TWAS hub - CRAMP1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1060	0.0440	0.00130	0.000	NA	-0.001	NA	-0.004	3.0e-01	NA	0.38000	NA	0.68000
2	YFS	Blood	0.0232	0.0091	0.00035	0.013	0.006	0.008	0.009	0.010	2.2e-05	0.0032	0.00098	6e-04	0.00016
3	TCGA	Esophageal Carcinoma	0.1060	0.0570	0.00110	0.083	0.075	0.046	NA	0.059	1.3e-03	0.0022	0.01400	NA	0.00610

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Impedance of arm (right)	7.0	32.4	40.8	-4.9	-5.7	-6.4
Illnesses of father: Heart disease	6.3	8.7	11.1	2.6	2.9	3.3
Impedance of arm (left)	6.2	28.8	36.5	-4.7	-5.2	-6.0
Impedance of whole body	6.1	31.2	37.6	-4.7	-5.8	-6.1
Hypothyroidism (self reported)	6.0	13.7	15.5	3.9	3.6	3.6
Pulse rate, automated reading	5.8	18.7	20.7	-4.3	-4.6	-4.1
Impedance of leg (right)	5.4	26.3	31.9	-3.9	-5.7	-5.6
Pulse rate	5.3	9.0	14.0	-1.8	-3.7	-3.1
Hypothyroidism/myxoedema (self-reported)	5.0	9.7	10.1	3.2	3.1	3.1
Impedance of leg (left)	4.9	23.9	29.6	-3.8	-5.4	-5.2
Medication: Levothyroxine sodium	4.6	7.8	8.4	2.6	2.9	2.8
Chronic bronchitis/emphysema (father)	4.5	5.3	6.2	2.5	2.0	2.4
Primary Biliary Cirrhosis	4.3	6.1	7.7	-2.8	-2.2	-2.4
Alzheimer’s Disease (in father)	4.1	4.4	5.4	-2.3	-1.6	-2.3
Mouth/teeth dental problems	4.0	6.2	7.7	-2.8	-2.0	-2.6
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	6.9	2.5	2.6	2.4
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	5.4	2.1	2.3	1.8
Happiness	3.5	4.2	4.7	2.0	2.2	2.0
Health satisfaction	3.4	4.5	5.2	2.3	2.2	1.9
Emphysema/chronic bronchitis	3.4	3.8	5.1	1.5	2.3	2.0
Alcohol intake frequency.	3.4	8.0	11.1	-2.4	-2.6	-3.3
Medication for pain relief, constipation, heartburn	3.2	5.5	8.3	-2.9	-1.9	-2.1
Forced expiratory volume in 1-second (FEV1)	3.1	10.6	11.7	-3.2	-3.4	-3.2
Hearing difficulty/problems with background noise	3.0	4.8	6.0	2.0	2.4	2.2
Lung cancer (father)	3.0	3.5	6.7	2.6	1.0	1.7
Medication: Omeprazole	3.0	3.6	5.0	1.6	2.2	1.7
Mouth/teeth dental problems: Bleeding gums	2.9	3.7	6.3	2.5	1.3	1.8
Rheumatoid Arthritis	2.8	3.9	4.2	1.9	1.9	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	8.9	9.0	-3.0	-3.0	-3.0
Financial situation satisfaction	2.8	3.5	4.3	1.8	2.1	1.7
Blood Platelet Count	2.7	31.4	36.0	-5.0	-5.8	-6.0
Pulse wave Arterial Stiffness index	2.7	3.2	4.2	-1.3	-1.9	-2.0
Loud music exposure frequency	2.7	3.0	3.5	1.4	1.9	1.8
Diabetes (father)	2.6	3.2	4.3	-1.7	-1.5	-2.1
Severe depression (siblings)	2.6	2.9	4.4	-2.1	-0.9	-1.9
Ever highly irritable/argumentative for 2 days	2.6	3.1	3.3	-1.8	-1.7	-1.8
Guilty feelings	2.6	4.0	5.0	2.2	2.0	1.7
Ever used hormone-replacement therapy (HRT)	2.5	3.2	3.7	1.9	1.9	1.5
Qualifications: CSEs or equivalent	2.5	3.3	4.6	-1.6	-1.7	-2.1
Pulse wave peak to peak time	2.5	3.0	3.9	1.2	1.9	2.0
Verbal and Numeric Reasoning (VNR)	2.4	5.7	8.9	1.6	3.0	2.4
Hearing difficulty/problems: Yes	2.4	3.6	5.1	1.3	2.2	2.0
Worry too long after embarrassment	2.4	4.1	4.2	2.1	1.9	2.1
Eye problems/disorders: None of the above	2.4	2.8	2.9	1.7	1.7	1.6
Mother’s age at death	2.4	3.0	3.6	-1.9	-1.5	-1.8
Forced vital capacity (FVC)	2.3	9.0	9.5	-2.9	-3.0	-3.1
Heart attack	2.3	2.9	5.4	2.3	1.1	1.4
Relative age voice broke	2.2	3.4	4.7	1.6	2.2	1.7
Taking other prescription medications	2.2	3.4	3.7	1.8	1.9	1.8
Forced vital capacity (FVC), Best measure	2.2	8.1	8.9	-2.7	-2.8	-3.0
Lung FVC	2.1	10.8	14.1	-2.6	-3.8	-3.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	4.2	2.0	2.0	1.3
Tinnitus: Yes, now most or all of the time	2.1	2.4	3.2	1.4	1.8	1.5
Risk taking	2.1	3.1	3.9	1.8	1.4	2.0
Heart attack/myocardial infarction (self-reported)	2.1	2.8	5.2	2.3	1.0	1.4
Schizophrenia vs Biploar Disorder	2.0	2.6	3.7	1.8	0.8	1.9
Osteoporosis (self-reported)	2.0	2.5	3.0	1.7	1.6	1.4
Serious illness, injury or assault to yourself	1.9	2.3	2.7	-1.6	-1.4	-1.5
Arm predicted mass (right)	1.9	9.7	13.3	2.0	3.6	3.4
Qualifications: nursing, teaching	1.9	3.0	3.4	1.6	1.7	1.8
Leg predicted mass (right)	1.9	9.9	14.9	1.9	3.9	3.4
Ever smoked	1.9	3.2	4.0	1.5	2.0	1.9
Basal cell carcinoma (self-reported)	1.9	2.2	3.2	1.8	1.3	1.4
Type 2 Diabetes (T2D) (2012)	1.8	2.1	2.4	-1.5	-1.3	-1.6
Type 2 Diabetes (T2D) (2018)	1.8	3.4	4.0	-2.0	-1.7	-1.8
Exposure to tobacco smoke outside home	1.8	2.4	3.3	1.8	1.1	1.6
Knee pain experienced in last month	1.8	2.7	4.2	1.1	1.7	2.0
Leg fat-free mass (right)	1.8	9.5	14.7	1.8	3.8	3.3
Fluid intelligence score	1.7	3.5	5.8	1.1	2.4	1.8
Medication: Lansoprazole	1.7	1.9	2.5	1.4	1.1	1.6
Birth weight of first child	1.7	3.0	4.4	-2.1	-1.4	-1.6
Arm fat-free mass (right)	1.7	8.7	12.3	1.8	3.5	3.2
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.0	-1.4	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	5.2	-2.3	-1.2	-1.9
Number of self-reported non-cancer illnesses	1.7	2.9	5.0	1.4	1.4	2.2
Average weekly spirits intake	1.6	2.0	2.7	1.2	1.4	1.7
Ever had hysterectomy (womb removed)	1.6	1.8	3.4	1.0	1.8	1.1
Hair/balding pattern: Pattern 3	1.6	2.4	3.3	1.8	0.9	1.8
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	5.1	1.3	2.3	1.1
Overall health rating	1.6	3.4	4.7	1.8	1.5	2.2
Ever had bowel cancer screening	1.6	1.8	2.1	1.1	1.5	1.5
Friendships satisfaction	1.6	2.0	2.2	1.3	1.5	1.5
Ever depressed for a whole week	1.6	2.0	2.7	1.1	1.6	1.5
Alzheimer’s Disease (in mother)	1.5	1.7	2.1	1.4	1.1	1.5
Crohns Disease (2012)	1.5	2.3	2.7	-1.7	-1.3	-1.6
Fasting Glucose	1.5	1.8	2.6	-1.6	-0.7	-1.5
Leg predicted mass (left)	1.5	7.9	12.4	1.6	3.5	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	3.6	1.9	1.4	1.2
Alcohol intake versus 10 years previously	1.5	2.2	3.1	-1.6	-1.0	-1.8
Medication: Atorvastatin	1.5	1.9	2.6	-1.2	-1.6	-1.3
Bipolar Disorder (2018)	1.4	2.2	3.9	-2.0	-1.3	-1.0
Intelligence (Savage-Jansen 2018)	1.4	4.3	6.2	1.2	2.5	2.3
Age at First Birth	1.4	2.0	2.3	1.5	1.2	1.5
Medication: Atenolol	1.4	1.7	2.5	-1.1	-1.6	-1.2
Birth weight	1.4	3.0	4.0	-2.0	-1.6	-1.6
Medication: Seretide 50 evohaler	1.4	1.6	2.2	1.0	1.2	1.5
Whole body fat-free mass	1.4	7.8	11.7	1.7	3.4	3.0
Average weekly beer plus cider intake	1.4	2.1	2.9	1.0	1.7	1.5
Relative age of first facial hair	1.3	2.6	3.7	1.1	1.9	1.7
Medication for hormone replacement therapy	1.3	1.5	2.2	1.5	1.1	1.0
Leg fat-free mass (left)	1.3	7.0	11.0	1.5	3.3	2.8
Multivitamins +/- minerals	1.3	1.7	3.1	-1.2	-0.8	-1.8
Past tobacco smoking	1.3	2.3	2.6	-1.6	-1.6	-1.4
Depression (self-reported)	1.3	1.6	2.3	-1.3	-0.8	-1.5
Medication: Blood pressure	1.3	2.3	4.8	-0.9	-2.2	-1.1
Whole body water mass	1.3	7.2	11.0	1.6	3.3	2.9
Medication: Lisinopril	1.3	1.7	2.9	1.7	1.1	0.9
Arm fat-free mass (left)	1.3	6.8	9.4	1.6	3.1	2.9
Arm predicted mass (left)	1.3	6.7	9.4	1.5	3.1	2.9
Prostate Cancer	1.2	1.7	2.5	-1.6	-0.8	-1.4
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.2	0.8	1.0	1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.4	-1.5	-0.4	-1.4
Leg pain on walking	1.2	1.5	2.2	1.2	1.5	0.9
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.3	0.5	1.5	1.4
Reaction Time	1.1	2.0	3.2	-1.0	-1.8	-1.3
Noisy workplace	1.1	1.4	1.5	1.2	1.1	1.2
Trunk predicted mass	1.1	6.1	9.4	1.5	3.1	2.6
Gout (self-reported)	1.1	1.4	2.7	1.1	0.7	1.6
High blood pressure (siblings)	1.1	1.6	2.6	1.4	0.4	1.6
Loneliness, isolation	1.1	1.5	3.1	1.1	1.8	0.6
Ulcerative Colitis	1.0	1.4	1.7	-1.3	-1.1	-1.2
Trunk fat-free mass	1.0	5.9	9.1	1.5	3.0	2.6
Glaucoma (self-reported)	1.0	1.2	1.6	-1.0	-1.0	-1.3
Medication: Allopurinol	1.0	1.3	2.5	0.9	0.8	1.6
Medication: Aspirin	1.0	1.3	1.7	1.2	1.3	1.0
Basal metabolic rate	1.0	5.5	8.6	1.2	2.9	2.5
Ulcerative Colitis (UC)	0.9	1.7	2.4	-1.0	-1.3	-1.6
Body Mass Index (BMI) (2010)	0.9	1.3	1.5	1.2	0.9	1.2
Heel T-Score	0.9	7.2	9.7	2.9	1.9	3.1
BMI	0.9	5.5	8.2	1.8	2.2	2.9
Body mass index (BMI)	0.9	3.8	5.9	1.3	2.0	2.4
Illnesses of father: None of the above (group 1)	0.9	1.1	1.5	-0.8	-1.0	-1.2
Wears glasses or contact lenses	0.9	1.0	2.0	-0.7	-1.4	-0.8
Ever taken oral contraceptive pill	0.9	1.0	1.1	-1.0	-0.9	-1.1
Ever had prostate specific antigen (PSA) test	0.9	1.1	1.3	1.1	0.8	1.1
Smoking Status	0.8	1.9	2.4	1.6	1.2	1.3
Hand grip strength (left)	0.8	2.1	4.0	-2.0	-0.9	-1.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.5	1.0	1.2	0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.7	1.0	1.3	0.7
Townsend deprivation index at recruitment	0.8	1.2	1.3	-1.1	-1.0	-1.1
Diabetes (self-reported)	0.8	1.3	1.5	-1.2	-1.0	-1.2
Migraine (self-reported)	0.8	1.0	1.4	-0.6	-1.2	-1.1
Eye problems/disorders: Glaucoma	0.8	0.9	1.5	-1.0	-0.4	-1.2
Blood White Count	0.7	5.3	8.4	-2.0	-2.9	-1.8
Systolic Blood Pressure	0.7	3.7	5.5	-1.4	-2.3	-1.9
Angina	0.7	1.0	1.4	0.9	0.8	1.2
Alcohol usually taken with meals	0.7	1.2	1.5	-1.2	-0.9	-1.1
Qualifications: None of the above	0.7	1.5	2.1	-0.8	-1.5	-1.3
Neck or shoulder pain in last month	0.7	1.0	1.3	1.1	0.9	1.0
Diabetes diagnosed by doctor	0.7	1.2	1.3	-1.1	-1.1	-1.0
Bipolar Disorder (2011)	0.6	0.6	1.7	0.0	0.0	-1.3
Triglycerides	0.6	1.0	1.8	-0.7	-0.8	-1.3
Trunk fat percentage	0.6	2.5	3.0	-1.7	-1.7	-1.4
Hand grip strength (right)	0.6	1.6	2.3	-1.5	-1.1	-1.0
Hair/balding pattern: Pattern 4	0.6	1.6	1.8	1.4	1.3	1.1
Blood clot in the leg (DVT)	0.6	0.8	1.1	0.6	1.0	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	1.1	0.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.3	0.4	1.1	0.9
Medication: Aspirin	0.6	0.8	1.2	1.0	1.1	0.6
Smoking status: Previous	0.6	0.9	1.6	1.3	0.7	0.7
Commuting to job workplace: Walk	0.6	0.7	1.3	0.2	1.1	0.9
Breast cancer (self-reported)	0.6	0.7	1.3	0.1	1.1	0.9
Miserableness	0.6	1.1	2.2	-0.9	-0.4	-1.5
Alcohol drinker status: Never	0.6	0.7	1.1	-0.4	-0.9	-1.0
Bipolar Disorder or Schizophrenia	0.5	1.2	2.7	-1.6	-0.7	-0.6
Number of treatments/medications taken	0.5	1.0	1.2	0.9	1.1	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.1	-1.0	-1.0	-1.1
Sitting height	0.5	3.7	5.1	-2.1	-1.3	-2.2
Mouth/teeth dental problems: Dentures	0.5	0.8	1.1	1.1	0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.7	0.8	0.6	0.8
Standing height	0.5	5.1	7.7	-2.8	-1.4	-2.4
Angina (self-reported)	0.5	0.7	1.0	0.7	0.7	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	0.8	0.1	1.1
Illnesses of siblings: Diabetes	0.5	0.7	1.3	-0.7	-1.2	-0.4
Long-standing illness, disability or infirmity	0.5	0.8	1.0	0.7	0.9	1.0
Hearing aid user	0.5	0.6	1.3	1.1	0.6	0.4
Medication: Bendroflumethiazide	0.5	0.7	1.1	0.9	-0.3	1.1
Pain experienced in last month	0.5	0.8	1.2	-0.3	-1.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.0	0.5	1.0	0.9
Depression (Nagel 2018)	0.4	0.6	0.7	0.7	0.8	0.8
Breast Cancer	0.4	1.0	1.3	-1.0	-0.9	-1.1
Lupus	0.4	0.7	0.9	-0.8	-1.0	-0.7
Neuroticism (2016)	0.4	0.6	1.2	0.7	1.1	0.3
Height	0.4	7.4	12.0	-3.5	-2.1	-2.4
Waist Hip Ratio (WHR)	0.4	1.7	2.0	-1.2	-1.4	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	0.8	0.7	0.6
Had menopause	0.4	0.5	0.8	-0.2	-0.9	-0.8
Hip circumference	0.4	1.7	2.5	0.5	1.5	1.6
Time employed in main current job	0.4	0.5	0.6	0.6	0.6	0.8
Father’s age at death	0.4	0.6	1.4	-0.5	-0.4	-1.2
Worrier / anxious feelings	0.4	0.8	1.7	0.7	1.3	0.1
Pulse wave reflection index	0.4	0.5	0.8	0.8	0.9	0.3
Body fat percentage	0.4	1.6	2.0	-1.4	-1.4	-1.0
Chest pain or discomfort	0.4	0.6	0.9	-0.8	-0.5	-1.0
Back pain experienced in last month	0.4	0.6	1.0	0.1	1.0	0.8
Medication: Blood pressure	0.4	0.7	1.3	0.8	0.2	1.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.0	-0.6	-1.0	-0.7
Mean Putamen Volume	0.3	0.4	0.7	0.2	0.6	0.8
HDL Cholesterol	0.3	0.5	0.6	0.5	0.8	0.7
Lung FEV1/FVC ratio	0.3	1.6	3.5	-1.0	-1.9	-0.7
Chronotype (morning person)	0.3	0.7	1.3	-0.8	-1.1	-0.4
Tanning	0.3	3.3	5.7	-1.4	-2.4	-1.5
Number of live births	0.3	0.4	0.6	0.6	0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	-1.1	0.0	-0.2
Length of working week for main job	0.3	0.3	0.8	-0.0	0.5	0.9
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.8	-0.1	0.6
Medication: Paracetamol	0.3	0.5	1.4	1.2	-0.2	0.5
Headache pain in last month	0.3	0.5	0.7	-0.7	-0.5	-0.8
Comparative height size at age 10	0.3	1.4	2.0	-1.3	-0.7	-1.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.8	0.5	0.5
Average weekly red wine intake	0.3	0.4	0.6	0.2	0.7	0.7
Mood swings	0.3	0.6	1.0	-0.7	0.6	-1.0
Medication for cholesterol	0.3	0.5	0.9	-0.9	-0.3	-0.7
Mineral and other dietary supplements	0.3	0.4	0.8	-0.6	-0.9	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.7	0.9	0.6	0.5
Alcohol drinker status: Previous	0.3	0.4	0.7	-0.0	-0.8	-0.6
Pack years of smoking	0.3	0.4	0.4	-0.6	-0.6	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	-0.5	0.4	-1.0
Major Depression (MDD)	0.2	0.3	0.8	0.0	0.0	-0.9
HbA1C	0.2	0.3	0.5	-0.7	-0.2	-0.4
LDL Cholesterol	0.2	0.3	0.5	-0.6	0.1	-0.7
Cardiovascular Disease	0.2	0.6	1.6	0.4	-1.3	0.2
Neuroticism	0.2	0.5	1.0	1.0	0.8	-0.1
Sensitivity / hurt feelings	0.2	0.3	0.7	0.8	0.3	-0.4
Systolic blood pressure, automated reading	0.2	0.7	1.4	-0.4	-1.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.4	-0.4	-0.4	0.7
Diabetes (mother)	0.2	0.2	0.3	-0.5	-0.2	-0.5
Pack years adult smoking proportion	0.2	0.2	0.4	-0.6	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.2	-0.2	0.5	1.1
Waist circumference	0.2	0.7	1.6	0.2	0.8	1.2
Nervous feelings	0.2	0.4	1.0	1.0	0.5	-0.1
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.4	0.6	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.6	-0.5	-0.3
Illnesses of siblings	0.2	0.3	0.6	-0.5	0.8	-0.2
Neuroticism score	0.2	0.4	0.7	0.8	0.6	-0.2
Weight	0.2	1.0	1.5	-0.0	1.2	1.2
Arm fat percentage (right)	0.2	0.8	1.4	-1.2	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.9	-0.1	0.9	0.4
Prospective memory result	0.2	0.2	0.6	0.8	0.1	0.2
Breastfed as a baby	0.2	0.2	0.4	-0.2	0.6	0.4
Tense / ‘highly strung’	0.2	0.4	0.8	-0.5	-0.4	-0.9
Medication: Amlodipine	0.2	0.3	0.6	0.1	-0.8	0.4
Comparative body size at age 10	0.2	0.5	1.2	-0.2	0.6	1.1
Age at first live birth	0.2	0.4	0.7	0.8	-0.5	0.6
Mean time to correctly identify matches	0.2	0.3	0.9	0.0	-0.9	-0.2
Age at last live birth	0.2	0.3	0.8	0.1	-0.9	-0.1
Medication: Gliclazide	0.2	0.2	0.3	-0.5	-0.5	-0.2
Arm fat mass (left)	0.2	0.7	1.2	0.0	1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.6	0.5	-0.4
Irritability	0.2	0.3	0.7	-0.4	-0.1	-0.8
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.8	-0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	-0.5	1.0	-0.6
Cholesterol lowering medication	0.2	0.3	0.6	0.3	0.4	0.8
Supplements: Calcium	0.2	0.3	0.7	-0.1	-0.1	-0.9
Leg fat mass (left)	0.2	0.6	1.1	0.2	0.8	1.1
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.4	0.8	-0.5
Schizophrenia (2018)	0.1	0.1	0.3	-0.5	0.3	0.1
Worry (Nagel 2018)	0.1	0.2	0.6	0.0	0.2	-0.7
Crohns Disease (2017)	0.1	0.3	0.6	0.4	0.3	0.8
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.0	-0.5	0.2
Schizophrenia (2014)	0.1	0.3	0.5	-0.0	0.7	0.6
Blood Eosinophil Count	0.1	0.9	2.3	-0.1	-1.5	-0.6
Blood Red Count	0.1	1.4	2.0	1.4	0.7	1.4
Allergy or Eczema	0.1	0.2	0.2	-0.4	-0.4	-0.4
Hair Pigment	0.1	3.1	3.6	1.5	1.8	1.9
Supplements: Zinc	0.1	0.1	0.3	0.1	-0.3	-0.5
Medication: Co-codamol	0.1	0.1	0.2	0.1	-0.1	-0.5
Medication: Metformin	0.1	0.1	0.3	-0.6	0.2	0.2
Current tobacco smoking	0.1	0.1	0.3	0.3	0.5	0.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.0	-0.5	-0.2
Fed-up feelings	0.1	0.2	0.6	-0.1	0.8	-0.3
Age when periods started (menarche)	0.1	0.2	0.4	-0.1	-0.6	-0.2
High blood pressure	0.1	0.3	0.7	0.1	-0.9	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.1	0.4	0.3	0.3
Supplements: Glucosamine	0.1	0.2	0.4	0.6	0.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.2	-0.6	-0.3
Trunk fat mass	0.1	0.4	1.0	-1.0	-0.5	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.4	0.4	-0.0
Had other major operations	0.1	0.1	0.2	0.1	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.3	-0.2	0.6
Allergy	0.1	0.2	0.3	0.4	0.3	0.6
Medication: Ramipril	0.1	0.1	0.4	0.2	-0.0	0.6
Falls in the last year	0.1	0.1	0.3	-0.3	0.6	0.0
Asthma	0.1	0.2	0.3	-0.4	-0.3	-0.5
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.4	-0.6	-0.1
Arm fat mass (right)	0.1	0.4	0.6	-0.3	0.7	0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.4	0.2	0.2
Leg fat percentage (right)	0.1	0.2	0.5	-0.3	-0.7	-0.0
Number of full brothers	0.1	0.1	0.1	-0.3	-0.3	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.0	0.7	0.3
Number of children fathered	0.1	0.1	0.2	-0.1	0.4	0.4
Shortness of breath walking on level ground	0.1	0.2	0.4	0.2	0.6	-0.3
Qualifications: College or University degree	0.1	0.3	0.6	-0.5	0.8	0.2
Heart disease (mother)	0.1	0.1	0.2	-0.4	-0.1	0.3
Leg fat mass (right)	0.1	0.4	0.7	0.2	0.6	0.9
Had major operations	0.1	0.1	0.1	0.3	-0.2	-0.4
Family relationship satisfaction	0.1	0.2	0.4	0.2	0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.3	0.2	0.3
Supplements: Vitamin C	0.1	0.2	0.4	0.6	0.1	-0.3
Hypertension (Self-reported)	0.1	0.4	0.8	0.3	-0.9	0.5
Arm fat percentage (left)	0.1	0.5	1.2	-1.1	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.0	0.4	0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.1	-0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.4	0.1	-0.2
Smoking status: Current	0.1	0.2	0.4	0.3	0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	-0.4	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.1	0.4	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.2	0.5	0.2
Medication: Paracetamol	0.1	0.1	0.3	0.3	-0.6	-0.1
Number of operations (self-reported)	0.1	0.1	0.3	-0.2	0.5	-0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.1	0.4	-0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.3	-0.1	-0.6	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.3	0.2
Heart disease (siblings)	0.1	0.2	0.5	0.1	-0.7	0.0
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.2	-0.2	-0.3
Ovarian Cancer	0.0	0.1	0.2	-0.4	-0.1	-0.1
Respiratory disease	0.0	0.0	0.1	0.1	0.3	0.1
Vitamin and mineral supplements	0.0	0.0	0.1	0.0	0.1	0.4
Maternal smoking around birth	0.0	0.0	0.1	-0.0	-0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	0.0	0.1	-0.1
High blood pressure (mother)	0.0	0.1	0.1	-0.3	-0.3	0.0
Number of incorrect matches in round	0.0	0.1	0.1	-0.1	0.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.0	0.1	0.1
Pain all over the body in last month	0.0	0.1	0.1	0.2	-0.2	-0.3
Medication: Simvastatin	0.0	0.1	0.1	-0.2	-0.3	0.2
Illnesses of mother	0.0	0.0	0.1	0.0	0.2	-0.3
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.4	-0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	-0.2	-0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.0	-0.1	-0.4
Medication: Ibuprofen	0.0	0.0	0.0	0.1	0.2	0.1
Whole body fat mass	0.0	0.2	0.5	-0.7	0.0	0.1
Number of full sisters	0.0	0.0	0.1	0.0	0.1	-0.3
Suffer from ‘nerves’	0.0	0.1	0.2	0.4	-0.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.1	0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	-0.4	-0.2	0.0
Asthma (self-reported)	0.0	0.1	0.2	-0.2	-0.3	-0.4
Osteoarthritis (self-reported)	0.0	0.0	0.1	-0.1	0.0	0.3
High cholesterol (Self-reported)	0.0	0.1	0.2	0.1	-0.1	0.5
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.2	-0.1	-0.3
Leg fat percentage (left)	0.0	0.1	0.3	-0.0	-0.2	0.5
Age started oral contraceptive pill	0.0	0.0	0.1	0.2	0.2	0.1
Myopia	0.0	0.0	0.0	-0.0	0.1	0.0

Hub : Genes

CRAMP1L

Models

Trait associations