Hub : Genes

MAPT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0530 0.0240 4.1e-10 0.092 0.091 0.086 0.090 0.090 3.0e-11 3.4e-11 1.1e-10 4.1e-11 4.5e-11
2 GTEx Artery Aorta 0.1390 0.0840 5.1e-05 0.082 NA 0.091 NA 0.070 2.7e-05 NA 1.0e-05 NA 1.0e-04
3 GTEx Brain Cerebellar Hemisphere 0.2430 0.1050 1.2e-06 0.261 NA 0.204 NA 0.248 2.2e-07 NA 5.9e-06 NA 4.7e-07
4 GTEx Brain Cerebellum 0.2160 0.0840 2.8e-09 0.330 NA 0.340 NA 0.328 1.6e-10 NA 7.9e-11 NA 1.9e-10
5 GTEx Brain Cortex 0.1370 0.0760 3.4e-04 0.105 NA 0.071 NA 0.058 7.9e-04 NA 5.3e-03 NA 1.0e-02
6 GTEx Brain Frontal Cortex BA9 0.1520 0.0779 1.2e-05 0.253 NA 0.255 NA 0.255 2.2e-07 NA 2.0e-07 NA 2.0e-07
7 GTEx Cells Transformed fibroblasts 0.0350 0.0290 6.7e-03 0.030 NA 0.011 NA 0.018 2.3e-03 NA 5.0e-02 NA 1.7e-02
8 GTEx Colon Sigmoid 0.1200 0.0580 1.1e-06 0.185 NA 0.172 NA 0.156 4.1e-07 NA 1.1e-06 NA 3.6e-06
9 GTEx Colon Transverse 0.0910 0.0470 1.8e-05 0.122 NA 0.072 NA 0.084 2.1e-06 NA 2.5e-04 NA 8.0e-05
10 GTEx Esophagus Mucosa 0.1550 0.0570 6.1e-16 0.263 NA 0.253 NA 0.268 1.0e-17 NA 5.5e-17 NA 4.3e-18
11 GTEx Esophagus Muscularis 0.0400 0.0320 9.1e-03 0.016 NA 0.006 NA 0.013 3.7e-02 NA 1.3e-01 NA 5.1e-02
12 GTEx Heart Left Ventricle 0.2370 0.0896 3.3e-09 0.162 NA 0.108 NA 0.136 5.3e-09 NA 2.2e-06 NA 1.1e-07
13 GTEx Lung 0.0533 0.0258 2.3e-06 0.090 NA 0.081 NA 0.084 2.0e-07 NA 8.2e-07 NA 5.1e-07
14 GTEx Muscle Skeletal 0.0602 0.0306 5.4e-06 0.027 NA 0.063 NA 0.053 1.0e-03 NA 8.7e-07 NA 6.3e-06
15 GTEx Skin Sun Exposed Lower leg 0.0360 0.0310 3.8e-03 0.036 NA 0.019 NA 0.022 5.8e-04 NA 9.7e-03 NA 5.6e-03
16 GTEx Testis 0.3180 0.0810 0.0e+00 0.536 NA 0.537 NA 0.530 1.0e-27 NA 9.4e-28 NA 3.2e-27
17 GTEx Thyroid 0.0900 0.0540 4.9e-06 0.043 NA 0.046 NA 0.050 2.9e-04 NA 1.8e-04 NA 1.1e-04
18 GTEx Uterus 0.1880 0.0910 1.7e-04 0.041 NA 0.080 NA 0.060 5.3e-02 NA 1.1e-02 NA 2.4e-02
19 METSIM Adipose 0.0241 0.0135 2.2e-04 0.016 0.016 0.010 0.015 0.016 1.7e-03 1.5e-03 1.0e-02 2.4e-03 1.4e-03
20 TCGA Glioblastoma Multiforme 0.1230 0.0710 9.6e-03 -0.001 0.050 0.034 NA 0.021 3.4e-01 1.3e-02 3.3e-02 NA 7.6e-02
21 TCGA Brain Lower Grade Glioma 0.0862 0.0288 1.2e-11 0.125 0.111 0.112 NA 0.120 4.5e-14 1.5e-12 1.2e-12 NA 1.8e-13
22 TCGA Lung Squamous Cell Carcinoma 0.0331 0.0153 3.3e-04 0.051 0.035 0.044 NA 0.049 1.6e-06 6.7e-05 9.3e-06 NA 2.5e-06
23 TCGA Ovarian Serous Cystadenocarcinoma 0.0880 0.0380 1.3e-05 0.040 0.075 0.066 NA 0.063 1.1e-03 8.6e-06 3.2e-05 NA 4.8e-05
24 TCGA Pheochromocytoma and Paraganglioma 0.2760 0.0970 4.9e-06 0.082 0.160 0.140 NA 0.120 3.8e-04 6.2e-07 3.5e-06 NA 1.7e-05
25 TCGA Prostate Adenocarcinoma 0.0495 0.0251 5.9e-04 0.045 0.039 0.027 NA 0.043 1.7e-05 6.2e-05 7.0e-04 NA 2.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Bipolar Disorder (2018) 0.9 1.4 2.5 -1.4 -0.5 -1.1 -0.1 -1.6 -1.1 -1.1 -1.4 -0.9 1.1 -1.2 -1.6 1.1 -0.9 1.2 1.3 -1.4 -1.1 1.4 -1.3 -1.3 -1.1 -1.4 -1.1 -1.2
Bipolar Disorder or Schizophrenia 0.7 1.8 6.9 0.9 1.5 1.5 2.6 -0.1 1.5 1.6 1.2 1.6 -1.3 0.6 -0.5 -1.6 1.7 -0.9 -1.2 0.4 1.4 -0.3 1.1 1.5 1.7 1.3 0.7 1.6
Depressed Affect (Nagel 2018) 35.7 75.0 91.2 -9.1 -6.8 -9.5 -7.3 -8.7 -9.5 -9.4 -9.1 -9.4 9.2 -8.7 -7.3 9.4 -8.2 8.0 9.6 -9.0 -8.7 8.6 -7.1 -8.9 -9.1 -8.9 -7.1 -9.1
Depression (Nagel 2018) 10.1 15.2 19.5 -4.2 -2.8 -4.1 -2.5 -3.8 -4.0 -4.1 -4.4 -4.1 4.1 -4.3 -3.9 4.0 -3.5 3.8 4.4 -4.3 -4.2 4.3 -2.0 -3.8 -3.9 -4.3 -3.6 -3.9
Intelligence (Savage-Jansen 2018) 7.4 22.8 35.2 5.1 5.8 4.9 4.2 3.7 4.9 5.0 5.9 4.9 -5.0 5.5 4.9 -4.8 3.5 -4.8 -4.9 4.7 5.1 -4.9 4.1 4.3 4.1 5.4 3.5 4.2
Neuroticism (Nagel 2018) 43.4 102.2 123.0 -10.7 -8.6 -11.0 -8.8 -10.0 -11.0 -11.0 -10.9 -10.9 10.8 -10.2 -8.6 11.0 -9.8 9.6 11.1 -10.1 -10.4 9.9 -7.9 -10.1 -10.6 -10.7 -7.8 -10.1
Schizophrenia (2018) 3.1 6.5 11.4 2.3 2.3 2.9 3.4 1.2 2.9 2.9 2.7 2.9 -2.7 1.8 0.7 -2.9 3.0 -2.2 -2.7 1.5 2.7 -1.6 2.5 3.0 3.1 2.9 1.8 3.0
Schizophrenia vs Biploar Disorder 7.5 9.9 15.1 3.1 2.2 3.8 3.2 2.5 3.8 3.8 3.5 3.9 -3.6 2.8 1.4 -3.8 3.4 -2.8 -3.7 2.8 3.2 -2.4 2.8 3.0 3.1 3.7 1.8 2.9
Worry (Nagel 2018) 22.5 47.4 58.6 -7.6 -5.9 -7.4 -5.7 -7.1 -7.4 -7.4 -7.7 -7.2 7.4 -7.0 -6.3 7.4 -6.6 6.7 7.6 -7.2 -7.0 7.0 -4.7 -6.7 -6.9 -7.3 -5.3 -6.8
Alzheimer’s Disease (in mother) 0.1 0.1 1.0 0.0 0.1 0.1 -0.6 0.0 0.0 0.1 0.4 0.1 0.1 0.3 0.1 -0.0 -0.5 0.4 -0.1 -0.1 0.1 0.1 -0.3 0.1 0.2 0.3 1.0 0.3
Alzheimer’s Disease (in father) 1.0 1.1 3.3 1.1 1.1 1.0 0.9 1.3 1.0 1.0 1.0 1.0 -1.1 0.9 0.7 -1.0 1.2 -1.3 -1.0 0.6 1.1 -0.7 -0.1 0.9 0.9 1.1 1.8 0.8
Alzheimer’s Disease (including proxy) 0.9 1.3 4.1 1.0 1.3 0.7 0.5 0.8 0.6 1.7 1.3 0.7 -0.6 0.8 0.4 -0.6 0.5 -0.5 -1.0 1.2 0.9 -0.4 0.7 1.7 1.8 1.6 2.0 1.8
Crohns Disease (2017) 2.9 6.3 10.3 2.4 2.0 2.8 2.9 2.3 2.8 2.8 2.2 2.8 -2.8 2.4 1.6 -2.9 2.9 -2.5 -2.7 2.3 2.5 -2.3 3.2 2.3 2.3 2.2 1.9 2.2
Irritable Bowel Disease (IBD) 2.3 5.6 10.4 2.3 1.3 2.7 2.3 2.3 2.6 2.6 2.2 2.5 -2.6 2.0 1.6 -2.6 3.2 -2.5 -2.7 2.3 2.5 -2.3 2.9 2.1 2.2 1.8 1.9 2.0
Ulcerative Colitis (UC) 1.2 2.3 4.9 1.6 0.4 1.7 1.2 1.5 1.7 1.7 1.4 1.6 -1.8 1.4 1.1 -1.6 2.2 -1.8 -1.9 1.7 1.8 -1.7 1.7 1.3 1.4 0.5 1.1 1.1
Major Depression (MDD) 0.7 0.9 4.1 -0.5 -0.6 -0.4 -0.9 -1.0 -1.4 -0.4 -0.6 -0.4 1.2 -0.2 0.1 2.0 -1.2 1.9 0.4 -0.1 -0.6 0.1 -0.1 -1.5 -0.7 -0.3 -1.3 -0.7
Reaction Time 1.0 1.9 13.3 -1.5 -2.3 -0.8 -0.5 -0.6 -0.8 -0.8 -2.2 -0.7 0.5 -1.5 -2.5 0.8 -0.1 0.0 0.8 -0.8 -1.9 1.6 -0.6 -0.9 -1.0 -3.6 -0.1 -0.9
Verbal and Numeric Reasoning (VNR) 7.8 18.7 31.5 4.7 5.6 4.5 4.4 3.3 4.5 4.6 5.5 4.5 -4.6 4.8 4.4 -4.5 3.5 -4.4 -4.4 4.0 4.9 -4.5 3.4 3.4 3.3 4.3 3.1 3.4
Breast Cancer 12.6 30.4 40.7 -5.9 -5.0 -6.4 -5.4 -5.5 -6.3 -6.2 -5.6 -6.3 6.2 -5.6 -4.1 6.3 -5.3 5.4 6.2 -5.6 -5.3 5.2 -4.2 -5.0 -5.2 -4.9 -4.8 -5.0
Ovarian Cancer 32.3 42.7 54.5 6.6 6.0 7.1 7.3 6.3 7.1 7.1 6.5 7.3 -7.4 6.3 4.6 -7.1 6.5 -7.1 -6.8 6.3 6.1 -5.7 6.3 6.7 6.7 5.8 5.2 6.6
Prostate Cancer 2.1 3.0 4.6 1.6 1.0 1.9 1.6 1.7 1.9 1.9 1.7 2.1 -1.8 1.9 1.5 -1.9 1.4 -1.5 -1.9 1.8 1.8 -1.8 -0.0 1.7 1.8 2.1 1.4 1.8
Age at First Birth 4.1 6.0 9.1 2.5 1.8 2.7 2.6 2.4 2.7 2.6 2.6 2.5 -2.8 2.6 2.4 -2.7 2.1 -3.0 -2.6 3.0 2.1 -2.6 1.1 2.0 2.0 2.1 2.5 2.0
Bipolar Disorder (2011) 2.4 2.3 5.8 -2.2 -1.5 -1.5 -0.9 -2.2 -1.5 -1.5 -2.0 -1.3 1.6 -1.8 -2.4 1.5 -1.4 1.6 1.7 -2.1 -1.7 2.1 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 3.2 -0.8 -0.2 -0.8 -0.6 -0.5 -0.8 -0.8 -1.2 -0.8 0.7 -0.5 -1.0 0.7 -1.2 0.6 0.9 -0.5 -1.3 1.0 -1.8 -0.7 -0.8 -0.3 -1.5 -0.7
Coronary Artery Disease (CAD) 3.0 3.5 8.2 -1.8 -0.2 -2.3 -2.8 -2.3 -2.2 -2.1 -1.5 -2.3 2.4 -1.0 -0.5 2.2 -2.9 2.4 2.1 -2.0 -1.3 1.1 -1.6 -1.5 -1.6 -1.6 -0.6 -1.5
Crohns Disease (2012) 6.5 10.4 14.1 3.2 3.1 3.5 3.7 2.6 3.6 3.5 3.3 3.6 -3.1 2.6 2.1 -3.7 3.5 -2.2 -3.3 2.3 3.7 -2.7 3.8 3.4 3.4 3.7 2.7 3.4
Mean Putamen Volume 10.8 12.3 17.7 -3.7 -3.4 -3.7 -3.4 -2.7 -3.7 -3.6 -3.9 -3.6 3.6 -3.4 -2.6 3.6 -3.1 3.2 3.7 -3.3 -3.5 3.1 -4.2 -3.9 -3.8 -3.8 -2.8 -3.9
Fasting Glucose 1.5 1.8 3.4 1.1 0.6 1.7 1.2 1.5 1.7 1.7 0.5 1.7 -1.7 1.1 0.2 -1.6 1.1 -1.7 -1.4 1.0 1.2 -0.9 1.3 1.8 1.7 1.3 0.5 1.8
HbA1C 0.7 0.7 1.6 -0.7 -1.2 -1.0 -1.2 -0.8 -1.0 -1.1 -0.9 -1.2 0.9 -0.9 0.0 1.0 -0.8 0.4 1.0 -0.8 -0.6 0.4 -0.6 -0.9 -0.8 -0.0 -1.1 -0.9
HDL Cholesterol 0.2 0.3 1.4 0.1 -0.2 -0.4 -0.8 -0.4 -0.4 -0.5 0.2 -0.8 0.9 -0.4 0.9 0.4 -0.2 1.2 0.3 -0.1 0.5 -0.4 -0.8 -0.4 -0.3 0.5 -0.1 -0.3
LDL Cholesterol 3.7 5.8 10.9 -2.3 -2.5 -2.4 -2.4 -1.9 -2.4 -2.5 -2.7 -2.5 2.4 -2.7 -2.1 2.5 -1.6 2.0 2.5 -2.1 -2.4 2.3 -1.4 -2.7 -2.6 -3.3 -2.3 -2.8
Lupus 6.8 10.2 13.9 3.5 3.3 3.5 3.1 2.4 3.4 3.5 3.6 3.4 -3.7 3.5 2.6 -3.4 3.0 -3.7 -3.5 2.9 3.4 -3.1 3.3 2.9 3.0 3.0 1.5 2.9
Neuroticism (2016) 20.7 29.9 38.9 -5.8 -4.8 -6.1 -5.8 -5.7 -6.2 -6.2 -5.8 -5.6 6.0 -5.3 -5.3 6.2 -5.9 6.2 5.9 -5.7 -5.8 5.8 -3.3 -4.7 -4.9 -4.7 -3.2 -4.4
Primary Biliary Cirrhosis 11.7 16.6 21.1 4.1 3.1 4.5 4.1 3.9 4.5 4.5 3.9 4.6 -4.5 4.0 2.8 -4.5 4.0 -4.0 -4.5 4.2 3.8 -3.7 3.9 4.3 4.2 4.1 3.3 4.2
Rheumatoid Arthritis 1.0 1.4 2.7 -1.2 -0.8 -1.0 -0.5 -1.2 -1.0 -1.0 -1.5 -1.1 1.3 -1.5 -1.6 1.0 -0.9 1.6 1.2 -1.1 -1.4 1.4 -0.6 -1.2 -1.1 -1.0 -0.7 -1.1
Schizophrenia (2014) 4.2 9.2 16.7 2.8 3.2 3.5 4.1 1.7 3.4 3.5 3.1 3.5 -3.1 2.4 1.1 -3.4 3.3 -2.3 -3.1 1.9 3.2 -2.0 2.9 3.4 3.5 3.6 2.4 3.4
Triglycerides 0.6 0.9 1.8 0.7 0.7 1.0 1.0 0.8 1.0 1.0 0.7 1.2 -1.3 1.0 0.2 -1.0 0.7 -1.4 -0.9 0.9 0.3 -0.6 1.0 1.3 1.3 1.1 -0.4 1.2
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.2 1.3 0.6 0.9 1.3 1.3 1.1 1.5 1.2 1.0 -1.4 0.8 0.8 -1.2 1.4 -1.6 -1.3 1.8 0.8 -1.0 1.7 0.9 1.1 1.1 0.5 1.0
Ulcerative Colitis 0.8 1.2 3.0 1.0 0.5 1.3 1.1 0.9 1.3 1.3 1.1 1.2 -1.0 0.3 0.1 -1.2 1.7 -0.7 -1.2 0.7 1.2 -0.6 1.5 1.1 1.1 1.3 1.3 0.9
Blood Eosinophil Count 15.6 120.0 141.6 11.2 9.4 11.8 9.7 10.6 11.8 11.8 11.1 11.7 -11.4 10.9 9.0 -11.8 10.3 -9.9 -11.7 10.3 11.3 -10.6 9.0 11.9 11.9 11.5 10.4 11.9
Blood Platelet Count 1.7 19.7 37.0 -4.1 -1.9 -5.0 -4.8 -5.5 -5.0 -4.9 -3.1 -5.0 5.4 -3.5 -2.1 5.0 -6.1 5.8 4.9 -4.0 -3.7 3.6 -5.6 -4.5 -4.4 -1.7 -3.3 -4.2
Blood Red Count 41.6 401.7 475.2 -21.0 -17.1 -21.8 -18.2 -19.6 -21.8 -21.8 -20.2 -21.8 21.6 -20.4 -16.3 21.8 -18.9 19.4 21.7 -20.0 -20.0 19.6 -18.6 -21.1 -21.0 -18.1 -16.5 -21.0
Blood White Count 3.2 24.0 48.4 -5.0 -3.7 -5.3 -5.0 -4.8 -5.4 -5.3 -5.1 -5.5 6.1 -4.9 -3.6 5.4 -5.5 7.0 5.4 -4.6 -4.8 4.6 -5.0 -4.2 -4.0 -2.5 -3.2 -4.0
Heel T-Score 12.2 97.1 139.2 10.1 8.9 10.5 9.9 8.8 10.5 10.5 11.8 10.4 -10.8 9.1 8.4 -10.5 10.4 -10.5 -10.6 9.3 10.5 -9.2 9.2 9.3 9.3 9.8 7.9 9.3
BMI 0.7 3.9 9.2 -1.6 -1.8 -2.4 -2.7 -1.0 -2.4 -2.4 -2.2 -2.3 2.3 -1.3 -0.3 2.5 -3.0 2.2 2.2 -0.8 -2.5 1.2 -2.2 -1.4 -1.5 -0.8 -2.2 -1.4
Height 5.1 98.5 139.2 10.8 8.6 10.5 8.4 10.7 10.6 10.5 10.3 10.2 -10.4 9.6 8.4 -10.6 9.0 -9.1 -10.6 10.8 9.1 -9.5 8.6 9.9 9.9 11.8 9.4 9.9
Waist Hip Ratio (WHR) 16.4 73.7 102.0 -8.8 -5.2 -9.6 -8.2 -9.3 -9.6 -9.5 -8.0 -9.3 9.5 -7.1 -5.3 9.6 -10.1 8.7 9.6 -8.5 -8.1 7.5 -8.4 -8.9 -8.9 -7.2 -8.7 -8.9
Systolic Blood Pressure 7.4 37.1 61.6 6.5 6.2 6.3 6.0 5.5 6.3 6.3 7.8 6.2 -6.4 5.8 6.1 -6.3 5.9 -5.9 -6.4 6.2 6.5 -6.0 7.2 4.8 4.8 6.8 3.7 4.7
Smoking Status 5.4 13.0 18.5 4.0 3.7 3.6 2.5 3.6 3.5 3.6 3.8 3.6 -3.6 4.3 4.1 -3.5 2.3 -3.2 -3.6 4.0 3.6 -4.1 4.1 3.9 3.8 3.8 1.7 3.8
Allergy or Eczema 0.7 1.9 15.4 1.5 1.3 1.2 1.1 1.5 1.2 1.2 1.0 1.3 -0.9 1.0 1.1 -1.1 0.7 -0.3 -1.1 1.4 0.9 -1.0 3.9 1.5 1.4 0.5 0.8 1.4
Cardiovascular Disease 0.7 2.4 5.2 1.9 1.8 1.4 1.6 1.3 1.4 1.4 2.2 1.4 -1.4 1.4 2.0 -1.4 1.4 -1.2 -1.5 1.6 1.9 -1.7 2.3 1.0 1.0 2.2 -0.0 0.9
Hypothyroidism (self reported) 2.0 4.7 9.4 -2.1 -1.5 -2.5 -3.0 -2.5 -2.5 -2.6 -2.1 -2.6 2.7 -1.5 -1.0 2.5 -3.1 2.7 2.4 -2.0 -2.0 1.5 -1.4 -1.8 -2.0 -1.4 -0.3 -1.9
Respiratory disease 0.4 0.9 11.8 0.7 0.5 0.5 1.0 1.0 0.5 0.4 0.9 0.5 -0.3 -0.5 0.4 -0.5 1.4 -0.1 -0.4 -0.2 0.8 -0.0 3.4 0.6 0.4 0.5 0.9 0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.4 -1.3 -0.8 -1.4 -1.3 -1.0 -1.4 -1.4 -1.3 -1.3 1.4 -1.2 -1.0 1.4 -1.6 1.3 1.5 -1.3 -1.5 1.3 0.3 -0.7 -0.8 -0.6 -1.3 -0.8
Lung FEV1/FVC ratio 3.6 18.0 23.9 4.6 4.4 4.8 4.1 4.4 4.7 4.8 4.3 4.9 -4.4 4.8 3.8 -4.7 3.1 -3.3 -4.6 4.8 4.1 -4.3 2.4 4.4 4.4 3.5 3.0 4.3
Lung FVC 40.5 205.9 243.4 14.9 12.8 15.3 13.6 13.6 15.3 15.3 15.5 15.1 -15.5 13.7 11.6 -15.3 14.5 -14.5 -15.3 13.5 14.8 -13.5 13.1 14.7 14.6 15.6 11.5 14.5
Neuroticism 40.5 97.7 118.8 -10.5 -7.7 -10.7 -8.4 -10.0 -10.7 -10.7 -10.6 -10.5 10.7 -9.8 -8.6 10.7 -9.7 9.8 10.9 -10.2 -10.1 9.9 -7.3 -10.0 -10.1 -10.3 -8.1 -10.0
Chronotype (morning person) 0.9 2.2 5.1 -1.3 -0.3 -1.6 -1.4 -1.3 -1.6 -1.6 -1.4 -1.6 1.7 -1.1 -0.6 1.6 -1.8 1.8 1.7 -1.6 -1.2 1.2 -1.6 -1.5 -1.4 -0.5 -2.3 -1.5
Hair Pigment 0.6 17.8 24.4 4.2 3.2 4.6 3.9 4.7 4.6 4.6 3.7 4.6 -4.4 3.8 3.0 -4.6 4.1 -3.7 -4.5 4.2 3.7 -3.7 4.0 4.9 4.8 3.2 4.9 4.8
Tanning 0.9 10.5 15.3 3.1 2.5 3.5 3.5 2.6 3.5 3.5 3.5 3.6 -3.8 3.1 2.0 -3.4 3.3 -3.9 -3.6 3.2 3.0 -2.8 2.1 3.5 3.6 3.2 2.7 3.4
Hand grip strength (left) 16.0 42.2 51.9 6.7 6.3 7.0 6.4 6.6 7.0 7.1 6.5 7.0 -7.2 6.5 4.9 -6.9 6.2 -6.8 -6.8 6.3 6.0 -5.9 6.0 6.8 6.8 6.8 4.6 6.7
Number of treatments/medications taken 1.2 2.2 3.7 -1.5 -1.1 -1.8 -1.9 -1.3 -1.8 -1.9 -1.2 -1.8 1.9 -1.6 -0.8 1.8 -1.6 1.9 1.8 -1.8 -1.3 1.5 0.5 -1.2 -1.3 -0.6 0.8 -1.2
Average weekly spirits intake 0.2 0.3 1.3 -0.1 0.3 -0.6 -0.7 -1.1 -0.6 -0.6 -0.1 -0.6 0.6 0.3 0.6 0.6 -1.2 0.7 0.5 -0.1 0.2 -0.3 -0.7 -0.3 -0.3 0.3 -0.0 -0.2
Sensitivity / hurt feelings 45.8 78.4 95.5 -9.4 -8.2 -9.5 -8.1 -8.5 -9.5 -9.5 -9.8 -9.5 9.5 -9.3 -8.1 9.5 -7.9 8.8 9.5 -9.0 -9.1 9.0 -7.9 -8.6 -8.6 -8.9 -6.3 -8.5
Frequency of depressed mood in last 2 weeks 10.6 14.8 21.1 -4.1 -3.0 -4.0 -2.5 -3.6 -3.9 -4.0 -4.6 -4.0 4.0 -4.3 -4.0 3.9 -3.2 3.7 4.2 -4.0 -4.3 4.2 -1.9 -3.9 -4.1 -4.4 -3.2 -4.0
Hearing difficulty/problems: Yes 6.6 10.1 17.4 -3.7 -3.0 -3.3 -3.0 -3.1 -3.4 -3.3 -4.2 -3.2 3.3 -2.8 -3.3 3.4 -3.6 3.1 3.4 -3.0 -3.8 3.2 -3.5 -2.5 -2.3 -3.3 -1.3 -2.5
Relative age of first facial hair 48.2 99.1 123.2 -10.4 -8.3 -11.1 -9.1 -10.2 -11.0 -11.1 -10.1 -11.0 10.9 -9.9 -7.3 11.0 -9.4 9.5 10.9 -10.0 -9.4 9.1 -9.6 -10.3 -10.4 -9.9 -7.3 -10.4
Other serious medical condition/disability diagnosed by doctor 2.5 3.2 7.1 -1.8 -1.4 -2.0 -2.1 -1.7 -2.0 -2.0 -2.2 -2.1 2.3 -1.6 -1.0 1.9 -2.2 2.7 2.0 -1.6 -1.6 1.3 0.2 -1.6 -1.5 -1.8 -0.8 -1.6
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.8 -1.1 -0.7 -1.2 -1.4 -1.0 -1.2 -1.2 -1.4 -1.3 1.4 -1.0 -1.2 1.1 -1.7 1.7 1.3 -1.1 -1.6 1.3 0.0 -0.2 -0.1 -0.2 1.2 -0.2
Ever had hysterectomy (womb removed) 0.9 1.0 2.9 -0.7 -0.0 -1.1 -1.6 -1.2 -1.1 -1.2 -0.6 -1.3 1.1 -0.2 0.1 1.1 -1.7 1.0 1.0 -0.5 -0.8 0.3 -1.2 -1.2 -1.1 -0.7 -0.1 -1.2
Systolic blood pressure, automated reading 10.0 29.0 42.7 6.0 5.1 5.7 4.3 5.5 5.7 5.7 6.5 5.6 -5.5 5.5 5.4 -5.7 4.4 -4.5 -5.8 5.9 5.4 -5.4 6.1 4.8 4.9 6.0 3.1 4.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 1.3 0.5 0.4 0.3 -0.3 0.8 0.3 0.2 0.0 0.4 -0.2 0.7 0.7 -0.3 -0.5 0.1 -0.2 0.6 0.1 -0.6 0.0 0.4 0.5 0.1 -1.2 0.5
Angina 0.1 0.1 1.0 -0.1 -0.2 -0.1 -0.4 0.1 -0.1 -0.1 -0.1 -0.0 0.1 0.2 0.3 0.1 -0.1 0.0 0.1 -0.1 0.2 -0.3 0.1 -0.2 -0.0 0.2 -1.0 -0.2
Medication for hormone replacement therapy 3.6 4.0 10.9 2.0 2.8 2.0 2.1 1.4 2.0 2.0 1.9 1.9 -1.9 2.1 1.6 -2.0 1.4 -1.7 -1.8 1.7 1.8 -1.8 1.4 2.2 2.2 2.1 3.3 2.2
Vitamin and mineral supplements 8.5 11.5 16.9 3.2 1.3 4.0 2.8 3.5 4.0 4.0 3.0 4.1 -3.9 3.2 1.8 -4.0 3.9 -3.4 -4.1 3.4 3.4 -3.1 2.4 3.6 3.7 3.4 2.2 3.6
Supplements: Zinc 4.2 4.6 6.5 -2.0 -1.2 -2.5 -2.1 -2.1 -2.5 -2.5 -1.9 -2.5 2.3 -1.9 -1.2 2.4 -2.3 1.8 2.5 -2.2 -2.1 2.0 -1.6 -2.5 -2.4 -2.5 -1.3 -2.4
Medication: Co-codamol 0.4 0.5 2.6 -0.6 0.5 -0.6 0.0 -0.7 -0.6 -0.6 -0.6 -0.4 0.5 -0.2 -0.6 0.6 -1.1 0.7 0.7 -0.3 -1.0 0.7 0.6 -0.7 -0.7 -0.2 -1.6 -0.7
Medication: Metformin 0.4 0.6 2.6 -0.6 -0.4 -0.8 -0.9 -0.8 -0.8 -0.8 -0.4 -0.8 0.8 -0.6 -0.4 0.8 -1.0 0.9 0.7 -0.6 -0.7 0.7 -0.4 -0.5 -0.7 -0.0 -1.6 -0.7
Diabetes (father) 2.2 2.7 5.8 -1.3 -1.9 -1.6 -1.4 -1.1 -1.5 -1.6 -1.3 -1.7 1.3 -1.7 -1.1 1.5 -0.9 0.8 1.4 -1.0 -1.5 1.3 -2.1 -2.3 -2.3 -2.1 -2.4 -2.3
Diabetes (mother) 0.1 0.2 1.0 0.3 -0.6 -0.2 -0.6 0.3 -0.2 -0.1 0.3 -0.2 -0.3 0.2 0.6 0.2 0.1 -1.0 -0.1 0.5 -0.0 -0.4 0.2 0.3 0.2 0.3 -0.7 0.3
Severe depression (siblings) 2.9 3.3 7.0 -1.9 -0.9 -1.6 -0.9 -2.4 -1.6 -1.5 -1.1 -1.6 1.6 -1.8 -1.8 1.6 -1.1 1.5 1.6 -2.1 -1.1 1.9 -1.9 -2.5 -2.5 -2.6 -1.7 -2.6
Pack years adult smoking proportion 1.3 2.1 4.3 -1.5 -1.3 -1.4 -1.2 -1.7 -1.5 -1.4 -1.6 -1.5 1.5 -1.6 -2.1 1.5 -1.4 1.6 1.5 -1.5 -1.7 1.9 -0.5 -0.8 -0.8 -0.3 -1.8 -0.9
Impedance of leg (right) 3.5 17.1 26.7 3.8 4.8 4.6 5.0 2.9 4.6 4.6 4.6 4.6 -4.4 3.8 2.3 -4.7 4.0 -3.5 -4.2 3.1 4.3 -3.1 5.2 4.2 4.1 4.1 3.6 4.1
Leg fat-free mass (left) 0.1 0.7 4.2 1.0 -0.2 0.0 -1.0 1.6 -0.0 0.0 0.3 -0.0 -0.1 0.9 2.1 0.0 -0.6 -0.1 -0.4 1.8 -0.1 -1.4 -0.4 0.2 0.2 1.4 -0.5 0.2
Trunk fat percentage 7.0 28.2 49.2 5.8 4.9 5.4 4.0 5.3 5.4 5.4 5.8 5.3 -5.1 5.6 5.4 -5.3 3.9 -4.1 -5.5 5.9 5.2 -5.5 5.3 5.6 5.6 7.0 3.9 5.7
Hand grip strength (right) 12.4 33.8 41.1 6.0 5.5 6.3 6.4 6.0 6.3 6.3 5.8 6.2 -6.4 5.2 4.1 -6.2 6.1 -6.0 -6.1 5.6 5.3 -5.0 5.3 5.9 5.9 6.4 4.3 5.9
Townsend deprivation index at recruitment 0.3 0.4 2.7 -0.4 -0.0 -0.4 -1.3 -0.5 -0.4 -0.4 -0.5 -0.4 0.6 0.3 -0.2 0.4 -1.6 1.2 0.3 -0.1 -0.6 0.1 -0.3 -0.4 -0.4 -0.3 -0.6 -0.4
Current tobacco smoking 1.3 2.1 3.7 1.6 1.6 1.5 1.0 1.2 1.4 1.5 1.5 1.5 -1.3 1.8 1.5 -1.4 0.7 -0.8 -1.4 1.5 1.5 -1.5 1.9 1.7 1.6 1.6 0.8 1.6
Average weekly fortified wine intake 4.0 4.7 6.4 2.3 2.2 2.2 2.2 2.5 2.2 2.2 2.0 2.3 -2.2 2.1 2.0 -2.2 2.1 -2.1 -2.1 1.9 2.2 -2.0 2.5 2.4 2.4 1.0 2.3 2.3
Maternal smoking around birth 0.1 0.1 0.8 -0.0 0.2 0.0 -0.5 -0.3 0.0 -0.0 -0.1 0.1 0.2 0.6 0.2 -0.0 -0.9 0.6 -0.0 0.1 -0.1 -0.3 0.4 -0.0 0.1 0.7 -0.0 0.1
Fed-up feelings 19.3 35.1 46.1 -6.0 -4.1 -6.7 -5.4 -6.0 -6.7 -6.7 -6.2 -6.8 6.4 -5.8 -4.6 6.6 -5.8 5.4 6.7 -6.1 -5.9 5.6 -4.9 -6.0 -6.2 -5.7 -4.7 -6.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.2 8.8 -2.0 -1.1 -2.0 -0.9 -1.7 -2.0 -2.0 -2.5 -2.1 2.1 -2.4 -2.3 2.0 -1.5 2.0 2.3 -2.1 -2.5 2.4 -0.7 -1.9 -2.0 -2.2 -3.0 -2.0
Relative age voice broke 30.3 46.3 55.9 -7.0 -5.9 -7.4 -5.9 -6.6 -7.4 -7.4 -7.1 -7.3 7.5 -6.8 -5.1 7.4 -6.4 6.9 7.4 -6.5 -6.6 6.3 -6.5 -7.2 -7.3 -6.4 -5.9 -7.2
Taking other prescription medications 0.5 0.8 1.9 -0.7 -0.8 -1.1 -1.4 -0.6 -1.1 -1.1 -1.1 -1.1 1.2 -0.7 -0.1 1.1 -1.1 1.1 1.1 -0.8 -0.7 0.4 0.8 -0.3 -0.4 -0.4 0.4 -0.3
Age when periods started (menarche) 6.0 14.4 19.7 -4.1 -3.1 -4.1 -3.9 -3.7 -4.1 -4.1 -4.2 -4.0 4.0 -3.4 -3.6 4.1 -4.4 3.7 4.1 -3.7 -4.4 3.9 -3.5 -3.4 -3.5 -3.3 -2.3 -3.4
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 3.6 -1.1 -1.1 -1.4 -1.6 -0.9 -1.4 -1.5 -1.5 -1.6 1.5 -1.4 -0.9 1.4 -1.3 1.6 1.4 -0.9 -1.5 1.1 -1.9 -1.1 -1.1 -1.2 0.7 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 6.1 13.9 21.9 4.0 3.7 3.8 3.9 3.2 3.8 3.9 4.7 3.7 -4.1 3.4 3.7 -3.8 4.2 -4.4 -3.9 3.8 4.3 -3.8 3.0 2.9 3.1 3.7 2.6 3.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 0.5 0.1 0.3 -0.1 0.2 0.3 0.3 0.6 0.3 -0.5 0.6 0.6 -0.4 0.5 -0.9 -0.5 0.2 0.7 -0.6 0.4 0.2 0.2 -0.1 0.1 0.1
Qualifications: CSEs or equivalent 7.2 9.5 15.6 -2.9 -1.8 -3.2 -2.5 -3.0 -3.3 -3.2 -2.6 -3.3 3.2 -2.7 -1.6 3.3 -3.0 2.7 3.2 -2.8 -2.7 2.4 -3.5 -3.9 -3.9 -3.0 -4.0 -3.9
Serious illness, injury or assault to yourself 1.0 1.2 3.5 -0.9 -1.4 -1.1 -1.9 -0.1 -1.1 -1.2 -1.6 -1.1 1.1 -0.6 -0.3 1.1 -1.1 1.0 1.0 -0.7 -1.0 0.4 -0.9 -1.1 -1.1 -1.8 -1.1 -1.1
High blood pressure 5.0 13.9 20.5 4.1 3.4 3.8 3.3 3.5 3.7 3.7 4.3 3.7 -3.7 3.6 3.7 -3.7 3.5 -3.4 -3.9 3.9 3.9 -3.8 4.2 3.7 3.8 4.5 2.1 3.6
Hayfever, allergic rhinitis or eczema 0.3 0.7 10.5 0.6 0.7 0.4 0.3 0.8 0.4 0.4 0.2 0.5 -0.1 0.3 0.5 -0.3 -0.2 0.6 -0.3 0.7 0.2 -0.3 3.2 0.8 0.8 -0.1 -0.4 0.7
Multivitamins +/- minerals 4.0 5.0 8.2 -1.9 -0.9 -2.8 -1.8 -2.2 -2.8 -2.8 -1.9 -2.9 2.7 -2.3 -1.1 2.8 -2.6 2.4 2.8 -2.0 -2.4 2.1 -1.5 -2.3 -2.3 -1.9 -1.1 -2.3
Stomach or abdominal pain in last month 1.8 2.3 3.6 -1.6 -1.8 -1.6 -1.3 -1.1 -1.6 -1.6 -1.9 -1.7 1.5 -1.8 -1.7 1.6 -0.6 1.1 1.6 -1.7 -1.5 1.6 -0.7 -1.6 -1.7 -1.5 -1.2 -1.6
Supplements: Glucosamine 0.1 0.2 1.0 -0.0 -0.2 -0.6 -1.0 0.0 -0.6 -0.6 0.0 -0.7 0.4 -0.0 0.7 0.6 -0.7 0.2 0.4 0.1 -0.5 -0.1 0.2 -0.1 -0.1 -0.2 -0.2 -0.1
Diverticular disease/diverticulitis (self-reported) 6.9 8.2 12.0 3.1 3.1 2.6 1.8 2.7 2.6 2.6 3.0 2.6 -2.3 3.0 3.4 -2.6 1.7 -1.7 -2.6 2.7 2.9 -3.0 3.5 3.4 3.4 3.4 3.2 3.3
Medication: Atenolol 1.4 1.7 5.0 1.1 1.7 1.1 0.8 0.6 1.1 1.0 1.4 1.2 -1.0 1.6 1.4 -1.1 0.3 -0.8 -1.0 1.0 1.4 -1.3 1.8 1.6 1.7 2.2 1.0 1.7
Medication: Levothyroxine sodium 3.6 6.1 8.7 -2.7 -2.3 -2.8 -2.9 -2.8 -2.7 -2.8 -2.4 -2.9 2.8 -2.3 -2.0 2.7 -2.8 2.6 2.6 -2.4 -2.4 2.3 -2.0 -2.3 -2.3 -2.1 -0.3 -2.3
Sitting height 15.1 107.1 136.9 11.3 8.3 11.2 9.4 11.7 11.2 11.2 10.7 11.0 -11.2 9.8 8.8 -11.2 10.6 -10.2 -11.3 11.2 9.9 -10.0 9.1 9.9 9.9 10.5 8.2 9.9
Chronic bronchitis/emphysema (father) 0.2 0.2 1.7 0.3 0.4 0.3 0.1 0.4 0.3 0.3 0.0 0.3 -0.3 0.6 0.4 -0.3 -0.2 -0.2 -0.2 0.7 -0.1 -0.5 1.3 0.3 0.3 0.2 0.6 0.4
High blood pressure (mother) 3.9 5.5 11.2 2.9 1.9 2.3 1.0 2.9 2.4 2.4 2.6 2.2 -2.2 2.7 3.4 -2.4 1.9 -1.8 -2.5 2.8 2.7 -3.1 1.9 1.8 1.8 2.1 1.9 1.7
Body mass index (BMI) 0.3 1.3 4.4 -0.6 -1.4 -1.2 -2.1 -0.3 -1.3 -1.3 -1.1 -1.3 1.4 -0.4 0.3 1.3 -1.9 1.6 1.0 0.1 -1.4 0.2 -1.2 -0.6 -0.5 -0.0 -1.6 -0.5
Impedance of leg (left) 4.1 20.1 29.1 4.1 5.2 5.0 5.4 3.2 5.0 5.0 4.8 5.0 -4.7 4.0 2.3 -5.0 4.5 -3.9 -4.6 3.3 4.7 -3.2 5.1 4.7 4.6 4.4 4.2 4.7
Leg predicted mass (left) 0.1 0.8 4.6 1.1 -0.1 0.1 -0.9 1.6 0.1 0.1 0.4 0.0 -0.1 1.0 2.1 -0.0 -0.6 -0.1 -0.4 1.9 0.0 -1.5 -0.3 0.2 0.2 1.4 -0.5 0.3
Trunk fat mass 4.5 19.2 36.0 4.9 3.7 4.3 2.9 4.7 4.3 4.3 4.7 4.3 -4.1 4.7 4.8 -4.3 3.0 -3.3 -4.5 5.2 4.1 -4.7 4.2 4.6 4.7 6.0 3.1 4.7
Waist circumference 1.2 4.2 12.1 -1.7 -1.8 -2.3 -3.0 -1.4 -2.4 -2.4 -1.9 -2.2 2.5 -1.1 -0.2 2.4 -3.5 2.8 2.1 -0.8 -2.3 1.2 -1.8 -1.7 -1.6 -0.4 -2.5 -1.6
Number of incorrect matches in round 3.8 6.3 11.9 -2.7 -2.8 -2.4 -3.0 -2.6 -2.4 -2.4 -3.0 -2.3 2.9 -1.7 -1.9 2.4 -3.2 3.5 2.4 -2.1 -2.2 1.8 -2.2 -2.3 -2.3 -3.2 -2.2 -2.2
Past tobacco smoking 6.7 12.4 15.4 -3.8 -3.5 -3.6 -3.3 -3.4 -3.6 -3.6 -3.8 -3.7 3.8 -3.8 -3.6 3.6 -3.3 3.9 3.6 -3.4 -3.8 3.7 -3.0 -3.4 -3.3 -3.4 -1.9 -3.3
Alcohol usually taken with meals 1.4 2.3 4.9 1.5 0.9 1.4 1.7 1.5 1.4 1.4 1.8 1.4 -1.4 1.0 1.6 -1.4 1.9 -1.4 -1.5 1.6 1.6 -1.6 1.1 1.6 1.6 1.3 2.2 1.5
Nervous feelings 18.7 34.9 44.6 -6.6 -5.9 -6.4 -5.0 -5.8 -6.4 -6.4 -6.7 -6.3 6.3 -6.3 -5.5 6.4 -5.3 5.5 6.4 -6.0 -6.2 6.0 -3.6 -5.6 -5.9 -6.1 -4.6 -5.7
Frequency of tenseness / restlessness in last 2 weeks 25.6 39.8 52.4 -6.6 -4.9 -6.8 -5.2 -5.8 -6.8 -6.8 -6.9 -6.8 6.6 -6.5 -5.5 6.7 -6.0 5.9 7.0 -6.2 -6.8 6.3 -4.4 -6.3 -6.5 -7.2 -5.7 -6.4
Hearing difficulty/problems with background noise 12.1 19.3 28.7 -4.7 -3.9 -4.6 -3.8 -3.9 -4.6 -4.6 -5.4 -4.4 4.6 -4.2 -4.3 4.6 -4.5 4.4 4.7 -4.0 -5.0 4.5 -4.4 -3.9 -3.9 -4.3 -4.3 -3.9
Hair/balding pattern: Pattern 2 18.2 23.1 37.7 -4.4 -4.0 -4.8 -4.6 -3.6 -4.8 -4.8 -5.0 -4.8 4.7 -4.2 -3.3 4.8 -4.3 4.2 4.8 -4.1 -4.7 4.0 -4.8 -6.1 -6.1 -5.7 -5.9 -6.1
Had menopause 0.1 0.1 0.5 -0.1 -0.7 0.1 -0.7 0.6 0.2 0.1 -0.3 0.2 -0.1 0.0 -0.4 -0.2 0.1 -0.0 -0.2 -0.1 -0.3 0.2 0.2 0.5 0.6 0.1 0.5 0.6
Had other major operations 0.1 0.2 0.9 -0.1 -0.0 -0.1 -0.6 0.1 -0.1 -0.1 -0.5 -0.1 0.3 0.2 -0.4 0.1 -1.0 0.8 0.2 0.1 -0.7 0.3 -0.1 -0.3 -0.3 -0.2 0.9 -0.3
Forced vital capacity (FVC) 34.0 130.8 169.0 12.1 10.7 11.9 10.6 11.1 11.9 12.0 12.4 11.7 -12.2 11.1 10.0 -11.9 11.0 -11.6 -12.0 11.2 11.5 -11.0 10.8 11.6 11.5 13.0 8.9 11.5
Heel bone mineral density (BMD) T-score, automated (right) 5.7 13.1 20.8 4.0 3.6 3.9 4.1 3.2 3.9 3.9 4.6 3.8 -4.1 3.5 3.4 -3.9 3.8 -4.1 -3.9 4.0 3.9 -3.6 2.4 2.5 2.6 3.3 2.2 2.5
Ever unenthusiastic/disinterested for a whole week 14.8 18.0 25.4 -4.5 -3.7 -4.4 -2.8 -3.9 -4.4 -4.4 -4.4 -4.4 4.5 -5.0 -4.3 4.4 -2.9 4.1 4.6 -4.9 -4.0 4.8 -3.5 -4.4 -4.4 -4.2 -3.7 -4.5
Qualifications: None of the above 2.9 6.1 10.5 -2.7 -2.4 -2.4 -1.9 -2.3 -2.4 -2.4 -3.2 -2.4 2.6 -2.7 -3.2 2.4 -2.1 2.8 2.6 -2.6 -2.9 3.0 -1.8 -2.0 -2.1 -3.1 -0.6 -1.9
Financial difficulties in last 2 years 5.4 7.2 9.2 -2.6 -1.5 -2.9 -2.4 -2.7 -2.9 -2.9 -2.9 -3.0 3.0 -2.3 -1.9 2.9 -2.9 3.0 3.0 -2.6 -2.6 2.3 -2.5 -3.0 -3.0 -2.7 -2.2 -2.9
Mouth/teeth dental problems 8.7 13.4 20.5 3.9 3.5 3.8 3.9 3.1 3.9 3.8 4.4 3.6 -4.0 3.1 3.3 -3.9 4.5 -4.2 -3.8 2.9 4.5 -3.6 3.7 3.4 3.3 3.2 1.9 3.3
Heart attack 0.3 0.3 1.2 -0.7 -1.0 -0.5 -0.3 0.1 -0.4 -0.5 -0.8 -0.4 0.3 -0.8 -0.7 0.3 0.0 0.1 0.5 -0.5 -0.7 0.7 -0.6 -0.7 -0.6 -1.1 -0.4 -0.6
Allergy 0.2 0.6 9.3 0.1 0.2 0.2 -0.0 -0.5 0.2 0.2 0.5 0.1 -0.5 0.8 0.4 -0.3 0.0 -1.1 -0.4 0.5 0.3 -0.6 -3.0 -0.1 -0.1 0.8 0.4 -0.0
Pain all over the body in last month 0.9 1.0 2.5 -1.2 -0.8 -0.9 -0.7 -1.2 -0.9 -0.9 -1.2 -0.8 1.1 -0.7 -1.2 0.9 -1.6 1.5 1.0 -0.7 -1.3 1.1 0.2 -0.6 -0.5 -1.0 -0.9 -0.4
Diabetes (self-reported) 0.0 0.1 0.4 -0.0 -0.2 -0.2 -0.4 -0.1 -0.2 -0.2 -0.1 -0.3 0.4 -0.2 0.2 0.2 -0.3 0.7 0.2 -0.0 -0.0 -0.0 0.4 0.2 0.1 0.3 -0.3 0.1
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.8 -0.1 0.2 -0.2 -0.1 0.5 -0.2 -0.2 -0.4 -0.1 0.3 -0.1 0.1 0.3 -0.6 0.6 0.3 0.2 -0.6 0.2 0.7 -0.3 -0.3 -0.9 -0.9 -0.4
Medication: Ramipril 0.3 0.4 1.8 0.5 -0.1 0.6 1.0 -0.3 0.6 0.6 1.0 0.4 -0.8 -0.2 -0.4 -0.6 1.3 -0.9 -0.7 0.6 0.4 -0.1 0.7 0.5 0.6 1.2 0.2 0.5
Medication: Simvastatin 0.2 0.2 1.1 0.5 0.8 0.4 -0.2 -0.0 0.4 0.3 0.6 0.4 -0.1 1.1 0.9 -0.4 -0.6 0.3 -0.4 0.5 0.7 -0.8 -0.3 0.1 0.2 0.4 0.0 0.0
Fluid intelligence score 7.3 15.2 26.3 4.4 5.1 3.9 3.7 3.1 3.9 4.0 4.8 3.9 -4.2 4.5 4.4 -3.9 2.9 -4.2 -3.9 3.9 4.3 -4.3 2.9 3.2 3.2 3.7 3.1 3.1
Illnesses of siblings 0.4 0.5 1.1 -0.6 -1.0 -0.9 -0.4 -0.7 -0.9 -0.8 -0.7 -1.0 0.7 -0.9 -0.2 0.9 -0.1 0.1 0.7 -0.3 -0.6 0.3 -1.0 -0.8 -0.9 -0.3 -0.6 -0.9
Neuroticism score 35.6 74.2 90.8 -9.3 -6.6 -9.1 -6.9 -9.1 -9.2 -9.1 -9.5 -9.0 9.1 -8.6 -8.2 9.2 -8.3 8.5 9.5 -9.2 -8.9 8.9 -6.5 -8.4 -8.7 -8.8 -7.3 -8.6
Weight 0.6 3.0 8.6 2.2 1.0 1.3 -0.1 2.5 1.2 1.3 1.6 1.2 -1.2 2.1 2.9 -1.2 0.2 -0.7 -1.6 2.9 1.0 -2.4 1.0 1.7 1.8 2.9 0.9 1.8
Impedance of arm (right) 9.5 44.1 60.4 6.8 7.4 6.9 6.5 5.2 6.9 6.9 7.8 6.9 -6.9 6.6 5.7 -6.9 6.0 -6.4 -6.7 5.6 7.4 -6.2 7.3 6.4 6.3 7.7 5.4 6.4
Arm fat percentage (right) 0.9 3.5 12.0 2.2 1.8 1.4 0.5 1.8 1.4 1.4 2.1 1.4 -1.3 2.4 2.9 -1.4 0.3 -0.8 -1.6 2.4 1.8 -2.4 1.8 2.0 2.1 3.5 0.3 2.1
Trunk fat-free mass 0.3 1.7 5.2 -0.6 -1.7 -1.4 -2.1 0.3 -1.4 -1.4 -1.4 -1.4 1.3 -0.7 0.2 1.4 -1.8 1.2 1.1 0.4 -1.8 0.3 -2.3 -1.1 -1.1 -0.5 -1.4 -1.1
Hip circumference 1.5 6.3 14.2 3.0 1.4 2.4 0.9 3.5 2.4 2.4 2.4 2.4 -2.2 2.9 3.2 -2.3 1.2 -1.6 -2.7 3.8 1.8 -3.0 2.4 2.5 2.5 3.1 2.0 2.6
Time employed in main current job 10.8 12.5 19.5 3.3 1.9 3.9 3.0 3.3 3.9 3.9 3.6 3.8 -3.6 2.7 2.2 -4.0 3.9 -2.8 -3.9 3.2 3.6 -2.9 3.6 4.3 4.4 3.8 3.0 4.3
Alcohol intake versus 10 years previously 0.1 0.2 1.0 -0.5 -0.1 -0.4 -0.2 -1.0 -0.4 -0.5 -0.2 -0.4 0.4 -0.4 -0.0 0.4 0.1 0.0 0.5 -1.0 0.4 0.1 0.3 0.1 0.0 0.4 0.2 0.2
Father’s age at death 1.5 2.0 4.5 1.3 1.2 1.5 1.4 1.2 1.6 1.5 1.6 1.4 -1.5 1.1 1.1 -1.6 1.7 -1.3 -1.6 1.5 1.6 -1.4 1.0 1.4 1.3 1.0 2.1 1.4
Worrier / anxious feelings 14.4 27.2 34.0 -5.8 -4.3 -5.5 -4.1 -5.5 -5.5 -5.5 -5.8 -5.5 5.4 -5.4 -5.2 5.5 -4.6 4.9 5.7 -5.7 -5.3 5.5 -3.7 -5.1 -5.3 -5.5 -3.9 -5.2
Frequency of tiredness / lethargy in last 2 weeks 4.4 7.1 9.6 -2.8 -1.3 -2.9 -1.8 -2.7 -2.9 -2.9 -3.0 -2.9 2.8 -2.5 -2.3 2.9 -2.9 2.6 3.1 -2.7 -3.1 2.7 -1.3 -2.9 -3.0 -2.9 -1.7 -3.0
Falls in the last year 5.5 7.4 10.1 -2.7 -3.2 -3.0 -3.2 -2.2 -3.0 -3.0 -3.0 -3.0 2.9 -2.5 -1.7 3.0 -2.6 2.6 2.7 -2.2 -2.6 2.1 -2.2 -2.9 -2.9 -3.0 -2.4 -2.9
Hair/balding pattern: Pattern 3 50.2 74.8 94.9 8.7 7.2 9.1 7.5 8.1 9.1 9.1 9.1 9.2 -9.0 8.7 7.2 -9.1 7.5 -7.8 -9.1 8.6 8.4 -8.1 9.3 9.7 9.7 9.1 7.2 9.7
Number of live births 12.6 17.8 23.2 -4.6 -3.6 -4.3 -3.7 -4.3 -4.4 -4.3 -4.3 -4.4 4.5 -4.7 -4.4 4.4 -3.5 4.2 4.4 -4.8 -4.2 4.7 -4.2 -4.4 -4.4 -3.7 -1.8 -4.4
Forced expiratory volume in 1-second (FEV1) 35.8 120.7 148.8 11.7 10.4 11.6 10.4 10.7 11.5 11.6 12.0 11.4 -11.8 10.7 9.7 -11.5 10.6 -11.2 -11.6 10.9 11.1 -10.6 9.9 11.0 10.9 12.2 7.9 10.9
Pulse rate 0.5 0.9 2.6 0.8 0.1 1.0 0.5 1.3 1.0 1.0 0.0 0.9 -0.9 0.6 0.4 -1.0 1.6 -0.9 -1.0 0.6 1.0 -1.0 1.2 1.2 1.2 -0.0 1.2 1.1
Happiness 2.7 3.2 5.8 -1.9 -1.8 -1.9 -1.2 -1.5 -1.9 -1.9 -1.8 -1.9 2.0 -2.4 -1.8 1.9 -1.1 2.0 1.9 -2.0 -1.7 2.2 -1.1 -1.8 -1.9 -1.6 -1.4 -1.9
Noisy workplace 9.5 11.8 19.3 -3.9 -3.5 -3.7 -3.4 -3.1 -3.7 -3.6 -4.4 -3.5 3.7 -3.3 -3.3 3.7 -3.5 3.6 3.7 -3.5 -3.8 3.4 -2.7 -3.0 -2.9 -3.1 -2.3 -2.9
Qualifications: A levels/AS levels or equivalent 8.1 18.0 25.3 4.8 4.8 4.5 3.8 4.3 4.5 4.5 5.0 4.4 -4.4 4.7 4.7 -4.5 3.5 -4.0 -4.5 4.5 4.7 -4.7 2.9 3.5 3.5 4.1 2.5 3.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.8 0.0 0.4 0.0 0.0 -0.7 -0.0 0.1 0.5 0.1 -0.2 0.4 0.4 0.0 -0.0 -0.4 -0.1 -0.2 0.5 -0.3 0.4 0.1 0.2 0.3 -0.9 0.2
Mouth/teeth dental problems: Dentures 0.3 0.4 1.6 -0.4 -0.4 0.3 -0.1 0.4 0.3 0.3 -0.9 0.5 0.1 0.1 -1.2 -0.3 -0.7 1.1 -0.1 0.0 -0.9 0.7 0.2 0.9 0.9 0.5 1.3 0.9
Asthma 0.8 1.6 8.6 1.1 0.9 1.1 1.5 1.4 1.1 1.1 1.4 1.0 -1.0 -0.1 0.2 -1.0 2.4 -1.0 -1.0 -0.1 1.4 -0.1 2.9 0.8 0.7 0.4 2.0 0.7
Medication: Ibuprofen (e.g. Nurofen) 12.8 16.2 24.8 -4.3 -3.5 -4.4 -3.9 -3.6 -4.4 -4.3 -4.5 -4.3 4.7 -4.2 -3.5 4.4 -4.2 5.0 4.5 -4.0 -4.2 4.1 -2.6 -3.7 -3.7 -3.6 -2.4 -3.7
Medication: Cholesterol lowering 0.1 0.2 1.0 -0.5 -0.6 -0.4 -0.5 -0.7 -0.3 -0.4 -0.1 -0.4 0.5 -0.5 -0.6 0.3 0.0 0.4 0.3 -1.0 0.1 0.6 -0.4 -0.2 -0.1 0.5 -0.5 -0.3
Depression (self-reported) 3.6 4.3 7.1 -2.5 -1.3 -2.1 -1.0 -2.1 -2.1 -2.1 -2.5 -2.0 2.4 -2.3 -2.6 2.1 -2.3 2.7 2.4 -2.2 -2.4 2.6 -0.8 -1.5 -1.6 -1.5 -1.6 -1.5
Medication: Lansoprazole 4.7 5.3 7.3 2.4 1.4 2.6 2.4 2.1 2.6 2.6 2.4 2.6 -2.6 2.2 1.6 -2.7 2.7 -2.5 -2.7 2.4 2.5 -2.2 1.9 1.8 1.9 1.8 2.3 1.9
Prospective memory result 2.6 3.2 4.7 -1.7 -1.9 -1.8 -1.7 -1.7 -1.8 -1.8 -1.9 -1.8 1.9 -1.7 -1.5 1.8 -1.9 2.2 1.7 -1.1 -2.0 1.6 -1.7 -1.9 -1.9 -2.0 -1.9 -1.8
Lung cancer (father) 0.1 0.2 0.5 0.3 -0.0 0.6 0.6 0.4 0.6 0.6 0.2 0.6 -0.3 0.3 0.1 -0.6 0.5 0.1 -0.5 0.5 0.3 -0.4 -0.5 -0.0 0.2 0.4 0.7 -0.0
Illnesses of mother 0.1 0.1 0.5 0.0 0.5 0.2 0.4 -0.2 0.2 0.2 -0.4 0.2 -0.2 0.5 0.1 -0.2 -0.2 -0.1 -0.0 0.1 0.1 -0.4 -0.0 0.6 0.7 0.4 -0.1 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 32.9 104.9 127.7 10.8 9.6 10.8 9.9 10.0 10.8 10.8 11.0 10.7 -11.0 9.9 8.8 -10.8 10.2 -10.5 -10.8 10.0 10.4 -9.8 9.3 10.3 10.1 11.3 7.6 10.2
Pulse wave Arterial Stiffness index 0.6 0.6 1.3 0.9 0.2 0.8 0.1 1.1 0.8 0.8 0.5 0.8 -0.7 0.8 1.0 -0.7 0.8 -0.4 -0.9 0.9 1.0 -1.1 0.4 1.0 1.1 0.8 0.2 1.1
Impedance of arm (left) 11.2 51.7 67.7 7.3 8.0 7.6 7.5 5.8 7.6 7.6 8.2 7.6 -7.5 6.9 5.8 -7.6 7.0 -6.8 -7.3 6.1 7.9 -6.4 7.7 6.7 6.7 8.0 6.3 6.8
Arm fat mass (right) 0.7 2.7 8.8 2.0 1.2 1.2 -0.1 2.0 1.1 1.1 1.7 1.1 -1.0 2.1 2.9 -1.1 -0.0 -0.5 -1.4 2.6 1.2 -2.2 1.1 1.7 1.8 3.0 0.1 1.8
Trunk predicted mass 0.3 1.6 4.7 -0.6 -1.7 -1.3 -2.0 0.3 -1.3 -1.3 -1.4 -1.4 1.2 -0.6 0.2 1.3 -1.8 1.2 1.1 0.4 -1.8 0.3 -2.2 -1.0 -1.0 -0.5 -1.4 -1.0
Standing height 3.8 38.1 51.8 7.0 5.8 6.3 5.0 6.9 6.3 6.3 6.6 6.1 -6.3 6.2 6.4 -6.3 5.2 -5.6 -6.4 7.0 5.8 -6.4 5.6 5.7 5.7 7.2 5.7 5.7
Length of working week for main job 0.9 1.0 1.8 1.0 0.4 1.3 1.2 1.2 1.3 1.3 0.8 1.3 -1.3 0.8 -0.0 -1.3 1.1 -1.1 -1.2 1.2 0.5 -0.5 -0.4 0.8 1.0 0.9 -0.2 0.9
Exposure to tobacco smoke at home 0.3 0.4 2.3 -0.6 0.3 -0.4 0.1 -1.1 -0.4 -0.3 -0.5 -0.5 0.0 -0.6 -1.5 0.3 0.0 -0.5 0.5 -1.1 -0.6 1.0 -0.1 -0.2 -0.3 -0.8 0.2 -0.2
Breastfed as a baby 0.4 0.4 4.5 0.4 0.3 0.2 -0.3 0.1 0.1 0.1 0.6 0.1 -0.3 0.7 0.9 -0.1 -0.0 -0.7 -0.3 0.4 0.5 -0.8 -0.3 0.9 0.8 0.7 2.1 0.9
Tense / ‘highly strung’ 7.1 11.8 18.5 -3.7 -2.4 -3.6 -2.6 -3.4 -3.6 -3.6 -4.3 -3.5 3.7 -3.4 -3.5 3.6 -3.7 3.7 3.9 -3.5 -4.0 3.6 -1.5 -3.2 -3.3 -3.7 -2.7 -3.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.3 -1.3 -0.5 -1.2 -1.0 -1.2 -1.2 -1.2 -1.0 -1.1 1.0 -0.8 -1.0 1.2 -1.1 0.6 1.2 -1.5 -1.0 1.2 -0.6 -1.0 -1.0 -0.3 -1.0 -1.1
Hair/balding pattern: Pattern 4 87.6 212.2 262.4 14.6 12.8 15.6 14.0 13.5 15.6 15.6 15.1 15.5 -15.3 13.6 10.9 -15.6 14.4 -13.7 -15.3 13.4 14.6 -13.1 14.8 16.2 16.1 15.0 12.3 16.1
Birth weight of first child 2.3 4.2 8.8 2.3 1.6 1.9 0.5 2.3 1.9 1.9 1.7 1.9 -2.1 3.0 2.6 -2.0 0.6 -2.0 -2.1 2.9 1.4 -2.7 2.3 2.0 2.1 2.5 0.4 1.9
Peak expiratory flow (PEF) 21.0 48.8 60.4 7.5 6.3 7.2 6.3 7.1 7.2 7.2 7.8 7.0 -7.5 6.7 6.6 -7.2 7.3 -7.4 -7.4 7.0 7.3 -7.0 5.8 7.0 7.0 7.0 5.5 6.9
Pulse wave reflection index 1.0 1.3 3.3 -1.0 -0.5 -1.3 -1.2 -1.2 -1.3 -1.2 -1.0 -1.3 1.5 -1.0 -0.5 1.3 -1.4 1.8 1.3 -1.0 -0.9 0.9 -1.1 -1.0 -0.9 -0.3 -1.3 -0.9
Ever highly irritable/argumentative for 2 days 5.2 6.3 9.1 -2.6 -1.8 -2.9 -1.6 -2.4 -3.0 -2.9 -2.9 -2.9 3.0 -2.6 -1.5 3.0 -2.4 2.6 3.0 -2.2 -2.6 2.2 -1.7 -2.5 -2.5 -2.5 -1.7 -2.5
Loud music exposure frequency 0.7 0.8 3.0 0.8 1.4 0.8 1.7 0.2 0.7 0.8 1.2 0.8 -1.0 0.5 0.4 -0.7 1.1 -1.2 -0.7 0.3 1.0 -0.3 0.9 0.7 0.7 1.2 -0.4 0.7
Qualifications: O levels/GCSEs or equivalent 5.5 8.7 16.9 3.4 4.1 2.9 2.3 2.9 2.9 2.9 3.5 2.8 -3.0 3.7 4.0 -2.9 2.0 -2.9 -2.9 3.0 3.4 -3.6 2.2 2.3 2.3 2.6 1.5 2.2
Mouth/teeth dental problems: Bleeding gums 3.9 5.0 11.4 -1.8 -2.1 -2.4 -2.5 -1.7 -2.4 -2.4 -2.4 -2.4 2.2 -1.6 -1.0 2.4 -2.4 1.6 2.2 -1.3 -2.3 1.4 -3.4 -2.7 -2.6 -2.7 -2.0 -2.7
Blood clot in the leg (DVT) 0.7 1.0 2.3 -1.1 -1.3 -1.0 -1.3 -0.4 -1.0 -1.0 -1.3 -0.8 1.1 -1.1 -1.1 0.9 -1.1 1.5 1.0 -0.8 -1.4 1.1 0.1 -0.5 -0.6 -0.3 -0.5 -0.5
Medication: Paracetamol 29.1 48.2 60.5 -7.5 -7.1 -7.7 -7.3 -6.7 -7.8 -7.7 -7.5 -7.6 7.6 -6.8 -5.6 7.8 -7.0 6.8 7.5 -6.9 -7.1 6.6 -4.9 -6.7 -6.8 -6.2 -4.4 -6.6
Headache pain in last month 32.9 56.5 68.5 -7.7 -6.3 -8.2 -7.5 -6.3 -8.2 -8.2 -8.3 -8.0 8.2 -6.9 -5.7 8.2 -7.9 7.7 8.2 -7.1 -7.9 7.0 -5.8 -7.9 -8.0 -7.4 -5.8 -7.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 3.8 -0.5 -0.1 -0.9 -0.6 -0.4 -0.9 -0.9 -0.9 -1.0 0.6 -0.5 -0.2 0.9 -0.8 0.2 0.9 -0.3 -1.1 0.4 -1.4 -1.0 -1.0 -1.9 -0.3 -0.9
Glaucoma (self-reported) 6.0 7.1 10.1 -3.0 -1.6 -2.8 -2.4 -2.7 -2.9 -2.9 -3.2 -2.8 2.8 -2.4 -2.6 2.9 -2.9 2.6 3.0 -3.2 -2.8 2.8 -2.3 -2.3 -2.4 -1.9 -2.5 -2.4
Gout (self-reported) 3.5 4.8 10.5 2.1 2.1 2.6 3.2 1.6 2.6 2.6 2.2 2.6 -2.8 1.9 0.6 -2.5 2.6 -2.9 -2.5 2.1 1.9 -1.4 1.7 2.1 2.1 1.0 0.7 2.0
Hypothyroidism/myxoedema (self-reported) 3.3 6.4 11.8 -2.5 -2.6 -2.8 -3.4 -2.4 -2.8 -2.8 -2.6 -2.8 3.1 -2.1 -1.4 2.7 -3.2 3.4 2.6 -2.1 -2.4 1.9 -1.8 -2.3 -2.4 -2.0 -0.2 -2.3
Medication: Amlodipine 3.4 4.8 8.4 2.0 0.8 2.5 1.9 2.5 2.4 2.4 2.0 2.6 -2.5 1.8 0.8 -2.4 2.3 -2.1 -2.5 2.1 1.6 -1.4 2.4 2.5 2.5 2.9 1.6 2.6
Medication: Ventolin 100micrograms inhaler 2.2 2.9 9.0 1.7 1.1 1.6 1.9 1.5 1.5 1.5 2.1 1.5 -1.7 0.7 1.1 -1.5 2.6 -2.1 -1.6 0.9 2.0 -1.1 3.0 1.4 1.3 1.0 2.5 1.3
Birth weight 0.1 0.2 2.4 0.2 0.7 -0.0 0.1 -0.7 -0.0 -0.0 0.6 -0.1 0.1 0.4 0.8 0.0 -0.1 -0.0 -0.0 -0.1 0.7 -0.6 0.5 0.1 0.1 0.5 -1.5 0.1
Chronic bronchitis/emphysema (mother) 5.5 6.4 11.5 -2.8 -3.4 -2.3 -1.8 -1.8 -2.3 -2.4 -2.9 -2.3 2.7 -3.4 -3.3 2.3 -1.7 3.2 2.4 -2.2 -3.1 3.3 -1.3 -2.2 -2.1 -2.5 -1.8 -2.2
High blood pressure (siblings) 6.4 9.3 12.4 3.4 3.5 3.4 2.6 3.0 3.4 3.4 3.5 3.4 -3.1 3.4 2.8 -3.5 2.2 -2.2 -3.2 2.9 3.2 -2.9 3.1 2.8 2.9 2.3 2.6 2.8
Forced vital capacity (FVC), Best measure 33.1 121.2 158.8 11.6 10.2 11.6 10.4 10.6 11.5 11.6 11.8 11.3 -11.7 10.6 9.4 -11.5 10.8 -11.1 -11.5 10.6 11.1 -10.5 10.6 11.2 11.1 12.6 8.4 11.1
Body fat percentage 3.4 13.4 27.7 4.0 3.3 3.6 2.4 3.6 3.6 3.6 4.0 3.6 -3.3 4.0 3.9 -3.5 2.2 -2.4 -3.7 4.2 3.4 -3.9 3.8 4.0 4.1 5.3 2.3 4.1
Leg fat percentage (right) 0.5 1.7 4.5 1.4 0.7 1.1 0.3 1.5 1.1 1.1 1.2 1.1 -0.8 1.5 1.6 -1.1 0.1 -0.1 -1.3 2.0 0.8 -1.4 1.6 1.7 1.8 2.1 0.1 1.8
Arm fat-free mass (right) 0.1 0.6 2.2 0.1 -1.1 -0.5 -1.4 1.1 -0.5 -0.5 -0.8 -0.5 0.6 -0.1 0.5 0.5 -1.1 0.9 0.2 1.1 -1.2 -0.2 -1.5 -0.2 -0.2 0.2 -0.7 -0.2
Exposure to tobacco smoke outside home 8.3 11.0 14.3 -3.6 -2.6 -3.7 -3.1 -3.8 -3.8 -3.7 -3.8 -3.7 3.6 -3.1 -2.9 3.8 -3.4 3.0 3.7 -3.6 -3.4 3.2 -2.5 -3.3 -3.2 -2.7 -1.8 -3.2
Comparative body size at age 10 1.7 4.6 8.1 -2.0 -1.9 -2.7 -2.4 -2.0 -2.7 -2.7 -1.3 -2.6 2.2 -1.7 -0.2 2.7 -2.2 1.2 2.3 -1.7 -1.8 1.4 -2.3 -2.4 -2.4 -1.0 -2.9 -2.4
Number of full brothers 9.2 11.5 15.4 -3.3 -2.4 -3.4 -3.2 -3.5 -3.5 -3.4 -3.9 -3.4 3.5 -2.8 -2.8 3.5 -3.7 3.5 3.5 -3.1 -3.4 2.9 -3.8 -3.6 -3.6 -3.9 -2.8 -3.7
Worry too long after embarrassment 11.7 19.7 25.1 -4.6 -3.5 -4.8 -3.9 -4.7 -4.7 -4.8 -5.0 -4.8 4.8 -4.2 -3.8 4.7 -4.6 4.6 4.9 -4.3 -4.7 4.2 -3.8 -4.1 -4.2 -4.7 -3.9 -4.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.0 -0.8 -0.4 -0.7 -0.4 -0.5 -0.7 -0.7 -0.6 -0.6 0.8 -0.9 -1.3 0.7 -0.9 1.0 0.8 -0.9 -1.0 1.4 1.4 -0.4 -0.6 -0.3 -0.8 -0.5
Wheeze or whistling in the chest in last year 3.2 5.6 7.8 -2.4 -2.8 -2.7 -2.7 -1.6 -2.7 -2.7 -2.4 -2.6 2.6 -2.6 -2.0 2.8 -2.1 2.4 2.5 -2.4 -2.6 2.6 -0.3 -2.3 -2.3 -2.5 -0.5 -2.3
Number of children fathered 1.1 1.2 2.6 -1.1 -1.6 -1.2 -1.1 -0.8 -1.2 -1.2 -1.3 -1.3 1.3 -1.6 -0.8 1.2 -0.4 1.2 1.2 -1.0 -1.1 0.9 -1.3 -1.0 -0.8 -1.1 0.0 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.2 -1.2 -1.4 -1.0 -0.6 -0.7 -1.0 -1.0 -1.3 -0.9 1.0 -1.3 -1.3 1.0 -0.6 1.0 1.0 -1.1 -1.1 1.3 -1.4 -0.7 -0.8 -1.3 -1.5 -0.6
Age at first live birth 6.2 10.9 15.9 3.4 2.5 3.3 2.6 2.5 3.3 3.3 3.8 3.4 -3.4 3.6 3.5 -3.3 2.9 -3.4 -3.5 3.2 3.9 -3.7 3.2 3.3 3.4 4.0 2.2 3.4
Pulse wave peak to peak time 0.1 0.1 0.3 -0.1 0.3 -0.1 0.4 -0.4 -0.1 -0.2 0.2 -0.1 -0.0 -0.2 -0.3 0.1 -0.2 -0.2 0.2 -0.1 -0.3 0.4 0.2 -0.4 -0.6 -0.1 0.3 -0.5
Health satisfaction 1.3 1.7 3.6 -1.2 -1.4 -1.3 -1.6 -1.0 -1.3 -1.2 -1.5 -1.4 1.5 -1.2 -1.2 1.3 -1.6 1.9 1.3 -0.8 -1.6 1.2 -1.3 -1.0 -0.9 -1.1 -1.2 -1.0
Shortness of breath walking on level ground 2.3 2.8 4.8 -1.7 -1.4 -1.8 -2.0 -1.5 -1.8 -1.8 -1.8 -1.8 2.0 -1.5 -1.6 1.8 -2.0 2.2 1.8 -1.8 -1.8 1.8 -0.9 -1.5 -1.4 -1.2 -0.3 -1.3
Qualifications: College or University degree 12.6 39.7 46.6 6.7 4.9 6.6 5.7 6.5 6.6 6.6 6.8 6.6 -6.6 6.0 5.9 -6.6 6.5 -6.3 -6.8 6.4 6.6 -6.4 6.1 6.4 6.4 6.3 4.0 6.3
Eye problems/disorders: None of the above 2.3 2.7 9.4 1.4 1.6 2.0 3.1 0.9 1.9 2.0 1.7 2.0 -1.9 0.6 -0.0 -1.9 2.7 -1.8 -1.7 0.9 1.4 -0.6 0.8 1.3 1.3 1.5 1.6 1.3
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.5 0.6 0.6 0.1 -0.4 0.7 0.1 0.1 0.0 0.2 -0.0 1.0 0.8 -0.1 -1.1 0.4 -0.1 1.1 -0.3 -0.6 1.2 0.4 0.6 0.2 0.3 0.4
Emphysema/chronic bronchitis 9.2 10.4 15.3 -3.5 -2.3 -3.4 -3.1 -3.4 -3.4 -3.5 -3.7 -3.3 3.5 -2.6 -2.8 3.4 -3.9 3.3 3.6 -3.3 -3.5 3.1 -0.9 -3.3 -3.4 -3.6 -1.8 -3.4
Medication for pain relief, constipation, heartburn 16.0 27.4 35.5 5.6 5.1 5.9 5.5 4.9 6.0 5.9 5.5 5.9 -5.9 5.4 4.1 -6.0 5.1 -5.3 -5.8 5.4 5.3 -5.1 3.6 5.0 5.1 4.8 2.1 5.0
Neck or shoulder pain in last month 1.8 2.5 4.0 1.5 1.3 1.8 1.2 1.7 1.7 1.8 1.4 1.8 -1.7 1.8 1.1 -1.7 1.3 -1.3 -1.7 1.6 1.4 -1.4 1.8 2.0 2.0 1.4 1.3 1.9
Medication: Blood pressure 1.3 2.2 5.6 1.4 0.7 1.6 1.1 1.3 1.6 1.5 1.8 1.6 -1.4 1.4 1.2 -1.5 1.1 -0.9 -1.7 1.6 1.5 -1.4 2.2 1.6 1.6 2.4 0.5 1.6
Angina (self-reported) 0.1 0.1 0.8 -0.1 -0.3 -0.1 -0.5 0.1 -0.1 -0.2 -0.2 -0.1 0.1 0.2 0.4 0.1 -0.1 -0.0 0.1 -0.1 0.1 -0.3 -0.0 -0.2 -0.1 0.2 -0.9 -0.2
Migraine (self-reported) 2.0 2.5 6.1 -1.5 -0.9 -1.6 -1.8 -1.3 -1.6 -1.6 -1.4 -1.6 2.0 -1.0 -0.6 1.6 -2.5 2.4 1.6 -1.1 -1.6 1.2 -0.9 -1.8 -1.8 -1.6 -0.4 -1.8
Medication: Ibuprofen 10.7 12.8 21.4 -3.8 -3.0 -3.9 -3.6 -3.0 -3.9 -3.9 -3.9 -4.0 4.3 -3.8 -2.9 3.9 -3.9 4.6 4.0 -3.4 -3.8 3.6 -2.3 -3.2 -3.3 -3.2 -1.4 -3.2
Medication: Allopurinol 2.7 3.6 5.9 2.2 2.1 1.9 1.5 1.7 1.9 2.0 2.3 1.9 -2.1 2.4 2.1 -1.9 1.4 -2.2 -2.1 2.3 2.0 -2.2 1.5 1.8 1.7 1.1 0.3 1.7
Medication: Omeprazole 2.1 2.5 4.5 2.0 1.2 1.6 0.8 1.7 1.6 1.5 1.8 1.4 -1.5 1.7 2.1 -1.6 1.4 -1.2 -1.7 1.9 1.9 -2.1 1.3 1.2 1.2 1.3 1.8 1.3
Medication: Seretide 50 evohaler 0.7 0.8 1.6 0.9 0.3 0.9 0.3 1.3 0.9 0.8 1.1 0.8 -0.9 0.5 0.7 -0.9 1.1 -0.8 -1.0 0.7 0.8 -0.6 1.2 1.0 1.1 1.2 0.6 1.0
Mean time to correctly identify matches 0.5 0.9 7.0 -0.8 -1.5 0.2 0.5 -0.2 0.2 0.2 -1.1 0.2 -0.5 -0.8 -2.3 -0.2 1.1 -0.9 -0.2 -0.4 -0.8 1.0 -0.2 0.0 0.0 -2.6 1.0 0.1
Heart disease (mother) 4.8 5.8 9.4 -2.5 -2.6 -2.4 -3.1 -1.6 -2.5 -2.4 -2.3 -2.4 2.5 -2.0 -2.0 2.5 -2.7 2.5 2.3 -2.0 -2.8 2.4 -1.7 -2.6 -2.7 -2.2 -2.4 -2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.6 6.7 13.0 -2.5 -2.2 -2.7 -2.6 -2.0 -2.7 -2.7 -2.9 -2.8 2.9 -2.4 -1.6 2.7 -2.5 2.9 2.7 -2.1 -2.5 2.1 -3.6 -2.9 -2.9 -2.8 -1.0 -2.8
Whole body fat mass 2.1 8.9 19.6 3.4 2.4 2.8 1.5 3.4 2.8 2.8 3.2 2.8 -2.6 3.4 3.7 -2.7 1.5 -1.8 -3.0 3.9 2.6 -3.4 2.8 3.2 3.3 4.4 1.7 3.3
Leg fat mass (right) 0.5 2.1 6.1 1.7 0.8 1.1 0.1 1.8 1.1 1.1 1.3 1.1 -0.9 1.8 2.2 -1.1 0.0 -0.3 -1.3 2.3 0.9 -1.8 1.4 1.8 1.8 2.5 0.2 1.8
Arm predicted mass (right) 0.2 1.0 3.3 -0.3 -1.5 -0.9 -1.8 0.8 -0.9 -0.9 -1.3 -1.0 1.0 -0.4 0.2 1.0 -1.5 1.2 0.7 0.7 -1.6 0.1 -1.6 -0.7 -0.6 -0.3 -1.1 -0.6
Pulse rate, automated reading 0.9 3.0 5.6 1.8 0.7 2.2 1.6 2.2 2.2 2.2 1.2 2.1 -2.0 1.5 0.4 -2.1 1.8 -1.3 -2.2 2.4 1.0 -1.3 2.4 1.7 1.7 1.0 0.1 1.8
Alcohol intake frequency. 14.7 34.3 40.8 -6.2 -5.2 -6.3 -5.3 -5.3 -6.2 -6.3 -6.1 -6.1 6.2 -5.8 -5.1 6.2 -5.9 5.6 6.3 -5.7 -6.2 6.0 -4.3 -6.3 -6.3 -5.7 -4.9 -6.4
Comparative height size at age 10 5.8 32.0 42.8 6.2 5.1 5.7 4.7 5.8 5.7 5.7 6.0 5.6 -5.9 6.0 6.0 -5.7 4.6 -5.6 -5.9 6.5 5.4 -6.2 5.2 5.4 5.4 6.0 5.3 5.4
Number of full sisters 1.4 1.7 2.4 -1.4 -1.3 -1.4 -1.1 -1.4 -1.5 -1.4 -1.2 -1.4 1.5 -1.5 -1.1 1.5 -1.1 1.5 1.4 -1.5 -1.2 1.4 -1.5 -1.2 -1.2 -1.1 -0.9 -1.0
Suffer from ‘nerves’ 9.2 14.4 22.9 -4.4 -3.4 -3.9 -3.4 -3.9 -3.9 -3.9 -4.8 -3.7 4.0 -3.3 -4.0 3.9 -4.5 4.0 4.1 -3.8 -4.4 4.0 -2.4 -3.3 -3.4 -3.5 -2.6 -3.4
Overall health rating 0.7 1.4 2.6 -1.0 -1.4 -1.2 -1.4 -0.6 -1.2 -1.2 -1.5 -1.3 1.3 -1.1 -0.8 1.2 -1.4 1.5 1.2 -0.4 -1.6 0.9 -0.2 -1.1 -1.1 -1.1 -1.6 -1.1
Chest pain or discomfort 0.5 0.7 2.7 0.9 0.5 0.8 0.2 1.3 0.8 0.8 0.5 0.8 -0.4 0.7 0.7 -0.7 0.0 0.4 -0.8 1.1 0.3 -0.6 1.6 1.1 1.1 1.3 0.6 1.1
Had major operations 1.0 1.2 5.2 -0.6 -1.2 -1.1 -2.3 -0.1 -1.1 -1.1 -1.0 -1.1 1.0 -0.2 0.1 1.1 -1.8 1.0 0.8 0.1 -1.4 0.2 -1.4 -1.1 -1.1 -1.6 -0.3 -1.0
Age at last live birth 3.4 4.9 11.0 2.3 1.4 2.2 1.3 2.0 2.2 2.2 2.5 2.2 -2.1 2.4 2.3 -2.1 1.6 -1.9 -2.3 2.3 2.4 -2.4 2.4 2.2 2.3 3.3 1.9 2.4
Family relationship satisfaction 1.3 1.6 4.9 -1.1 -1.4 -1.5 -1.7 -0.7 -1.5 -1.5 -1.5 -1.5 1.8 -1.0 -0.2 1.5 -1.8 2.2 1.4 -0.6 -1.3 0.7 0.2 -0.7 -0.8 -1.0 -0.7 -0.8
Leg pain on walking 8.8 11.1 16.8 -3.0 -3.3 -3.7 -4.1 -2.1 -3.7 -3.7 -3.6 -3.8 3.7 -3.0 -1.9 3.7 -3.7 3.6 3.5 -2.3 -3.8 2.7 -2.9 -3.4 -3.3 -3.5 -2.4 -3.5
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 5.3 -1.2 -1.0 -1.5 -1.3 -0.8 -1.5 -1.5 -0.8 -1.5 1.2 -1.4 -0.8 1.5 -1.3 0.7 1.4 -0.8 -1.8 1.4 -1.3 -1.6 -1.6 -1.3 -2.3 -1.7
Commuting to job workplace: Car/motor vehicle 3.6 4.1 6.0 -2.2 -1.4 -2.2 -1.4 -1.8 -2.2 -2.2 -2.0 -2.1 2.0 -2.2 -2.0 2.2 -1.9 1.4 2.3 -2.3 -2.3 2.5 -2.4 -2.0 -1.9 -1.9 -1.3 -2.0
Illness, injury, bereavement, stress in last 2 years 4.5 5.5 7.7 2.6 2.6 2.4 2.2 1.9 2.4 2.3 2.8 2.3 -2.4 2.4 2.7 -2.4 2.1 -2.3 -2.3 2.2 2.8 -2.6 2.7 2.3 2.3 2.1 1.0 2.2
Medication: Aspirin 0.9 1.2 2.7 -1.1 -1.6 -1.2 -1.3 -0.7 -1.2 -1.3 -0.8 -1.3 1.1 -1.5 -0.8 1.2 -0.3 0.6 1.0 -1.1 -0.9 1.1 -1.6 -1.0 -1.0 -0.8 0.2 -1.0
Supplements: Vitamin C 8.8 10.4 16.3 -3.0 -1.6 -3.6 -3.1 -2.8 -3.6 -3.6 -2.8 -3.6 3.5 -2.6 -1.3 3.6 -3.7 2.9 3.6 -2.8 -3.0 2.5 -3.2 -4.0 -4.0 -3.9 -2.4 -4.0
Knee pain experienced in last month 0.5 0.7 2.5 -0.5 -0.1 -1.0 -1.5 -0.2 -1.0 -1.0 -1.2 -1.1 1.2 -0.1 0.3 1.0 -1.6 1.4 1.0 -0.5 -0.8 0.2 0.3 -0.3 -0.5 -0.5 -0.6 -0.3
Hypertension (Self-reported) 4.5 12.6 17.8 3.9 3.0 3.6 2.9 3.5 3.6 3.5 4.0 3.5 -3.6 3.5 3.6 -3.5 3.2 -3.2 -3.7 3.8 3.6 -3.7 4.1 3.5 3.6 4.2 2.1 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 5.7 6.6 8.7 3.0 2.7 2.7 2.4 2.9 2.8 2.7 2.9 2.6 -2.8 2.5 2.2 -2.8 2.4 -2.6 -2.7 2.9 2.2 -2.4 2.9 2.3 2.3 1.9 2.1 2.2
Illnesses of father: Heart disease 7.2 10.0 13.0 -3.3 -2.7 -3.2 -3.0 -2.3 -3.1 -3.2 -3.3 -3.1 3.3 -3.2 -2.7 3.1 -2.9 3.3 3.2 -3.1 -3.3 3.2 -3.2 -3.6 -3.5 -3.3 -3.1 -3.6
Illnesses of siblings: Diabetes 0.5 0.6 2.3 -0.5 -1.3 -0.6 -1.0 0.2 -0.6 -0.5 -0.7 -0.5 0.5 -0.6 -0.4 0.6 -0.5 0.5 0.5 -0.3 -0.8 0.6 -1.5 -1.2 -1.1 -0.4 -1.0 -1.2
Smoking status: Previous 6.6 9.9 12.5 3.4 3.1 3.3 2.7 3.1 3.3 3.3 3.4 3.3 -3.5 3.5 3.3 -3.3 2.8 -3.5 -3.3 3.2 3.2 -3.4 2.4 3.2 3.1 3.1 1.5 3.1
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 4.3 1.9 1.9 1.6 1.3 1.9 1.6 1.6 1.4 1.5 -1.8 1.9 2.0 -1.6 1.3 -2.1 -1.6 1.9 1.5 -2.0 1.3 0.9 0.8 1.2 0.4 0.8
Whole body fat-free mass 0.1 0.8 2.8 0.1 -1.1 -0.8 -1.7 0.9 -0.8 -0.8 -0.8 -0.8 0.7 0.0 1.0 0.8 -1.4 0.7 0.5 1.0 -1.1 -0.4 -1.5 -0.5 -0.5 0.3 -0.9 -0.5
Leg fat-free mass (right) 0.1 0.6 3.9 1.0 -0.1 -0.0 -1.0 1.5 -0.1 -0.0 0.2 -0.1 -0.0 0.8 2.0 0.1 -0.6 -0.0 -0.3 1.7 -0.1 -1.3 -0.6 0.1 0.1 1.3 -0.3 0.2
Arm fat percentage (left) 1.3 5.2 14.9 2.6 2.1 2.0 1.1 2.3 1.9 2.0 2.6 2.0 -1.8 2.6 3.1 -1.9 1.0 -1.3 -2.1 2.8 2.2 -2.7 2.2 2.5 2.6 3.9 0.8 2.6
Average weekly red wine intake 3.7 5.4 8.9 2.5 1.7 2.7 2.7 2.4 2.7 2.7 1.9 2.6 -2.5 2.1 1.5 -2.7 2.3 -1.9 -2.6 3.0 1.8 -2.3 2.1 2.3 2.3 1.6 2.2 2.3
Handedness (chirality/laterality): Left-handed 23.1 27.8 35.5 5.7 5.3 5.2 3.8 5.0 5.2 5.2 6.0 5.0 -5.2 5.6 5.7 -5.2 4.3 -4.8 -5.3 5.2 5.7 -5.7 5.3 5.5 5.6 5.9 4.6 5.4
Mood swings 30.4 54.9 66.1 -7.9 -5.6 -7.8 -5.7 -7.6 -7.8 -7.8 -8.1 -7.8 7.9 -7.8 -7.1 7.8 -6.5 7.3 8.1 -8.1 -7.4 7.8 -5.7 -7.5 -7.6 -7.7 -6.2 -7.6
Loneliness, isolation 11.8 16.3 20.0 -4.2 -3.8 -4.2 -3.4 -3.3 -4.3 -4.2 -4.5 -4.2 4.2 -4.3 -3.8 4.3 -3.3 3.9 4.3 -4.1 -4.3 4.3 -3.1 -4.1 -4.3 -4.0 -3.9 -4.2
Long-standing illness, disability or infirmity 0.7 1.1 2.0 -1.0 -1.0 -1.2 -1.3 -1.2 -1.1 -1.2 -1.1 -1.2 1.3 -0.8 -0.4 1.1 -1.2 1.4 1.1 -0.8 -0.7 0.6 0.7 -1.0 -1.0 -1.1 -0.9 -1.1
Ever had bowel cancer screening 5.3 6.2 10.4 2.3 1.2 2.7 1.2 2.4 2.6 2.7 2.1 2.7 -2.5 2.6 1.8 -2.6 2.0 -1.9 -2.7 2.4 2.3 -2.4 2.5 3.1 3.2 3.1 2.8 3.2
Diabetes diagnosed by doctor 0.1 0.1 0.8 0.1 -0.4 -0.1 -0.6 0.1 -0.1 -0.2 0.1 -0.2 0.3 -0.0 0.2 0.1 -0.3 0.5 0.0 0.2 -0.0 -0.1 0.9 0.4 0.4 0.6 -0.4 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.4 -0.0 -0.1 -0.5 -0.6 -0.3 -0.5 -0.5 0.0 -0.7 0.3 -0.1 0.6 0.5 -0.3 -0.0 0.3 0.1 -0.1 -0.3 -0.3 -0.3 -0.2 -0.0 0.6 -0.3
Friendships satisfaction 2.4 3.0 5.0 -2.2 -1.9 -1.8 -1.2 -1.9 -1.8 -1.8 -1.7 -1.7 1.9 -2.1 -1.9 1.8 -1.2 1.7 1.9 -2.2 -1.5 2.1 -0.9 -1.5 -1.6 -1.1 -1.2 -1.6
Qualifications: nursing, teaching 4.5 7.0 12.1 2.8 1.4 2.6 1.1 3.5 2.6 2.6 2.7 2.5 -2.5 2.6 2.8 -2.6 2.4 -2.2 -2.9 2.8 2.7 -2.9 1.9 2.9 2.9 2.8 3.5 2.8
Commuting to job workplace: Walk 0.2 0.2 0.6 0.5 0.5 0.3 -0.2 0.0 0.3 0.3 0.5 0.3 -0.3 0.7 0.8 -0.3 -0.0 -0.2 -0.4 0.5 0.6 -0.8 0.5 0.2 0.1 -0.0 0.2 0.1
Eye problems/disorders: Cataract 2.0 2.3 3.9 -1.7 -1.8 -1.6 -2.0 -1.2 -1.6 -1.6 -1.5 -1.6 1.6 -1.2 -1.3 1.6 -2.0 1.7 1.5 -1.1 -1.8 1.5 -0.6 -1.3 -1.3 -1.7 -0.8 -1.4
Mouth/teeth dental problems: Mouth ulcers 21.5 34.2 42.0 -6.2 -5.3 -6.4 -5.8 -5.6 -6.5 -6.4 -6.0 -6.3 6.3 -5.4 -4.5 6.5 -6.3 5.9 6.2 -5.1 -6.3 5.4 -4.6 -6.2 -6.3 -5.3 -4.2 -6.2
Medication for cholesterol 7.7 11.6 18.9 -3.7 -4.3 -3.5 -2.8 -2.6 -3.5 -3.5 -4.0 -3.4 3.6 -4.0 -3.4 3.6 -2.4 3.3 3.5 -3.2 -3.6 3.5 -2.3 -3.3 -3.4 -3.6 -3.3 -3.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 4.8 0.1 -0.3 0.4 0.2 0.6 0.4 0.4 -0.1 0.5 -0.3 0.3 -0.3 -0.4 0.1 0.1 -0.4 0.3 -0.2 0.0 2.2 0.9 0.8 0.3 0.4 0.8
Back pain experienced in last month 0.2 0.3 1.5 0.0 -0.6 0.4 0.1 0.8 0.4 0.4 -0.6 0.5 -0.4 0.2 -0.3 -0.4 0.5 -0.3 -0.4 0.4 -0.1 -0.2 1.1 0.9 0.8 0.2 1.2 0.9
Mineral and other dietary supplements 0.8 1.1 2.9 1.0 0.2 1.3 0.3 1.7 1.3 1.4 0.7 1.4 -1.2 1.1 0.3 -1.3 0.9 -0.7 -1.4 1.3 0.6 -0.8 -0.0 1.1 1.2 1.3 0.1 1.2
Breast cancer (self-reported) 7.0 8.4 13.0 3.4 2.5 3.3 2.1 3.6 3.4 3.3 2.5 3.3 -3.0 3.4 2.8 -3.4 2.2 -2.2 -3.3 3.6 2.7 -3.3 1.3 2.8 2.7 1.7 2.5 2.7
Asthma (self-reported) 0.7 1.3 8.2 0.9 0.8 1.0 1.4 1.2 0.9 1.0 1.2 0.9 -0.9 -0.3 -0.0 -0.9 2.2 -0.9 -0.8 -0.3 1.2 0.1 2.9 0.7 0.6 0.3 2.0 0.7
Osteoporosis (self-reported) 5.4 6.7 10.3 -2.8 -2.9 -2.9 -2.9 -3.2 -2.9 -2.9 -2.9 -2.9 2.9 -2.5 -2.2 2.9 -2.4 2.5 2.7 -2.7 -2.3 2.2 -0.9 -2.1 -2.2 -2.8 -1.9 -2.2
Osteoarthritis (self-reported) 0.3 0.4 2.2 -0.3 -0.9 -0.2 -0.7 0.7 -0.2 -0.2 -0.8 -0.2 0.7 -0.6 -0.6 0.2 -0.6 1.5 0.3 0.1 -0.9 0.6 0.1 0.6 0.6 0.3 1.2 0.7
Medication: Aspirin 0.6 0.8 1.9 -0.9 -1.1 -1.0 -1.2 -0.6 -1.0 -1.1 -0.5 -1.1 0.9 -1.1 -0.5 1.0 -0.4 0.5 0.9 -1.0 -0.7 0.9 -1.4 -0.9 -0.9 -0.9 0.0 -0.9
Medication: Gliclazide 1.7 2.0 3.9 -1.7 -1.2 -1.4 -1.1 -1.5 -1.4 -1.5 -1.5 -1.4 1.4 -1.6 -1.8 1.4 -1.3 1.3 1.5 -1.6 -1.8 1.8 -0.2 -0.9 -1.0 -0.2 -2.0 -0.9
Illnesses of father: None of the above (group 1) 4.3 5.4 7.8 2.4 2.7 2.1 2.0 1.6 2.0 2.1 2.4 2.1 -2.2 2.7 2.6 -2.0 1.3 -2.1 -2.1 2.4 2.2 -2.5 2.8 2.7 2.7 2.6 2.2 2.7
Smoking status: Current 1.5 2.4 4.9 1.8 2.0 1.6 1.3 1.3 1.6 1.6 1.7 1.6 -1.4 1.8 1.6 -1.5 0.8 -1.0 -1.5 1.6 1.7 -1.6 2.2 1.6 1.5 1.5 0.9 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 29.2 61.6 74.2 8.1 6.3 8.2 7.6 7.8 8.2 8.2 8.4 8.1 -8.5 6.9 6.2 -8.2 8.6 -8.5 -8.3 7.3 7.9 -7.1 7.5 8.3 8.3 8.4 6.5 8.2
Whole body water mass 0.1 0.9 3.0 0.0 -1.1 -0.9 -1.7 0.8 -0.9 -0.9 -0.9 -0.9 0.8 -0.1 0.9 0.9 -1.5 0.8 0.6 0.9 -1.2 -0.3 -1.6 -0.6 -0.6 0.2 -1.1 -0.6
Leg predicted mass (right) 0.1 0.6 3.5 0.9 -0.2 -0.1 -1.1 1.4 -0.2 -0.1 0.1 -0.2 0.1 0.8 1.9 0.2 -0.7 0.0 -0.2 1.6 -0.2 -1.2 -0.7 0.1 0.1 1.3 -0.3 0.1
Arm fat mass (left) 0.6 2.6 8.8 2.0 1.3 1.2 0.1 2.0 1.1 1.2 1.7 1.1 -1.0 2.1 2.7 -1.1 0.0 -0.5 -1.4 2.5 1.2 -2.1 1.2 1.7 1.8 3.0 0.3 1.8
Number of self-reported non-cancer illnesses 0.4 0.7 2.4 -0.8 -1.3 -0.8 -1.0 -0.0 -0.8 -0.8 -0.9 -0.7 1.1 -1.2 -0.7 0.8 -0.4 1.6 0.7 -0.7 -0.7 1.0 1.3 -0.5 -0.5 -0.3 0.2 -0.6
Average weekly champagne plus white wine intake 13.9 19.1 23.5 4.6 4.2 4.8 4.1 4.7 4.8 4.8 4.3 4.8 -4.4 4.4 3.8 -4.8 3.7 -3.2 -4.6 4.6 4.2 -4.2 4.3 4.4 4.4 4.3 4.1 4.4
Miserableness 18.3 31.7 43.4 -6.2 -3.8 -5.9 -3.1 -6.4 -5.9 -5.8 -5.9 -5.8 5.6 -6.2 -6.3 5.9 -4.6 4.7 6.2 -6.5 -6.0 6.6 -3.8 -5.5 -5.8 -5.7 -5.1 -5.7
Guilty feelings 14.2 21.4 28.6 -4.9 -2.9 -5.1 -3.8 -4.9 -5.1 -5.0 -4.8 -5.1 5.0 -4.4 -4.1 5.0 -5.2 4.6 5.2 -4.3 -5.3 4.9 -2.9 -4.3 -4.4 -4.6 -4.3 -4.4
Wears glasses or contact lenses 0.5 0.5 1.4 -0.9 -0.9 -0.6 -0.9 -0.6 -0.7 -0.7 -1.2 -0.5 0.6 -0.5 -1.1 0.7 -0.9 0.6 0.7 -0.8 -0.9 0.9 -1.1 -0.4 -0.3 -0.3 -0.3 -0.4
Ever taken oral contraceptive pill 4.8 5.4 10.3 -2.6 -3.2 -2.4 -2.6 -1.6 -2.4 -2.4 -2.8 -2.2 2.6 -2.2 -1.7 2.4 -2.4 2.6 2.3 -1.9 -2.4 1.9 -1.2 -2.1 -2.1 -1.9 -2.7 -2.1
Hearing aid user 3.2 3.6 5.0 -2.2 -1.7 -2.2 -1.6 -1.7 -2.2 -2.2 -2.1 -2.0 2.0 -1.8 -1.6 2.2 -2.1 1.6 2.2 -2.1 -2.2 2.0 -1.3 -1.9 -1.8 -1.4 -0.6 -1.9
Mother’s age at death 0.3 0.4 1.1 0.7 0.5 0.8 0.2 0.2 0.7 0.8 0.7 0.7 -0.4 0.9 0.7 -0.7 0.1 0.3 -0.8 0.8 1.1 -0.9 -0.5 0.4 0.5 -0.3 0.0 0.5
Financial situation satisfaction 0.3 0.3 0.9 -0.2 -0.8 -0.6 -0.2 -0.2 -0.6 -0.6 -0.2 -0.8 0.4 -0.9 -0.3 0.6 0.2 0.1 0.4 -0.2 -0.5 0.5 0.5 -0.8 -0.9 -0.4 -0.6 -0.9
Tinnitus: Yes, now most or all of the time 1.7 2.0 4.7 -1.5 -1.4 -1.3 -1.6 -0.6 -1.3 -1.3 -2.0 -1.2 1.5 -1.3 -1.7 1.4 -1.8 1.9 1.4 -0.9 -2.2 1.6 -1.1 -0.9 -0.7 -0.9 -1.6 -0.8
Commuting to job workplace: Public transport 3.8 4.5 6.2 2.1 2.1 2.4 2.0 1.6 2.4 2.4 2.0 2.4 -2.4 2.3 1.4 -2.4 2.2 -2.2 -2.3 1.6 2.4 -2.1 1.2 2.5 2.4 1.8 1.4 2.5
Eye problems/disorders: Glaucoma 7.0 8.2 11.1 -3.1 -1.8 -3.0 -2.4 -2.7 -3.0 -3.0 -3.3 -3.0 3.0 -2.7 -2.6 3.0 -2.7 2.8 3.1 -3.2 -2.8 2.8 -3.2 -2.9 -2.9 -2.6 -2.9 -2.9
Medication: Blood pressure 11.2 21.2 28.7 5.1 4.8 4.8 4.0 4.1 4.9 4.8 5.4 4.8 -5.1 5.1 4.4 -4.9 3.9 -4.9 -4.9 4.7 4.7 -4.7 3.9 4.2 4.4 4.7 3.3 4.2
Pain type(s) experienced in last month: Hip pain 3.2 4.1 7.3 -1.7 -1.5 -2.2 -2.7 -2.0 -2.2 -2.2 -2.3 -2.4 2.3 -1.3 -0.8 2.1 -2.6 2.4 2.1 -1.6 -1.8 1.1 -2.2 -2.0 -2.0 -2.2 -1.4 -2.0
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.6 -0.2 -0.1 -0.3 0.6 -0.5 -0.3 -0.3 0.1 -0.3 0.1 -0.3 0.2 0.3 0.3 -0.4 0.3 -0.2 0.1 0.0 0.3 -0.7 -0.8 -0.6 -0.0 -0.7
High cholesterol (Self-reported) 1.1 1.9 4.4 1.3 1.0 1.3 1.2 0.7 1.3 1.3 1.8 1.3 -1.2 1.1 1.0 -1.4 1.4 -1.0 -1.4 0.8 1.8 -1.1 1.8 1.7 1.7 2.1 1.0 1.7
Medication: Bendroflumethiazide 3.9 5.9 10.4 2.9 2.0 2.5 1.6 2.5 2.5 2.5 3.2 2.4 -2.5 2.5 2.9 -2.5 2.1 -2.1 -2.7 2.9 2.6 -2.8 1.8 2.2 2.2 2.4 1.5 2.2
Medication: Paracetamol 28.7 44.4 57.0 -7.2 -6.7 -7.5 -7.0 -6.4 -7.5 -7.5 -7.1 -7.4 7.4 -6.7 -5.1 7.5 -6.6 6.5 7.3 -6.7 -6.7 6.3 -4.6 -6.4 -6.5 -6.1 -3.5 -6.3
Medication: Lisinopril 3.1 4.0 7.2 2.2 1.3 1.8 1.4 2.3 1.7 1.7 2.6 1.8 -2.1 2.0 2.7 -1.7 1.7 -2.4 -2.0 2.6 1.8 -2.2 2.0 1.7 1.7 2.1 2.1 1.6
Medication: Atorvastatin 0.2 0.2 1.7 -0.3 -1.3 -0.2 -0.2 -0.0 -0.2 -0.2 -0.1 -0.3 -0.1 -0.8 -0.5 0.2 1.1 -0.6 0.0 -0.6 0.1 0.3 0.2 0.1 0.1 0.5 0.4 0.1
Illnesses of father: High blood pressure 1.4 1.8 2.5 1.3 0.6 1.4 1.2 1.1 1.5 1.4 1.5 1.4 -1.4 1.0 0.9 -1.5 1.5 -1.2 -1.5 1.4 1.4 -1.2 1.5 1.6 1.4 1.4 0.2 1.5
Alcohol drinker status: Never 1.7 2.0 4.4 -1.4 -1.1 -1.3 -1.3 -0.9 -1.3 -1.3 -1.2 -1.1 1.3 -0.9 -0.9 1.3 -1.5 1.2 1.3 -1.2 -1.2 1.2 -1.4 -2.1 -2.1 -1.9 -1.8 -2.1
Ever smoked 4.3 7.5 10.8 2.8 3.0 2.6 2.6 2.2 2.6 2.6 2.9 2.7 -2.9 3.0 3.1 -2.6 2.5 -3.3 -2.6 2.4 3.1 -3.0 2.6 2.9 2.8 2.7 1.4 2.8
Basal metabolic rate 0.1 0.6 2.2 0.6 -0.6 -0.4 -1.3 1.3 -0.4 -0.4 -0.3 -0.4 0.4 0.5 1.5 0.4 -1.1 0.5 0.1 1.5 -0.7 -0.8 -0.9 -0.1 -0.1 0.9 -0.7 -0.1
Leg fat percentage (left) 0.6 2.2 5.6 1.6 0.8 1.4 0.5 1.7 1.4 1.4 1.3 1.4 -1.1 1.6 1.6 -1.3 0.4 -0.3 -1.5 2.1 1.0 -1.6 1.6 2.0 2.1 2.4 0.5 2.1
Arm fat-free mass (left) 0.2 0.9 3.2 -0.1 -1.2 -0.9 -1.8 0.8 -0.9 -0.9 -1.0 -0.9 0.9 -0.1 0.6 0.9 -1.6 1.1 0.6 1.0 -1.4 -0.1 -1.5 -0.4 -0.4 0.1 -1.1 -0.4
Number of operations (self-reported) 2.9 4.3 11.3 -1.8 -2.2 -2.3 -3.4 -1.0 -2.3 -2.3 -2.3 -2.4 2.2 -1.5 -1.1 2.4 -2.7 2.1 2.0 -1.1 -2.7 1.5 -1.9 -2.0 -2.0 -2.1 -0.5 -2.0
Average weekly beer plus cider intake 3.0 4.3 6.6 2.2 2.0 2.1 1.2 2.3 2.1 2.2 2.1 2.1 -2.4 2.6 1.6 -2.1 1.1 -2.3 -2.2 2.4 1.2 -1.8 2.6 2.3 2.3 1.8 1.6 2.3
Irritability 17.9 30.4 36.1 -5.8 -4.7 -5.9 -4.4 -5.4 -5.9 -5.9 -6.0 -5.8 5.9 -5.6 -4.8 5.9 -5.0 5.3 6.0 -5.6 -5.6 5.4 -4.8 -5.8 -5.8 -5.7 -3.8 -5.9
Risk taking 1.7 2.5 4.8 -1.8 -1.4 -1.5 -1.3 -1.7 -1.5 -1.5 -2.0 -1.5 1.4 -1.5 -2.2 1.5 -1.5 1.3 1.6 -1.6 -2.0 1.9 -1.5 -1.2 -1.3 -2.1 -1.1 -1.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.1 0.2 0.2 0.4 -0.5 0.7 0.4 0.4 0.3 0.5 -0.0 0.7 0.9 -0.4 -0.3 0.5 -0.3 0.0 0.7 -0.6 -0.3 0.4 0.4 0.9 1.1 0.5
Fractured/broken bones in last 5 years 9.0 11.6 18.7 -3.4 -3.2 -3.6 -3.5 -2.4 -3.6 -3.6 -4.0 -3.6 3.3 -3.3 -2.7 3.6 -2.9 2.7 3.5 -3.3 -3.6 3.1 -3.3 -3.9 -3.9 -4.3 -1.6 -4.0
Age started oral contraceptive pill 2.5 3.1 5.5 2.0 1.6 1.8 0.9 1.7 1.8 1.8 2.0 1.7 -1.7 2.2 2.3 -1.8 1.4 -1.6 -1.9 1.9 2.2 -2.3 0.5 1.6 1.7 1.1 1.6 1.7
Diastolic blood pressure, automated reading 2.8 8.6 14.3 3.1 2.1 3.3 2.5 3.8 3.3 3.3 2.9 3.2 -3.1 2.6 2.0 -3.3 2.9 -2.2 -3.3 3.4 2.3 -2.5 3.6 2.7 2.7 3.3 2.1 2.7
Ever depressed for a whole week 10.8 13.4 19.4 -4.2 -3.2 -3.7 -2.5 -3.4 -3.7 -3.8 -4.0 -3.5 3.8 -4.0 -3.9 3.7 -3.0 3.5 4.0 -4.4 -3.5 4.3 -2.7 -3.8 -3.6 -3.6 -3.4 -3.9
Unable to work because of sickness or disability 0.3 0.3 2.4 -0.3 -0.1 -0.6 -0.7 -0.4 -0.5 -0.6 -0.5 -0.6 0.6 -0.1 0.1 0.5 -0.8 0.6 0.5 -0.1 -0.4 0.1 0.8 -0.6 -0.6 -0.4 -1.5 -0.6
Commuting to job workplace: Cycle 0.2 0.2 1.4 0.1 0.5 0.1 1.2 -0.6 0.1 0.1 0.5 0.1 -0.4 -0.2 -0.0 -0.0 0.8 -1.0 -0.1 -0.2 0.4 -0.0 0.3 0.3 0.3 0.6 0.4 0.2
Myopia 9.1 13.2 16.2 3.7 3.4 3.7 3.4 2.9 3.7 3.7 3.8 3.8 -4.0 3.7 3.0 -3.7 3.3 -4.0 -3.7 3.5 3.6 -3.5 3.3 3.8 3.9 3.8 3.5 4.0
Vascular/heart problems diagnosed by doctor 3.6 9.8 14.2 -3.4 -2.7 -3.2 -2.8 -2.8 -3.2 -3.2 -3.6 -3.2 3.2 -3.1 -3.0 3.1 -2.9 2.9 3.3 -3.3 -3.3 3.2 -3.7 -3.0 -3.2 -3.8 -1.5 -3.0
Cholesterol lowering medication 1.3 1.9 3.1 1.4 1.2 1.3 0.8 1.1 1.3 1.3 1.8 1.3 -1.2 1.5 1.5 -1.3 0.9 -1.0 -1.4 1.3 1.6 -1.4 1.6 1.6 1.5 1.4 1.4 1.6
Medication: Omeprazole (e.g. Zanprol) 3.2 3.9 5.8 2.4 1.6 2.0 1.3 1.9 2.0 2.0 2.4 1.8 -2.0 2.0 2.3 -2.0 2.2 -1.9 -2.2 2.1 2.4 -2.4 1.8 1.4 1.4 1.3 2.1 1.5
Pain experienced in last month 8.4 14.0 21.5 4.0 3.4 4.2 4.1 3.1 4.2 4.2 4.6 4.1 -4.3 3.5 3.0 -4.3 4.2 -4.2 -4.2 3.5 4.3 -3.6 2.1 3.1 3.2 3.7 1.6 3.1
Supplements: Calcium 0.8 0.8 2.5 -0.5 -0.2 -1.1 -1.6 -0.7 -1.1 -1.2 -0.7 -1.3 1.2 -0.5 0.1 1.1 -1.5 1.1 1.1 -0.5 -0.9 0.5 -0.2 -0.7 -0.7 -1.0 -0.3 -0.6
Basal cell carcinoma (self-reported) 0.1 0.2 1.4 0.1 0.3 -0.2 -0.3 -0.2 -0.1 -0.2 -0.2 -0.2 0.4 0.1 0.3 0.1 -0.7 0.7 0.3 0.1 -0.2 -0.2 1.2 -0.1 -0.2 -0.6 0.6 -0.1
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.9 -0.7 -0.9 -0.4 -0.3 0.0 -0.4 -0.4 -0.7 -0.3 0.2 -0.6 -0.6 0.3 -0.0 -0.1 0.4 -0.4 -0.7 0.6 -0.7 -0.6 -0.5 -0.9 -0.5 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.9 -0.9 -1.2 -0.7 -1.1 -0.1 -0.7 -0.7 -1.1 -0.6 0.9 -0.9 -1.0 0.7 -0.9 1.4 0.8 -0.6 -1.2 1.0 0.2 -0.1 -0.3 0.1 -0.1 -0.1
Heart disease (siblings) 9.0 11.0 14.5 -3.7 -2.6 -3.5 -3.2 -3.8 -3.5 -3.5 -3.5 -3.5 3.6 -3.2 -3.1 3.5 -3.3 3.3 3.6 -3.8 -3.1 3.3 -2.6 -3.0 -3.1 -3.4 -2.7 -3.1
Alcohol drinker status: Previous 0.3 0.3 3.1 0.5 0.0 0.5 0.2 0.5 0.5 0.5 0.7 0.6 -0.3 0.6 0.5 -0.5 -0.2 0.3 -0.6 0.9 0.2 -0.3 1.8 0.1 0.1 -0.0 -0.7 0.0
Pack years of smoking 1.4 2.1 4.5 -1.5 -1.5 -1.4 -1.5 -1.5 -1.4 -1.4 -1.7 -1.5 1.6 -1.6 -2.1 1.5 -1.5 1.8 1.4 -1.5 -1.8 1.9 -0.5 -0.8 -0.8 -0.3 -1.5 -0.8
Impedance of whole body 9.3 47.4 59.6 6.8 7.6 7.5 7.4 5.5 7.5 7.5 7.7 7.4 -7.2 6.4 4.9 -7.5 6.8 -6.3 -7.1 5.7 7.4 -5.8 7.6 6.7 6.7 7.5 5.9 6.8
Leg fat mass (left) 0.6 2.2 6.2 1.7 0.9 1.2 0.1 1.8 1.1 1.2 1.3 1.2 -1.0 1.8 2.1 -1.1 0.1 -0.3 -1.4 2.2 1.0 -1.8 1.2 1.8 1.9 2.5 0.4 1.9
Arm predicted mass (left) 0.1 0.6 2.2 0.2 -1.1 -0.5 -1.5 1.1 -0.5 -0.5 -0.7 -0.5 0.5 0.1 0.8 0.5 -1.1 0.8 0.2 1.2 -1.1 -0.4 -1.3 -0.1 -0.1 0.4 -1.1 -0.0