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chr19:8,738,746-11,140,703

Best TWAS P=1.28e-14 · Best GWAS P=5.24e-15 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RAVER1	0.06	0.03	bslmm	388	0.04	2.5e-05	5.5	6.4	1.9e-10	0.22	0.06	0.80	TRUE
2	CommonMind	Brain Pre-frontal Cortex	ZNF266	0.32	0.52	bslmm	399	0.53	1.6e-76	6.8	-5.5	3.7e-08	-0.66	0.81	0.19	FALSE
3	GTEx	Adipose Subcutaneous	ZNF266	0.43	0.61	lasso	9	0.62	2.0e-63	6.8	-6.7	2.4e-11	-0.74	0.75	0.25	FALSE
4	GTEx	Adipose Visceral Omentum	ZNF266	0.48	0.59	lasso	11	0.61	2.4e-39	7.0	-6.7	2.7e-11	-0.72	0.67	0.33	FALSE
5	GTEx	Adrenal Gland	ZNF266	0.40	0.58	enet	19	0.59	1.6e-25	6.9	-6.9	3.8e-12	-0.73	0.66	0.34	FALSE
6	GTEx	Artery Aorta	ZNF266	0.48	0.61	enet	21	0.63	5.4e-44	6.8	-6.1	1.2e-09	-0.72	0.74	0.26	FALSE
7	GTEx	Artery Coronary	ZNF266	0.43	0.50	lasso	24	0.49	7.5e-19	6.8	-6.8	1.0e-11	-0.75	0.42	0.58	FALSE
8	GTEx	Artery Tibial	ZNF266	0.46	0.68	lasso	7	0.68	1.3e-71	6.9	-6.9	4.6e-12	-0.73	0.73	0.27	FALSE
9	GTEx	Brain Caudate basal ganglia	ZNF266	0.33	0.49	lasso	5	0.47	4.3e-15	6.9	-6.9	4.1e-12	-0.73	0.55	0.45	FALSE
10	GTEx	Brain Cerebellar Hemisphere	ZNF266	0.44	0.60	lasso	11	0.58	3.5e-18	6.8	-7.0	3.1e-12	-0.73	0.50	0.50	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CTD-2623N2.3	0.12	0.07	enet	30	0.10	1.4e-03	6.9	-7.7	1.3e-14	-0.67	0.06	0.51	TRUE
12	GTEx	Brain Cerebellum	ZNF266	0.46	0.62	enet	11	0.59	2.1e-21	6.8	-6.9	6.0e-12	-0.73	0.64	0.36	FALSE
13	GTEx	Brain Cortex	ZNF266	0.38	0.39	enet	15	0.48	5.4e-15	6.8	-6.9	5.2e-12	-0.73	0.61	0.39	FALSE
14	GTEx	Brain Hippocampus	ZNF266	0.29	0.37	lasso	11	0.36	2.2e-09	7.0	-7.0	3.6e-12	-0.73	0.42	0.57	FALSE
15	GTEx	Brain Hypothalamus	ZNF266	0.35	0.32	lasso	9	0.33	1.9e-08	6.9	-7.0	2.8e-12	-0.73	0.46	0.52	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	ZNF266	0.34	0.43	enet	13	0.32	2.8e-09	7.0	-6.9	4.7e-12	-0.73	0.56	0.44	FALSE
17	GTEx	Brain Putamen basal ganglia	ZNF266	0.40	0.41	enet	14	0.40	1.7e-10	7.0	-7.0	3.7e-12	-0.73	0.51	0.48	FALSE
18	GTEx	Breast Mammary Tissue	ZNF266	0.41	0.56	lasso	9	0.57	2.9e-35	7.0	-6.8	1.0e-11	-0.73	0.65	0.35	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	ZNF266	0.60	0.74	enet	19	0.74	4.1e-34	6.8	-6.7	1.6e-11	-0.73	0.75	0.25	FALSE
20	GTEx	Cells Transformed fibroblasts	ZNF426	0.15	0.04	lasso	13	0.04	1.0e-03	-4.9	-5.2	1.6e-07	-0.25	0.88	0.01	TRUE
21	GTEx	Cells Transformed fibroblasts	ZNF266	0.44	0.62	lasso	1	0.61	1.4e-57	6.8	-6.8	7.7e-12	-0.72	0.75	0.25	FALSE
22	GTEx	Colon Sigmoid	ZNF266	0.43	0.63	enet	16	0.62	3.0e-27	6.8	-6.5	1.1e-10	-0.74	0.57	0.43	FALSE
23	GTEx	Colon Transverse	ZNF266	0.47	0.63	lasso	8	0.63	1.8e-37	6.8	-6.6	4.6e-11	-0.74	0.75	0.25	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	ZNF266	0.48	0.61	lasso	4	0.61	2.7e-27	6.8	-7.0	2.2e-12	-0.73	0.69	0.31	FALSE
25	GTEx	Esophagus Mucosa	ZNF266	0.46	0.65	enet	22	0.64	1.2e-55	6.9	-6.4	1.8e-10	-0.72	0.77	0.23	FALSE
26	GTEx	Esophagus Muscularis	ZNF266	0.42	0.55	lasso	2	0.56	5.8e-41	6.8	-6.8	1.0e-11	-0.73	0.80	0.20	FALSE
27	GTEx	Heart Atrial Appendage	ZNF266	0.28	0.45	enet	19	0.46	4.2e-23	6.8	-6.8	1.5e-11	-0.74	0.51	0.49	FALSE
28	GTEx	Heart Left Ventricle	ZNF266	0.25	0.39	lasso	5	0.38	1.2e-21	6.8	-6.8	9.1e-12	-0.73	0.68	0.32	FALSE
29	GTEx	Heart Left Ventricle	ZNF699	0.11	0.09	lasso	3	0.08	7.0e-05	6.9	-7.5	6.5e-14	-0.73	0.26	0.58	TRUE
30	GTEx	Liver	ZNF266	0.31	0.23	lasso	16	0.22	7.3e-07	6.8	-6.2	7.3e-10	-0.73	0.27	0.71	FALSE
31	GTEx	Lung	ZNF266	0.40	0.63	enet	26	0.63	5.1e-61	6.8	-7.0	3.3e-12	-0.74	0.72	0.28	FALSE
32	GTEx	Muscle Skeletal	ZNF266	0.29	0.50	lasso	12	0.50	8.8e-56	6.9	-6.7	1.5e-11	-0.74	0.72	0.28	FALSE
33	GTEx	Nerve Tibial	ZNF266	0.53	0.68	enet	20	0.68	2.5e-64	6.9	-6.6	4.9e-11	-0.74	0.77	0.23	FALSE
34	GTEx	Ovary	ZNF561	0.30	0.17	lasso	4	0.20	1.3e-05	3.0	-5.5	5.1e-08	-0.63	0.13	0.51	FALSE
35	GTEx	Ovary	ZNF266	0.47	0.57	lasso	4	0.56	1.7e-16	7.0	-7.0	2.8e-12	-0.72	0.54	0.46	FALSE
36	GTEx	Pancreas	ZNF266	0.48	0.58	lasso	2	0.60	6.2e-31	6.8	-6.8	7.6e-12	-0.72	0.72	0.28	FALSE
37	GTEx	Pituitary	ZNF266	0.37	0.45	lasso	2	0.43	5.1e-12	6.8	-6.8	7.4e-12	-0.72	0.49	0.51	FALSE
38	GTEx	Prostate	ZNF426	0.33	0.04	lasso	3	0.02	9.0e-02	-5.4	-5.2	1.6e-07	-0.20	0.06	0.06	FALSE
39	GTEx	Prostate	ZNF266	0.49	0.54	lasso	7	0.56	1.2e-16	6.9	-6.9	5.0e-12	-0.73	0.51	0.49	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	ZNF266	0.29	0.42	lasso	5	0.42	4.3e-25	6.9	-7.0	3.5e-12	-0.73	0.68	0.32	FALSE
41	GTEx	Skin Sun Exposed Lower leg	ZNF266	0.42	0.62	lasso	5	0.62	3.4e-65	6.8	-6.8	1.0e-11	-0.72	0.75	0.25	FALSE
42	GTEx	Spleen	ZNF266	0.74	0.62	lasso	9	0.60	6.5e-19	7.0	-7.0	2.4e-12	-0.73	0.64	0.36	FALSE
43	GTEx	Stomach	ZNF266	0.42	0.52	lasso	7	0.51	4.0e-28	6.8	-6.8	8.1e-12	-0.72	0.73	0.27	FALSE
44	GTEx	Testis	ZNF266	0.55	0.61	lasso	8	0.61	3.5e-33	6.8	-6.9	5.2e-12	-0.73	0.71	0.29	FALSE
45	GTEx	Thyroid	ZNF266	0.45	0.67	lasso	8	0.69	1.5e-71	6.8	-6.8	1.5e-11	-0.76	0.75	0.25	FALSE
46	GTEx	Uterus	ZNF266	0.40	0.48	lasso	9	0.47	5.1e-11	6.8	-6.9	6.1e-12	-0.72	0.47	0.52	FALSE
47	GTEx	Vagina	ZNF266	0.44	0.50	enet	18	0.51	1.4e-13	7.0	-7.1	1.5e-12	-0.75	0.46	0.54	FALSE
48	GTEx	Whole Blood	ZNF266	0.28	0.23	lasso	3	0.22	8.1e-20	6.9	-7.0	2.8e-12	-0.73	0.73	0.27	FALSE
49	NTR	Blood	ZNF121	0.02	0.01	enet	11	0.02	2.7e-08	-4.8	-6.0	2.4e-09	-0.45	0.94	0.05	FALSE
50	NTR	Blood	ZNF266	0.08	0.14	lasso	12	0.14	7.7e-43	6.8	-6.0	1.5e-09	-0.72	0.78	0.22	FALSE
51	NTR	Blood	ZNF561	0.01	0.01	bslmm	375	0.01	1.7e-04	3.0	-5.5	4.6e-08	-0.68	0.41	0.54	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	ZNF266	0.42	0.65	lasso	9	0.66	2.2e-115	6.8	-6.4	1.5e-10	-0.72	0.82	0.18	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	CTC-325H20.2	0.07	0.05	lasso	2	0.04	3.4e-06	7.0	6.5	8.1e-11	0.67	0.47	0.53	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF266	0.20	0.32	enet	11	0.32	8.0e-28	7.0	-6.9	5.1e-12	-0.70	0.05	0.95	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF121	0.01	0.01	lasso	1	0.01	6.8e-04	-5.4	-5.4	5.9e-08	-0.23	0.07	0.03	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF266	0.10	0.20	lasso	2	0.19	2.6e-38	6.8	-6.8	7.5e-12	-0.72	0.12	0.88	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZNF266	0.20	0.28	enet	8	0.32	2.0e-16	6.8	-5.9	3.1e-09	-0.74	0.06	0.94	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF121	0.08	0.09	enet	17	0.08	2.1e-05	-5.4	-6.5	7.2e-11	-0.39	0.50	0.26	FALSE
59	The Cancer Genome Atlas	Esophageal Carcinoma	ZNF266	0.16	0.10	blup	50	0.12	1.1e-04	6.8	-7.2	4.1e-13	-0.83	0.04	0.92	FALSE
60	The Cancer Genome Atlas	Glioblastoma Multiforme	ZNF266	0.23	0.26	blup	46	0.24	5.2e-08	6.8	-7.5	4.2e-14	-0.73	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	ZNF559	0.45	0.02	enet	15	0.07	3.6e-03	-1.2	6.5	8.8e-11	0.45	0.02	0.45	TRUE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF266	0.11	0.17	blup	45	0.17	1.4e-18	7.2	-6.8	1.1e-11	-0.79	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF266	0.19	0.28	lasso	5	0.28	5.3e-31	6.8	-6.8	7.7e-12	-0.76	0.07	0.93	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF266	0.14	0.21	enet	25	0.19	2.9e-11	7.0	-6.6	3.9e-11	-0.73	0.04	0.96	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF266	0.27	0.47	lasso	12	0.49	4.9e-64	6.9	-6.9	5.3e-12	-0.72	0.06	0.94	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF426	0.05	0.04	blup	30	0.04	8.7e-06	-5.4	-6.6	3.5e-11	-0.50	0.64	0.28	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF266	0.10	0.11	enet	12	0.12	4.6e-06	6.8	-7.0	3.6e-12	-0.73	0.05	0.95	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF266	0.21	0.27	enet	13	0.27	6.0e-32	6.8	-6.1	1.1e-09	-0.69	0.12	0.88	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF266	0.10	0.24	lasso	4	0.24	2.4e-26	6.9	-6.3	3.5e-10	-0.73	0.07	0.93	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZNF266	0.09	0.07	enet	14	0.08	8.1e-06	6.9	-6.2	5.2e-10	-0.67	0.04	0.96	FALSE
71	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF266	0.35	0.41	lasso	11	0.41	1.1e-18	6.8	-7.0	3.1e-12	-0.74	0.04	0.96	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZNF266	0.23	0.34	lasso	1	0.33	1.2e-13	6.8	-6.8	7.4e-12	-0.72	0.07	0.93	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF266	0.32	0.55	enet	21	0.57	8.0e-72	6.9	-6.3	2.2e-10	-0.73	0.11	0.89	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	ZNF266	0.26	0.13	enet	13	0.15	2.7e-04	7.3	-7.6	3.3e-14	-0.73	0.02	0.72	TRUE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF266	0.11	0.14	lasso	11	0.13	4.0e-08	7.0	-6.9	5.7e-12	-0.75	0.06	0.94	FALSE
76	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZNF266	0.17	0.10	blup	45	0.11	7.5e-04	-3.9	-5.7	9.9e-09	-0.71	0.03	0.86	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF266	0.16	0.20	lasso	6	0.23	5.9e-17	6.9	-5.8	9.0e-09	-0.71	0.06	0.94	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZNF266	0.47	0.35	lasso	7	0.37	6.5e-14	6.8	-6.5	9.5e-11	-0.75	0.06	0.94	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF266	0.25	0.51	enet	22	0.52	3.4e-59	6.9	-6.9	5.1e-12	-0.77	0.09	0.91	FALSE
80	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF266	0.25	0.39	enet	27	0.32	1.2e-09	7.0	-6.6	3.5e-11	-0.78	0.04	0.96	FALSE