Best TWAS P=1.08e-17 · Best GWAS P=1.2e-37 conditioned to 3.38e-19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | 6.7 | 8.6 | 1.1e-17 | 0.77 | 0.06 | 0.67 | TRUE |
| 2 | GTEx | Thyroid | CCDC9 | 0.22 | 0.09 | lasso | 4 | 0.16 | 3.6e-12 | 2.0 | -6.0 | 2.2e-09 | -0.32 | 0.98 | 0.00 | TRUE |
| 3 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | 5.8 | 8.1 | 7.6e-16 | 0.61 | 0.61 | 0.39 | FALSE |
| 4 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | 7.8 | 6.6 | 3.3e-11 | 0.56 | 0.99 | 0.01 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRLF1 | 0.04 | 0.04 | blup | 51 | 0.03 | 7.0e-05 | -3.4 | -5.4 | 7.9e-08 | -0.04 | 0.47 | 0.02 | TRUE |