Best TWAS P=1.12e-09 · Best GWAS P=1.08e-10 conditioned to 0.406
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SNAP47 | 0.23 | 0.19 | lasso | 7 | 0.19 | 5.7e-23 | -5.4 | 5.8 | 7.8e-09 | -0.33 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Subcutaneous | CDC42BPA | 0.10 | 0.05 | lasso | 5 | 0.02 | 3.6e-03 | 4.7 | -5.9 | 4.4e-09 | 0.65 | 0.35 | 0.58 | FALSE |
3 | GTEx | Brain Cortex | SNAP47 | 0.21 | 0.05 | lasso | 9 | 0.04 | 2.2e-02 | -5.2 | 5.9 | 4.4e-09 | -0.34 | 0.06 | 0.55 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | SNAP47 | 0.17 | 0.12 | enet | 18 | 0.12 | 1.9e-09 | -5.2 | 5.2 | 2.6e-07 | -0.24 | 0.04 | 0.96 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | ADCK3 | 0.23 | 0.12 | lasso | 9 | 0.09 | 3.6e-04 | -4.2 | -5.3 | 1.3e-07 | 0.35 | 0.46 | 0.05 | FALSE |
6 | GTEx | Esophagus Muscularis | ADCK3 | 0.07 | 0.02 | lasso | 5 | 0.01 | 4.1e-02 | 3.9 | -5.4 | 6.8e-08 | 0.49 | 0.09 | 0.67 | FALSE |
7 | GTEx | Muscle Skeletal | SNAP47 | 0.09 | 0.08 | lasso | 10 | 0.08 | 7.7e-08 | -5.4 | 5.5 | 4.8e-08 | -0.30 | 0.02 | 0.98 | FALSE |
8 | GTEx | Testis | SNAP47 | 0.23 | 0.21 | enet | 15 | 0.21 | 7.5e-10 | -5.3 | 5.4 | 7.5e-08 | -0.26 | 0.03 | 0.96 | FALSE |
9 | NTR | Blood | ADCK3 | 0.06 | 0.08 | enet | 9 | 0.08 | 2.5e-23 | 5.5 | 5.3 | 9.2e-08 | -0.45 | 0.49 | 0.51 | TRUE |
10 | YFS | Blood | JMJD4 | 0.11 | 0.12 | lasso | 4 | 0.12 | 3.7e-36 | -5.2 | -5.4 | 5.8e-08 | 0.35 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSEN2 | 0.14 | 0.06 | lasso | 4 | 0.07 | 5.4e-05 | -5.8 | 6.1 | 1.1e-09 | -0.42 | 0.00 | 1.00 | TRUE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNAP47 | 0.05 | 0.05 | lasso | 3 | 0.06 | 2.4e-04 | -5.2 | 5.8 | 8.7e-09 | -0.34 | 0.01 | 0.90 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSEN2 | 0.02 | 0.02 | blup | 51 | 0.02 | 1.6e-03 | -4.3 | 5.3 | 1.1e-07 | -0.39 | 0.02 | 0.72 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNAP47 | 0.08 | 0.06 | blup | 54 | 0.08 | 1.2e-09 | -5.2 | 5.7 | 1.6e-08 | -0.34 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SNAP47 | 0.07 | 0.05 | blup | 54 | 0.05 | 2.9e-03 | -5.2 | 5.9 | 3.9e-09 | -0.31 | 0.01 | 0.67 | TRUE |
16 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNAP47 | 0.03 | 0.02 | enet | 4 | 0.02 | 1.5e-03 | -5.3 | 5.5 | 4.0e-08 | -0.27 | 0.01 | 0.97 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CABC1 | 0.08 | 0.02 | enet | 6 | 0.05 | 6.6e-06 | -5.8 | -5.2 | 1.7e-07 | 0.54 | 0.23 | 0.65 | FALSE |