	-0.5	-1.1	-0.5	-0.9	-1.1	-0.6	-1.0
Impedance of arm (left)	0.7	3.3	8.0	-1.8	-1.7	-1.6	-2.0	-2.2	-1.6	-1.8	-2.0	-1.6	-0.2	-1.7	-2.8	-2.7	-1.5	-1.6	-1.7	-1.6	-1.0
Ever had bowel cancer screening	0.7	0.8	2.3	1.1	1.0	0.7	0.7	1.0	0.9	1.1	1.0	0.6	0.6	1.5	-0.1	0.6	0.7	0.7	1.3	0.9	0.7
Osteoarthritis (self-reported)	0.7	0.9	2.0	1.3	1.1	0.8	0.4	0.8	0.8	1.3	1.3	0.5	-0.1	1.4	0.1	0.8	1.4	0.0	1.2	0.3	1.0
Medication: Paracetamol	0.7	1.1	3.4	0.6	0.7	1.0	1.0	0.8	0.8	0.5	0.7	0.9	1.1	0.7	1.7	1.8	1.1	0.8	0.7	1.5	1.1
Depression (Nagel 2018)	0.6	0.9	2.1	0.8	0.9	1.1	1.0	0.9	1.1	0.8	0.8	0.9	0.2	0.7	0.3	0.5	1.0	1.4	0.9	0.9	1.5
Fasting Glucose	0.6	0.7	1.9	-0.7	-0.8	-0.8	0.3	-0.2	-1.0	-0.7	-0.7	-0.8	-1.4	-0.7	-0.8	-1.3	-0.6	-0.5	-0.7	-0.9	-1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.9	1.3	1.2	0.7	0.2	0.8	1.0	1.4	1.3	1.1	0.8	1.1	0.7	1.4	0.7	0.5	1.0	1.3	1.1
Serious illness, injury or assault to yourself	0.6	0.7	5.2	-0.8	-0.8	-0.9	-0.4	-0.6	-0.6	-0.8	-0.8	-0.6	-2.3	-0.8	-0.7	-0.7	-1.1	-0.5	-0.3	-0.4	-0.5
Supplements: Glucosamine	0.6	0.8	2.1	1.0	1.0	0.9	0.8	0.8	0.9	1.0	1.0	0.8	0.5	1.4	0.7	0.8	1.1	1.2	0.3	0.3	0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	-0.9	-0.9	-1.0	-1.0	-0.9	-0.9	-0.8	-0.8	-1.1	-0.2	-0.9	-0.3	-0.7	-0.7	-0.7	-0.6	-1.1	-1.2
Standing height	0.6	6.3	20.3	2.0	2.2	2.5	4.5	3.4	2.5	2.1	1.7	2.9	-0.2	2.6	-1.8	-0.3	2.2	2.9	1.7	3.2	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.2	0.9	0.9	0.9	0.6	1.0	0.9	0.9	1.0	0.9	0.3	1.0	1.0	1.5	0.9	0.8	1.0	1.3	1.3
Pulse wave reflection index	0.6	0.8	4.0	-0.5	-0.5	-0.7	-0.6	-0.3	-0.6	-0.4	-0.6	-1.0	-2.0	-0.5	-0.4	-0.7	-0.7	-0.7	-1.1	-1.1	-1.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	-0.9	-0.9	-1.0	-1.1	-0.7	-1.0	-0.9	-1.0	-0.8	-0.5	-1.1	-0.8	-0.7	-1.0	-0.3	-0.3	-0.9	-1.3
Pulse rate, automated reading	0.6	1.9	3.6	1.1	1.2	1.4	0.9	0.9	1.4	1.0	1.2	1.5	1.1	1.9	1.6	1.6	1.3	0.5	1.8	1.8	1.6
Supplements: Vitamin C	0.6	0.8	1.5	-0.9	-1.0	-0.8	-0.5	-0.5	-0.8	-0.9	-0.8	-1.0	-1.1	-0.8	0.1	-0.7	-0.9	-1.0	-1.2	-0.8	-1.2
Knee pain experienced in last month	0.6	1.0	1.8	-1.0	-1.0	-0.9	-1.2	-1.0	-1.1	-1.0	-0.9	-1.3	-1.1	-0.6	-0.9	-0.8	0.1	-1.3	-0.4	-1.0	-1.0
Medication for cholesterol	0.6	0.9	1.8	-0.8	-0.9	-1.1	-1.1	-0.6	-1.1	-0.7	-0.7	-1.3	-0.9	-1.3	-0.4	-0.5	-1.0	-0.8	-1.0	-1.3	-1.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.8	-0.8	-0.7	-0.7	0.1	-0.9	-0.6	-0.8	-0.9	-0.1	-0.9	-1.4	-1.7	-1.0	-1.5	0.0	-1.0	-0.4	-0.1
Fractured/broken bones in last 5 years	0.6	0.8	3.1	-1.0	-1.0	-0.7	-0.8	-0.8	-0.9	-1.0	-1.0	-0.9	-1.8	-0.8	0.5	-0.7	-0.7	-0.6	-0.6	-0.9	-1.1
Schizophrenia vs Biploar Disorder	0.5	0.6	1.4	-1.1	-1.0	-0.8	-1.0	-1.2	-0.8	-1.1	-0.9	-0.7	-0.3	-0.7	-0.2	-0.8	-0.5	-0.9	0.1	-0.0	-0.5
HbA1C	0.5	0.5	1.7	0.6	0.6	0.5	1.3	1.1	0.6	0.6	0.5	1.1	-0.5	0.3	0.6	0.5	0.3	0.5	0.2	0.8	1.1
Neuroticism (2016)	0.5	0.7	1.7	-1.1	-1.0	-0.6	-0.9	-1.3	-0.9	-1.1	-1.1	-0.8	0.3	-0.8	-1.1	-0.7	-0.9	0.1	-0.9	-0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	4.0	-0.5	-0.6	-0.5	-2.0	-1.0	-0.8	-0.5	-0.4	-0.9	-0.5	-0.4	-0.4	-0.3	0.5	-1.0	-0.2	-0.9	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.5	-1.0	-0.9	-0.6	-0.7	-0.8	-0.7	-1.0	-1.0	-0.7	-0.0	-0.7	-0.8	-1.2	-0.6	-0.3	-0.7	-0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	0.7	0.8	0.9	1.2	0.7	1.0	0.7	0.7	0.9	-0.3	0.0	-0.0	0.5	0.5	1.5	0.9	0.9	1.2
Relative age voice broke	0.5	0.8	2.7	-1.0	-0.8	-0.8	-0.3	-1.0	-0.6	-1.0	-1.0	-0.6	-0.6	-1.4	-1.6	-1.4	-0.7	0.3	-0.5	-0.4	-1.0
Stomach or abdominal pain in last month	0.5	0.6	1.3	-0.8	-0.8	-1.1	-0.8	-0.9	-0.8	-0.8	-0.8	-0.8	0.1	-0.8	-0.6	-0.5	-1.0	-0.8	-0.6	-0.7	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	1.0	0.9	0.5	0.3	1.1	0.6	1.1	1.0	0.3	0.4	0.6	1.1	1.0	0.5	0.2	0.9	1.0	0.5
Lung cancer (father)	0.5	0.6	1.9	1.1	0.9	0.3	-0.2	0.6	0.5	1.1	1.1	0.3	0.8	0.3	1.0	1.4	-0.0	0.1	1.4	0.2	0.8
Illnesses of mother	0.5	0.6	1.2	-1.1	-1.0	-0.9	0.3	-0.7	-0.8	-1.1	-1.1	-0.6	-0.4	-0.7	-1.1	-0.7	-1.0	-0.7	-0.3	-0.4	-0.3
Medication: Amlodipine	0.5	0.7	1.6	0.9	0.9	0.8	0.1	0.7	0.9	0.9	1.0	0.8	1.0	1.3	0.9	0.8	1.1	-0.5	0.6	0.5	0.6
High blood pressure (siblings)	0.5	0.7	1.8	1.2	1.0	0.7	0.1	1.0	0.7	1.2	1.2	0.7	-0.1	1.3	0.4	1.1	0.5	-0.6	0.7	0.6	0.8
Number of full brothers	0.5	0.6	1.5	-1.0	-0.9	-0.6	-0.7	-1.2	-0.6	-1.0	-1.0	-0.5	-1.1	-0.9	-0.3	-0.8	-0.1	-0.6	-0.5	-0.3	-0.5
Smoking status: Previous	0.5	0.8	2.8	-0.8	-1.0	-0.9	-0.4	-0.9	-1.0	-0.8	-0.8	-1.1	-0.7	-0.4	-0.5	-1.0	-0.5	-1.7	-1.2	-0.9	-0.4
Average weekly red wine intake	0.5	0.7	2.1	-0.9	-0.7	-0.9	-0.4	-0.9	-0.6	-0.9	-0.9	-0.5	-0.1	-1.4	-1.2	-1.0	-1.4	-0.3	-1.0	-0.7	-0.0
Hearing aid user	0.5	0.5	1.9	0.7	0.7	0.9	0.5	0.4	0.7	0.7	0.7	0.6	0.9	0.8	0.9	0.8	1.4	0.8	0.4	0.6	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.7	0.9	0.9	0.8	0.1	0.8	0.6	0.9	0.9	0.2	0.8	1.3	0.9	0.5	1.3	-0.2	0.6	-0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	0.9	0.8	0.6	0.6	0.6	0.7	0.9	1.1	0.7	0.3	0.8	0.4	1.3	0.6	-0.4	0.4	0.5	1.0
Illnesses of father: High blood pressure	0.5	0.6	2.6	-0.5	-0.5	-0.8	-1.3	-0.6	-0.6	-0.5	-0.5	-0.9	0.1	0.0	0.0	-0.5	-0.7	-1.6	-1.0	-0.8	-0.8
Commuting to job workplace: Cycle	0.5	0.6	2.7	-0.7	-0.8	-0.9	-0.5	-0.7	-0.9	-0.7	-0.8	-0.9	-0.2	-0.3	-1.6	-1.1	-0.7	-0.6	-0.1	-0.2	-0.4
Myopia	0.5	0.7	2.9	0.8	0.8	0.5	1.7	0.7	0.7	0.8	0.8	0.9	0.7	0.7	0.8	1.0	-0.3	0.8	0.4	0.7	0.8
Bipolar Disorder (2018)	0.4	0.6	2.0	0.9	0.9	0.8	0.4	0.3	0.9	0.9	0.9	1.0	1.4	0.5	0.2	0.9	0.1	0.6	0.6	0.8	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	0.8	0.8	1.0	0.6	0.5	0.7	0.8	1.0	0.7	0.9	1.2	1.1	1.0	1.2	1.1	0.5	0.3	0.9
Ulcerative Colitis (UC)	0.4	0.8	2.4	0.8	0.9	1.1	1.1	0.9	0.9	0.8	0.8	1.1	0.2	0.7	0.9	0.8	0.8	1.6	1.0	0.9	0.1
Systolic blood pressure, automated reading	0.4	1.2	5.2	-0.6	-0.7	-0.9	-1.6	-1.8	-0.7	-0.6	-0.7	-0.6	0.3	-0.7	-0.8	-1.1	-1.1	-1.4	-2.3	-0.9	-0.4
Alcohol usually taken with meals	0.4	0.6	1.7	0.9	0.9	0.6	0.5	0.6	0.9	0.9	0.7	0.6	0.5	1.0	-1.1	-0.2	0.3	1.0	1.0	0.5	1.3
Forced vital capacity (FVC)	0.4	1.6	6.5	-1.1	-1.0	-1.0	0.8	0.0	-0.9	-1.1	-1.3	-0.7	-1.8	-0.9	-2.6	-1.7	-1.9	-0.6	-1.7	-0.5	-0.6
Qualifications: None of the above	0.4	0.8	1.5	-1.0	-0.9	-0.7	-1.0	-1.2	-0.7	-1.0	-0.9	-0.7	-1.2	-0.7	-1.2	-0.8	-0.0	-0.5	-1.0	-0.9	0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.5	-0.8	-0.8	-0.6	-0.1	-0.3	-0.6	-0.8	-0.9	-0.3	-1.2	-0.8	-0.9	-1.0	-0.8	-0.5	-0.9	-0.4	-0.6
Impedance of arm (right)	0.4	1.7	5.0	-1.3	-1.1	-1.0	-1.5	-1.7	-1.0	-1.3	-1.4	-1.0	0.3	-1.3	-2.2	-2.2	-1.1	-1.3	-1.1	-0.9	-0.4
Medication: Lansoprazole	0.4	0.4	1.9	-0.2	-0.4	-0.5	-0.1	0.0	-0.5	-0.2	-0.1	-0.5	-1.4	-0.5	0.8	0.5	-0.5	-1.3	-0.8	-0.5	-0.7
Exposure to tobacco smoke outside home	0.4	0.6	1.9	0.9	0.9	0.8	0.1	0.7	0.8	0.9	0.9	0.4	1.0	0.8	-0.2	0.6	1.4	-0.1	0.9	0.2	0.3
Worry too long after embarrassment	0.4	0.7	2.6	-0.7	-0.7	-0.9	-0.3	-0.7	-0.8	-0.7	-0.7	-0.5	-1.0	-0.8	-1.6	-1.3	-1.5	-0.2	-0.9	-0.3	0.6
Average weekly champagne plus white wine intake	0.4	0.5	2.0	0.3	0.3	0.4	-0.6	-0.5	0.1	0.3	0.5	-0.1	1.4	1.1	1.4	0.8	1.3	-0.8	0.5	-0.1	0.0
Guilty feelings	0.4	0.6	2.0	-0.5	-0.5	-0.7	-0.3	-0.4	-0.8	-0.4	-0.5	-0.8	-1.0	-0.6	-1.4	-0.8	-0.9	-0.7	-0.7	-1.3	-0.5
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	0.8	0.8	0.7	0.9	0.9	0.7	0.8	0.7	0.6	-0.1	0.6	0.2	0.9	0.7	0.6	0.7	0.3	0.2
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	-0.9	-0.8	-0.9	-1.2	-1.4	-0.7	-0.9	-0.9	-0.7	-0.3	-1.1	-0.6	-0.6	-1.1	-1.2	-1.0	0.0	-0.4
Age at First Birth	0.3	0.4	1.1	0.6	0.6	0.7	0.8	0.4	0.6	0.6	0.5	1.0	-0.3	0.4	-0.4	0.2	0.5	1.1	0.7	0.8	1.0
Coronary Artery Disease (CAD)	0.3	0.3	1.1	0.3	0.4	0.5	0.8	0.4	0.5	0.3	0.3	0.4	0.0	0.9	-0.1	0.7	1.0	0.9	0.8	0.6	0.0
Lupus	0.3	0.5	1.8	0.6	0.5	0.6	0.3	0.3	0.6	0.6	0.6	0.3	1.3	0.4	1.2	0.5	1.1	0.4	0.8	0.2	1.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.0	0.5	0.5	0.3	0.5	0.5	0.7	0.5	0.4	0.7	-0.4	0.1	0.1	0.5	0.0	1.4	0.4	0.9	0.0
Allergy or Eczema	0.3	0.9	2.1	1.1	1.0	1.0	0.6	1.5	0.9	1.1	1.0	0.7	0.1	1.4	0.2	0.5	0.9	0.7	1.4	0.9	0.7
Medication: Co-codamol	0.3	0.4	1.3	-0.5	-0.6	-0.8	-0.7	-0.4	-0.7	-0.5	-0.5	-0.5	0.2	-0.8	-0.5	-0.4	-1.1	-1.0	0.4	-0.2	-0.6
Multivitamins +/- minerals	0.3	0.4	2.4	0.5	0.5	0.4	0.4	0.3	0.3	0.5	0.6	0.1	1.1	0.9	1.6	0.6	0.5	0.2	0.2	0.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	0.5	0.5	0.6	0.7	0.6	0.4	0.5	0.5	0.5	-0.3	0.7	1.2	0.6	0.5	-0.1	0.4	0.3	0.1
High blood pressure (mother)	0.3	0.4	1.5	0.8	0.7	0.5	0.2	0.5	0.5	0.8	0.7	0.5	0.5	0.5	1.2	0.6	0.1	0.5	-0.1	0.7	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.9	-0.5	-0.5	-0.4	-0.1	-0.3	-0.5	-0.5	-0.4	-0.3	-1.1	-0.9	0.2	-0.0	-0.8	-1.4	-0.2	-0.3	-0.8
Medication: Ramipril	0.3	0.4	1.9	0.4	0.4	0.4	-1.3	-0.0	0.2	0.4	0.4	-0.0	1.4	0.8	0.2	-0.2	1.1	-0.2	-0.1	-0.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	-0.8	-0.7	-0.7	0.7	-0.4	-0.8	-0.8	-0.7	-0.3	-0.2	-1.0	0.2	0.1	-0.8	-0.3	-0.8	-0.1	-0.3
Prospective memory result	0.3	0.4	0.9	-0.9	-0.8	-0.4	-0.8	-0.8	-0.7	-0.9	-0.8	-0.6	0.1	-0.4	-0.1	-0.9	0.2	-0.3	-0.5	-0.6	-0.0
Pulse wave Arterial Stiffness index	0.3	0.4	2.2	-0.5	-0.5	-0.5	-0.2	-0.3	-0.6	-0.5	-0.4	-0.7	-1.5	-0.4	0.4	-0.2	-0.7	-0.4	-0.6	-0.3	-0.8
Blood clot in the leg (DVT)	0.3	0.3	3.3	0.4	0.3	0.3	0.7	0.7	0.2	0.3	0.3	0.3	-1.8	0.2	-0.4	-0.1	0.4	0.3	0.3	0.6	-0.6
Comparative body size at age 10	0.3	1.0	1.6	1.1	1.1	1.0	1.1	1.0	0.9	1.1	1.1	1.0	1.2	0.7	1.0	1.2	0.7	0.8	1.3	0.6	0.1
Pulse wave peak to peak time	0.3	0.4	1.7	0.4	0.5	0.5	0.4	0.3	0.6	0.4	0.3	0.8	1.3	0.4	-0.5	0.1	0.6	0.5	0.5	0.5	0.9
Eye problems/disorders: None of the above	0.3	0.3	1.9	-0.5	-0.4	-0.5	0.7	0.1	-0.2	-0.4	-0.6	-0.0	-0.6	-0.8	0.2	-0.5	-1.4	0.2	-0.8	0.1	0.0
Chest pain or discomfort	0.3	0.4	1.4	0.7	0.7	0.5	0.5	1.0	0.6	0.7	0.7	0.2	-0.5	0.7	-0.4	0.1	1.2	0.4	0.1	0.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.0	-0.8	-0.7	-0.7	-0.1	-0.5	-0.5	-0.8	-0.7	-0.3	-0.1	-0.8	-0.7	-0.6	-1.0	-0.1	0.0	0.3	-0.2
Wears glasses or contact lenses	0.3	0.3	1.0	0.5	0.5	0.4	-0.0	0.4	0.4	0.5	0.5	0.1	0.4	0.9	1.0	0.7	0.6	0.4	0.8	0.0	0.6
Eye problems/disorders: Glaucoma	0.3	0.3	1.3	-0.0	0.0	0.3	-0.6	-0.9	0.2	-0.0	-0.0	0.1	0.7	0.8	-0.2	-0.2	0.5	1.2	-0.6	-0.9	0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.9	0.8	0.4	-0.1	0.6	0.5	0.9	0.8	0.5	0.7	0.8	0.6	0.7	0.0	0.2	0.3	-0.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	4.4	0.1	0.0	0.0	0.6	0.5	-0.1	0.1	0.1	0.0	-2.1	-0.1	-0.6	-0.2	0.3	0.2	0.2	0.4	-0.6
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-0.6	-0.7	-0.5	-0.8	-0.8	-0.9	-0.6	-0.5	-0.9	-0.4	-0.7	-0.2	-0.5	-0.6	-0.7	-0.9	-0.9	-0.3
Rheumatoid Arthritis	0.2	0.3	1.1	-0.1	-0.2	-0.4	-0.7	-0.2	-0.3	-0.1	-0.1	-0.2	-1.1	-0.8	0.3	-0.0	-1.0	-0.2	-0.3	0.0	-0.9
Blood White Count	0.2	1.2	2.1	1.2	1.1	1.0	1.1	1.4	1.2	1.2	1.3	1.0	-0.5	1.4	1.4	0.9	0.8	1.2	0.8	1.3	0.5
Waist Hip Ratio (WHR)	0.2	0.7	4.9	0.3	0.1	-0.7	-2.2	-0.8	-0.4	0.3	0.2	-0.6	0.6	-0.6	-0.3	-0.1	-0.8	-1.4	-1.0	-0.5	1.2
Hypothyroidism (self reported)	0.2	0.5	1.6	-0.6	-0.7	-0.8	-0.4	-0.6	-0.8	-0.6	-0.7	-0.8	-0.8	-0.8	0.1	-0.7	-0.9	-0.1	-1.3	-0.9	-0.6
Tanning	0.2	2.0	3.7	-1.5	-1.6	-1.5	-1.6	-1.7	-1.8	-1.5	-1.4	-1.7	-0.0	-1.8	-1.1	-1.1	-0.6	-1.5	-1.9	-1.2	-0.9
Average weekly spirits intake	0.2	0.2	1.4	-0.3	-0.3	-0.3	0.4	-0.4	-0.0	-0.3	-0.4	0.1	0.2	-0.9	-1.2	-0.8	-0.2	0.2	-0.5	-0.4	0.1
Diabetes (father)	0.2	0.2	0.5	-0.5	-0.5	-0.2	-0.7	-0.4	-0.5	-0.5	-0.6	-0.4	-0.4	0.1	-0.4	-0.7	-0.1	-0.5	0.0	-0.4	-0.3
Diabetes (mother)	0.2	0.3	1.4	0.3	0.4	0.7	0.1	0.4	0.5	0.3	0.3	0.5	-0.3	0.7	0.6	0.1	1.2	0.6	0.1	0.7	0.2
Age when periods started (menarche)	0.2	0.5	2.0	-0.7	-0.8	-1.0	0.1	-0.6	-0.8	-0.8	-0.9	-0.4	-0.1	-0.3	-0.6	-0.6	-1.4	-0.3	-0.6	-0.5	-0.2
Hair/balding pattern: Pattern 2	0.2	0.3	1.5	-0.3	-0.4	-0.2	-0.3	-0.3	-0.2	-0.3	-0.2	-0.3	0.7	-1.2	-0.2	-0.5	0.2	-0.9	-0.8	-0.5	-0.6
Had other major operations	0.2	0.2	1.6	0.2	0.1	0.2	0.3	0.1	-0.0	0.2	0.1	-0.1	-1.2	0.3	1.1	0.3	-0.2	0.6	-0.4	-0.5	-0.4
Diabetes (self-reported)	0.2	0.3	2.1	-0.3	-0.3	-0.4	-1.4	-1.0	-0.4	-0.3	-0.3	-0.3	0.5	-0.2	-0.6	-0.4	0.0	-1.0	-0.5	-0.2	0.1
Illnesses of siblings	0.2	0.3	0.7	-0.6	-0.6	-0.4	-0.0	-0.5	-0.4	-0.6	-0.6	-0.6	0.6	-0.8	0.4	-0.4	0.1	0.4	-0.8	-0.3	-0.8
Pulse rate	0.2	0.3	1.2	0.3	0.3	0.6	0.4	0.4	0.5	0.2	0.4	0.7	0.7	0.3	1.1	0.6	0.8	0.1	0.6	0.7	0.4
Happiness	0.2	0.2	1.0	-0.3	-0.4	-0.3	-0.2	-0.2	-0.4	-0.3	-0.3	-0.4	-0.0	-0.4	-0.5	-0.4	-0.0	-1.0	-0.4	0.0	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	0.9	0.8	0.4	0.6	0.7	0.5	1.0	0.8	0.5	0.2	0.4	-0.9	-0.1	-0.0	0.6	0.5	0.7	-0.0
Length of working week for main job	0.2	0.2	1.6	-0.2	-0.1	0.5	0.3	-0.6	0.1	-0.2	-0.2	0.2	-0.5	0.6	1.2	-0.2	0.6	-0.0	-0.3	-0.5	-0.1
Exposure to tobacco smoke at home	0.2	0.2	1.8	-0.3	-0.3	-0.5	-0.5	-0.6	-0.3	-0.3	-0.3	-0.3	-0.1	-0.3	-1.3	-0.8	-0.0	-0.6	-0.2	0.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.4	1.0	0.8	0.5	1.2	1.0	0.3	1.0	0.9	0.5	0.2	0.3	0.3	0.3	-0.0	0.4	0.1	0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	1.7	0.4	0.4	0.4	0.4	0.3	0.4	0.4	0.4	0.4	1.3	0.1	-0.1	0.2	0.1	0.6	-0.0	-0.1	-0.4
Glaucoma (self-reported)	0.2	0.2	0.8	-0.2	-0.1	-0.1	-0.4	-0.7	-0.0	-0.2	-0.3	0.0	0.1	0.3	-0.6	-0.5	-0.1	0.9	-0.9	-0.9	0.1
Forced vital capacity (FVC), Best measure	0.2	0.8	5.5	-0.5	-0.3	0.0	1.7	0.4	0.0	-0.5	-0.7	0.4	-0.6	-0.3	-2.4	-1.2	-0.6	0.7	-1.0	0.3	0.4
Qualifications: College or University degree	0.2	0.6	2.1	-0.5	-0.6	-0.9	-1.1	-0.8	-0.7	-0.5	-0.7	-0.6	-0.6	-0.6	-0.8	-0.7	-1.4	-1.2	-0.4	0.1	-0.7
Neck or shoulder pain in last month	0.2	0.2	0.9	0.3	0.3	0.5	0.4	0.3	0.5	0.3	0.3	0.5	-0.3	0.1	0.8	0.1	0.8	0.9	-0.0	0.5	0.2
Medication: Seretide 50 evohaler	0.2	0.3	1.0	0.7	0.5	0.3	-0.1	0.3	0.3	0.7	0.7	0.3	0.7	0.2	0.7	1.0	0.3	0.5	0.2	-0.4	0.3
Heart disease (mother)	0.2	0.2	1.1	0.2	0.1	0.0	-0.3	0.9	-0.0	0.2	0.3	-0.0	-0.7	0.2	0.6	0.0	0.6	-1.0	0.5	0.6	-0.5
Comparative height size at age 10	0.2	1.0	3.9	0.4	0.5	0.8	2.0	1.5	0.5	0.5	0.4	0.6	-1.8	1.1	-1.7	-0.5	1.3	0.1	0.3	0.8	0.8
Family relationship satisfaction	0.2	0.2	1.3	0.0	0.0	-0.1	0.5	0.3	0.1	0.0	-0.1	0.1	-0.7	-0.2	-0.2	-0.3	-0.3	-0.4	-1.1	0.5	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	0.2	0.2	0.1	0.9	0.6	0.2	0.2	0.3	0.5	-0.1	-0.3	1.0	0.8	-0.2	-0.0	-0.1	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.6	-0.8	-0.7	-0.3	0.8	-0.4	-0.5	-0.8	-1.0	-0.1	-0.9	-0.4	-1.3	-1.2	-0.8	0.3	-0.8	-0.1	0.1
Mood swings	0.2	0.3	1.0	0.3	0.4	0.7	0.8	0.3	0.3	0.3	0.5	0.5	0.5	0.9	1.0	0.7	0.8	0.8	-0.2	-0.0	0.5
Eye problems/disorders: Cataract	0.2	0.3	1.3	0.4	0.4	0.5	-0.3	0.1	0.3	0.4	0.5	0.2	0.7	0.3	0.2	0.5	1.1	-0.4	1.1	0.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.3	-0.4	-0.5	0.2	-0.2	-0.5	-0.3	-0.3	-0.1	-1.0	0.0	-0.2	-0.2	-1.0	-1.0	-0.5	-0.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	-0.3	-0.3	-0.5	-0.9	-0.3	-0.3	-0.3	-0.2	-0.6	-0.6	-0.9	-0.7	0.0	-0.9	-0.3	0.1	-0.3	0.1
Mineral and other dietary supplements	0.2	0.3	0.7	-0.7	-0.6	-0.5	-0.5	-0.6	-0.5	-0.7	-0.6	-0.3	-0.3	-0.8	-0.6	-0.5	-0.7	-0.5	0.0	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	-0.5	-0.4	-0.7	0.1	0.1	-0.5	-0.5	-0.5	-0.7	-0.8	0.0	-0.5	-0.3	-1.0	-0.5	-0.9	-0.7	-1.1
Medication: Lisinopril	0.2	0.3	1.4	0.3	0.2	-0.1	-0.5	0.3	-0.0	0.3	0.3	-0.7	1.2	0.8	0.5	-0.0	0.8	-0.6	0.4	-0.4	-0.6
Ever smoked	0.2	0.4	3.1	-0.5	-0.6	-0.3	-0.2	-0.6	-0.7	-0.5	-0.4	-0.7	-0.4	0.4	0.3	-0.3	0.4	-1.8	-0.6	-0.8	-0.4
Age started oral contraceptive pill	0.2	0.3	0.8	0.3	0.4	0.4	0.5	0.6	0.5	0.3	0.3	0.7	-0.1	0.7	-0.9	-0.2	0.5	0.8	0.8	0.7	0.3
Alcohol drinker status: Previous	0.2	0.2	1.1	-0.6	-0.5	-0.2	-0.4	-0.3	-0.3	-0.6	-0.4	-0.5	0.5	-0.5	0.1	-0.6	0.8	-1.1	-0.0	-0.1	-0.3
Bipolar Disorder (2011)	0.1	0.1	0.5	0.2	0.3	0.2	0.5	0.1	0.4	0.2	0.2	0.5	0.7	-0.4	-0.1	0.0	-0.1	0.7	0.3	0.3	0.0
Blood Eosinophil Count	0.1	0.6	3.1	-0.2	-0.2	-0.3	0.8	0.2	-0.2	-0.2	-0.4	-0.1	-0.6	-1.8	-0.7	-0.8	-1.0	1.2	-1.2	-0.8	-0.4
Respiratory disease	0.1	0.2	0.7	-0.3	-0.3	-0.5	-0.8	-0.5	-0.2	-0.3	-0.3	-0.3	-0.3	-0.6	-0.6	-0.3	-0.6	0.3	-0.1	-0.6	0.2
Hair Pigment	0.1	2.1	4.2	-1.2	-1.3	-1.4	-1.8	-1.1	-1.4	-1.3	-1.3	-1.7	-1.3	-0.9	-0.2	-1.4	-1.2	-2.0	-2.0	-1.8	-1.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	1.1	-0.4	-0.4	-0.2	0.2	-0.3	-0.3	-0.4	-0.2	-0.4	-1.1	-0.3	-0.5	-0.2	-0.3	0.2	-0.5	-0.5	0.0
Angina	0.1	0.2	1.3	0.1	0.1	-0.2	-1.1	0.0	-0.1	0.1	0.2	-0.2	-0.3	0.2	-0.3	-0.1	0.0	-0.8	-0.5	-0.4	-0.2
Supplements: Zinc	0.1	0.1	0.9	-0.1	0.0	0.2	0.3	0.0	0.3	-0.1	-0.2	0.1	1.0	-0.2	-0.2	-0.4	0.3	0.6	-0.4	0.3	0.7
Fed-up feelings	0.1	0.1	0.6	-0.2	-0.2	0.1	-0.6	-0.8	-0.2	-0.2	-0.0	-0.3	-0.0	0.2	0.4	0.1	0.3	0.1	-0.6	-0.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.2	-0.2	-0.1	0.1	-0.2	-0.1	-0.2	-0.1	0.0	-0.7	-0.6	0.2	-0.0	-0.6	-0.1	-0.3	-0.1	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.2	0.6	0.6	0.4	0.3	1.1	0.5	0.6	0.5	0.4	-0.7	0.7	-0.4	0.1	0.1	0.6	0.6	0.2	0.3
Mouth/teeth dental problems	0.1	0.1	0.3	-0.3	-0.3	-0.4	-0.3	-0.3	-0.4	-0.3	-0.4	-0.5	-0.4	-0.1	0.1	-0.0	-0.4	0.5	-0.1	-0.3	-0.3
Allergy	0.1	0.2	0.7	-0.4	-0.3	-0.1	-0.1	-0.7	-0.3	-0.4	-0.3	-0.3	0.9	-0.3	0.7	-0.1	0.2	-0.6	-0.3	0.1	-0.1
Time employed in main current job	0.1	0.1	0.5	0.4	0.2	0.2	-0.4	0.0	-0.1	0.4	0.4	0.1	0.7	0.1	0.2	0.1	0.3	-0.4	0.2	-0.1	-0.2
Number of live births	0.1	0.2	1.2	-0.5	-0.4	-0.3	-0.1	-0.3	-0.3	-0.5	-0.5	-0.3	-1.0	-1.1	-0.3	-0.3	-0.1	0.1	-0.3	0.0	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.6	-0.0	0.0	-0.0	1.3	1.1	0.0	-0.0	-0.2	0.1	-1.1	0.3	-1.1	-0.4	-0.8	-0.1	-0.4	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.4	0.4	0.4	-0.1	0.6	0.5	0.4	0.5	0.3	-0.3	0.2	0.5	0.1	0.8	-0.6	0.5	0.5	0.4
Asthma	0.1	0.1	0.5	-0.1	-0.1	-0.2	-0.3	-0.3	0.0	-0.1	-0.1	-0.0	0.7	-0.4	-0.4	0.2	-0.5	0.5	-0.3	-0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	2.9	0.2	0.3	0.5	1.7	1.1	0.5	0.2	0.0	0.5	-0.2	0.7	-1.1	-0.3	0.1	0.6	-0.2	0.7	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.8	0.1	0.1	-0.1	0.2	-0.1	-0.0	0.2	0.2	-0.1	-0.7	-0.9	0.6	0.3	-0.7	-0.4	0.0	-0.1	-0.3
Loud music exposure frequency	0.1	0.2	0.6	0.3	0.3	-0.0	-0.1	0.8	0.2	0.3	0.3	0.3	0.3	0.5	0.4	0.3	-0.4	-0.0	0.6	0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.7	-0.2	-0.2	-0.4	-0.1	-0.3	-0.3	-0.2	-0.2	-0.3	-0.0	-0.2	0.1	-0.4	-0.4	0.5	-0.8	-0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.7	-0.3	-0.2	0.1	-0.2	-0.5	0.0	-0.3	-0.2	0.1	0.7	0.3	0.6	0.2	0.2	0.8	-0.2	0.4	0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.6	0.1	0.0	-0.0	0.1	0.3	0.0	0.1	0.2	0.2	0.5	-0.2	0.4	0.4	0.0	0.8	-0.1	-0.1	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.6	0.4	0.3	0.1	0.2	0.2	0.4	0.4	0.4	0.4	-0.0	-0.3	-0.4	0.3	0.0	-0.0	0.8	0.2	0.2
Angina (self-reported)	0.1	0.2	0.7	0.5	0.4	0.1	-0.8	0.4	0.2	0.5	0.6	0.0	-0.2	0.5	0.1	0.3	0.3	-0.3	-0.2	-0.3	0.1
Migraine (self-reported)	0.1	0.1	1.3	-0.1	-0.1	0.1	-0.2	-0.5	-0.1	-0.1	-0.1	-0.1	-0.3	-0.2	1.1	0.3	-0.3	0.5	-0.1	-0.6	-0.1
Age at last live birth	0.1	0.1	0.6	-0.2	-0.2	0.1	-0.0	0.2	-0.1	-0.2	-0.2	-0.2	-0.4	-0.5	-0.6	-0.1	0.1	-0.7	0.4	-0.4	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.5	0.0	-0.1	-0.1	-0.4	-0.1	-0.2	-0.0	-0.0	0.1	0.6	0.7	-0.4	-0.3	-0.4	-0.0	-0.6	-0.5	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.7	-0.0	-0.0	-0.2	-0.1	0.3	-0.1	-0.1	-0.0	0.2	-0.8	-0.2	-0.7	-0.4	-0.7	0.1	0.5	-0.0	-0.1
Loneliness, isolation	0.1	0.1	0.5	-0.2	-0.2	-0.0	0.4	-0.5	-0.1	-0.2	-0.1	-0.2	0.1	-0.0	-0.3	-0.1	0.1	0.7	-0.2	-0.3	0.3
Diabetes diagnosed by doctor	0.1	0.2	2.1	-0.0	-0.1	-0.2	-1.5	-0.8	-0.2	-0.0	-0.1	-0.1	0.5	0.2	-0.4	-0.1	0.3	-0.7	-0.2	0.0	0.2
Commuting to job workplace: Walk	0.1	0.1	0.6	-0.1	0.1	0.4	0.2	0.0	0.2	-0.1	-0.0	0.1	-0.1	0.5	0.8	-0.1	0.7	0.2	-0.1	0.2	0.3
Breast cancer (self-reported)	0.1	0.1	0.9	-0.3	-0.2	-0.2	-0.3	-0.6	-0.1	-0.3	-0.3	-0.1	-0.2	-0.2	-1.0	-0.6	-0.4	-0.5	-0.1	0.1	0.1
Asthma (self-reported)	0.1	0.1	0.5	-0.2	-0.2	-0.3	-0.4	-0.3	-0.1	-0.2	-0.2	-0.1	0.2	-0.5	-0.6	0.1	-0.6	0.1	-0.3	-0.7	0.4
Medication: Gliclazide	0.1	0.1	0.3	0.2	0.1	0.2	0.2	0.5	0.1	0.1	0.2	0.3	-0.3	0.6	-0.0	-0.1	0.5	0.1	0.3	0.2	-0.0
Miserableness	0.1	0.2	0.8	-0.1	-0.2	-0.1	-0.4	-0.1	-0.4	-0.1	0.1	-0.5	-0.9	0.5	0.3	-0.1	-0.0	-0.6	-0.3	-0.6	-0.5
Financial situation satisfaction	0.1	0.2	0.8	0.3	0.3	0.2	0.9	0.5	0.3	0.4	0.3	0.3	-0.4	0.5	-0.4	0.2	0.3	-0.4	-0.3	0.3	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	1.3	-0.2	-0.2	-0.0	-0.1	-0.0	-0.2	-0.2	-0.1	-0.2	0.4	-0.0	-0.1	-0.4	0.7	-1.1	-0.3	-0.2	0.2
Diastolic blood pressure, automated reading	0.1	0.2	1.4	0.3	0.3	0.0	0.1	-0.2	0.3	0.3	0.3	0.3	1.2	0.5	0.8	0.6	-0.2	-0.5	-0.6	0.2	0.6
Ever depressed for a whole week	0.1	0.2	0.9	-0.3	-0.3	-0.3	-0.2	-0.3	-0.3	-0.3	-0.2	-0.2	-0.9	-0.5	-0.2	-0.1	-0.5	-0.6	-0.2	-0.3	-0.5
Heart disease (siblings)	0.1	0.2	0.5	-0.0	0.1	0.3	0.3	-0.0	0.2	-0.1	-0.2	0.6	-0.7	0.3	-0.7	-0.6	-0.3	-0.0	0.0	0.6	0.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Vitamin and mineral supplements	0.0	0.1	0.6	0.1	0.1	0.1	-0.3	0.0	0.1	0.0	-0.0	0.2	-0.1	-0.5	-0.8	0.0	-0.0	0.3	0.3	0.0	-0.0
Medication: Levothyroxine sodium	0.0	0.1	0.4	-0.2	-0.1	-0.2	-0.2	-0.4	-0.1	-0.2	-0.2	0.0	0.1	-0.5	-0.0	-0.3	-0.3	0.5	-0.6	0.0	0.2
Worrier / anxious feelings	0.0	0.1	0.2	-0.0	-0.0	0.2	0.2	-0.0	-0.1	-0.0	0.0	-0.2	-0.5	0.1	0.3	-0.1	0.5	0.4	-0.1	-0.1	-0.2
Irritability	0.0	0.1	0.4	0.2	0.1	0.3	0.6	-0.1	-0.0	0.2	0.2	0.4	0.5	0.3	0.2	-0.0	-0.2	-0.0	-0.2	-0.0	0.0
Unable to work because of sickness or disability	0.0	0.0	0.2	0.1	0.1	-0.2	-0.1	-0.0	0.1	0.1	0.2	-0.1	-0.0	0.1	-0.2	0.3	0.0	0.3	0.2	0.4	0.4

Hub : Genes

SP1

Models

Trait associations