TWAS hub - GRLF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0679	0.0347	0.00130	0.009	0.027	0.022	NA	0.024	2.9e-02	0.00043	0.0012	NA	0.00090
2	TCGA	Lung Squamous Cell Carcinoma	0.0401	0.0211	0.00034	0.040	0.035	0.016	NA	0.029	2.1e-05	0.00007	0.0058	NA	0.00025

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Chronic bronchitis/emphysema (father)	7.3	8.5	16.2	-4.0	-0.9
Ever smoked	5.9	10.3	18.5	-4.3	1.4
Blood clot in the leg (DVT)	5.3	6.9	8.8	2.2	3.0
Vitamin and mineral supplements	5.0	6.8	12.8	-3.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	5.0	6.5	6.6	2.5	2.6
Other serious medical condition/disability diagnosed by doctor	4.8	6.3	7.8	2.2	2.8
Intelligence (Savage-Jansen 2018)	4.3	13.3	26.6	-5.2	0.2
Unable to work because of sickness or disability	4.3	5.6	7.4	1.9	2.7
Fluid intelligence score	4.2	8.7	15.1	-3.9	-1.5
Verbal and Numeric Reasoning (VNR)	4.1	9.9	19.8	-4.4	-0.0
Past tobacco smoking	4.1	7.5	12.5	3.5	-1.6
Breast cancer (self-reported)	4.1	4.8	9.1	3.0	0.8
Impedance of whole body	3.9	19.7	38.8	0.8	-6.2
Supplements: Fish oil (including cod liver oil)	3.8	5.0	6.9	2.6	1.8
Age at First Birth	3.6	5.2	5.4	-2.3	-2.3
Average weekly spirits intake	3.5	4.3	4.5	2.0	2.1
Overall health rating	3.4	7.2	9.2	2.3	3.0
Supplements: Vitamin C	3.4	4.1	5.4	2.3	1.6
Breast Cancer	3.3	7.9	15.5	-3.9	-0.6
Primary Biliary Cirrhosis	3.3	4.7	8.4	2.9	-1.0
Arm fat-free mass (right)	3.3	16.9	33.6	0.4	5.8
Impedance of leg (left)	3.2	15.3	28.8	1.3	-5.4
Arm predicted mass (right)	3.2	16.1	32.2	0.3	5.7
Whole body fat-free mass	3.2	18.0	36.0	-0.1	6.0
Whole body water mass	3.2	18.2	36.4	-0.0	6.0
Trunk fat-free mass	3.1	17.8	35.5	0.3	6.0
Arm fat-free mass (left)	3.1	15.8	31.7	-0.1	5.6
Multivitamins +/- minerals	3.0	3.8	6.8	2.6	0.9
Qualifications: None of the above	3.0	6.5	10.5	3.2	1.6
Trunk predicted mass	3.0	17.4	34.8	0.2	5.9
Mineral and other dietary supplements	3.0	4.0	6.0	-2.5	-1.4
Leg fat-free mass (left)	2.9	15.6	30.5	-0.8	5.5
Leg predicted mass (left)	2.9	15.5	30.5	-0.8	5.5
Comparative body size at age 10	2.9	7.9	9.0	-3.0	2.6
Suffer from ‘nerves’	2.9	4.6	4.6	-2.1	-2.1
Smoking status: Previous	2.9	4.4	7.3	-2.7	1.2
Basal metabolic rate	2.9	16.1	32.0	-0.4	5.7
Arm predicted mass (left)	2.9	14.7	29.4	-0.0	5.4
Number of incorrect matches in round	2.8	4.6	7.0	-2.6	-1.5
Chest pain or discomfort	2.8	4.1	8.1	-2.8	-0.3
Hearing difficulty/problems with background noise	2.7	4.3	4.9	-1.9	2.2
Impedance of arm (right)	2.7	12.7	25.4	-0.0	-5.0
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	6.1	-2.5	-1.6
Medication: Ventolin 100micrograms inhaler	2.7	3.5	6.2	-2.5	-0.9
Leg fat-free mass (right)	2.7	14.3	28.4	-0.5	5.3
Leg predicted mass (right)	2.7	14.2	28.2	-0.6	5.3
Impedance of arm (left)	2.6	12.2	24.4	-0.0	-4.9
Blood White Count	2.5	18.3	35.5	-1.0	-6.0
Lung FVC	2.5	12.7	17.2	-2.8	-4.1
Impedance of leg (right)	2.5	12.1	23.6	0.8	-4.9
Current tobacco smoking	2.5	4.1	4.9	-2.2	1.8
Medication: Paracetamol	2.5	4.1	4.3	2.1	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	10.3	-0.6	-3.2
Long-standing illness, disability or infirmity	2.3	3.5	4.0	-1.8	2.0
Smoking status: Current	2.3	3.6	3.8	-1.9	1.8
Smoking Status	2.2	5.2	8.1	-2.9	1.5
Medication: Co-codamol	2.2	2.5	4.8	0.4	2.2
Medication: Cholesterol lowering	2.2	3.4	5.3	-2.3	-1.2
Medication: Gliclazide	2.2	2.5	4.8	0.3	2.2
Eye problems/disorders: Diabetes related eye disease	2.0	2.3	3.3	1.1	1.8
Supplements: Zinc	2.0	2.2	2.2	1.5	1.5
Worry too long after embarrassment	2.0	3.4	4.9	-2.2	-1.4
Knee pain experienced in last month	2.0	3.1	6.2	-0.0	2.5
Diabetes diagnosed by doctor	2.0	3.3	6.1	0.8	2.5
Waist circumference	1.9	7.1	10.9	-1.8	3.3
Hip circumference	1.9	8.2	12.5	-2.0	3.5
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	4.2	2.0	1.9
Risk taking	1.9	2.8	5.4	-2.3	0.5
BMI	1.8	10.5	12.1	-3.0	3.5
Number of treatments/medications taken	1.8	3.2	6.4	0.0	2.5
Alcohol usually taken with meals	1.8	3.0	4.9	2.2	-1.0
Weight	1.8	8.8	15.8	-1.4	4.0
Average weekly red wine intake	1.8	2.7	5.0	-2.2	-0.5
Hypothyroidism (self reported)	1.7	3.9	7.3	0.7	2.7
Taking other prescription medications	1.7	2.6	5.0	-0.4	2.2
Forced vital capacity (FVC), Best measure	1.7	6.3	9.0	-1.9	-3.0
Supplements: Calcium	1.7	1.9	3.6	1.9	0.4
Rheumatoid Arthritis	1.6	2.2	3.6	0.9	1.9
Chronotype (morning person)	1.6	3.7	7.3	-2.7	-0.2
Body mass index (BMI)	1.6	6.7	8.4	-2.3	2.9
Forced vital capacity (FVC)	1.6	6.1	6.2	-2.4	-2.5
Arm fat mass (right)	1.6	6.4	7.5	-2.3	2.7
Hair/balding pattern: Pattern 4	1.6	3.9	7.7	-2.8	-0.4
Age at first live birth	1.6	2.9	3.5	-1.5	-1.9
Leg pain on walking	1.6	2.1	2.8	1.1	1.7
Fasting Glucose	1.5	1.8	2.1	1.4	1.2
Cardiovascular Disease	1.5	5.0	5.8	-2.4	2.0
Depression (self-reported)	1.5	1.8	2.4	1.1	1.5
Hypothyroidism/myxoedema (self-reported)	1.5	2.8	5.5	0.4	2.4
Alcohol intake frequency.	1.5	3.4	6.4	2.5	0.7
Arm fat mass (left)	1.5	6.0	6.1	-2.5	2.4
Irritability	1.5	2.5	3.2	-1.8	-1.3
Cholesterol lowering medication	1.5	2.3	3.7	0.9	1.9
Had other major operations	1.4	1.8	2.7	1.6	-0.9
Exposure to tobacco smoke outside home	1.4	1.9	3.3	1.8	0.7
Number of children fathered	1.4	1.6	3.1	-0.2	1.8
Heart disease (mother)	1.4	1.6	3.2	-1.8	0.3
Leg fat mass (right)	1.4	5.5	5.7	-2.3	2.4
Commuting to job workplace: Walk	1.4	1.5	2.8	1.7	0.3
Eye problems/disorders: Cataract	1.4	1.6	2.0	-1.4	-1.1
Eye problems/disorders: Glaucoma	1.4	1.7	2.9	-1.7	0.7
Schizophrenia vs Biploar Disorder	1.3	1.8	2.6	-1.6	-1.0
Average weekly fortified wine intake	1.3	1.6	3.0	-1.7	0.3
Nervous feelings	1.3	2.4	4.4	0.6	-2.1
Qualifications: A levels/AS levels or equivalent	1.3	2.9	3.1	-1.7	-1.8
Pulse wave reflection index	1.3	1.6	2.9	-1.7	-0.6
Ever depressed for a whole week	1.3	1.7	2.4	0.9	1.6
Leg fat mass (left)	1.3	5.2	5.2	-2.2	2.3
Depression (Nagel 2018)	1.2	1.8	3.2	0.7	1.8
Lung FEV1/FVC ratio	1.2	6.0	9.0	1.8	3.0
Hand grip strength (left)	1.2	3.1	6.1	-2.5	0.2
Ever had hysterectomy (womb removed)	1.2	1.4	1.6	1.1	1.3
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	1.6	1.2	1.1
Diabetes (self-reported)	1.2	1.8	3.3	0.6	1.8
Leg fat percentage (right)	1.2	4.2	7.8	-2.8	0.7
Family relationship satisfaction	1.2	1.5	2.8	0.5	1.7
Hypertension (Self-reported)	1.2	3.4	6.0	-2.5	0.9
Guilty feelings	1.2	1.8	3.2	-0.6	-1.8
Number of operations (self-reported)	1.2	1.7	3.4	1.9	0.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.8	0.2	-1.7
Alzheimer’s Disease (in mother)	1.1	1.3	1.3	1.1	1.1
Alzheimer’s Disease (including proxy)	1.1	1.5	2.0	1.4	1.1
Ulcerative Colitis (UC)	1.1	2.0	3.8	1.9	-0.5
LDL Cholesterol	1.1	1.8	3.4	0.5	1.8
Respiratory disease	1.1	2.4	4.7	-2.2	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.3	1.5	-0.1
High blood pressure	1.1	3.2	5.1	-2.3	1.1
Arm fat percentage (right)	1.1	4.3	7.6	-2.8	1.0
Prospective memory result	1.1	1.4	2.7	0.3	1.6
Loud music exposure frequency	1.1	1.2	1.5	1.2	-0.9
Glaucoma (self-reported)	1.1	1.3	1.3	-1.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.6	-0.0	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.6	-1.3	-0.9
Average weekly champagne plus white wine intake	1.1	1.5	2.8	-1.7	0.6
Medication: Paracetamol	1.1	1.8	2.2	1.5	1.1
Triglycerides	1.0	1.6	1.8	-1.2	1.3
Type 2 Diabetes (T2D) (2018)	1.0	1.8	2.8	0.9	1.7
Sensitivity / hurt feelings	1.0	1.7	2.9	-1.7	-0.6
Relative age of first facial hair	1.0	2.0	3.7	1.9	0.5
Supplements: Glucosamine	1.0	1.3	2.1	1.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	2.8	1.4	1.7
Asthma	1.0	2.0	3.9	-2.0	-0.0
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.2	-0.3	-1.5
Neck or shoulder pain in last month	1.0	1.4	1.5	1.2	1.2
Whole body fat mass	1.0	4.3	4.5	-2.1	2.0
Pulse rate, automated reading	1.0	3.3	6.5	2.5	0.4
Arm fat percentage (left)	1.0	4.1	7.0	-2.6	1.1
Asthma (self-reported)	1.0	2.0	3.9	-2.0	-0.2
Osteoporosis (self-reported)	1.0	1.2	1.9	-1.4	-0.8
Reaction Time	0.9	1.7	3.2	-0.5	1.8
Angina	0.9	1.2	2.3	-1.5	0.3
Trunk fat mass	0.9	4.0	4.8	-2.2	1.8
Time employed in main current job	0.9	1.0	1.8	0.4	-1.3
Falls in the last year	0.9	1.3	1.6	-1.0	1.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.7	1.6	0.4
Health satisfaction	0.9	1.2	1.5	1.2	1.0
Comparative height size at age 10	0.9	5.0	6.4	1.9	2.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.3	-1.2	0.8
Miserableness	0.9	1.5	2.5	-1.6	-0.8
Leg fat percentage (left)	0.9	3.2	6.0	-2.4	0.6
Prostate Cancer	0.8	1.1	1.2	1.0	1.1
Coronary Artery Disease (CAD)	0.8	0.9	1.3	-0.8	-1.1
Neuroticism	0.8	2.0	2.3	-1.3	-1.5
Medication: Metformin	0.8	1.1	1.3	-1.0	1.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.8	-1.4	0.3
Neuroticism score	0.8	1.8	2.2	-1.1	-1.5
Number of full brothers	0.8	1.0	1.3	0.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.8	-1.3	0.0
Qualifications: College or University degree	0.8	2.5	3.1	-1.7	-1.4
Ever had bowel cancer screening	0.8	1.0	1.2	-0.9	1.1
Qualifications: nursing, teaching	0.8	1.3	2.3	-0.5	-1.5
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	1.2	0.7
Wears glasses or contact lenses	0.8	0.9	1.7	-0.3	-1.3
Alcohol drinker status: Never	0.8	1.0	1.6	1.3	-0.6
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.2	1.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.1	-1.4	-0.1
Heart disease (siblings)	0.8	0.9	1.7	-1.3	-0.4
Mean Putamen Volume	0.7	0.8	1.1	-1.1	0.6
Severe depression (siblings)	0.7	0.7	1.3	1.1	0.4
Pack years adult smoking proportion	0.7	1.1	1.9	1.4	0.5
Relative age voice broke	0.7	1.1	1.6	0.7	-1.2
Medication: Levothyroxine sodium	0.7	1.1	2.1	0.4	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	0.6	1.3
Financial difficulties in last 2 years	0.7	1.0	1.9	0.0	1.4
Mouth/teeth dental problems	0.7	1.1	2.2	1.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.3	-1.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	2.3	-1.5	-1.4
Headache pain in last month	0.7	1.2	1.6	0.8	1.3
Body fat percentage	0.7	2.9	5.5	-2.4	0.4
Medication: Blood pressure	0.7	1.2	2.4	-1.5	-0.0
Angina (self-reported)	0.7	1.0	1.6	-1.3	0.6
Medication: Omeprazole	0.7	0.8	1.0	-1.0	-0.8
Medication: Aspirin	0.7	0.9	1.1	-0.9	1.1
High cholesterol (Self-reported)	0.7	1.3	1.9	-0.8	1.4
Average weekly beer plus cider intake	0.7	1.0	1.4	-1.2	-0.8
Fractured/broken bones in last 5 years	0.7	1.0	1.5	-1.2	0.6
Pack years of smoking	0.7	1.0	1.9	1.4	0.3
Neuroticism (Nagel 2018)	0.6	1.3	2.0	-0.8	-1.4
Lupus	0.6	0.9	1.4	1.2	0.6
Diabetes (mother)	0.6	0.7	1.5	0.0	1.2
Trunk fat percentage	0.6	2.4	4.8	-2.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	0.0	1.3
Age when periods started (menarche)	0.6	1.3	2.1	1.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	1.5	1.2	1.2
Qualifications: CSEs or equivalent	0.6	0.8	1.7	-0.2	1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	0.9	-1.0	-0.7
Heart attack	0.6	0.8	1.5	-1.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.2	-1.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	0.5	1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.6	-1.3	0.2
Wheeze or whistling in the chest in last year	0.6	1.1	1.7	-1.3	0.7
Medication: Aspirin	0.6	0.8	1.1	-0.8	1.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	-1.1	0.4
Alzheimer’s Disease (in father)	0.5	0.6	0.7	-0.6	-0.9
Major Depression (MDD)	0.5	0.6	1.1	0.4	1.1
Neuroticism (2016)	0.5	0.7	1.4	0.2	-1.2
Blood Platelet Count	0.5	5.5	9.5	-1.2	-3.1
Height	0.5	9.7	10.3	3.0	3.2
Stomach or abdominal pain in last month	0.5	0.6	1.2	0.0	1.1
Worrier / anxious feelings	0.5	1.0	1.5	1.2	-0.6
Medication: Ibuprofen	0.5	0.6	1.1	1.1	0.1
Medication: Seretide 50 evohaler	0.5	0.6	0.8	-0.6	0.9
Mean time to correctly identify matches	0.5	0.9	1.5	-0.6	1.2
Friendships satisfaction	0.5	0.6	1.3	-1.1	0.2
Financial situation satisfaction	0.5	0.7	1.3	1.2	0.0
Myopia	0.5	0.7	1.3	1.1	-0.2
Worry (Nagel 2018)	0.4	0.8	1.6	0.1	-1.3
HDL Cholesterol	0.4	0.7	1.3	0.3	-1.1
Waist Hip Ratio (WHR)	0.4	1.8	3.5	1.9	0.0
Systolic Blood Pressure	0.4	2.0	3.3	0.8	1.8
Maternal smoking around birth	0.4	0.6	0.6	-0.8	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	0.5	0.6	0.7
Father’s age at death	0.4	0.5	0.8	-0.9	-0.5
Standing height	0.4	4.1	5.6	1.6	2.4
Length of working week for main job	0.4	0.4	0.7	-0.9	0.2
Tense / ‘highly strung’	0.4	0.7	1.5	-0.1	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-1.1	-0.2
High blood pressure (siblings)	0.4	0.6	1.1	-1.1	0.2
Shortness of breath walking on level ground	0.4	0.5	0.5	0.7	0.7
Emphysema/chronic bronchitis	0.4	0.4	0.8	-0.9	-0.2
Had major operations	0.4	0.4	0.7	-0.3	-0.9
Age at last live birth	0.4	0.6	0.7	-0.9	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.8	-0.9	0.3
Illnesses of siblings: Diabetes	0.4	0.5	0.7	0.8	0.6
Mood swings	0.4	0.8	1.4	-1.2	-0.5
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	-1.1	0.2
Medication: Lisinopril	0.4	0.5	0.7	-0.8	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	1.0	-0.2
Diastolic blood pressure, automated reading	0.4	1.1	1.8	-0.6	1.3
Ovarian Cancer	0.3	0.4	0.7	0.1	0.8
Blood Red Count	0.3	2.6	5.2	2.3	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.5	-0.6	0.7
Hearing difficulty/problems: Yes	0.3	0.4	0.8	-0.3	0.9
Medication for hormone replacement therapy	0.3	0.3	0.3	-0.6	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	0.8	-0.4
Happiness	0.3	0.3	0.6	0.7	0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.9	0.4
Lung cancer (father)	0.3	0.4	0.6	0.4	0.7
Breastfed as a baby	0.3	0.4	0.5	-0.5	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.8	0.3
Birth weight	0.3	0.7	1.0	-0.5	1.0
Number of full sisters	0.3	0.4	0.5	0.7	0.5
Illnesses of father: Heart disease	0.3	0.4	0.5	-0.6	0.7
Medication for cholesterol	0.3	0.4	0.7	0.3	-0.8
Back pain experienced in last month	0.3	0.5	0.8	-0.4	0.9
Medication: Atorvastatin	0.3	0.3	0.7	-0.8	0.0
Age started oral contraceptive pill	0.3	0.3	0.6	0.4	-0.7
Commuting to job workplace: Cycle	0.3	0.4	0.6	0.5	0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	0.9	-0.0
Schizophrenia (2018)	0.2	0.4	0.6	0.8	-0.4
Crohns Disease (2017)	0.2	0.4	0.4	-0.7	0.6
HbA1C	0.2	0.2	0.3	-0.5	0.4
Schizophrenia (2014)	0.2	0.4	0.7	0.9	-0.3
Tanning	0.2	2.6	4.4	0.9	2.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.4	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.8	-0.1
Fed-up feelings	0.2	0.4	0.5	-0.4	0.7
Medication: Atenolol	0.2	0.2	0.4	0.0	-0.7
High blood pressure (mother)	0.2	0.3	0.5	-0.7	0.1
Allergy	0.2	0.4	0.8	0.1	-0.9
Pain all over the body in last month	0.2	0.2	0.3	0.5	0.4
Medication: Ramipril	0.2	0.2	0.4	-0.6	0.1
Illnesses of siblings	0.2	0.3	0.5	-0.7	-0.4
Pulse rate	0.2	0.3	0.4	0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	-0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	0.6	-0.4
Illnesses of mother	0.2	0.2	0.4	0.6	0.0
Gout (self-reported)	0.2	0.3	0.3	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	-0.3	-0.8
Medication: Allopurinol	0.2	0.3	0.5	-0.2	-0.7
Loneliness, isolation	0.2	0.2	0.4	-0.4	0.6
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.6	-0.1
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.4	0.6
Bipolar Disorder (2018)	0.1	0.2	0.2	0.4	0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.6	-0.2
Ulcerative Colitis	0.1	0.2	0.3	0.5	-0.2
Blood Eosinophil Count	0.1	0.6	1.3	1.1	0.1
Heel T-Score	0.1	1.2	1.3	1.0	1.2
Allergy or Eczema	0.1	0.3	0.5	0.7	-0.0
Systolic blood pressure, automated reading	0.1	0.3	0.4	0.4	0.7
Hand grip strength (right)	0.1	0.1	0.3	-0.2	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.4	-0.1
Had menopause	0.1	0.1	0.1	0.4	0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.2	0.4	-0.3
Number of live births	0.1	0.2	0.2	0.5	0.4
Medication: Lansoprazole	0.1	0.1	0.2	0.5	0.0
Birth weight of first child	0.1	0.1	0.3	-0.1	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.1	0.4
Pulse wave peak to peak time	0.1	0.2	0.2	0.5	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.3	-0.1
Migraine (self-reported)	0.1	0.1	0.1	-0.3	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	-0.5	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.2	0.3
Mother’s age at death	0.1	0.1	0.2	0.2	0.4
Medication: Blood pressure	0.1	0.2	0.3	-0.6	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.1	0.3	0.4
Pain experienced in last month	0.1	0.2	0.2	0.4	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.2	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.2	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.1	2.2	-0.0	-1.5
Diabetes (father)	0.0	0.0	0.1	-0.2	0.2
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.4	-0.2
Sitting height	0.0	0.3	0.3	0.4	0.6
Medication: Simvastatin	0.0	0.0	0.0	0.1	-0.2
Noisy workplace	0.0	0.0	0.1	0.2	-0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.2	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	-0.1
Peak expiratory flow (PEF)	0.0	0.0	0.0	-0.1	-0.0
Medication: Amlodipine	0.0	0.0	0.1	-0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.0	0.1
Hearing aid user	0.0	0.0	0.0	0.1	0.0
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.1	-0.1
Illnesses of father: High blood pressure	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

GRLF1

Models

Trait associations