[Hub]/) : Traits : Impedance of leg (left) : ← →

chr17:42,413,481-43,913,030

Best TWAS P=6.82e-11 · Best GWAS P=7.83e-09 conditioned to 0.321

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Aorta	DCAKD	0.22	0.16	enet	26	0.19	1.1e-10	4.7	-6.5	6.8e-11	-0.62	0.34	0.64	TRUE
11	GTEx	Brain Putamen basal ganglia	CRHR1-IT1	0.14	0.22	enet	11	0.21	1.2e-05	-5.0	-5.7	1.5e-08	-0.18	0.01	0.93	TRUE
28	GTEx	Muscle Skeletal	DCAKD	0.12	0.06	enet	16	0.07	9.9e-08	4.7	-6.0	2.4e-09	-0.75	0.06	0.93	FALSE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LOC644172	0.19	-0.01	blup	81	0.03	1.3e-02	-2.7	-5.8	5.9e-09	-0.47	0.02	0.42	FALSE
8	GTEx	Brain Cortex	CRHR1-IT1	0.28	0.15	lasso	12	0.15	5.6e-05	-5.0	-5.6	1.7e-08	-0.26	0.01	0.96	FALSE
20	GTEx	Colon Transverse	DCAKD	0.28	0.18	lasso	8	0.26	1.5e-12	4.6	-5.6	2.0e-08	-0.64	0.23	0.76	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	HEXIM1	0.05	0.05	blup	47	0.04	8.5e-05	5.1	-5.6	2.2e-08	-0.74	0.05	0.92	FALSE
29	GTEx	Pancreas	CRHR1-IT1	0.37	0.45	enet	22	0.44	3.5e-20	-5.0	-5.6	2.3e-08	-0.21	0.01	0.98	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC644172	0.08	0.00	blup	79	0.04	3.2e-04	-3.6	-5.6	2.6e-08	-0.57	0.02	0.77	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC644172	0.15	0.01	blup	77	0.06	1.0e-06	-3.9	-5.5	2.8e-08	-0.32	0.23	0.08	FALSE
27	GTEx	Lung	DCAKD	0.22	0.05	enet	27	0.10	5.2e-08	-4.9	-5.5	3.1e-08	-0.56	0.18	0.81	FALSE
4	GTEx	Artery Tibial	NMT1	0.11	0.09	lasso	5	0.10	6.3e-08	4.7	5.5	3.5e-08	0.58	0.15	0.84	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC644172	0.14	0.07	enet	10	0.12	1.2e-23	-2.7	-5.5	3.7e-08	-0.36	0.95	0.00	FALSE
15	GTEx	Breast Mammary Tissue (Male)	RP11-669E14.6	0.05	0.02	enet	12	0.00	3.9e-01	-5.0	5.5	3.9e-08	0.13	0.00	0.26	FALSE
1	GTEx	Adrenal Gland	PLEKHM1	0.21	0.00	enet	20	0.08	1.0e-03	-3.7	-5.5	4.1e-08	-0.22	0.07	0.24	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	NMT1	0.24	0.21	lasso	4	0.22	2.8e-08	-4.9	5.5	4.1e-08	0.62	0.12	0.87	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD4	0.04	0.01	enet	7	0.03	2.2e-04	-3.7	5.5	4.4e-08	0.64	0.03	0.71	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAKD	0.07	0.07	lasso	4	0.07	1.4e-08	4.7	-5.5	4.8e-08	-0.70	0.02	0.97	FALSE
37	GTEx	Thyroid	CRHR1-IT1	0.37	0.53	enet	31	0.53	1.0e-47	-5.0	-5.5	4.9e-08	-0.16	0.01	0.98	FALSE
13	GTEx	Breast Mammary Tissue (Male)	DCAKD	0.36	0.29	lasso	8	0.33	1.4e-08	4.6	-5.4	5.9e-08	-0.71	0.12	0.83	FALSE
16	GTEx	Breast Mammary Tissue (Female)	CRHR1	0.25	0.28	lasso	11	0.28	3.7e-09	-5.0	-5.4	5.9e-08	-0.17	0.01	0.98	FALSE
7	GTEx	Brain Cerebellum	MAPT	0.22	0.33	enet	22	0.34	7.9e-11	-5.0	5.4	6.9e-08	0.10	0.01	0.98	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DCAKD	0.04	0.02	blup	66	0.02	3.5e-03	5.0	-5.4	7.3e-08	-0.71	0.01	0.97	FALSE
34	GTEx	Skin Sun Exposed Lower leg	DCAKD	0.33	0.20	enet	30	0.31	2.4e-26	4.7	-5.4	7.7e-08	-0.59	0.34	0.65	FALSE
23	GTEx	Esophagus Mucosa	DCAKD	0.33	0.32	enet	20	0.35	5.6e-24	4.7	-5.3	8.6e-08	-0.69	0.33	0.66	FALSE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC644172	0.20	0.01	enet	12	0.06	4.5e-03	2.8	-5.3	9.3e-08	-0.43	0.05	0.11	FALSE
26	GTEx	Heart Left Ventricle	DCAKD	0.17	0.17	lasso	3	0.17	2.3e-09	4.7	-5.3	1.1e-07	-0.80	0.08	0.91	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	DCAKD	0.30	0.21	lasso	6	0.20	5.0e-11	4.7	-5.3	1.1e-07	-0.73	0.16	0.83	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	CRHR1-IT1	0.18	0.22	lasso	4	0.22	1.0e-07	-5.0	-5.3	1.2e-07	-0.14	0.01	0.98	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DCAKD	0.03	0.04	lasso	2	0.03	3.8e-04	5.1	-5.3	1.3e-07	-0.67	0.01	0.98	FALSE
14	GTEx	Breast Mammary Tissue (Male)	CRHR1-IT1	0.35	0.41	lasso	11	0.41	1.5e-10	-5.0	-5.3	1.4e-07	-0.14	0.01	0.98	FALSE
3	GTEx	Artery Aorta	MAPT	0.14	0.08	enet	17	0.09	1.0e-05	-5.0	5.2	1.6e-07	0.12	0.01	0.97	FALSE
40	YFS	Blood	NMT1	0.02	0.01	lasso	6	0.01	5.0e-03	-3.9	5.2	1.6e-07	0.53	0.10	0.66	FALSE
10	GTEx	Brain Hypothalamus	CRHR1-IT1	0.12	0.03	lasso	9	-0.01	4.7e-01	-5.0	-5.2	1.7e-07	-0.16	0.01	0.76	FALSE
36	GTEx	Spleen	LRRC37A4P	0.55	0.50	lasso	16	0.48	5.8e-14	-5.0	5.2	1.9e-07	0.15	0.08	0.92	FALSE
38	METSIM	Adipose	NMT1	0.13	0.11	lasso	6	0.11	5.7e-16	4.9	5.2	2.0e-07	0.71	0.06	0.94	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	DCAKD	0.42	0.36	lasso	7	0.37	3.8e-14	4.7	-5.2	2.1e-07	-0.73	0.22	0.77	FALSE
44	The Cancer Genome Atlas	Esophageal Carcinoma	LOC644172	0.19	0.12	lasso	3	0.05	8.2e-03	5.0	-5.2	2.2e-07	-0.66	0.02	0.54	FALSE
6	GTEx	Brain Cerebellum	ACBD4	0.40	0.06	lasso	8	0.17	1.0e-05	-4.2	5.2	2.5e-07	0.32	0.09	0.18	FALSE
12	GTEx	Breast Mammary Tissue	CRHR1-IT1	0.48	0.60	lasso	12	0.60	1.5e-37	-5.0	-5.2	2.5e-07	-0.13	0.01	0.98	FALSE
19	GTEx	Colon Sigmoid	CRHR1	0.32	0.49	lasso	13	0.46	3.0e-18	-5.0	-5.2	2.5e-07	-0.13	0.01	0.98	FALSE
9	GTEx	Brain Frontal Cortex BA9	LRRC37A4P	0.48	0.52	lasso	12	0.50	3.4e-15	-5.0	5.2	2.6e-07	0.13	0.08	0.92	FALSE
24	GTEx	Esophagus Muscularis	CRHR1	0.28	0.41	enet	24	0.41	7.2e-27	-5.0	-5.2	2.6e-07	-0.20	0.01	0.98	FALSE
5	GTEx	Artery Tibial	DCAKD	0.27	0.21	lasso	8	0.20	6.6e-16	4.7	-5.1	2.7e-07	-0.66	0.34	0.65	FALSE
25	GTEx	Esophagus Muscularis	NMT1	0.13	0.12	lasso	2	0.14	1.5e-08	-4.9	5.1	2.7e-07	0.57	0.12	0.87	FALSE
39	YFS	Blood	DCAKD	0.26	0.24	enet	47	0.27	1.3e-88	4.7	-5.1	2.7e-07	-0.67	0.36	0.63	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	LRRC37A4P	0.52	0.64	lasso	4	0.62	2.0e-25	-5.0	5.1	2.8e-07	0.13	0.08	0.92	FALSE
35	GTEx	Skin Sun Exposed Lower leg	LRRC37A4P	0.43	0.57	lasso	13	0.56	4.1e-56	-5.0	5.1	2.8e-07	0.13	0.08	0.92	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	LRRC37A4P	0.45	0.47	enet	34	0.50	6.3e-31	-5.0	5.1	2.9e-07	0.13	0.08	0.92	FALSE
31	GTEx	Prostate	NMT1	0.43	0.28	lasso	6	0.25	5.3e-07	-4.6	5.1	3.0e-07	0.50	0.15	0.76	FALSE
30	GTEx	Pituitary	CRHR1-IT1	0.33	0.43	lasso	5	0.44	1.6e-12	-5.1	-5.1	3.1e-07	-0.15	0.01	0.98	FALSE