TWAS
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Traits
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Traits
:
Impedance of leg (left)
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chr2:189,611,749-191,029,604
Best TWAS P=5.17e-10 · Best GWAS P=1.94e-09 conditioned to 0.00895
189.6M
189.8M
190M
190.2M
190.4M
190.6M
190.8M
191M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
COL5A2
0.04
0.00
blup
79
0.02
0.0059
-5.4
6.2
5.2e-10
-0.65
0.03
0.54
TRUE
1
GTEx
Adipose Subcutaneous
WDR75
0.05
0.04
lasso
2
0.03
0.0012
-5.7
5.8
5.9e-09
-0.85
0.04
0.87
FALSE
3
GTEx
Skin Sun Exposed Lower leg
WDR75
0.05
0.04
lasso
4
0.03
0.0012
-5.5
5.6
2.6e-08
-0.89
0.05
0.93
FALSE
2
GTEx
Breast Mammary Tissue (Male)
WDR75
0.16
0.00
lasso
9
0.00
0.2640
-5.5
5.4
8.1e-08
-0.72
0.04
0.29
FALSE