Best TWAS P=7.99e-09 · Best GWAS P=2.41e-08 conditioned to 0.345
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FURIN | 0.12 | 0.14 | lasso | 2 | 0.13 | 1.2e-15 | -5.1 | 5.1 | 3.0e-07 | 0.84 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | FES | 0.28 | 0.17 | enet | 21 | 0.20 | 2.8e-15 | 5.0 | -5.5 | 3.3e-08 | -0.89 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FES | 0.06 | 0.05 | blup | 46 | 0.07 | 7.4e-14 | 5.0 | -5.8 | 8.0e-09 | -0.89 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | FES | 0.08 | 0.07 | blup | 46 | 0.06 | 3.4e-04 | 5.1 | -5.8 | 8.8e-09 | -0.92 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | FES | 0.12 | 0.06 | enet | 6 | 0.06 | 5.7e-03 | 5.6 | -5.3 | 9.5e-08 | -0.96 | 0.00 | 0.93 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FES | 0.06 | 0.03 | blup | 46 | 0.05 | 5.6e-06 | 5.6 | -5.3 | 1.1e-07 | -0.81 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FES | 0.10 | 0.07 | enet | 5 | 0.05 | 2.8e-06 | 5.4 | -5.5 | 3.2e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | FES | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-05 | 5.0 | -5.6 | 2.4e-08 | -0.88 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | FES | 0.30 | 0.30 | lasso | 7 | 0.32 | 1.3e-31 | 5.0 | -5.5 | 3.4e-08 | -0.86 | 0.04 | 0.95 | FALSE |