Best TWAS P=6.07e-13 · Best GWAS P=1.12e-12 conditioned to 0.00077
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | UBXN6 | 0.10 | 0.00 | enet | 21 | 0.02 | 8.0e-03 | 6.4 | 5.1 | 2.7e-07 | -0.40 | 0.01 | 0.95 | FALSE |
| 2 | GTEx | Artery Aorta | UBXN6 | 0.13 | 0.02 | lasso | 5 | 0.03 | 5.7e-03 | 6.4 | 6.4 | 1.3e-10 | -0.32 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | UBXN6 | 0.18 | 0.07 | lasso | 3 | 0.14 | 6.3e-11 | -4.3 | 5.8 | 5.1e-09 | -0.31 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | CTB-50L17.9 | 0.45 | 0.25 | lasso | 8 | 0.23 | 8.6e-07 | -4.8 | 6.5 | 6.2e-11 | -0.23 | 0.07 | 0.89 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | UBXN6 | 0.09 | 0.10 | lasso | 1 | 0.08 | 1.5e-06 | 6.4 | 6.5 | 1.1e-10 | -0.38 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | AC007292.4 | 0.19 | 0.07 | enet | 29 | 0.07 | 3.6e-06 | 5.0 | -5.3 | 1.0e-07 | 0.25 | 0.06 | 0.92 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | UBXN6 | 0.34 | 0.12 | lasso | 6 | 0.21 | 6.5e-10 | -4.8 | 6.1 | 1.2e-09 | -0.30 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Heart Left Ventricle | UBXN6 | 0.21 | 0.14 | lasso | 6 | 0.16 | 5.6e-09 | 6.4 | 6.5 | 7.8e-11 | -0.36 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Muscle Skeletal | UBXN6 | 0.19 | 0.14 | lasso | 5 | 0.18 | 4.1e-17 | 6.4 | 6.5 | 5.6e-11 | -0.32 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Stomach | AC007292.4 | 0.27 | 0.09 | lasso | 5 | 0.04 | 4.0e-03 | 6.3 | -5.8 | 4.8e-09 | 0.44 | 0.02 | 0.88 | FALSE |
| 11 | GTEx | Whole Blood | UBXN6 | 0.06 | 0.03 | lasso | 4 | 0.01 | 4.1e-02 | 6.2 | 6.0 | 2.7e-09 | -0.42 | 0.01 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBXN6 | 0.03 | 0.03 | lasso | 3 | 0.03 | 2.3e-06 | 6.4 | 6.6 | 4.1e-11 | -0.41 | 0.12 | 0.87 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | SEMA6B | 0.24 | -0.01 | blup | 42 | 0.05 | 1.1e-02 | -5.2 | -5.4 | 6.2e-08 | 0.60 | 0.00 | 0.39 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UBXN6 | 0.05 | 0.01 | blup | 57 | 0.04 | 6.6e-05 | -4.8 | 7.2 | 6.1e-13 | -0.62 | 0.10 | 0.70 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UBXN6 | 0.13 | 0.10 | lasso | 2 | 0.10 | 1.3e-10 | -4.8 | 5.3 | 1.3e-07 | -0.20 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | UBXN6 | 0.16 | 0.12 | lasso | 2 | 0.12 | 5.4e-12 | -4.8 | 5.2 | 2.4e-07 | -0.17 | 1.00 | 0.00 | FALSE |