TWAS hub - FURIN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.122	0.0350	4.5e-05	0.135	0.040	0.113	0.120	0.131	4.0e-16	1.1e-05	1.4e-13	1.8e-14	1.2e-15
2	GTEx	Brain Caudate basal ganglia	0.387	0.1110	7.8e-04	0.093	NA	0.024	NA	0.021	1.2e-03	NA	6.6e-02	NA	8.2e-02
3	YFS	Blood	0.105	0.0243	2.7e-10	0.029	0.049	0.060	0.056	0.051	6.3e-10	8.7e-16	8.4e-19	1.1e-17	3.0e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Systolic Blood Pressure	17.6	87.9	151.3	12.3	0.3	-10.6
Vascular/heart problems diagnosed by doctor	16.1	43.9	72.1	-7.7	0.2	8.5
Hypertension (Self-reported)	13.9	38.5	63.8	7.2	0.5	-8.0
High blood pressure	13.6	37.9	60.8	7.3	-0.2	-7.8
High blood pressure (mother)	13.1	18.4	28.7	5.4	-0.5	-5.1
Medication: Blood pressure	12.8	24.3	40.8	6.4	-0.8	-5.6
Systolic blood pressure, automated reading	12.7	37.0	59.3	7.7	0.4	-7.2
Angina	12.7	16.7	26.7	5.2	0.9	-4.7
Angina (self-reported)	12.0	15.8	25.8	5.1	0.9	-4.6
Medication: Blood pressure	11.4	20.0	36.7	4.8	0.2	-6.1
Medication: Atenolol	11.0	13.7	20.7	4.6	1.2	-4.4
Birth weight of first child	11.0	19.9	31.9	-5.7	-1.4	5.1
Schizophrenia (2018)	10.6	22.0	47.2	-6.9	1.1	4.2
Cardiovascular Disease	10.3	34.1	53.5	7.3	-0.4	-7.0
Illnesses of father: None of the above (group 1)	10.3	12.7	21.7	-3.9	1.2	4.7
Bipolar Disorder or Schizophrenia	10.0	24.5	53.0	-7.3	1.2	4.4
Medication for cholesterol, blood pressure or diabetes	9.4	15.6	28.0	-4.3	0.3	5.3
Birth weight	9.2	20.0	32.7	-5.1	0.9	5.7
Illnesses of father: High blood pressure	8.9	11.1	20.4	3.6	-0.2	-4.5
Father’s age at death	8.8	11.8	17.1	-3.3	2.7	4.1
Medication: Bendroflumethiazide	8.6	13.0	19.8	3.9	-2.0	-4.5
Illnesses of father: Heart disease	8.3	11.5	20.2	3.6	-1.2	-4.5
Medication: Aspirin	8.3	10.8	16.8	4.1	0.4	-3.9
Medication: Amlodipine	8.2	11.5	20.5	3.5	-1.3	-4.5
Medication: Aspirin	8.2	10.8	17.3	3.9	0.5	-4.2
Schizophrenia (2014)	7.9	17.5	35.5	-6.0	0.7	4.1
Heart attack	7.3	9.3	16.1	4.0	0.7	-3.4
Sensitivity / hurt feelings	7.2	12.4	30.3	-5.5	-1.6	2.1
Major Depression (MDD)	6.9	8.4	13.1	-3.6	-1.2	3.3
Pulse wave peak to peak time	6.9	8.2	14.0	-3.2	-0.6	3.7
Heart attack/myocardial infarction (self-reported)	6.7	8.7	15.1	3.9	0.6	-3.2
Number of incorrect matches in round	6.5	10.8	28.9	-5.4	-1.0	1.6
High blood pressure (siblings)	6.5	9.4	16.5	3.2	-1.3	-4.1
Bipolar Disorder (2011)	6.3	6.1	16.0	0.0	1.5	4.0
Diastolic blood pressure, automated reading	6.3	19.5	30.7	5.5	0.1	-5.3
Breast Cancer	6.1	14.6	24.8	5.0	0.1	-4.4
Pulse wave Arterial Stiffness index	5.9	6.9	11.8	3.0	0.5	-3.4
Risk taking	5.6	8.2	12.2	-3.5	-1.4	3.2
Number of operations (self-reported)	5.5	8.2	16.6	-4.1	-0.5	2.8
Medication: Cholesterol lowering	5.4	8.4	13.4	3.4	-0.4	-3.7
Supplements: Vitamin C	5.3	6.3	12.1	2.4	3.5	-0.9
Handedness (chirality/laterality): Left-handed	5.0	6.0	15.8	-4.0	-0.2	1.5
Medication for cholesterol	4.8	7.4	10.9	-3.3	-0.5	3.3
Hand grip strength (left)	4.4	11.7	20.2	-3.4	-1.8	4.5
Tinnitus: Yes, but not now, but have in the past	4.4	4.7	10.5	1.6	3.2	-1.0
Mean time to correctly identify matches	4.4	8.5	13.1	-3.2	1.5	3.6
Medication: Ramipril	4.3	5.5	10.0	2.4	-1.0	-3.2
Illnesses of mother	4.2	5.1	8.2	-2.9	-0.5	2.6
Ovarian Cancer	4.0	5.3	7.1	2.1	-2.1	-2.7
Allergy	4.0	9.3	15.9	4.0	1.8	-2.9
Headache pain in last month	4.0	6.9	15.2	-2.2	0.6	3.9
Reaction Time	3.9	7.5	12.1	-2.9	1.3	3.5
Neuroticism	3.9	9.4	23.0	-4.8	-0.4	2.2
Tense / ‘highly strung’	3.9	6.5	14.8	-3.9	1.1	1.9
Heart disease (siblings)	3.9	4.8	7.8	2.4	1.0	-2.8
Mean Putamen Volume	3.8	4.3	10.6	-3.3	-0.3	1.5
Number of live births	3.7	5.2	12.7	-3.6	-0.3	1.7
Mineral and other dietary supplements	3.7	4.9	11.1	-3.3	0.3	1.9
Asthma (self-reported)	3.6	7.1	11.0	-3.3	-1.9	2.6
Frequency of depressed mood in last 2 weeks	3.5	4.9	7.6	-2.8	2.3	1.3
Medication: Simvastatin	3.5	5.2	9.8	2.4	-0.3	-3.1
Age at First Birth	3.3	4.8	7.3	2.7	0.3	-2.7
Hair/balding pattern: Pattern 3	3.3	5.0	9.6	2.0	1.2	-3.1
Mouth/teeth dental problems: Mouth ulcers	3.3	5.2	10.8	-1.7	-3.3	1.4
Asthma	3.2	6.3	10.0	-3.2	-1.8	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	5.0	9.2	-3.0	0.8	2.2
Respiratory disease	3.1	6.8	13.5	-3.7	-2.0	1.8
Severe depression (siblings)	3.1	3.4	7.5	-2.7	-1.1	1.2
Chronic bronchitis/emphysema (father)	3.1	3.6	5.8	-2.2	-0.3	2.4
Breastfed as a baby	3.1	3.8	4.5	2.1	-1.6	-2.1
Supplements: Fish oil (including cod liver oil)	3.1	4.0	8.8	3.0	-0.8	-1.6
Alcohol usually taken with meals	3.0	4.8	12.4	3.5	0.3	-1.4
Hair/balding pattern: Pattern 4	3.0	7.4	11.6	3.4	-1.8	-2.7
Age started oral contraceptive pill	3.0	3.7	6.1	2.2	0.1	-2.5
Bipolar Disorder (2018)	2.9	4.6	10.4	-3.2	0.6	1.8
Neuroticism (Nagel 2018)	2.9	6.7	18.7	-4.3	0.3	1.2
Irritable Bowel Disease (IBD)	2.9	6.8	10.2	1.9	-3.2	-2.6
Vitamin and mineral supplements	2.9	4.0	6.3	-2.5	-1.9	1.4
Comparative height size at age 10	2.9	15.8	34.0	-3.6	0.5	5.8
Smoking Status	2.8	6.7	7.6	-2.8	2.7	2.2
Illnesses of siblings	2.8	3.9	6.5	-2.2	0.6	2.5
Blood White Count	2.7	19.9	32.0	5.7	0.3	-5.3
Had other major operations	2.7	3.3	5.4	-2.3	-0.2	2.1
Medication: Seretide 50 evohaler	2.7	3.1	4.6	-2.1	-0.5	2.1
Impedance of leg (left)	2.6	12.5	26.3	5.1	-0.3	-3.3
Prostate Cancer	2.5	3.6	7.1	-2.7	-0.5	1.8
Lupus	2.5	3.8	5.9	-2.4	-1.6	1.7
Ulcerative Colitis	2.5	3.6	5.2	1.3	-2.3	-2.0
Leg predicted mass (right)	2.5	13.1	20.1	-4.5	1.2	4.2
Ever smoked	2.5	4.4	9.2	-3.0	-0.1	2.0
Crohns Disease (2017)	2.4	5.4	5.8	2.4	-2.3	-2.2
Impedance of leg (right)	2.4	11.5	25.8	5.1	0.1	-3.0
Leg fat-free mass (left)	2.4	12.9	18.8	-4.3	1.5	4.2
Number of children fathered	2.4	2.7	4.9	-1.7	-2.2	0.6
Leg fat-free mass (right)	2.4	12.8	19.7	-4.4	1.2	4.1
Medication: Atorvastatin	2.4	3.0	5.1	2.2	0.1	-2.0
Coronary Artery Disease (CAD)	2.3	2.8	4.6	1.8	0.7	-2.1
Leg predicted mass (left)	2.3	12.4	18.1	-4.3	1.4	4.1
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	7.6	-2.8	0.8	0.6
Lung cancer (father)	2.3	2.6	6.4	-2.5	0.3	1.2
Ever had bowel cancer screening	2.3	2.7	5.6	-2.4	0.1	1.6
Stomach or abdominal pain in last month	2.2	2.8	7.6	-0.4	2.8	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	4.0	-1.9	1.0	2.0
Ulcerative Colitis (UC)	2.1	4.0	8.9	0.6	-3.0	-1.6
Neuroticism (2016)	2.1	3.1	8.7	-2.9	0.2	0.7
Hand grip strength (right)	2.1	5.7	11.1	-2.3	-0.9	3.3
Past tobacco smoking	2.1	3.9	8.5	2.9	-0.8	-1.6
Age at last live birth	2.1	3.1	4.6	-1.3	1.7	2.2
Medication: Lisinopril	2.1	2.7	4.2	2.1	0.4	-1.9
Height	2.0	38.2	78.5	-5.8	1.4	8.9
Neuroticism score	2.0	4.2	11.4	-3.4	0.3	1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	5.7	-2.4	1.2	0.2
Heart disease (mother)	2.0	2.4	4.8	1.4	0.7	-2.2
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	6.9	-2.6	0.2	0.9
Hayfever, allergic rhinitis or eczema	1.9	4.1	7.2	-2.7	-1.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	7.3	-2.7	0.6	1.1
Mouth/teeth dental problems	1.9	3.0	4.9	-2.2	1.1	1.7
Mouth/teeth dental problems: Dentures	1.9	3.2	4.5	2.1	0.8	-2.1
Whole body water mass	1.9	10.6	15.0	-3.8	1.4	3.9
Average weekly beer plus cider intake	1.9	2.8	5.6	-0.8	-2.4	1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.2	2.4	1.6	-1.5	-1.3
Had major operations	1.8	2.1	3.7	-1.9	-0.9	1.4
Whole body fat-free mass	1.8	10.3	14.8	-3.7	1.5	3.8
Irritability	1.8	3.0	9.0	-3.0	-0.1	0.2
Blood Eosinophil Count	1.7	13.2	36.2	-1.8	-6.0	-0.5
Maternal smoking around birth	1.7	2.4	4.5	-2.1	-0.2	1.6
Mood swings	1.7	3.1	7.4	-2.7	1.3	0.4
Basal metabolic rate	1.7	9.2	13.1	-3.6	1.3	3.6
Fractured/broken bones in last 5 years	1.7	2.2	3.0	1.5	1.7	-1.2
Pack years adult smoking proportion	1.6	2.4	6.0	-2.4	0.8	0.8
Trunk fat-free mass	1.6	9.1	13.9	-3.3	1.6	3.7
Trunk predicted mass	1.6	8.9	13.6	-3.3	1.6	3.7
Pulse wave reflection index	1.6	1.9	4.1	2.0	0.7	-1.1
Pack years of smoking	1.6	2.3	6.0	-2.5	0.4	0.9
Number of treatments/medications taken	1.5	2.6	6.9	0.9	0.5	-2.6
Hearing difficulty/problems: Yes	1.5	2.2	4.2	-2.0	-1.0	1.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.5	1.2	0.3	-1.9
Worrier / anxious feelings	1.5	2.8	4.4	-2.0	2.1	-0.0
Blood clot in the leg (DVT)	1.5	2.0	5.4	-2.3	0.2	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.6	-1.6	0.7	1.3
Breast cancer (self-reported)	1.5	1.8	3.0	-1.5	-0.3	1.7
Myopia	1.5	2.2	4.1	2.0	-0.1	-1.6
Depression (Nagel 2018)	1.4	2.1	4.5	-2.1	1.3	0.3
Crohns Disease (2012)	1.4	2.3	3.2	1.4	-1.8	-1.3
Waist Hip Ratio (WHR)	1.4	6.2	8.5	-2.6	2.9	1.8
Medication for pain relief, constipation, heartburn	1.4	2.3	3.8	-0.7	-1.9	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.2	-0.5	2.1	-0.6
Guilty feelings	1.4	2.1	6.0	-2.5	0.4	-0.1
Worry (Nagel 2018)	1.3	2.7	7.8	-2.8	0.2	0.4
Financial difficulties in last 2 years	1.3	1.7	2.8	-1.3	0.9	1.7
Happiness	1.3	1.5	3.4	-1.8	0.4	1.0
Standing height	1.3	13.3	30.1	-2.4	1.9	5.5
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.5	-1.6	-1.0	1.2
Mother’s age at death	1.3	1.6	4.0	-2.0	-0.3	0.9
Medication: Paracetamol	1.3	2.0	3.7	-0.9	1.9	1.3
Alcohol drinker status: Never	1.3	1.5	2.3	0.7	1.5	-1.3
Depressed Affect (Nagel 2018)	1.2	2.4	6.6	-2.6	0.8	0.4
Allergy or Eczema	1.2	3.2	6.6	-2.6	-1.2	1.2
Diabetes (father)	1.2	1.5	3.6	-1.9	-0.5	0.9
Hearing difficulty/problems with background noise	1.2	2.0	4.6	-2.1	0.6	1.0
Depression (self-reported)	1.2	1.5	4.2	-2.0	-0.3	0.4
Medication: Lansoprazole	1.2	1.3	3.8	-0.0	1.9	-0.4
Worry too long after embarrassment	1.2	1.9	3.7	-1.9	0.1	1.4
Wheeze or whistling in the chest in last year	1.2	2.1	4.0	-2.0	-0.4	1.4
Loneliness, isolation	1.2	1.7	3.5	-1.9	0.6	1.1
Alcohol drinker status: Previous	1.2	1.4	3.8	-0.2	2.0	0.5
Fasting Glucose	1.1	1.4	2.8	-0.1	1.7	1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.3	1.5	-0.4	-1.2
Current tobacco smoking	1.1	1.8	2.8	-1.7	0.9	1.3
Fed-up feelings	1.1	2.0	3.8	-2.0	1.1	-0.9
Had menopause	1.1	1.4	1.9	0.7	-1.4	-1.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.2	-1.8	-1.1	-0.0
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.6	-1.6	0.8	0.7
Arm predicted mass (right)	1.1	5.5	7.6	-2.8	1.4	2.6
Leg pain on walking	1.1	1.4	2.4	-1.3	-1.6	-0.2
High cholesterol (Self-reported)	1.1	2.0	3.0	1.7	0.2	-1.7
Arm fat-free mass (left)	1.1	5.5	7.5	-2.7	1.7	2.4
Commuting to job workplace: Cycle	1.1	1.4	2.2	1.3	1.5	-0.5
Arm predicted mass (left)	1.1	5.6	8.8	-3.0	1.3	2.5
Intelligence (Savage-Jansen 2018)	1.0	3.0	4.2	2.1	1.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.3	-1.8	0.7	-0.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.5	-1.6	-0.4	0.9
Hair/balding pattern: Pattern 2	1.0	1.2	2.5	0.2	1.6	1.0
Weight	1.0	5.0	8.7	-3.0	1.1	2.2
Medication: Ibuprofen	1.0	1.1	3.1	-0.5	1.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.9	0.9	1.6	1.7
Osteoporosis (self-reported)	1.0	1.3	2.5	-1.2	-0.1	1.6
Hearing aid user	1.0	1.2	1.6	-0.7	-1.2	1.2
Eye problems/disorders: Glaucoma	1.0	1.1	3.0	0.5	-0.4	-1.7
Supplements: Calcium	1.0	1.1	2.8	0.7	-0.4	1.7
Average weekly spirits intake	0.9	1.1	1.8	-1.3	-1.0	0.7
Supplements: Zinc	0.9	1.0	1.9	0.8	0.6	1.4
Age when periods started (menarche)	0.9	2.2	3.8	1.9	1.3	-1.0
Supplements: Glucosamine	0.9	1.1	2.4	0.7	0.6	-1.6
Alcohol intake versus 10 years previously	0.9	1.3	2.4	1.6	1.2	0.3
Prospective memory result	0.9	1.1	2.0	-1.0	-1.4	-0.4
Medication: Paracetamol	0.9	1.5	3.1	-0.4	1.8	1.1
Eye problems/disorders: None of the above	0.9	1.1	1.9	1.4	-0.9	0.8
Pulse rate, automated reading	0.9	3.0	4.6	-2.1	-2.0	0.4
Back pain experienced in last month	0.9	1.4	3.4	0.1	0.8	1.9
Average weekly champagne plus white wine intake	0.9	1.2	3.3	-0.3	1.8	0.4
Pain experienced in last month	0.9	1.5	2.2	1.3	-0.7	-1.5
Body Mass Index (BMI) (2010)	0.8	1.1	1.6	-1.3	1.0	0.9
HDL Cholesterol	0.8	1.3	2.1	1.3	-0.1	-1.4
LDL Cholesterol	0.8	1.2	2.3	1.5	0.9	0.7
Taking other prescription medications	0.8	1.2	3.2	-1.8	0.1	-0.6
Trunk fat mass	0.8	3.5	6.6	-2.6	0.9	1.8
Waist circumference	0.8	2.9	5.3	-2.3	1.4	1.2
Arm fat percentage (right)	0.8	3.2	8.1	-2.9	0.4	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.7	0.1	1.6	-0.5
Arm fat mass (right)	0.8	3.3	7.7	-2.8	0.7	1.3
Arm fat-free mass (right)	0.8	4.1	5.9	-2.4	1.2	2.2
Shortness of breath walking on level ground	0.8	1.0	1.8	1.1	1.3	0.1
Migraine (self-reported)	0.8	1.0	3.0	1.7	0.4	-0.2
Illnesses of siblings: Diabetes	0.8	1.0	1.7	-1.1	0.1	1.3
Qualifications: nursing, teaching	0.8	1.2	1.6	-1.2	0.8	1.3
Smoking status: Current	0.8	1.3	2.6	-1.6	0.6	1.1
Arm fat mass (left)	0.8	3.2	7.5	-2.7	0.6	1.4
Unable to work because of sickness or disability	0.8	1.0	2.8	-1.7	0.4	-0.4
Schizophrenia vs Biploar Disorder	0.7	0.9	2.6	0.0	-1.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.5	1.2	1.1	-1.6
Diabetes (mother)	0.7	0.9	1.5	1.2	1.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.4	-1.5	1.1	0.0
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.9	-1.4	-0.8	0.4
Comparative body size at age 10	0.7	2.0	4.3	0.4	-2.1	-1.3
Number of full brothers	0.7	0.9	2.5	-0.3	1.6	0.1
Emphysema/chronic bronchitis	0.7	0.8	2.0	-1.4	0.6	0.1
Whole body fat mass	0.7	2.8	5.7	-2.4	0.9	1.3
Chest pain or discomfort	0.7	1.0	1.7	0.6	0.9	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.9	1.4	0.6	-0.4
Smoking status: Previous	0.7	1.0	1.9	-1.4	0.9	0.6
Osteoarthritis (self-reported)	0.7	0.9	2.1	-0.6	0.3	-1.4
Wears glasses or contact lenses	0.7	0.9	1.6	0.9	-0.3	-1.3
Commuting to job workplace: Public transport	0.7	0.8	1.5	0.2	-0.9	-1.2
Cholesterol lowering medication	0.7	1.0	1.5	0.8	0.9	-1.2
Impedance of whole body	0.7	3.8	10.3	3.2	0.0	-1.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	0.2	-0.9	1.1
Primary Biliary Cirrhosis	0.6	0.9	1.6	-0.7	1.3	0.8
Hypothyroidism (self reported)	0.6	1.5	2.5	-1.4	1.6	0.2
Lung FEV1/FVC ratio	0.6	3.2	8.7	0.6	3.0	-0.7
Relative age of first facial hair	0.6	1.2	3.5	-0.0	-1.9	0.5
Age at first live birth	0.6	1.1	1.5	1.2	0.7	1.1
Medication: Allopurinol	0.6	0.8	1.8	-1.3	-0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.6	0.8	1.3	0.4
Number of full sisters	0.6	0.8	2.0	0.5	-1.4	-0.1
Knee pain experienced in last month	0.6	0.9	2.3	-1.5	-0.0	0.6
Arm fat percentage (left)	0.6	2.6	6.5	-2.5	0.2	1.1
Long-standing illness, disability or infirmity	0.6	0.9	1.5	-1.2	1.0	0.2
Eye problems/disorders: Cataract	0.6	0.7	1.3	-0.9	1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	-0.7	1.3	-0.3
BMI	0.5	3.1	8.8	-3.0	-0.1	0.6
Hair Pigment	0.5	14.8	15.2	-3.9	-3.7	3.9
Qualifications: CSEs or equivalent	0.5	0.7	2.0	1.4	0.3	-0.0
Pulse rate	0.5	0.9	1.5	-1.2	-1.1	-0.2
Peak expiratory flow (PEF)	0.5	1.1	1.6	-0.6	1.2	1.2
Glaucoma (self-reported)	0.5	0.6	1.5	0.4	-0.1	-1.2
Health satisfaction	0.5	0.7	0.9	-0.8	0.9	-0.8
Neck or shoulder pain in last month	0.5	0.7	1.5	-0.7	1.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.8	-0.9	-0.8	0.5
Commuting to job workplace: Walk	0.5	0.5	0.7	0.7	0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.6	0.8	-0.8	-1.3
Number of self-reported non-cancer illnesses	0.5	0.9	2.5	-0.5	-0.0	-1.6
Ever taken oral contraceptive pill	0.5	0.6	1.2	-0.5	-0.6	1.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.5	-1.2	-0.4	0.0
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	0.6	0.9	0.6
Triglycerides	0.4	0.6	1.0	-1.0	-0.2	1.0
Heel T-Score	0.4	3.2	9.2	-0.7	-3.0	0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.4	0.2	1.2	-0.2
Relative age voice broke	0.4	0.7	1.6	-0.6	-1.2	0.1
Medication: Levothyroxine sodium	0.4	0.7	1.8	0.3	1.4	-0.2
Nervous feelings	0.4	0.7	1.5	-0.2	-1.2	-0.8
Qualifications: None of the above	0.4	0.8	2.1	0.5	-1.4	-0.4
Pain all over the body in last month	0.4	0.4	0.7	-0.3	-0.7	-0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.0	-0.9	1.0	0.9
Length of working week for main job	0.4	0.5	0.5	0.7	-0.6	-0.7
Gout (self-reported)	0.4	0.6	1.4	-0.5	-1.2	-0.3
Medication: Omeprazole	0.4	0.4	1.0	0.3	0.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.9	-0.6	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.1	-1.0	0.6	0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.7	1.0	-0.1
Trunk fat percentage	0.3	1.2	2.7	-1.6	0.5	0.7
Multivitamins +/- minerals	0.3	0.3	0.8	0.9	-0.2	-0.4
Body mass index (BMI)	0.3	1.4	3.9	-2.0	0.4	-0.3
Forced vital capacity (FVC)	0.3	1.0	2.7	-0.2	0.4	1.7
Diabetes (self-reported)	0.3	0.5	0.9	-0.4	-0.7	-1.0
Time employed in main current job	0.3	0.3	0.7	0.9	0.2	-0.4
Falls in the last year	0.3	0.4	0.6	-0.6	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.3	0.8	1.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.1	-1.1	-0.2
Qualifications: College or University degree	0.3	0.8	1.5	-0.2	1.0	1.2
Leg fat mass (right)	0.3	1.1	2.7	-1.6	0.8	0.1
Alcohol intake frequency.	0.3	0.8	1.3	-0.7	1.1	0.8
Overall health rating	0.3	0.7	1.9	0.1	0.5	-1.4
Family relationship satisfaction	0.3	0.3	0.9	-0.1	-1.0	-0.3
Ever depressed for a whole week	0.3	0.4	1.1	-1.0	-0.3	-0.2
Leg fat mass (left)	0.3	1.1	2.7	-1.6	0.8	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.2	0.5
HbA1C	0.2	0.2	0.4	-0.1	-0.6	0.6
Rheumatoid Arthritis	0.2	0.3	0.5	0.4	0.7	0.6
Blood Red Count	0.2	2.0	3.2	1.3	-1.8	-1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	-0.2	-1.1	-0.4
Lung FVC	0.2	1.2	2.2	-0.1	-1.1	-1.5
Chronotype (morning person)	0.2	0.4	1.0	1.0	-0.5	0.1
Tanning	0.2	2.2	6.3	-0.4	-0.3	2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	0.8	0.2	-0.9	-0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.0	0.3	0.7
Impedance of arm (right)	0.2	0.8	1.4	0.8	0.5	1.2
Noisy workplace	0.2	0.2	0.5	0.2	0.1	0.7
Impedance of arm (left)	0.2	0.9	1.6	1.0	0.1	1.3
Loud music exposure frequency	0.2	0.2	0.5	-0.2	0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.5	0.9	0.1
Body fat percentage	0.2	0.9	2.4	-1.5	0.4	0.3
Leg fat percentage (right)	0.2	0.8	1.7	-0.3	0.8	-1.3
Exposure to tobacco smoke outside home	0.2	0.3	0.5	-0.5	0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.3	-0.8	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.8	-0.4	-0.5
Miserableness	0.2	0.3	0.8	-0.1	0.3	-0.9
Financial situation satisfaction	0.2	0.3	0.3	-0.5	-0.6	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.3	-0.7	0.2
Leg fat percentage (left)	0.2	0.8	2.0	-0.3	0.6	-1.4
Blood Platelet Count	0.1	0.6	0.8	0.8	0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	-0.5	0.4	-0.4
Medication: Co-codamol	0.1	0.1	0.1	-0.3	0.3	0.4
Medication: Metformin	0.1	0.1	0.1	-0.3	-0.3	-0.3
Average weekly fortified wine intake	0.1	0.1	0.1	0.2	0.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.6	0.2	0.1
Sitting height	0.1	0.7	1.4	0.3	0.8	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.2	-0.5	-0.5	-0.1
Fluid intelligence score	0.1	0.2	0.3	-0.1	-0.5	-0.6
Hip circumference	0.1	0.3	0.6	-0.8	0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.1	0.0	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	0.4	0.9	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.4	0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.1	0.4	-0.7
Suffer from ‘nerves’	0.1	0.2	0.4	-0.6	0.4	-0.3
Friendships satisfaction	0.1	0.1	0.4	-0.6	-0.1	0.0
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.3	-0.2	0.1
Medication for hormone replacement therapy	0.0	0.0	0.0	-0.2	-0.2	0.1
Townsend deprivation index at recruitment	0.0	0.1	0.1	-0.3	0.3	-0.0
Forced vital capacity (FVC), Best measure	0.0	0.2	0.3	-0.4	-0.2	0.6
Average weekly red wine intake	0.0	0.1	0.1	-0.4	-0.2	0.2
Medication: Gliclazide	0.0	0.0	0.1	0.0	-0.1	0.3

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