Hub : Genes

PSEN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.3560	0.0510	0.0e+00	0.374	NA	0.398	NA	0.099	2.1e-29	NA	1.1e-31	NA	6.9e-08
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1500	0.0600	7.0e-03	0.055	NA	0.037	NA	0.045	5.7e-04	NA	4.2e-03	NA	1.7e-03
3	GTEx	Skin Sun Exposed Lower leg	0.0960	0.0400	2.6e-03	0.039	NA	0.015	NA	0.020	3.2e-04	NA	1.8e-02	NA	7.9e-03
4	GTEx	Spleen	0.3240	0.1090	1.9e-03	0.352	NA	0.241	NA	0.339	6.9e-10	NA	7.0e-07	NA	1.6e-09
5	GTEx	Thyroid	0.1060	0.0400	6.4e-04	0.037	NA	0.033	NA	0.003	7.2e-04	NA	1.3e-03	NA	1.7e-01
6	ROSMAP	Brain Pre-frontal Cortex	0.1686	0.0393	3.3e-13	0.140	0.133	0.130	0.146	0.137	1.5e-17	1.1e-16	2.4e-16	2.8e-18	2.8e-17
7	TCGA	Colon Adenocarcinoma	0.1360	0.0580	1.4e-05	0.060	0.064	0.072	NA	0.073	2.2e-04	1.5e-04	5.7e-05	NA	5.4e-05
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0208	0.0118	3.8e-03	0.023	0.021	0.004	NA	0.011	1.1e-03	1.6e-03	1.0e-01	NA	1.8e-02
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0840	0.0500	3.4e-03	0.003	0.039	0.029	NA	0.003	2.0e-01	2.6e-03	8.8e-03	NA	2.1e-01
10	TCGA	Lung Adenocarcinoma	0.0278	0.0162	2.6e-03	0.018	0.025	0.028	NA	0.014	3.4e-03	5.8e-04	2.8e-04	NA	7.8e-03
11	TCGA	Thyroid Carcinoma	0.0360	0.0190	9.1e-04	0.014	0.019	0.020	NA	0.016	1.4e-02	5.7e-03	4.1e-03	NA	9.8e-03
12	TCGA	Uterine Corpus Endometrial Carcinoma	0.1740	0.0860	2.5e-03	0.046	0.104	0.049	NA	0.043	2.0e-02	7.8e-04	1.7e-02	NA	2.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.5	2.1	0.1	0.5	0.1	-0.7	1.5	1.5	0.1	0.6	0.1	0.3	0.7	0.0
Bipolar Disorder or Schizophrenia	1.8	4.3	6.8	2.0	2.3	1.7	-2.4	2.6	1.8	1.5	2.2	2.2	1.7	2.0	2.3
Depressed Affect (Nagel 2018)	2.3	4.9	8.1	2.5	2.2	1.5	-2.4	2.1	2.2	2.0	2.7	1.6	2.9	2.2	1.9
Depression (Nagel 2018)	1.2	1.8	3.1	1.2	1.3	1.1	-1.8	1.2	1.6	0.7	1.6	1.1	1.5	1.6	0.8
Intelligence (Savage-Jansen 2018)	1.0	3.1	5.9	-1.7	-2.2	-1.3	2.3	-1.2	-2.4	-0.9	-1.6	-2.1	-1.5	-1.4	-1.8
Neuroticism (Nagel 2018)	5.2	12.1	16.5	3.9	3.8	3.0	-3.9	3.7	3.3	2.9	4.1	2.8	3.6	3.6	2.9
Schizophrenia (2018)	2.5	5.2	8.9	2.5	2.6	2.0	-2.5	2.2	1.2	1.9	2.4	2.7	2.0	2.0	3.0
Schizophrenia vs Biploar Disorder	0.3	0.3	2.0	0.3	0.3	0.5	-0.2	-0.0	-0.3	-0.3	0.1	1.2	0.0	0.3	1.4
Worry (Nagel 2018)	9.8	20.7	29.2	5.1	4.9	4.1	-5.4	5.0	4.4	3.3	5.2	3.5	4.3	4.7	4.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	0.9	0.9	0.3	-1.1	0.5	0.9	0.7	1.3	1.0	0.8	0.8	0.6
Alzheimer’s Disease (in father)	0.1	0.2	0.7	0.1	-0.1	0.2	-0.2	0.2	0.8	0.3	0.1	-0.6	0.1	0.5	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.9	1.0	0.7	-1.5	0.8	1.1	0.6	1.1	0.7	0.6	1.1	0.2
Crohns Disease (2017)	0.2	0.4	1.4	-0.1	-1.2	-0.4	0.4	-0.8	0.5	0.6	0.4	-0.5	1.1	-0.0	0.3
Irritable Bowel Disease (IBD)	2.7	6.5	13.4	2.8	1.2	1.0	-2.2	2.2	2.1	2.7	3.1	2.1	3.7	2.7	3.4
Ulcerative Colitis (UC)	7.4	13.8	22.2	4.1	2.6	1.8	-3.3	3.9	2.9	3.7	4.2	3.7	4.5	4.2	4.7
Major Depression (MDD)	2.7	3.3	5.3	1.8	2.3	1.4	-2.2	1.4	1.3	1.6	2.1	1.6	1.8	2.2	1.6
Reaction Time	1.0	1.9	4.1	1.2	1.0	1.3	-0.9	0.9	1.8	1.9	1.2	2.0	1.1	1.6	0.6
Verbal and Numeric Reasoning (VNR)	1.5	3.5	8.3	-2.1	-2.9	-1.8	2.6	-1.3	-2.5	-0.5	-1.6	-1.7	-1.2	-1.4	-1.5
Breast Cancer	0.4	1.1	2.1	1.1	1.1	1.0	-1.2	0.9	1.4	0.7	1.1	-0.6	0.8	1.5	0.5
Ovarian Cancer	0.2	0.3	0.6	0.5	0.5	-0.1	-0.6	0.8	0.8	0.8	0.7	0.2	0.4	0.4	0.3
Prostate Cancer	2.7	3.8	6.7	2.0	1.8	1.4	-2.2	2.6	1.9	1.5	2.2	1.5	2.3	1.9	1.6
Age at First Birth	0.5	0.7	2.5	0.7	0.5	1.0	-0.9	1.6	0.5	0.2	0.8	0.4	0.8	0.9	0.6
Bipolar Disorder (2011)	0.7	0.7	2.1	1.0	0.3	0.4	-1.0	0.4	1.4	0.6	1.1	0.1	1.0	0.8	0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.7	0.2	-0.7	-0.7	0.3	0.7	0.2	0.6	0.8	0.5	0.7	0.6
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.4	-0.8	-1.3	1.0	-0.5	-0.5	-0.1	-0.6	-0.2	-1.1	-0.2	-0.9
Crohns Disease (2012)	0.1	0.1	0.4	-0.0	-0.5	0.2	0.1	-0.4	0.5	0.4	0.4	-0.4	0.6	0.2	0.1
Mean Putamen Volume	1.1	1.2	2.1	-1.5	-1.2	-1.2	1.4	-1.3	-1.0	-0.6	-1.4	0.1	-0.7	-1.4	-0.5
Fasting Glucose	0.1	0.1	0.4	0.4	-0.4	-0.6	0.4	0.2	-0.1	0.5	0.2	-0.3	0.2	0.2	-0.1
HbA1C	0.3	0.3	1.8	-0.4	0.5	1.3	0.3	0.6	-0.1	-0.3	-0.4	-0.0	-0.5	-0.2	-0.6
HDL Cholesterol	2.3	3.8	9.3	-1.8	-1.3	-1.0	1.5	-1.4	-1.7	-3.0	-2.5	-1.9	-2.7	-2.0	-1.6
LDL Cholesterol	0.1	0.2	1.0	-0.4	-0.2	-0.2	0.2	0.0	-1.0	-0.4	-0.4	-0.2	-0.0	-0.7	-0.0
Lupus	0.3	0.4	1.4	-0.6	-0.9	-0.6	0.7	1.2	-0.3	-0.7	-0.5	-0.6	-0.4	0.3	-0.6
Neuroticism (2016)	5.6	8.1	11.7	3.1	2.9	1.7	-2.9	2.5	1.8	2.9	3.4	3.3	3.0	2.8	3.2
Primary Biliary Cirrhosis	1.1	1.5	3.0	1.7	0.6	0.3	-1.0	1.3	0.9	1.7	1.3	1.3	1.2	1.4	1.3
Rheumatoid Arthritis	0.6	0.9	2.2	-0.3	-0.5	-1.2	0.6	-0.6	-0.2	-1.5	-1.3	-0.9	-1.3	-0.6	-0.9
Schizophrenia (2014)	2.2	4.9	8.5	2.3	2.4	1.9	-2.5	2.6	1.3	1.4	2.2	2.4	2.0	2.0	2.9
Triglycerides	1.8	2.9	4.6	2.1	1.4	1.3	-1.6	1.8	0.8	2.0	2.0	1.6	2.1	1.6	1.7
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	0.0	-0.5	-0.2	0.0	-0.1	-0.2	0.7	0.5	0.3	0.7	0.3	0.4
Ulcerative Colitis	5.2	7.6	11.6	3.1	1.9	1.3	-2.5	3.1	2.3	2.5	3.0	2.8	3.2	3.4	3.3
Blood Eosinophil Count	1.7	12.9	19.0	3.4	4.4	3.0	-4.0	3.7	3.7	3.4	3.7	3.9	2.9	3.7	2.9
Blood Platelet Count	0.1	1.5	8.4	-0.4	-0.1	1.1	1.1	-0.4	-0.4	2.9	0.6	1.8	0.9	1.3	0.9
Blood Red Count	0.7	6.9	14.8	2.7	3.9	2.7	-3.5	2.9	3.0	1.4	2.7	2.2	1.5	2.0	1.5
Blood White Count	0.1	1.1	3.3	0.3	-0.2	0.2	0.3	-0.6	1.3	1.6	0.4	1.8	1.5	1.4	0.4
Heel T-Score	5.6	44.3	59.4	7.0	7.1	5.9	-7.3	6.8	6.6	6.3	7.7	5.6	6.0	7.2	5.7
BMI	1.4	8.2	13.5	-2.7	-2.1	-2.0	2.7	-2.8	-2.5	-2.9	-3.1	-3.5	-2.8	-3.7	-3.1
Height	0.4	8.1	26.0	2.6	-1.2	-3.4	-0.0	1.9	0.6	5.1	3.3	2.2	3.0	3.3	3.3
Waist Hip Ratio (WHR)	1.7	7.7	12.8	2.9	2.0	1.4	-2.4	3.6	0.9	3.3	3.3	3.1	3.2	2.7	3.1
Systolic Blood Pressure	0.4	2.1	4.9	1.9	2.1	2.2	-1.1	1.1	1.9	1.4	1.4	0.6	0.1	1.3	0.6
Smoking Status	1.6	3.7	12.3	-1.5	-3.3	-3.5	2.6	-1.1	-2.1	-0.2	-1.4	-1.4	-1.0	-1.0	-1.1
Allergy or Eczema	0.4	1.1	2.8	0.6	1.6	1.3	-1.7	1.4	0.8	-0.6	0.6	-0.9	-0.9	0.2	-0.3
Cardiovascular Disease	0.2	0.5	1.8	0.5	0.2	-0.2	0.2	1.2	-0.7	1.2	0.4	1.4	0.5	0.4	0.3
Hypothyroidism (self reported)	2.1	4.9	8.2	1.9	1.9	0.9	-2.4	2.3	1.5	2.0	2.6	2.5	2.9	2.7	2.3
Respiratory disease	0.3	0.8	2.3	-0.1	1.5	1.3	-0.7	0.6	-0.5	-0.6	-0.2	-0.4	-1.0	-0.6	-1.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.1	0.0	-0.4	-0.5	0.4	0.0	-1.0	-0.0	-0.2	1.0	0.3	-0.7	0.8
Lung FEV1/FVC ratio	1.9	9.8	23.3	-3.5	-3.3	-3.4	3.9	-3.2	-4.8	-1.2	-3.0	-0.7	-2.7	-3.7	-1.7
Lung FVC	0.4	2.2	4.4	-1.9	-1.9	-1.6	1.5	-1.1	-0.5	-2.1	-1.8	-1.3	-1.5	-1.2	-0.5
Neuroticism	7.3	17.5	24.5	4.7	4.4	3.1	-4.6	5.0	3.3	3.4	4.8	3.7	4.4	4.3	4.1
Chronotype (morning person)	2.4	5.4	8.0	-2.8	-2.6	-2.1	2.6	-1.9	-1.7	-2.6	-2.5	-2.0	-2.6	-2.5	-1.7
Hair Pigment	0.6	18.3	29.6	-4.8	-5.1	-3.8	4.8	-5.4	-4.4	-3.9	-4.5	-3.0	-3.1	-4.4	-3.2
Tanning	0.6	6.8	15.4	1.9	3.9	3.9	-3.7	3.3	1.5	0.3	2.0	1.9	2.1	2.1	1.8
Hand grip strength (left)	1.6	4.3	7.7	-2.8	-2.5	-1.6	2.5	-2.6	-1.1	-1.7	-2.4	-1.1	-2.2	-1.9	-1.5
Number of treatments/medications taken	0.6	1.1	2.3	1.5	1.2	0.9	-0.9	1.0	0.4	1.3	1.0	1.1	1.1	1.0	0.2
Average weekly spirits intake	0.4	0.5	1.3	-0.8	-0.4	0.0	1.1	-0.2	-1.0	-0.0	-0.5	-1.0	-0.7	-0.8	-1.0
Sensitivity / hurt feelings	0.1	0.2	0.9	0.3	0.4	-0.3	-0.4	1.0	0.2	-0.0	0.4	-0.6	-0.1	0.3	-0.5
Frequency of depressed mood in last 2 weeks	2.5	3.5	5.7	2.0	1.0	0.8	-1.5	2.4	1.0	2.1	2.4	1.8	2.3	2.2	2.0
Hearing difficulty/problems: Yes	0.7	1.1	2.6	1.4	1.4	1.1	-1.6	1.4	0.1	0.2	1.2	0.4	1.0	0.6	0.5
Relative age of first facial hair	2.2	4.5	7.2	-2.5	-2.1	-2.1	1.6	-2.3	-0.7	-2.7	-2.2	-2.0	-2.0	-2.3	-2.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.6	-0.1	-1.0	-0.3	0.2	-0.5	0.6	0.5	0.5	0.5	0.5	0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.8	-0.2	-0.2	-0.1	0.3	0.0	-0.3	-0.4	-0.4	-1.7	-0.8	-0.2	-1.4
Ever had hysterectomy (womb removed)	2.2	2.5	4.0	-1.6	-1.6	-1.5	2.0	-1.9	-2.0	-0.8	-1.4	-1.2	-1.5	-1.5	-1.6
Systolic blood pressure, automated reading	0.3	1.0	3.3	1.2	1.8	1.7	-0.8	0.6	1.0	0.9	0.8	0.2	0.3	0.6	0.2
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	5.4	-1.4	-1.8	-2.3	1.6	-1.5	-2.0	-0.8	-1.4	0.4	-1.3	-1.6	-0.2
Angina	0.3	0.4	1.8	-0.2	-0.7	-0.3	0.8	-0.4	-1.3	0.9	0.4	0.3	0.6	-0.4	0.4
Medication for hormone replacement therapy	0.9	1.0	2.1	1.1	1.3	1.3	-1.0	1.5	1.0	0.9	0.9	0.4	0.2	1.3	0.4
Vitamin and mineral supplements	0.2	0.2	0.9	-0.2	-0.8	-0.9	0.7	-0.0	0.2	0.3	-0.1	-0.2	0.2	-0.8	0.2
Supplements: Zinc	1.0	1.0	2.4	1.1	1.0	0.8	-1.0	1.3	0.2	0.7	0.8	1.2	1.1	0.9	1.5
Medication: Co-codamol	0.4	0.4	2.7	0.0	-0.8	-1.6	0.4	0.0	-0.8	-0.0	-0.3	0.4	0.3	-0.7	0.2
Medication: Metformin	1.6	2.3	5.6	-1.3	-1.9	-2.4	1.5	-1.3	-1.8	-1.5	-1.5	-0.2	-0.6	-1.9	-0.6
Diabetes (father)	0.4	0.5	1.1	-0.6	-1.0	-0.4	1.1	-0.3	-0.5	-0.3	-0.5	-0.7	-0.9	-0.6	-0.8
Diabetes (mother)	0.2	0.2	1.3	0.3	-0.1	-0.2	-0.4	1.1	0.5	-0.7	0.1	-0.1	0.0	0.1	0.3
Severe depression (siblings)	0.4	0.5	1.3	1.0	0.8	0.5	-0.9	1.1	0.8	-0.1	0.4	0.5	0.0	0.7	-0.1
Pack years adult smoking proportion	0.8	1.2	3.5	0.9	1.0	1.7	-1.2	0.5	1.1	0.6	1.1	0.7	1.9	1.0	0.7
Impedance of leg (right)	4.3	21.0	41.3	4.9	4.1	4.1	-3.9	4.5	2.2	6.4	5.4	4.2	5.1	4.7	4.0
Leg fat-free mass (left)	1.5	7.9	19.4	-2.9	-4.0	-4.4	3.5	-2.8	-2.0	-1.9	-2.7	-1.9	-2.2	-2.5	-1.5
Trunk fat percentage	0.1	0.4	2.1	-0.5	-0.2	-0.3	0.7	-0.8	-1.4	1.1	0.1	-0.2	0.3	-0.5	-0.5
Hand grip strength (right)	2.2	5.9	10.8	-2.9	-2.8	-1.9	2.8	-3.3	-1.3	-1.8	-2.6	-1.9	-2.7	-2.2	-2.4
Townsend deprivation index at recruitment	0.1	0.2	1.5	-0.1	-0.0	0.2	0.1	1.2	-0.7	-0.1	-0.1	-0.4	-0.4	-0.1	-0.3
Current tobacco smoking	0.8	1.3	3.0	-1.3	-1.7	-1.6	1.4	-1.7	-0.4	-0.7	-1.0	-0.7	-0.4	-0.9	-0.6
Average weekly fortified wine intake	1.5	1.7	4.2	-0.8	-1.1	-0.1	0.9	-1.0	-0.8	-2.0	-1.5	-1.9	-1.4	-1.3	-1.5
Maternal smoking around birth	6.3	9.1	11.5	-3.4	-3.0	-2.5	3.0	-3.1	-2.4	-2.8	-3.1	-3.0	-3.0	-3.4	-3.3
Fed-up feelings	1.7	3.0	6.9	1.9	1.1	0.5	-1.4	1.6	1.0	2.4	2.4	1.6	2.6	1.4	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.9	1.0	1.0	0.9	-1.4	1.3	1.2	0.9	1.5	1.7	1.4	1.7	1.3
Relative age voice broke	0.3	0.5	1.5	-0.7	-0.4	-0.2	0.1	-1.2	0.5	-0.9	-0.3	-0.8	-0.2	-0.8	-1.2
Taking other prescription medications	0.5	0.8	1.6	1.2	0.5	-0.4	-0.6	1.1	0.3	1.3	1.1	0.7	1.0	0.9	0.5
Age when periods started (menarche)	0.1	0.1	0.8	-0.1	0.2	0.9	0.3	-0.6	-0.2	0.1	-0.4	0.4	0.2	-0.0	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-0.9	-0.6	-0.3	1.1	-0.5	-1.4	-0.7	-1.0	-0.8	-1.3	-1.1	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	8.0	18.2	25.5	4.9	4.4	2.6	-4.8	4.2	3.4	4.0	5.0	4.0	4.5	4.6	4.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	-0.0	-0.1	-0.1	0.2	0.2	-0.7	0.5	0.3	0.9	1.1	0.0	0.7
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.3	-0.1	0.4	0.1	-0.4	-0.3	-0.0	-0.3	-0.3	-0.5	0.1	-0.1
Serious illness, injury or assault to yourself	0.6	0.7	2.6	-0.0	-1.3	-1.6	0.6	-0.9	-0.9	-0.7	-0.4	-0.9	-0.3	-0.8	0.2
High blood pressure	0.7	2.0	5.1	-1.2	-1.1	-1.0	1.8	-0.7	-2.3	-1.0	-1.6	-0.9	-1.3	-1.7	-1.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.0	0.4	1.4	1.4	-1.4	1.1	0.4	-0.9	0.2	-0.4	-0.8	0.1	-0.3
Multivitamins +/- minerals	0.3	0.4	1.7	-0.5	0.3	0.8	-0.0	-1.3	-0.3	-0.8	-0.6	-0.3	-0.7	0.1	-0.9
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	-0.3	-0.2	0.5	0.1	-0.2	-0.1	-0.2	0.0	-0.1	-0.1	0.4
Supplements: Glucosamine	0.3	0.3	2.0	-0.4	-0.4	0.1	0.8	-1.4	-0.5	0.7	-0.2	-0.0	-0.1	0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.0	-0.6	-1.0	-1.7	1.2	-1.1	-2.0	0.1	-0.9	0.5	-0.5	-0.6	-0.6
Medication: Atenolol	0.2	0.2	0.8	0.3	-0.2	0.2	0.8	-0.2	-0.6	-0.2	-0.4	-0.9	-0.5	-0.4	-0.7
Medication: Levothyroxine sodium	4.4	7.4	11.6	2.5	2.3	1.4	-2.8	2.8	2.1	2.5	2.9	3.0	3.2	3.4	3.0
Sitting height	0.3	2.0	4.0	1.1	-0.5	-0.8	-0.3	1.4	1.8	1.9	1.6	1.0	1.5	2.0	1.9
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-0.7	-0.4	0.8	0.6	-0.4	-0.2	-0.9	-0.7	-0.5	-0.4	-1.1	-0.5
High blood pressure (mother)	0.9	1.2	2.7	-0.6	-0.8	-0.7	1.2	-0.1	-1.4	-1.2	-1.3	-1.4	-1.6	-1.2	-0.7
Body mass index (BMI)	2.3	9.7	12.4	-3.2	-3.0	-3.0	3.2	-3.3	-3.1	-2.8	-3.1	-3.3	-2.7	-3.5	-3.1
Impedance of leg (left)	4.3	20.9	37.1	4.9	4.4	4.4	-4.2	4.5	2.4	6.1	5.3	4.2	4.8	4.9	3.8
Leg predicted mass (left)	1.5	7.7	19.4	-2.9	-4.0	-4.4	3.5	-2.8	-2.0	-1.9	-2.6	-1.8	-2.1	-2.4	-1.4
Trunk fat mass	0.4	1.5	3.3	-1.2	-1.4	-1.7	1.7	-1.5	-1.8	0.6	-0.6	-0.8	-0.2	-1.0	-1.0
Waist circumference	0.5	1.9	4.5	-1.2	-1.7	-2.1	1.6	-1.4	-1.8	-0.5	-1.1	-1.2	-0.6	-1.2	-1.0
Number of incorrect matches in round	1.3	2.2	3.5	1.4	1.4	0.7	-1.4	1.7	1.9	1.5	1.6	1.5	1.5	1.4	1.5
Past tobacco smoking	1.1	2.1	7.2	0.8	2.3	2.7	-2.1	0.2	2.0	-0.2	1.1	0.8	0.9	0.7	0.8
Alcohol usually taken with meals	0.2	0.4	1.3	0.4	1.1	1.1	-0.6	0.8	-0.4	0.3	0.4	-0.6	-0.3	0.3	-0.0
Nervous feelings	6.7	12.5	16.8	4.1	3.8	3.5	-4.1	3.4	3.5	3.0	4.1	2.4	3.4	3.4	3.2
Frequency of tenseness / restlessness in last 2 weeks	4.1	6.3	13.3	2.6	2.0	1.4	-2.8	3.6	2.3	2.0	2.9	2.3	2.5	2.6	2.6
Hearing difficulty/problems with background noise	1.6	2.6	4.7	1.9	2.0	2.2	-1.7	1.9	1.0	1.0	1.5	1.5	1.1	1.6	1.4
Hair/balding pattern: Pattern 2	0.5	0.6	2.3	1.0	0.2	-0.3	-0.7	0.3	-0.3	1.5	1.1	0.5	0.5	0.7	0.9
Had menopause	2.3	2.9	4.5	1.8	1.4	1.6	-1.8	1.6	1.3	1.9	2.1	1.0	2.1	1.8	1.5
Had other major operations	1.5	1.9	6.5	-1.1	-1.8	-2.1	1.5	-0.7	-2.6	-0.5	-1.1	-0.2	-1.1	-1.1	-0.2
Forced vital capacity (FVC)	0.1	0.5	2.2	0.0	-0.7	-0.5	-0.0	0.2	1.3	0.7	0.5	0.6	0.4	0.6	1.5
Heel bone mineral density (BMD) T-score, automated (right)	7.4	16.9	23.0	4.6	4.6	3.5	-4.7	3.7	3.3	3.8	4.8	3.8	4.3	4.1	4.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	1.1	0.2	0.2	-0.5	0.8	-0.1	0.9	1.0	0.7	1.2	0.8	1.1
Qualifications: None of the above	1.1	2.4	5.4	1.3	1.2	0.5	-1.2	1.6	1.6	1.4	1.6	2.3	1.9	1.2	1.9
Financial difficulties in last 2 years	0.2	0.3	0.6	0.8	0.2	-0.6	-0.6	0.2	0.1	0.6	0.7	0.6	0.4	0.5	0.3
Mouth/teeth dental problems	0.5	0.8	2.6	-0.3	1.0	1.6	-0.4	-0.7	1.2	-1.0	-0.3	-1.3	-0.8	-0.5	-0.8
Heart attack	0.7	0.9	2.0	-0.4	-1.4	-1.4	1.4	-1.0	-1.1	0.2	-0.6	-0.7	-0.6	-0.8	-0.6
Allergy	0.6	1.3	3.7	0.2	-1.1	-0.9	0.9	-0.3	-0.3	1.9	0.7	1.2	1.8	0.7	1.9
Pain all over the body in last month	0.9	1.0	1.6	-1.1	-1.3	-1.3	0.8	-1.1	0.7	-1.0	-0.8	-1.1	-0.7	-0.6	-1.2
Diabetes (self-reported)	0.4	0.7	1.9	-0.6	-1.1	-1.3	0.7	-0.6	-0.5	-1.4	-0.8	0.5	-0.2	-0.8	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.0	-0.9	1.2	1.2	-0.4	-0.6	-0.0	-1.7	-0.8	-0.9	-1.6	-0.9	-1.0
Medication: Ramipril	0.3	0.3	0.6	0.3	-0.3	-0.6	0.8	0.6	-0.6	-0.3	-0.6	-0.3	-0.6	-0.8	-0.7
Medication: Simvastatin	0.4	0.6	2.4	-0.8	-1.0	-1.2	1.0	-0.3	-1.5	0.2	-0.4	0.6	0.2	-0.7	-0.1
Fluid intelligence score	1.2	2.4	4.4	-1.9	-2.1	-1.3	1.7	-1.2	-2.0	-0.9	-1.5	-1.7	-1.3	-1.2	-1.3
Illnesses of siblings	1.4	2.0	4.7	1.3	0.8	1.3	-1.2	0.4	1.4	1.3	1.3	1.6	2.2	1.6	1.9
Neuroticism score	6.7	14.1	22.2	4.4	3.9	3.0	-4.1	4.7	3.2	3.1	4.2	3.0	3.8	3.7	3.5
Weight	1.0	4.7	11.7	-2.0	-3.0	-3.4	2.7	-2.2	-2.3	-0.7	-1.7	-1.9	-1.3	-1.8	-1.5
Impedance of arm (right)	5.2	24.1	31.2	5.1	5.3	5.5	-4.8	4.2	3.3	5.6	5.3	5.2	4.7	4.8	4.7
Arm fat percentage (right)	0.4	1.4	3.1	-1.2	-0.7	-0.7	1.1	-1.8	-1.7	-0.5	-0.9	-1.2	-0.7	-1.6	-1.3
Trunk fat-free mass	1.1	6.3	18.9	-2.3	-3.9	-4.3	3.1	-2.2	-1.6	-1.4	-2.1	-2.1	-1.6	-1.8	-1.4
Hip circumference	1.6	6.9	12.0	-2.6	-3.1	-3.2	3.0	-3.5	-2.5	-1.7	-2.5	-2.2	-2.0	-2.6	-1.9
Time employed in main current job	0.7	0.8	2.2	-0.4	-0.3	-0.3	0.7	-0.2	-0.6	-1.1	-1.5	-0.6	-1.4	-0.6	-1.4
Alcohol intake versus 10 years previously	2.1	3.2	6.6	2.2	2.4	2.6	-2.4	1.9	1.7	0.5	1.7	0.6	1.1	1.2	1.7
Father’s age at death	0.1	0.2	0.5	-0.7	-0.3	0.3	0.0	0.5	-0.4	-0.5	-0.4	0.4	0.1	-0.5	0.1
Worrier / anxious feelings	5.0	9.5	14.1	3.3	3.8	2.8	-3.4	3.5	3.1	2.2	3.3	2.6	2.7	2.9	3.0
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	4.9	1.9	0.8	-0.3	-1.6	2.1	0.7	1.7	2.0	1.5	2.2	1.6	1.9
Falls in the last year	0.1	0.1	0.9	-0.1	-0.4	-0.9	-0.0	-0.2	0.4	0.2	0.0	0.4	0.1	-0.3	0.3
Hair/balding pattern: Pattern 3	0.2	0.4	2.3	-0.1	0.6	1.5	-0.1	-0.5	1.1	0.1	-0.0	0.4	0.2	0.2	-0.2
Number of live births	2.0	2.8	6.7	-1.6	-2.6	-2.6	1.7	-1.7	-1.5	-1.6	-1.7	-1.0	-1.2	-1.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.8	-1.3	-1.9	-1.6	1.4	-0.7	-0.5	-0.3	-0.8	-0.1	-0.8	-0.7	0.4
Pulse rate	0.1	0.2	1.0	0.5	0.3	0.3	-0.7	0.3	1.0	0.1	0.5	-0.2	0.1	0.4	0.3
Happiness	0.3	0.3	1.6	0.7	-0.1	0.6	-0.4	0.5	-0.2	0.5	0.7	-0.3	0.7	0.2	1.2
Noisy workplace	0.6	0.8	1.4	0.8	0.6	1.2	-0.5	-0.5	0.9	1.0	0.6	1.1	1.0	0.7	0.9
Qualifications: A levels/AS levels or equivalent	1.5	3.3	8.2	-1.4	-0.8	0.1	1.2	0.9	-1.2	-2.5	-2.0	-2.9	-2.7	-1.9	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.3	-1.5	-1.0	-1.0	0.9	-0.4	-1.8	-2.1	-1.4	-1.7	-1.1	-1.8	-1.0
Mouth/teeth dental problems: Dentures	6.5	11.0	21.5	-3.3	-4.6	-4.5	4.0	-3.5	-3.6	-1.8	-3.3	-1.4	-2.6	-2.8	-2.8
Asthma	0.5	1.0	3.8	0.8	2.0	1.6	-1.4	1.2	0.6	-0.1	0.5	-0.3	-0.4	0.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.6	-0.7	-0.2	0.1	0.9	-0.5	-0.2	-1.0	-1.1	-1.5	-1.3	-1.5	-1.6
Medication: Cholesterol lowering	0.3	0.5	1.8	0.1	0.8	0.8	-0.1	0.6	-0.9	1.0	0.4	1.4	0.4	-0.0	0.3
Depression (self-reported)	0.9	1.1	2.4	1.2	1.1	1.2	-1.1	1.1	0.1	1.4	1.5	0.5	1.1	1.1	0.0
Medication: Lansoprazole	1.3	1.5	3.5	-1.0	-0.8	-0.6	1.1	0.0	-1.9	-1.1	-1.2	-1.6	-1.6	-1.6	-0.8
Prospective memory result	0.2	0.3	0.7	-0.2	-0.7	-0.7	0.8	-0.6	-0.9	0.6	0.0	-0.0	-0.3	-0.2	0.2
Lung cancer (father)	2.7	3.2	6.8	-1.8	-2.6	-1.8	1.9	-2.2	-1.7	-1.4	-1.6	-1.7	-1.4	-1.4	-1.6
Illnesses of mother	0.2	0.3	0.8	-0.2	0.1	0.9	-0.3	-0.0	0.6	0.7	0.2	0.7	0.7	0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.6	-0.1	-0.6	-0.7	0.1	0.4	0.1	0.6	0.4	0.7	0.3	0.2	1.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	-0.4	-0.7	-0.8	0.9	-0.8	-0.1	0.7	-0.2	-0.4	0.3	-0.2	-0.4
Impedance of arm (left)	3.8	17.5	24.1	4.3	4.3	4.5	-3.9	3.7	2.7	4.9	4.5	4.6	4.1	4.1	4.1
Arm fat mass (right)	1.0	4.3	6.6	-2.1	-2.3	-2.6	2.4	-2.3	-2.5	-1.0	-1.8	-1.9	-1.5	-2.2	-1.7
Trunk predicted mass	1.1	6.5	18.7	-2.4	-3.9	-4.3	3.1	-2.3	-1.7	-1.4	-2.1	-2.1	-1.7	-1.8	-1.4
Standing height	0.6	6.2	18.7	2.2	-0.5	-1.3	-0.5	1.9	1.1	4.3	2.8	2.6	2.9	3.2	3.2
Length of working week for main job	0.8	0.9	2.2	-0.9	-1.0	-1.0	1.2	-0.6	-1.5	0.4	-0.9	-0.1	-1.0	-0.7	-1.3
Exposure to tobacco smoke at home	0.2	0.2	0.9	0.4	0.4	0.3	-0.7	1.0	0.4	-0.1	0.6	-0.4	0.1	0.3	-0.1
Breastfed as a baby	2.8	3.5	7.2	1.9	2.5	1.9	-2.4	1.7	2.0	0.9	1.6	1.5	1.2	2.7	1.3
Tense / ‘highly strung’	6.7	11.0	19.2	3.8	3.4	2.8	-3.5	4.4	2.8	2.8	3.8	2.6	3.0	3.3	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	6.3	9.7	17.9	3.4	3.1	1.9	-3.5	4.2	2.4	2.7	3.5	2.4	3.0	3.5	2.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.9	-0.9	-0.6	-0.9	1.0	-0.8	-0.7	-0.1	-1.1	-0.7	-0.7	-0.6	-1.4
Birth weight of first child	1.6	2.8	7.8	-2.0	-1.8	-2.8	1.6	-1.4	-0.7	-2.1	-1.8	-0.5	-1.4	-1.5	-1.3
Peak expiratory flow (PEF)	2.3	5.4	9.4	-2.6	-3.1	-2.5	2.6	-1.8	-2.5	-1.8	-2.5	-2.1	-2.6	-2.2	-1.1
Pulse wave reflection index	1.1	1.4	5.3	-1.0	-1.8	-2.3	1.7	-1.3	-0.9	0.1	-0.9	-0.1	-0.7	-0.5	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	0.7	0.2	0.4	-0.3	0.8	-0.3	0.7	0.6	0.6	0.3	0.6	0.6
Loud music exposure frequency	0.4	0.5	1.3	-0.4	-1.1	-1.0	0.9	-0.7	-1.1	-0.2	-0.4	0.1	0.2	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	2.2	0.4	0.6	0.6	-0.6	1.5	0.7	-0.3	0.2	-1.3	-0.8	0.2	-0.6
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	6.8	1.8	1.4	0.9	-1.9	2.6	0.8	1.1	1.6	1.2	1.4	1.7	1.2
Blood clot in the leg (DVT)	0.2	0.3	0.9	0.6	0.6	0.6	-0.6	0.2	0.8	0.2	0.6	0.2	0.5	1.0	0.2
Medication: Paracetamol	0.5	0.9	2.1	1.2	1.4	1.3	-1.1	0.5	1.3	0.9	0.8	0.1	0.8	0.7	0.2
Headache pain in last month	4.7	8.0	10.3	3.2	3.2	3.1	-2.9	2.1	2.8	2.4	3.0	2.2	3.1	2.8	3.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.6	0.8	0.5	0.5	-1.2	0.0	1.2	-0.4	0.7	-0.3	0.4	0.9	0.8
Glaucoma (self-reported)	0.1	0.2	0.5	0.6	-0.0	-0.0	-0.2	0.5	-0.3	0.2	0.4	0.4	0.4	0.2	0.7
Gout (self-reported)	0.1	0.2	0.6	-0.3	-0.4	-0.1	-0.2	-0.6	0.5	-0.8	-0.1	-0.3	-0.6	0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	3.7	7.3	12.9	2.2	2.2	1.4	-2.8	2.6	2.1	2.4	3.0	3.0	3.6	3.4	2.9
Medication: Amlodipine	0.6	0.8	1.7	-1.1	-0.9	-0.4	1.3	-0.1	-0.8	-0.6	-1.2	-0.3	-0.7	-1.2	-1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.3	1.5	1.8	1.3	-1.8	1.4	0.6	-0.2	0.9	0.6	0.6	1.0	0.8
Birth weight	0.3	0.5	2.1	-0.3	-0.6	-1.0	0.0	-0.8	0.3	-0.5	-0.2	1.4	0.7	0.3	1.2
Chronic bronchitis/emphysema (mother)	2.2	2.6	10.8	-1.1	-1.8	-3.3	1.5	-1.6	-1.2	-1.2	-1.4	-0.5	-1.9	-1.0	-1.2
High blood pressure (siblings)	0.3	0.5	2.1	-0.3	-0.2	-0.6	0.3	0.5	-0.9	-0.6	-0.5	-0.8	-1.4	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	4.2	1.0	0.3	0.1	-1.1	1.5	1.6	1.4	1.4	1.3	1.2	1.4	2.0
Body fat percentage	0.2	0.7	2.6	-0.7	-0.5	-0.6	1.0	-1.1	-1.6	0.7	-0.2	-0.6	0.1	-0.8	-0.9
Leg fat percentage (right)	0.4	1.4	3.7	-1.0	-1.0	-0.9	1.4	-1.3	-1.9	0.4	-0.6	-1.3	-0.2	-1.3	-1.3
Arm fat-free mass (right)	1.7	8.9	24.6	-3.1	-4.4	-5.0	3.7	-2.5	-2.2	-1.6	-2.6	-2.4	-2.1	-2.2	-2.0
Exposure to tobacco smoke outside home	0.1	0.2	0.6	-0.8	-0.6	-0.2	0.5	-0.6	0.2	0.2	-0.1	0.5	0.0	0.1	-0.7
Comparative body size at age 10	0.2	0.6	2.5	-0.9	-1.2	-1.2	0.8	-0.3	-0.0	-0.4	-0.3	-1.6	-0.1	-0.1	-0.6
Number of full brothers	0.2	0.3	1.5	-0.3	0.2	-0.6	-0.0	0.0	1.2	0.2	0.2	1.1	0.4	0.3	0.1
Worry too long after embarrassment	2.6	4.4	6.2	2.5	2.5	2.3	-2.4	2.4	1.6	1.8	2.1	1.7	1.3	2.2	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	4.1	5.3	9.3	2.7	2.4	1.9	-2.7	3.0	2.2	1.3	2.4	1.8	2.4	2.1	2.0
Wheeze or whistling in the chest in last year	0.1	0.2	1.0	0.0	0.1	-0.2	-0.1	0.5	0.0	-0.3	-0.1	-0.8	-0.5	-0.2	-1.0
Number of children fathered	0.2	0.2	0.5	-0.2	0.6	-0.1	-0.4	-0.7	0.5	0.1	-0.1	0.7	0.4	-0.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.6	0.9	0.8	0.1	-0.6	0.4	1.0	1.6	1.0	0.6	0.5	1.2	0.3
Age at first live birth	0.7	1.2	5.9	0.6	1.8	2.4	-1.1	1.7	0.4	0.0	0.1	-0.1	-0.4	-0.0	-0.6
Pulse wave peak to peak time	0.3	0.4	1.0	0.7	0.7	0.8	-1.0	1.0	0.2	-0.2	0.5	0.6	0.0	0.5	0.6
Health satisfaction	1.4	1.8	3.2	-0.6	-1.6	-1.0	1.6	-1.6	-1.7	-0.4	-1.1	-1.8	-1.5	-1.5	-0.7
Shortness of breath walking on level ground	3.9	4.6	7.5	2.5	1.6	1.0	-1.9	1.8	1.7	2.5	2.4	2.2	2.7	2.4	2.4
Qualifications: College or University degree	0.2	0.7	3.4	0.1	1.1	1.3	-0.7	1.9	0.9	-0.1	0.0	-0.1	-0.0	0.8	0.3
Eye problems/disorders: None of the above	0.7	0.8	1.7	-0.8	-0.6	-0.3	0.9	-1.1	-0.3	-1.2	-1.3	-0.9	-1.2	-0.8	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.2	0.2	0.5	0.8	-0.7	1.5	-0.1	0.1	0.7	-0.2	0.3	0.3	-0.3
Emphysema/chronic bronchitis	1.2	1.4	2.7	-0.9	-1.2	-1.2	1.3	-0.8	-1.6	-1.2	-1.4	0.1	-0.9	-1.1	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.6	2.8	-0.9	-0.5	0.2	0.1	0.1	-0.8	-1.7	-0.7	-1.2	-0.5	-0.4	-0.6
Neck or shoulder pain in last month	0.2	0.3	1.6	0.2	0.4	-0.3	-0.2	0.5	0.1	0.7	0.4	1.3	0.4	0.1	0.5
Medication: Blood pressure	0.7	1.3	2.9	-1.2	-0.8	-0.6	1.4	-0.4	-1.4	-0.8	-1.3	-0.9	-1.2	-1.3	-1.7
Angina (self-reported)	0.3	0.4	1.7	-0.2	-0.7	-0.3	0.7	-0.3	-1.3	0.9	0.5	0.3	0.7	-0.3	0.5
Migraine (self-reported)	0.4	0.5	1.5	0.3	0.4	1.2	-0.3	-1.0	1.2	0.3	0.3	-0.2	0.2	0.8	-0.6
Medication: Ibuprofen	1.4	1.7	3.3	-1.2	-0.8	-0.0	1.2	-1.0	-0.2	-1.5	-1.5	-1.7	-1.4	-1.7	-1.8
Medication: Allopurinol	0.3	0.4	1.0	-0.8	-0.8	-0.7	0.2	-0.4	-0.1	-1.0	-0.5	-0.3	-0.7	0.0	-0.7
Medication: Omeprazole	0.6	0.7	2.1	1.2	-0.2	-0.0	-0.3	0.6	0.2	1.5	0.9	0.5	0.8	1.2	1.0
Medication: Seretide 50 evohaler	0.9	1.1	3.0	0.9	0.9	0.9	-0.7	0.2	0.1	1.7	1.2	1.2	1.4	1.0	0.9
Mean time to correctly identify matches	3.3	6.3	9.7	2.6	1.9	1.6	-2.1	2.5	2.6	3.1	2.7	3.0	2.5	3.0	1.9
Heart disease (mother)	0.2	0.2	0.5	0.7	-0.5	-0.3	0.2	0.3	-0.6	0.6	0.6	-0.5	0.7	-0.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	3.6	-0.4	-0.2	0.1	0.4	-1.1	-0.2	-1.5	-1.0	-1.9	-0.9	-1.7	-1.1
Whole body fat mass	0.7	2.9	5.1	-1.7	-2.0	-2.3	2.1	-2.0	-2.1	-0.2	-1.3	-1.4	-0.9	-1.6	-1.6
Leg fat mass (right)	1.0	4.0	7.3	-1.9	-2.5	-2.7	2.5	-2.2	-2.5	-0.2	-1.4	-1.8	-1.0	-2.0	-1.7
Arm predicted mass (right)	1.6	8.2	22.5	-2.9	-4.2	-4.7	3.5	-2.4	-1.9	-1.7	-2.5	-2.4	-2.1	-2.1	-1.9
Pulse rate, automated reading	1.4	4.6	12.5	-2.3	-3.5	-3.5	2.8	-2.4	-1.8	-0.1	-1.5	-0.8	-1.3	-1.7	-0.8
Alcohol intake frequency.	0.7	1.7	3.8	1.8	1.3	0.3	-1.3	1.1	0.9	0.6	1.1	1.3	1.1	1.5	2.0
Comparative height size at age 10	1.4	7.9	30.0	2.4	-0.5	-1.5	-0.4	1.8	0.1	5.5	3.1	3.4	3.3	3.3	3.0
Number of full sisters	0.3	0.4	1.3	-0.7	-0.2	0.4	0.2	0.5	-0.6	-0.6	-0.5	-0.9	-1.1	-0.5	-0.8
Suffer from ‘nerves’	1.3	2.0	4.9	1.7	1.0	0.8	-1.6	2.2	0.9	0.9	1.8	1.1	1.2	1.3	1.5
Overall health rating	0.8	1.7	3.7	1.4	0.6	-0.4	-1.0	1.3	0.9	1.4	1.5	1.9	1.4	1.6	1.6
Chest pain or discomfort	0.5	0.7	1.6	1.0	1.1	1.1	-0.7	1.3	0.6	1.1	0.7	0.9	0.6	0.6	0.2
Had major operations	0.3	0.4	1.2	0.4	1.1	1.1	-0.5	-0.1	0.9	0.1	0.3	1.0	0.3	0.3	-0.1
Age at last live birth	0.3	0.5	2.3	0.7	0.7	1.5	-0.5	1.3	0.4	-0.2	-0.1	0.2	-0.2	0.1	0.0
Family relationship satisfaction	1.9	2.3	5.0	1.4	1.0	0.8	-1.8	0.9	1.6	1.0	2.0	1.4	2.0	1.3	2.2
Leg pain on walking	2.6	3.3	5.0	-1.7	-1.7	-0.8	2.2	-1.8	-2.2	-1.1	-2.0	-2.1	-2.0	-1.8	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	-0.5	-0.4	-0.3	0.4	-1.2	-1.0	-0.9	-0.7	-1.0	-1.2	-0.7	-1.1
Commuting to job workplace: Car/motor vehicle	3.8	4.4	10.4	-2.2	-1.9	-2.3	2.0	-3.2	-2.3	-1.1	-1.8	-1.7	-1.1	-2.4	-2.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	2.6	-1.4	-1.1	-1.2	1.4	-1.3	0.3	-1.0	-1.6	-0.5	-1.4	-1.2	-1.4
Medication: Aspirin	0.6	0.8	3.3	0.8	1.0	0.4	-0.6	-0.1	0.7	1.0	0.8	1.8	1.0	0.6	0.7
Supplements: Vitamin C	0.7	0.9	2.2	0.7	1.0	0.8	-0.9	1.5	-0.4	1.2	0.8	1.0	0.7	1.1	0.5
Knee pain experienced in last month	0.3	0.5	1.1	-0.9	-0.7	-0.8	1.0	-1.0	-0.4	-0.1	-0.5	-0.3	-0.6	-0.7	-0.7
Hypertension (Self-reported)	1.0	2.7	5.8	-1.4	-1.3	-1.2	2.0	-1.0	-2.4	-1.2	-1.9	-1.2	-1.4	-1.9	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.1	1.4	0.8	0.4	-0.7	1.8	0.8	1.4	1.1	-0.1	0.1	1.1	0.5
Illnesses of father: Heart disease	1.0	1.4	2.8	-1.3	-1.2	-0.6	1.4	-0.7	-1.1	-0.6	-0.9	-1.7	-1.5	-1.2	-1.4
Illnesses of siblings: Diabetes	0.1	0.1	0.5	-0.5	-0.1	-0.1	0.2	0.5	0.1	-0.3	-0.2	-0.3	-0.7	0.1	-0.6
Smoking status: Previous	0.7	1.0	3.6	-0.0	-1.6	-1.9	1.4	0.1	-1.5	1.1	-0.3	-0.2	-0.2	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.6	11.4	2.5	1.4	0.5	-2.1	2.4	1.8	3.4	3.0	3.0	2.9	3.0	3.3
Whole body fat-free mass	1.2	7.1	20.2	-2.6	-4.0	-4.5	3.3	-2.5	-1.7	-1.7	-2.4	-2.0	-1.9	-2.0	-1.5
Leg fat-free mass (right)	1.5	7.8	18.1	-3.0	-3.8	-4.3	3.3	-2.8	-1.9	-2.2	-2.8	-1.9	-2.4	-2.4	-1.5
Arm fat percentage (left)	0.6	2.4	4.1	-1.7	-1.3	-1.2	1.6	-2.0	-1.9	-0.9	-1.3	-1.6	-1.1	-1.9	-1.5
Average weekly red wine intake	0.6	0.8	2.8	-0.9	-0.6	0.4	1.1	-0.4	-0.7	-0.9	-0.8	-1.7	-0.6	-0.6	-1.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	0.3	0.1	0.0	-0.3	-1.1	-0.6	0.6	0.6	0.9	1.1	0.1	0.7
Mood swings	1.8	3.3	5.5	2.2	1.6	1.2	-1.9	1.8	1.6	2.0	2.3	1.5	2.3	1.2	1.7
Loneliness, isolation	1.3	1.7	3.3	1.6	0.7	0.4	-1.2	1.5	-0.1	1.2	1.7	1.4	1.8	1.2	1.7
Long-standing illness, disability or infirmity	0.1	0.2	0.8	0.0	-0.2	-0.9	0.3	-0.2	-0.6	-0.5	-0.4	0.7	-0.2	-0.3	-0.3
Ever had bowel cancer screening	0.3	0.3	1.0	0.5	0.9	1.0	-0.4	0.7	0.8	-0.7	-0.2	0.1	0.2	0.4	0.0
Diabetes diagnosed by doctor	0.8	1.4	2.8	-1.0	-1.7	-1.6	1.4	-0.7	-1.4	-1.2	-1.1	0.3	-0.8	-1.5	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.4	0.6	-0.5	-0.7	0.1	1.2	-1.0	0.9	0.6	0.9	0.5	0.9	0.8
Friendships satisfaction	2.2	2.7	6.4	1.9	1.3	1.7	-1.5	0.5	1.7	1.5	1.8	1.3	1.6	1.7	2.5
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.6	-0.4	0.1	0.5	-0.0	-0.6	-0.3	-0.7	-0.4	-0.6	-0.2	-0.2
Commuting to job workplace: Walk	0.7	0.7	2.0	0.6	0.8	0.7	-1.3	1.4	0.8	-0.1	0.6	0.6	0.9	1.0	0.7
Eye problems/disorders: Cataract	2.3	2.7	5.5	1.6	0.8	0.6	-1.4	1.5	1.1	2.4	2.1	1.8	1.9	1.8	1.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	4.4	1.5	0.5	-0.4	-0.5	2.0	-0.1	1.8	1.2	1.3	0.8	1.1	2.1
Medication for cholesterol	0.1	0.2	0.6	0.1	0.3	0.6	-0.5	0.4	0.2	0.8	0.6	0.1	0.3	0.1	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.2	-1.0	-1.8	-1.7	1.8	-1.6	-1.2	0.2	-1.1	0.1	-1.1	-1.0	-0.9
Back pain experienced in last month	0.1	0.2	1.0	0.5	-0.2	-0.4	0.1	0.4	-0.4	0.3	0.4	0.5	-0.0	-0.1	1.0
Mineral and other dietary supplements	0.2	0.2	0.9	-0.2	-0.4	-0.6	-0.1	0.3	0.4	-1.0	-0.4	-0.4	-0.3	-0.2	-0.3
Breast cancer (self-reported)	1.8	2.2	4.5	-1.3	-1.3	-1.2	1.4	-1.8	-1.0	-1.6	-1.6	-1.3	-1.3	-1.4	-2.1
Asthma (self-reported)	0.7	1.3	4.8	1.0	2.2	1.8	-1.6	1.6	0.6	0.4	0.9	0.2	-0.1	0.6	-0.4
Osteoporosis (self-reported)	0.7	0.8	1.8	1.4	0.6	-0.1	-0.7	0.7	-0.1	1.3	1.0	0.8	1.1	1.1	1.0
Osteoarthritis (self-reported)	0.2	0.2	1.0	0.1	0.1	0.1	0.2	-0.4	-1.0	0.8	0.3	0.3	0.3	-0.3	0.4
Medication: Aspirin	0.3	0.3	1.4	0.4	0.9	0.4	-0.3	-0.4	0.4	0.7	0.5	1.2	0.7	0.2	0.3
Medication: Gliclazide	3.5	3.9	5.8	-1.9	-2.4	-1.6	2.4	-2.1	-2.3	-1.6	-1.8	-1.7	-1.5	-2.4	-1.8
Illnesses of father: None of the above (group 1)	0.3	0.3	0.7	0.6	0.4	-0.6	-0.6	0.0	0.3	0.7	0.6	0.5	0.6	0.7	0.9
Smoking status: Current	1.3	2.0	3.7	-1.7	-1.9	-1.8	1.7	-1.7	-0.6	-1.2	-1.4	-1.2	-0.9	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.7	-0.2	0.6	0.7	-0.2	0.3	-0.4	0.3	0.1	0.3	-0.0	-0.1	0.8
Whole body water mass	1.4	7.9	21.6	-2.8	-4.1	-4.7	3.4	-2.5	-1.8	-1.8	-2.5	-2.2	-2.1	-2.2	-1.7
Leg predicted mass (right)	1.5	7.8	18.3	-3.0	-3.9	-4.3	3.3	-2.8	-1.9	-2.2	-2.7	-1.8	-2.4	-2.3	-1.5
Arm fat mass (left)	1.3	5.2	7.7	-2.4	-2.7	-2.8	2.7	-2.5	-2.6	-1.1	-2.0	-2.0	-1.7	-2.4	-1.9
Number of self-reported non-cancer illnesses	0.7	1.3	3.9	1.3	2.0	1.7	-1.2	0.9	0.5	1.0	1.1	0.9	0.8	0.9	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	2.6	1.0	1.0	1.6	-0.8	1.1	0.9	0.7	0.7	-0.4	0.9	0.4	0.1
Miserableness	4.1	7.1	11.0	2.9	2.3	1.6	-2.7	2.8	2.3	2.5	2.9	2.7	2.8	2.9	3.3
Guilty feelings	4.0	6.0	10.1	2.4	2.6	2.5	-2.3	3.2	1.2	2.8	2.8	2.6	2.2	2.0	2.3
Wears glasses or contact lenses	0.7	0.8	3.4	-0.6	-1.5	-1.9	1.0	-0.4	-1.0	-0.2	-0.8	-0.1	-0.0	-0.5	-0.5
Ever taken oral contraceptive pill	2.0	2.2	4.1	-1.4	-1.6	-1.3	1.7	-0.5	-1.2	-1.0	-1.6	-1.8	-2.0	-1.2	-1.7
Hearing aid user	2.1	2.3	4.0	1.9	1.7	1.2	-2.0	1.9	1.6	0.5	1.4	1.6	1.2	1.4	1.2
Mother’s age at death	1.8	2.3	4.4	1.9	2.0	2.1	-2.0	1.7	0.4	1.1	1.6	0.2	1.4	1.2	1.0
Financial situation satisfaction	0.1	0.2	0.7	0.1	-0.5	-0.2	0.2	-0.1	-0.8	0.2	0.3	-0.1	0.5	-0.4	0.8
Tinnitus: Yes, now most or all of the time	3.2	3.8	7.6	2.7	1.6	1.0	-2.0	1.9	1.8	1.4	2.1	1.5	2.0	1.8	2.8
Commuting to job workplace: Public transport	1.3	1.6	7.8	1.0	0.9	1.5	-1.1	2.8	1.0	0.2	0.8	0.8	0.5	1.3	1.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.6	0.0	-0.4	-0.3	0.7	-0.5	0.7	0.7	0.7	0.6	0.3	0.6
Medication: Blood pressure	0.7	1.4	2.1	-0.7	-1.0	-1.4	1.3	-1.4	-1.1	-1.2	-1.4	-0.7	-0.9	-1.4	-1.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.0	-0.4	-0.5	-0.1	0.6	-0.2	-1.0	-0.4	-0.9	0.5	-0.7	-0.6	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	0.9	1.0	0.9	-0.6	0.0	0.0	1.4	1.0	1.0	1.1	0.5	0.8
High cholesterol (Self-reported)	4.2	7.5	13.2	2.7	2.8	2.2	-2.5	2.7	1.9	3.2	2.7	3.6	2.9	3.0	2.3
Medication: Bendroflumethiazide	0.8	1.2	4.3	-0.9	-1.0	-1.0	1.1	-2.1	-1.0	-0.5	-1.2	-0.6	-0.8	-1.2	-1.1
Medication: Paracetamol	0.3	0.4	2.0	0.7	1.0	1.4	-0.5	-0.1	0.9	-0.2	0.0	-0.5	0.2	-0.1	-0.2
Medication: Lisinopril	0.9	1.1	2.4	-1.2	-0.4	-0.0	0.7	-1.4	-0.2	-1.5	-1.1	-0.9	-1.1	-1.3	-1.4
Medication: Atorvastatin	5.0	6.2	8.9	2.9	2.7	2.9	-2.5	2.0	1.8	2.3	2.8	2.1	3.0	2.5	2.3
Illnesses of father: High blood pressure	1.0	1.3	2.7	-1.0	-1.2	-1.3	1.6	-0.8	-0.9	-0.2	-1.1	-1.1	-1.3	-1.4	-1.1
Alcohol drinker status: Never	0.6	0.7	2.4	0.5	0.4	0.2	-0.1	0.4	-0.1	1.5	0.6	1.1	1.2	1.2	1.0
Ever smoked	0.5	0.8	3.9	-0.6	-1.6	-2.0	1.3	0.1	-0.6	0.6	-0.5	-0.1	-0.2	0.2	-0.4
Basal metabolic rate	1.4	7.6	20.2	-2.7	-4.0	-4.5	3.4	-2.6	-2.1	-1.6	-2.4	-2.2	-2.0	-2.2	-1.6
Leg fat percentage (left)	0.5	1.8	4.2	-1.4	-1.1	-1.1	1.5	-1.6	-2.0	-0.2	-0.9	-1.6	-0.7	-1.5	-1.6
Arm fat-free mass (left)	1.5	7.5	20.9	-2.7	-4.0	-4.6	3.4	-2.3	-2.3	-1.4	-2.3	-2.3	-1.9	-2.1	-1.8
Number of operations (self-reported)	0.6	0.8	2.5	-0.8	-0.9	-0.9	1.2	-1.4	-1.6	0.1	-0.6	0.5	-0.6	-1.0	-0.2
Average weekly beer plus cider intake	0.4	0.6	1.6	0.5	0.3	0.5	-0.5	0.7	0.6	1.2	1.0	0.6	1.3	0.5	1.2
Irritability	4.0	6.7	9.6	3.0	2.3	1.4	-2.4	2.9	2.8	3.1	2.9	2.4	2.8	2.6	2.0
Risk taking	0.1	0.1	0.6	0.2	0.1	0.6	-0.4	0.8	-0.1	0.4	0.3	0.4	-0.1	0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.4	0.7	-0.3	-0.6	0.7	0.0	0.0	0.2	0.7	0.3	0.1	0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.6	0.2	-0.4	-0.8	-0.0	-0.8	0.3	1.2	0.8	0.8	0.8	0.6	0.4
Age started oral contraceptive pill	0.4	0.5	1.5	-0.3	-0.1	-0.5	0.1	-0.7	0.5	-1.2	-0.5	-1.1	-0.5	-0.8	-1.2
Diastolic blood pressure, automated reading	0.4	1.2	6.3	0.2	0.9	1.8	-0.0	0.1	1.4	-0.0	0.1	-2.5	-0.5	-0.0	-1.4
Ever depressed for a whole week	1.7	2.0	3.3	1.8	1.2	0.9	-1.1	1.1	1.0	1.7	1.5	1.7	1.8	1.2	1.6
Unable to work because of sickness or disability	1.8	2.3	5.3	1.9	0.5	0.1	-1.0	1.0	0.7	2.3	2.0	1.4	2.1	1.5	1.8
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.6	0.1	0.3	0.4	-0.1	-0.4	-0.3	-0.4	0.3	-0.3	-0.3	-0.0
Myopia	1.1	1.6	3.8	1.6	2.0	1.7	-1.6	1.6	1.3	-0.1	1.1	-0.9	0.5	0.8	0.5
Vascular/heart problems diagnosed by doctor	0.9	2.4	6.6	1.2	1.1	1.1	-1.9	0.8	2.6	0.9	1.6	1.1	1.4	2.1	1.8
Cholesterol lowering medication	0.4	0.5	1.8	0.7	-0.4	-0.7	-0.0	0.2	-0.2	0.3	0.5	1.1	1.3	0.9	0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.4	0.0	-1.2	-1.0	0.8	-0.3	-0.8	0.6	-0.2	0.1	-0.1	0.1	0.0
Pain experienced in last month	0.2	0.3	1.3	-0.3	-0.3	-0.1	-0.1	0.3	-0.3	-0.4	-0.3	-1.1	-0.6	-0.3	-0.9
Supplements: Calcium	1.4	1.6	3.0	1.0	0.8	0.9	-0.9	0.5	1.3	1.7	1.3	1.7	1.7	1.7	0.8
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	0.5	1.0	0.9	-0.5	0.2	0.4	0.7	0.8	0.7	0.9	0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.9	-0.3	-1.4	-1.3	1.2	-0.9	-1.0	0.2	-0.5	-0.6	-0.4	-0.7	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.5	0.9	1.0	1.0	-1.0	0.4	1.2	0.4	0.9	0.4	0.9	1.1	0.5
Heart disease (siblings)	4.2	5.2	9.8	-2.0	-1.4	-1.9	1.7	-2.2	-1.9	-2.8	-2.4	-2.0	-2.5	-2.8	-3.1
Alcohol drinker status: Previous	0.7	0.8	2.6	0.6	1.2	0.4	-1.0	1.6	0.6	-0.4	0.5	0.9	0.5	0.9	1.1
Pack years of smoking	0.7	1.0	3.1	0.7	1.0	1.7	-1.2	0.4	1.0	0.5	0.9	0.7	1.7	0.9	0.5
Impedance of whole body	4.8	24.7	37.9	5.2	5.1	4.9	-4.7	4.7	2.8	6.2	5.6	5.1	5.0	5.1	4.5
Leg fat mass (left)	1.1	4.4	7.5	-2.1	-2.5	-2.7	2.5	-2.3	-2.5	-0.6	-1.7	-1.9	-1.3	-2.1	-1.9
Arm predicted mass (left)	1.5	7.6	21.7	-2.7	-4.0	-4.7	3.4	-2.3	-2.3	-1.4	-2.4	-2.2	-1.9	-2.1	-1.7