Hub : Genes

ADCK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0770	0.0260	6.0e-05	0.043	0.037	0.027	0.038	0.027	5.5e-06	2.4e-05	2.7e-04	1.7e-05	2.6e-04
2	GTEx	Adipose Visceral Omentum	0.1090	0.0510	5.2e-03	-0.002	NA	0.025	NA	0.014	4.5e-01	NA	1.7e-02	NA	6.1e-02
3	GTEx	Esophagus Gastroesophageal Junction	0.2340	0.0760	2.7e-04	0.115	NA	0.082	NA	0.091	6.1e-05	NA	6.5e-04	NA	3.6e-04
4	GTEx	Esophagus Muscularis	0.0660	0.0310	9.2e-03	0.024	NA	0.006	NA	0.015	1.3e-02	NA	1.2e-01	NA	4.1e-02
5	GTEx	Whole Blood	0.1400	0.0340	3.5e-10	0.166	NA	0.153	NA	0.167	3.9e-15	NA	5.7e-14	NA	3.4e-15
6	NTR	Blood	0.0611	0.0159	5.6e-17	0.085	0.040	0.076	0.006	0.001	5.0e-26	7.0e-13	2.5e-23	3.9e-03	9.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.5	0.7	2.6	0.5	1.6	-0.0	1.2	-0.2	-0.3
Bipolar Disorder or Schizophrenia	0.9	2.3	4.1	-1.5	0.4	-1.9	-0.6	2.0	1.9
Depressed Affect (Nagel 2018)	1.6	3.3	8.2	0.1	-0.4	-2.9	-2.4	1.7	1.7
Depression (Nagel 2018)	0.9	1.3	2.6	-0.7	0.4	-1.6	-1.0	1.5	1.2
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.5	-0.9	-1.9	1.6	-0.2	0.5	0.5
Neuroticism (Nagel 2018)	3.9	9.2	20.2	-0.6	-1.5	-4.5	-3.5	3.2	3.2
Schizophrenia (2018)	2.4	4.9	7.5	-2.3	-0.7	-2.4	-1.8	2.7	2.7
Schizophrenia vs Biploar Disorder	0.4	0.6	1.8	-0.2	1.4	0.3	0.4	-0.9	-0.6
Worry (Nagel 2018)	6.2	13.0	33.6	-0.6	-2.1	-5.8	-3.7	3.6	3.6
Alzheimer’s Disease (in mother)	2.1	2.5	4.2	-1.8	-1.3	-1.2	-0.8	2.0	1.9
Alzheimer’s Disease (in father)	0.8	0.9	1.8	-0.2	0.6	0.1	1.1	-1.4	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.8	-1.3	-0.3	-0.9	0.8	0.8	0.7
Crohns Disease (2017)	0.5	1.1	2.7	-1.0	1.6	-0.5	-1.5	0.6	0.3
Irritable Bowel Disease (IBD)	1.7	4.0	9.9	-0.6	0.9	-3.1	-3.1	1.4	1.3
Ulcerative Colitis (UC)	2.5	4.8	15.7	0.3	0.9	-4.0	-3.2	0.9	0.9
Major Depression (MDD)	1.1	1.4	3.8	0.2	-0.4	-2.0	-1.5	0.8	1.2
Reaction Time	1.0	1.9	6.8	2.6	1.4	-1.2	-1.1	-0.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.9	-0.1	-0.4	2.0	-0.8	0.2	0.2
Breast Cancer	0.5	1.3	3.4	1.4	-0.5	-1.9	-0.9	0.8	0.8
Ovarian Cancer	0.4	0.5	0.8	-0.5	0.9	-0.5	-0.8	0.7	0.7
Prostate Cancer	2.3	3.3	5.7	-1.2	-2.4	-2.1	-0.9	2.0	1.9
Age at First Birth	0.7	1.1	3.3	-0.6	-1.8	-0.9	-0.7	0.8	0.9
Bipolar Disorder (2011)	0.5	0.5	2.4	0.1	1.6	-0.6	-0.4	0.1	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	0.2	-0.1	-0.7	-0.0	0.1	0.1
Coronary Artery Disease (CAD)	0.3	0.3	1.1	-0.2	0.6	1.1	0.5	-0.1	-0.3
Crohns Disease (2012)	0.3	0.5	1.5	-0.8	1.2	-0.5	-0.8	0.4	0.0
Mean Putamen Volume	0.5	0.6	2.2	-0.3	-0.4	1.5	1.0	0.1	-0.2
Fasting Glucose	1.2	1.5	3.2	1.5	1.8	-0.2	-0.2	-1.4	-1.0
HbA1C	1.4	1.5	4.9	1.8	2.2	0.0	-1.1	-0.1	0.1
HDL Cholesterol	0.5	0.9	3.0	-0.3	0.7	1.7	1.2	-0.0	-0.0
LDL Cholesterol	0.8	1.2	3.3	-1.1	-1.3	0.9	1.8	-0.6	-0.3
Lupus	0.7	1.0	3.9	0.2	2.0	1.2	0.8	0.3	0.2
Neuroticism (2016)	3.5	5.0	10.1	-1.2	-1.7	-3.2	-2.3	2.1	2.5
Primary Biliary Cirrhosis	1.1	1.5	2.4	-0.7	0.2	-1.5	-1.4	1.4	1.5
Rheumatoid Arthritis	0.8	1.0	2.2	1.5	1.4	0.8	0.5	-0.8	-0.7
Schizophrenia (2014)	1.2	2.6	4.8	-1.1	-0.1	-2.2	-1.5	1.9	2.0
Triglycerides	1.1	1.7	3.2	-0.5	-1.8	-1.7	-0.8	1.2	1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.0	0.0	-0.5	0.7	1.4	-1.7	-1.3
Ulcerative Colitis	1.7	2.4	9.1	0.7	1.3	-3.0	-1.6	0.5	0.6
Blood Eosinophil Count	0.3	2.5	12.5	-0.0	0.9	-3.5	-1.2	-0.2	0.1
Blood Platelet Count	0.1	0.9	1.6	-0.8	0.9	0.7	-1.3	1.3	0.6
Blood Red Count	0.7	7.0	11.7	-3.1	-1.7	-2.7	0.8	3.4	3.2
Blood White Count	4.3	31.8	69.2	3.8	5.3	2.0	3.7	-7.9	-8.3
Heel T-Score	3.2	25.6	53.1	-3.0	-1.2	-7.3	-5.0	5.7	5.6
BMI	0.3	1.7	5.7	-0.0	0.9	2.4	0.8	-1.3	-1.1
Height	0.9	16.6	39.1	-3.0	-5.9	-2.8	-6.2	1.8	2.4
Waist Hip Ratio (WHR)	3.1	13.7	17.3	-3.6	-3.9	-3.0	-3.4	4.1	4.2
Systolic Blood Pressure	1.0	5.0	12.9	2.1	0.8	-2.4	-3.6	2.1	1.5
Smoking Status	0.5	1.2	4.6	-0.9	1.0	2.1	-0.1	-0.5	-0.6
Allergy or Eczema	1.5	4.0	7.1	-0.5	-1.1	-2.4	-1.6	2.6	2.7
Cardiovascular Disease	1.1	3.5	8.6	0.0	-0.7	-1.3	-2.9	2.3	2.2
Hypothyroidism (self reported)	0.5	1.2	4.6	-2.1	0.3	-1.4	-0.5	0.4	0.5
Respiratory disease	0.9	2.0	4.5	-0.0	0.2	-1.4	-1.2	1.9	2.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.4	-1.2	-0.1	0.0	-0.8	0.6	0.7
Lung FEV1/FVC ratio	1.1	5.4	21.3	-0.5	-2.0	4.6	1.8	-1.3	-1.3
Lung FVC	0.4	1.9	3.6	0.3	1.6	1.7	1.9	-1.0	-1.3
Neuroticism	5.4	13.1	27.4	-0.8	-1.8	-5.2	-4.2	3.8	3.9
Chronotype (morning person)	0.4	1.0	5.2	0.1	0.5	2.3	0.8	-0.1	-0.1
Hair Pigment	0.5	13.5	31.5	-2.7	0.0	5.6	4.8	-3.2	-3.0
Tanning	0.2	3.0	8.0	-1.1	-2.2	-1.8	2.8	0.6	0.6
Hand grip strength (left)	3.7	9.7	19.1	0.4	0.8	4.4	3.5	-3.5	-3.7
Number of treatments/medications taken	2.0	3.5	6.4	-1.1	-1.2	-1.6	-2.1	2.5	2.2
Average weekly spirits intake	0.1	0.2	0.4	0.5	-0.3	0.7	0.3	-0.3	-0.3
Sensitivity / hurt feelings	0.4	0.6	1.0	0.9	1.0	-0.8	-0.9	0.5	0.6
Frequency of depressed mood in last 2 weeks	2.7	3.8	6.1	-1.4	-1.2	-2.0	-1.9	2.4	2.5
Hearing difficulty/problems: Yes	1.2	1.8	4.0	-0.4	-1.0	-1.7	-0.2	1.7	2.0
Relative age of first facial hair	1.0	2.0	4.9	-0.1	0.5	2.0	2.2	-1.2	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.1	-1.8	-1.1	-0.3	-0.1	0.3	0.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.1	-1.0	-0.8	-0.3	-0.5	2.0	2.0
Ever had hysterectomy (womb removed)	1.5	1.7	5.0	-1.6	1.4	2.2	0.8	-0.3	-0.2
Systolic blood pressure, automated reading	0.3	0.8	1.8	1.3	0.4	-1.3	-1.0	0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.1	-0.8	0.2	1.8	1.1	-1.7	-1.5
Angina	2.2	2.9	4.9	-1.9	-1.3	-0.2	-1.7	2.1	2.2
Medication for hormone replacement therapy	0.2	0.2	0.9	0.1	-0.1	-1.0	0.0	0.3	0.3
Vitamin and mineral supplements	0.3	0.4	1.7	0.3	0.3	-0.4	-1.3	0.4	0.2
Supplements: Zinc	0.6	0.7	2.0	-0.4	-0.5	-1.4	-1.1	0.4	0.5
Medication: Co-codamol	0.7	0.8	3.2	-1.8	-1.1	0.1	-0.6	0.4	0.5
Medication: Metformin	0.7	0.9	3.9	-2.0	-0.5	0.8	-0.2	0.4	0.7
Diabetes (father)	0.7	0.9	1.7	-0.5	0.5	1.2	0.4	-1.3	-1.1
Diabetes (mother)	1.2	1.5	5.0	-1.5	-2.2	-0.0	1.2	0.7	0.4
Severe depression (siblings)	1.2	1.3	3.4	0.5	-0.1	-1.2	-1.9	1.1	1.2
Pack years adult smoking proportion	0.2	0.4	1.3	-0.3	0.4	-0.5	1.1	-0.5	-0.5
Impedance of leg (right)	4.1	20.0	29.8	-1.3	-3.5	-5.0	-5.5	4.9	5.2
Leg fat-free mass (left)	1.1	5.7	13.2	-1.2	0.3	3.6	1.2	-3.0	-3.0
Trunk fat percentage	0.4	1.6	4.1	-2.0	-1.4	0.7	-0.6	0.9	1.4
Hand grip strength (right)	2.0	5.3	14.0	0.3	0.3	3.7	2.5	-2.4	-2.4
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.4	-0.3	-0.0	-0.5	0.1	0.2
Current tobacco smoking	1.4	2.3	3.9	0.4	1.0	2.0	1.6	-1.8	-1.8
Average weekly fortified wine intake	1.1	1.3	2.8	1.0	0.7	0.9	0.7	-1.7	-1.6
Maternal smoking around birth	2.2	3.2	11.8	-0.5	0.2	3.4	2.0	-1.2	-1.3
Fed-up feelings	1.6	2.9	4.5	-0.5	-1.5	-1.8	-2.1	1.8	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	-1.3	0.0	-0.7	-0.4	0.9	0.6
Relative age voice broke	0.3	0.4	0.8	-0.9	-0.7	0.4	0.8	-0.4	-0.5
Taking other prescription medications	2.0	3.1	4.5	-2.1	-1.3	-1.4	-1.5	2.1	1.9
Age when periods started (menarche)	0.2	0.5	0.7	-0.8	-0.8	0.3	0.4	0.8	0.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	2.4	-1.4	-0.3	1.2	-0.0	1.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	4.9	11.1	24.1	-2.5	-1.8	-4.9	-3.8	2.9	3.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.4	-1.2	0.7	0.5	0.6	-0.6	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-0.4	-0.4	0.2	-1.0	0.6	0.8
Serious illness, injury or assault to yourself	0.6	0.8	1.6	-1.0	-1.3	0.3	-0.5	0.8	1.1
High blood pressure	0.3	0.7	1.7	0.6	-0.8	0.4	-1.3	0.9	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.3	-0.4	-0.7	-1.5	-0.6	1.3	1.4
Multivitamins +/- minerals	0.8	1.0	3.1	-0.4	-0.0	1.2	1.7	-1.0	-0.8
Stomach or abdominal pain in last month	0.3	0.4	1.1	-0.6	-0.4	-0.5	-1.0	0.4	0.5
Supplements: Glucosamine	0.9	1.1	2.6	0.3	0.2	1.1	0.8	-1.5	-1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	4.0	-2.0	-1.7	0.8	0.4	0.8	0.7
Medication: Atenolol	0.3	0.3	1.1	0.6	-1.1	0.1	-0.8	0.0	-0.1
Medication: Levothyroxine sodium	2.0	3.3	7.0	-1.4	0.9	-2.6	-1.9	1.8	1.9
Sitting height	0.5	3.2	11.2	-2.4	-1.0	-1.1	-3.3	-0.0	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.1	0.9	0.1	0.5	0.4	0.4
High blood pressure (mother)	1.0	1.4	3.1	1.8	0.4	1.1	0.2	-1.4	-1.4
Body mass index (BMI)	0.9	4.0	11.2	-0.9	0.6	3.3	2.2	-1.9	-1.7
Impedance of leg (left)	4.2	20.4	29.2	-1.3	-3.2	-5.3	-5.4	5.0	5.3
Leg predicted mass (left)	1.1	5.6	12.9	-1.2	0.3	3.6	1.1	-3.0	-3.0
Trunk fat mass	0.4	1.5	4.7	-2.2	-1.3	1.5	-0.4	-0.0	0.4
Waist circumference	0.4	1.5	4.6	-2.1	-1.4	1.5	-0.1	-0.5	-0.3
Number of incorrect matches in round	0.6	1.1	3.1	-0.8	0.2	-1.8	-1.3	0.5	0.8
Past tobacco smoking	0.8	1.5	2.4	1.4	0.1	-0.7	1.3	-1.5	-1.5
Alcohol usually taken with meals	0.4	0.7	1.1	0.1	-0.8	-0.9	-1.0	0.8	0.9
Nervous feelings	4.6	8.7	21.1	-0.6	-2.6	-4.6	-2.3	3.0	3.1
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.4	7.8	-1.6	-1.0	-2.8	-1.8	2.5	2.4
Hearing difficulty/problems with background noise	1.0	1.6	4.6	0.1	-0.2	-2.1	-1.6	1.1	1.1
Hair/balding pattern: Pattern 2	0.9	1.2	2.4	-0.6	-1.3	-0.8	-0.8	1.2	1.5
Had menopause	0.6	0.8	1.8	-1.3	0.7	-1.4	-0.2	0.4	0.5
Had other major operations	1.1	1.3	2.9	-1.7	-1.6	1.5	0.4	0.2	0.0
Forced vital capacity (FVC)	0.1	0.5	1.0	-0.9	-1.0	0.0	-0.7	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	5.1	11.6	22.0	-3.0	-2.1	-4.7	-3.5	3.3	3.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.4	-0.4	-0.5	-0.9	-2.1	0.9	1.1
Qualifications: None of the above	1.1	2.4	4.0	-2.0	0.3	-1.7	-1.2	1.9	1.7
Financial difficulties in last 2 years	0.3	0.3	0.8	-0.1	-0.9	-0.3	0.0	0.7	0.8
Mouth/teeth dental problems	0.2	0.3	0.8	0.9	-0.1	0.0	0.3	-0.3	-0.7
Heart attack	1.7	2.2	3.1	-1.7	-1.1	0.7	-1.8	1.6	1.7
Allergy	0.3	0.8	1.5	0.9	-0.4	0.9	0.2	-1.1	-1.2
Pain all over the body in last month	0.5	0.5	1.4	-0.2	0.1	1.0	0.6	-0.6	-1.2
Diabetes (self-reported)	0.6	1.0	4.9	-2.2	-0.3	0.9	0.1	-0.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	-0.2	-1.1	-0.4	0.8	1.2	1.0
Medication: Ramipril	2.0	2.5	4.5	0.2	-1.2	-1.0	-1.9	2.1	2.1
Medication: Simvastatin	0.4	0.5	2.3	-1.5	-0.6	0.6	-0.2	0.2	0.2
Fluid intelligence score	0.2	0.5	2.2	-0.4	-0.4	1.5	0.3	0.2	0.2
Illnesses of siblings	0.2	0.2	0.5	-0.2	-0.7	-0.7	-0.4	-0.4	-0.4
Neuroticism score	6.1	12.6	24.3	-0.8	-1.8	-4.9	-4.1	3.9	4.0
Weight	0.5	2.3	5.4	-2.0	-1.2	2.3	-0.2	-1.2	-1.0
Impedance of arm (right)	3.4	16.0	25.3	-0.7	-3.4	-4.7	-3.8	4.8	5.0
Arm fat percentage (right)	0.3	1.3	3.6	-1.9	-1.0	1.4	0.7	0.4	0.7
Trunk fat-free mass	0.9	5.1	11.5	-1.0	-0.3	2.8	0.5	-3.2	-3.4
Hip circumference	0.8	3.5	9.1	-1.3	-0.3	3.0	0.7	-2.3	-2.1
Time employed in main current job	1.1	1.2	2.1	1.4	1.2	1.0	1.5	-0.5	-0.7
Alcohol intake versus 10 years previously	1.1	1.6	5.8	-0.0	-0.4	-2.4	-1.5	0.8	0.8
Father’s age at death	1.0	1.3	3.4	-0.2	-0.3	0.8	1.9	-1.3	-1.4
Worrier / anxious feelings	3.8	7.2	17.6	-0.5	-0.9	-4.2	-3.3	2.7	2.5
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.3	7.1	-2.0	-2.3	-2.3	-1.9	2.5	2.7
Falls in the last year	0.4	0.6	1.7	-1.1	1.3	0.7	0.3	-0.1	-0.0
Hair/balding pattern: Pattern 3	1.3	2.0	4.4	1.6	2.1	-0.1	0.7	-1.4	-1.6
Number of live births	0.9	1.3	3.6	-1.4	-0.7	1.9	1.1	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.7	-1.0	-1.6	1.5	0.0	0.3	0.0
Pulse rate	0.2	0.4	1.6	-1.3	0.2	0.0	-0.0	0.5	0.5
Happiness	1.8	2.2	4.0	-0.4	-0.8	-1.2	-2.0	1.7	1.9
Noisy workplace	1.3	1.6	3.2	1.4	1.8	-0.1	0.4	-1.5	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	3.9	9.7	3.1	0.3	1.1	1.6	-2.3	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.1	-0.7	0.8	0.7	-0.1	0.1
Mouth/teeth dental problems: Dentures	4.7	7.9	21.4	-0.9	1.4	4.6	3.6	-2.3	-2.2
Asthma	1.8	3.6	6.2	-0.9	0.3	-2.1	-2.5	2.2	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	0.9	1.1	1.0	0.3	-0.1	-0.0
Medication: Cholesterol lowering	1.1	1.8	3.8	-1.2	-1.2	-0.8	-2.0	1.2	1.3
Depression (self-reported)	0.9	1.0	1.9	0.9	-0.7	-1.4	-1.3	0.9	0.8
Medication: Lansoprazole	0.2	0.2	0.4	0.7	-0.0	0.6	-0.3	-0.3	-0.3
Prospective memory result	0.9	1.1	2.5	1.6	-0.0	0.5	0.0	-1.5	-1.2
Lung cancer (father)	1.5	1.7	5.4	0.2	0.3	2.3	1.8	-0.9	-0.7
Illnesses of mother	0.1	0.1	0.4	0.6	0.0	-0.2	-0.1	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.3	-0.5	-2.1	0.3	-0.3	0.5	0.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-1.2	0.0	0.5	-1.0	0.8	0.6
Impedance of arm (left)	2.4	11.1	19.9	-0.5	-2.4	-3.7	-3.1	4.2	4.5
Arm fat mass (right)	0.5	2.0	6.0	-1.8	-0.7	2.4	1.0	-1.0	-0.7
Trunk predicted mass	0.9	5.2	11.4	-0.9	-0.2	2.8	0.5	-3.2	-3.4
Standing height	0.8	8.1	21.5	-2.6	-3.9	-1.7	-4.6	1.1	1.2
Length of working week for main job	0.7	0.8	1.2	0.6	1.1	0.8	-1.1	-0.8	-0.8
Exposure to tobacco smoke at home	0.9	1.0	2.2	-1.5	-0.3	-1.0	-0.6	1.1	0.9
Breastfed as a baby	1.2	1.5	4.1	2.0	0.5	-1.4	0.5	-1.2	-1.0
Tense / ‘highly strung’	4.8	7.9	16.4	-1.4	-1.1	-4.0	-3.3	2.9	2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	5.7	8.7	14.4	-1.2	-1.8	-3.8	-2.7	3.5	3.6
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.7	-0.1	1.0	0.1	-0.3	-0.6
Birth weight of first child	1.4	2.6	5.8	-0.4	0.8	2.4	2.4	-1.1	-1.4
Peak expiratory flow (PEF)	1.0	2.3	7.3	-1.4	-1.8	2.7	0.9	0.4	0.2
Pulse wave reflection index	0.6	0.7	2.0	-1.4	0.1	1.4	0.1	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.1	0.4	-0.8	-1.4	0.4	0.5
Loud music exposure frequency	0.2	0.2	0.7	-0.8	-0.4	0.4	-0.6	0.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.6	2.1	0.8	-0.2	0.1	-1.4	-1.2
Mouth/teeth dental problems: Bleeding gums	5.4	7.0	13.3	-1.3	-2.0	-3.0	-1.7	3.3	3.6
Blood clot in the leg (DVT)	0.2	0.3	1.3	-1.1	0.4	-0.5	0.1	0.2	0.3
Medication: Paracetamol	0.3	0.6	1.3	0.4	-0.3	-0.9	-0.5	1.1	0.9
Headache pain in last month	3.9	6.7	14.7	0.6	-0.1	-3.8	-3.6	2.6	2.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.6	-0.2	0.3	-0.2	1.6	-0.7	-0.6
Glaucoma (self-reported)	3.5	4.1	7.1	-1.8	-0.8	-1.3	-2.7	2.4	2.5
Gout (self-reported)	0.1	0.1	0.4	-0.3	-0.1	-0.2	0.6	-0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	5.2	-2.3	0.3	-2.0	-0.8	0.8	0.9
Medication: Amlodipine	1.1	1.5	4.2	1.6	2.0	0.5	0.5	-0.9	-1.0
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.9	-0.9	-1.3	-1.7	-1.0	1.4	1.4
Birth weight	1.6	3.5	7.8	-0.1	0.8	1.6	1.9	-2.6	-2.8
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.8	-0.7	-0.4	1.3	0.5	0.5	0.4
High blood pressure (siblings)	0.6	0.9	1.9	0.3	0.3	-0.1	-1.3	1.3	1.4
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-0.2	-1.3	-1.0	-1.0	0.8	0.5
Body fat percentage	0.4	1.7	4.6	-2.1	-1.3	0.9	-0.6	0.9	1.4
Leg fat percentage (right)	0.5	1.7	5.7	-2.4	-0.9	0.9	-0.7	0.9	1.3
Arm fat-free mass (right)	1.2	6.2	12.1	-1.1	0.7	3.4	0.7	-3.4	-3.5
Exposure to tobacco smoke outside home	2.0	2.7	6.5	0.9	2.6	1.1	1.2	-1.8	-1.7
Comparative body size at age 10	0.9	2.4	4.5	1.9	2.1	0.8	-0.2	-1.7	-1.6
Number of full brothers	1.1	1.3	3.6	0.2	1.9	0.8	1.4	-0.8	-1.0
Worry too long after embarrassment	3.5	5.9	9.2	-0.8	-1.9	-3.0	-2.1	3.0	3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.7	8.9	-0.7	-1.3	-3.0	-1.7	2.2	1.9
Wheeze or whistling in the chest in last year	0.6	1.2	2.2	-0.5	-0.8	-1.0	-1.0	1.4	1.5
Number of children fathered	0.9	1.0	2.7	-1.2	0.7	1.0	1.6	-0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.1	-0.1	-1.4	-0.4	-0.1	0.2	0.1
Age at first live birth	1.6	2.8	5.9	1.3	-1.6	-1.2	-0.6	2.4	2.2
Pulse wave peak to peak time	0.4	0.4	0.8	0.9	-0.5	-0.7	0.8	-0.6	-0.4
Health satisfaction	0.3	0.4	1.0	0.4	-0.4	0.6	-1.0	0.4	0.6
Shortness of breath walking on level ground	1.9	2.3	5.9	-0.5	-0.4	-2.4	-2.4	1.0	0.9
Qualifications: College or University degree	0.2	0.5	1.5	1.2	-0.0	-0.5	0.4	-0.7	-0.8
Eye problems/disorders: None of the above	4.0	4.6	6.3	2.1	1.5	1.8	2.4	-2.5	-2.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-0.5	-1.0	-0.4	-0.1	0.8	1.1
Emphysema/chronic bronchitis	1.2	1.3	1.9	1.0	0.5	1.3	1.3	-1.4	-1.1
Medication for pain relief, constipation, heartburn	0.9	1.5	2.9	1.2	0.3	0.3	1.6	-1.7	-1.3
Neck or shoulder pain in last month	1.9	2.7	6.8	-2.6	-0.7	-0.5	-1.4	1.9	1.8
Medication: Blood pressure	0.5	0.8	2.4	1.5	0.7	0.4	-1.4	0.2	0.2
Angina (self-reported)	2.3	3.0	5.0	-2.1	-1.2	-0.3	-1.5	2.2	2.2
Migraine (self-reported)	0.6	0.8	2.1	-1.4	1.3	0.3	0.4	0.7	0.4
Medication: Ibuprofen	1.1	1.3	4.0	1.0	2.0	1.6	0.5	-0.5	-0.4
Medication: Allopurinol	0.1	0.2	0.5	-0.7	0.1	0.3	0.6	-0.2	-0.3
Medication: Omeprazole	1.6	2.0	4.5	-1.3	-0.7	-0.9	-2.1	1.5	1.4
Medication: Seretide 50 evohaler	2.1	2.5	4.4	-1.8	-1.4	-1.3	-2.1	1.2	1.4
Mean time to correctly identify matches	1.8	3.4	7.8	1.9	1.4	-2.8	-2.5	0.6	0.5
Heart disease (mother)	1.0	1.3	3.1	-1.8	-1.7	-0.1	-0.4	0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.4	0.8	0.4	0.6	-0.3	-0.2
Whole body fat mass	0.4	1.7	4.9	-2.2	-1.1	2.0	-0.2	-0.2	0.1
Leg fat mass (right)	0.5	1.9	6.1	-2.5	-1.0	2.0	-0.4	-0.3	0.1
Arm predicted mass (right)	1.3	6.4	13.7	-0.6	0.9	3.2	0.7	-3.6	-3.7
Pulse rate, automated reading	1.4	4.6	16.1	-4.0	-0.2	2.5	-0.3	1.4	1.8
Alcohol intake frequency.	0.9	2.2	4.2	-1.0	-0.5	-1.6	-2.1	1.7	1.5
Comparative height size at age 10	1.1	6.0	15.9	-1.8	-2.8	-1.8	-4.0	1.6	1.8
Number of full sisters	0.4	0.4	1.1	-0.8	-0.2	0.3	-0.4	1.0	0.7
Suffer from ‘nerves’	2.6	4.1	6.6	-1.5	-2.4	-1.9	-0.8	2.4	2.6
Overall health rating	0.4	0.9	2.4	-1.2	0.1	-1.2	-1.5	0.2	0.3
Chest pain or discomfort	0.2	0.2	1.3	-0.0	-0.4	-1.1	0.0	0.2	0.1
Had major operations	0.2	0.3	0.7	0.8	0.3	-0.6	-0.1	0.5	0.3
Age at last live birth	0.2	0.3	0.6	0.5	-0.5	-0.4	-0.3	0.8	0.8
Family relationship satisfaction	0.3	0.4	2.0	-0.7	-0.2	-1.4	0.2	0.0	0.2
Leg pain on walking	2.3	2.9	5.1	1.4	1.1	2.2	0.8	-2.1	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	2.0	1.2	0.7	0.8	-0.6	-0.2
Commuting to job workplace: Car/motor vehicle	3.8	4.3	8.8	-0.9	-0.4	3.0	2.6	-2.1	-2.3
Illness, injury, bereavement, stress in last 2 years	3.3	4.0	6.6	2.4	2.6	1.2	0.9	-2.1	-2.3
Medication: Aspirin	1.8	2.4	5.8	-2.4	-1.2	-0.5	-1.0	1.9	1.6
Supplements: Vitamin C	0.6	0.7	1.2	0.2	-0.6	-1.0	-0.7	1.1	1.1
Knee pain experienced in last month	0.1	0.1	0.4	-0.2	-0.4	0.6	-0.2	-0.1	0.0
Hypertension (Self-reported)	0.2	0.5	1.5	0.6	-0.4	0.6	-1.2	0.7	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.6	0.4	0.7	-2.0	-2.4	1.1	1.0
Illnesses of father: Heart disease	1.0	1.4	3.0	-0.5	0.1	0.6	-1.7	1.4	1.7
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.4	0.4	0.1	0.0	0.8	0.5
Smoking status: Previous	1.0	1.5	2.7	-1.2	-0.0	0.0	-1.6	1.5	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	6.0	0.7	-0.6	-1.9	-2.4	-0.2	-0.1
Whole body fat-free mass	1.0	5.6	11.4	-1.1	0.1	3.1	0.8	-3.3	-3.4
Leg fat-free mass (right)	1.1	5.8	12.5	-1.1	0.5	3.5	1.3	-3.1	-3.1
Arm fat percentage (left)	0.3	1.3	3.8	-1.7	-0.4	2.0	1.0	-0.1	0.2
Average weekly red wine intake	0.3	0.4	1.1	0.3	-0.4	0.9	1.1	0.3	-0.0
Handedness (chirality/laterality): Left-handed	1.4	1.6	2.8	-0.0	-1.6	0.5	1.7	-1.6	-1.3
Mood swings	1.6	2.9	4.2	-1.2	-0.9	-2.0	-1.7	2.0	2.0
Loneliness, isolation	2.2	3.0	7.2	-1.5	-2.7	-1.4	-1.0	1.6	1.9
Long-standing illness, disability or infirmity	1.0	1.5	5.0	-2.2	-1.2	0.3	-0.2	1.2	1.0
Ever had bowel cancer screening	0.8	0.9	1.4	1.2	1.2	-0.9	0.2	-0.9	-0.9
Diabetes diagnosed by doctor	0.6	1.0	4.2	-2.0	-0.2	1.2	-0.1	0.2	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.9	-0.8	-1.0	-0.6	-1.7	1.1	1.5
Friendships satisfaction	0.7	0.9	3.1	0.1	0.3	-1.7	-1.4	0.4	0.3
Qualifications: nursing, teaching	0.3	0.4	1.2	1.1	0.5	0.8	0.6	-0.3	-0.3
Commuting to job workplace: Walk	0.3	0.3	1.3	0.4	-0.5	-1.1	-0.2	-0.4	-0.2
Eye problems/disorders: Cataract	6.4	7.4	10.2	-2.7	-1.7	-2.1	-3.0	3.2	3.1
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	7.0	0.7	-0.6	-1.5	-2.7	0.9	0.9
Medication for cholesterol	0.3	0.5	1.5	1.2	0.6	-0.3	-0.4	-0.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.4	0.9	1.1	0.1	-0.1	-0.4
Back pain experienced in last month	0.8	1.2	2.5	-1.6	-1.6	-0.1	-0.5	0.8	1.1
Mineral and other dietary supplements	0.3	0.5	1.2	-0.1	1.1	0.4	1.1	-0.3	-0.4
Breast cancer (self-reported)	2.5	3.0	3.9	1.9	1.9	1.2	1.2	-1.9	-2.0
Asthma (self-reported)	1.9	3.9	5.8	-1.0	0.4	-2.3	-2.4	2.3	2.4
Osteoporosis (self-reported)	0.6	0.8	2.8	-0.1	-1.7	-0.8	-1.0	0.3	0.3
Osteoarthritis (self-reported)	1.9	2.5	8.1	-2.9	-1.1	0.1	-0.8	1.5	1.6
Medication: Aspirin	1.8	2.4	5.8	-2.4	-1.0	-0.5	-1.0	1.8	1.6
Medication: Gliclazide	0.7	0.8	2.6	-1.3	0.1	1.6	0.4	-0.3	-0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	0.3	-0.4	0.1	0.2	-0.7	-0.9
Smoking status: Current	1.4	2.2	4.4	0.6	1.2	2.1	1.3	-1.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	0.9	-0.7	0.1	-0.4	-1.0	-1.1
Whole body water mass	1.0	5.8	11.6	-1.0	0.2	3.3	0.8	-3.3	-3.4
Leg predicted mass (right)	1.1	5.7	12.5	-1.1	0.5	3.5	1.3	-3.1	-3.1
Arm fat mass (left)	0.6	2.3	7.6	-1.5	-0.4	2.8	1.0	-1.3	-1.0
Number of self-reported non-cancer illnesses	0.7	1.2	2.8	-1.1	-0.2	-1.7	-0.8	1.1	1.0
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.5	-0.4	-0.8	-0.6	0.3	0.2
Miserableness	1.7	2.9	8.9	0.4	0.1	-3.0	-2.7	0.5	0.9
Guilty feelings	2.7	4.1	7.5	0.0	-1.5	-2.7	-2.3	2.0	2.2
Wears glasses or contact lenses	0.1	0.2	0.4	-0.3	0.2	0.3	-0.6	0.4	0.5
Ever taken oral contraceptive pill	0.9	1.0	2.3	1.5	0.3	1.0	-0.7	0.9	0.9
Hearing aid user	1.1	1.2	3.0	-0.5	-0.5	-1.4	-0.3	1.7	1.4
Mother’s age at death	1.5	1.9	4.1	-0.1	-0.9	-2.0	-2.0	1.0	1.2
Financial situation satisfaction	0.9	1.1	2.3	-0.8	-0.8	-0.7	-0.5	1.5	1.5
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.7	0.2	-1.0	-1.9	-1.8	0.7	0.9
Commuting to job workplace: Public transport	2.2	2.6	5.1	-0.1	-0.3	-1.5	-2.0	2.0	2.3
Eye problems/disorders: Glaucoma	4.8	5.7	8.4	-2.8	-1.7	-1.0	-2.6	2.9	2.8
Medication: Blood pressure	0.6	1.2	2.3	-1.5	-0.8	0.7	-0.4	1.5	1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	-1.3	0.1	0.7	0.6	0.5	0.7
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.5	-0.8	-1.9	-0.9	-1.6	1.0	1.1
High cholesterol (Self-reported)	1.4	2.5	6.7	-0.3	-1.3	-2.6	-1.9	1.3	1.1
Medication: Bendroflumethiazide	0.5	0.7	1.9	0.5	-0.4	0.7	-0.3	-1.2	-1.4
Medication: Paracetamol	0.3	0.5	1.3	0.6	-0.5	-0.5	0.2	1.1	0.9
Medication: Lisinopril	0.3	0.4	0.9	-0.1	-0.2	0.9	0.6	0.8	0.8
Medication: Atorvastatin	2.7	3.3	6.2	-1.8	-1.0	-2.5	-2.1	1.6	1.6
Illnesses of father: High blood pressure	0.6	0.8	2.2	1.5	0.4	0.7	-0.8	-0.7	-0.6
Alcohol drinker status: Never	0.4	0.5	0.9	-1.0	-0.6	-0.0	-0.9	0.9	0.6
Ever smoked	0.2	0.4	1.3	-1.1	0.2	0.5	-0.5	0.6	0.6
Basal metabolic rate	0.9	4.7	10.1	-1.4	-0.3	3.2	0.6	-2.8	-2.8
Leg fat percentage (left)	0.4	1.4	5.5	-2.3	-0.7	1.1	-0.3	0.6	1.1
Arm fat-free mass (left)	0.9	4.8	9.1	-1.3	-0.3	3.0	0.4	-3.0	-3.0
Number of operations (self-reported)	0.3	0.4	1.4	-0.5	-0.8	1.2	0.3	0.2	-0.1
Average weekly beer plus cider intake	1.3	1.9	3.6	1.9	1.8	-1.3	-1.8	-0.5	-0.0
Irritability	2.9	4.9	10.0	-1.1	-0.3	-3.1	-3.2	2.1	2.2
Risk taking	0.4	0.6	1.8	-1.3	-0.9	0.4	0.2	0.7	0.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	4.6	-1.2	-2.1	-0.6	-0.5	0.8	1.0
Fractured/broken bones in last 5 years	0.7	0.9	4.5	-2.1	-0.7	0.3	-0.0	-0.6	-0.5
Age started oral contraceptive pill	0.6	0.7	2.0	-0.9	-0.1	0.2	1.4	0.9	0.8
Diastolic blood pressure, automated reading	1.0	3.1	13.0	3.6	1.8	-0.9	-0.8	-0.5	-0.9
Ever depressed for a whole week	1.9	2.3	4.4	-0.2	-0.4	-1.4	-1.9	2.1	1.9
Unable to work because of sickness or disability	4.4	5.7	8.3	-2.7	-1.9	-1.7	-2.0	2.9	2.9
Commuting to job workplace: Cycle	0.1	0.1	0.6	-0.7	-0.1	0.1	-0.4	-0.1	0.1
Myopia	0.9	1.3	4.2	1.0	-0.1	-2.0	-1.2	0.9	0.7
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.3	-0.3	1.5	-0.4	1.8	-1.6	-1.5
Cholesterol lowering medication	0.7	1.0	4.0	-2.0	-1.3	0.1	0.6	0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.9	-1.7	-0.5	0.5	-0.8	0.6	0.5
Pain experienced in last month	0.5	0.8	3.0	1.0	0.7	0.5	1.7	-0.5	-0.3
Supplements: Calcium	0.3	0.3	1.0	0.2	1.0	-0.5	-0.2	-0.3	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-1.2	-0.5	-0.4	-0.2	0.3	0.3
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.8	-1.6	-0.8	0.5	-2.0	1.3	1.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.9	0.3	-0.8	0.2	0.3	0.3
Heart disease (siblings)	1.7	2.1	7.5	-0.9	-0.8	1.7	2.7	0.6	0.4
Alcohol drinker status: Previous	0.4	0.4	1.1	-1.1	0.2	-0.8	-0.0	0.7	0.4
Pack years of smoking	0.5	0.7	2.2	-0.1	0.8	-0.4	1.5	-0.8	-0.9
Impedance of whole body	3.7	19.0	29.6	-0.9	-3.2	-5.1	-4.6	5.1	5.4
Leg fat mass (left)	0.5	1.9	5.7	-2.4	-0.9	2.1	-0.1	-0.4	-0.1
Arm predicted mass (left)	0.9	4.7	9.4	-1.1	-0.1	2.9	0.5	-3.0	-3.1