Hub : Genes

COL5A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1440 0.0350 4.2e-13 0.127 0.124 0.121 0.126 0.125 3.7e-15 8.1e-15 1.8e-14 4.3e-15 6.3e-15
2 GTEx Brain Putamen basal ganglia 0.3370 0.1080 7.8e-03 -0.013 NA 0.005 NA -0.011 9.2e-01 NA 2.4e-01 NA 7.6e-01
3 GTEx Cells EBV-transformed lymphocytes 0.4010 0.1670 5.3e-03 0.042 NA 0.108 NA 0.007 1.7e-02 NA 2.2e-04 NA 1.8e-01
4 GTEx Cells Transformed fibroblasts 0.1760 0.0450 7.0e-09 0.106 NA 0.178 NA 0.159 2.3e-08 NA 2.5e-13 NA 5.9e-12
5 ROSMAP Brain Pre-frontal Cortex 0.0582 0.0223 8.7e-05 0.060 0.021 0.047 0.030 0.055 3.8e-08 9.2e-04 9.9e-07 8.9e-05 1.2e-07
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0397 0.0215 1.4e-03 -0.001 0.016 -0.001 NA 0.001 5.2e-01 5.9e-03 4.4e-01 NA 2.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.7 1.9 -1.3 0.3 0.0 -0.5 -1.4 0.7
Bipolar Disorder or Schizophrenia 0.6 1.5 3.3 -1.7 0.2 0.0 -1.0 -1.4 1.8
Depressed Affect (Nagel 2018) 0.2 0.4 1.4 0.9 1.2 0.0 -0.3 0.2 0.5
Depression (Nagel 2018) 0.5 0.7 1.5 0.6 0.9 0.0 0.7 1.0 -1.2
Intelligence (Savage-Jansen 2018) 0.7 2.2 10.4 1.0 -3.2 0.0 -0.1 0.5 -1.2
Neuroticism (Nagel 2018) 0.3 0.6 2.5 1.0 1.6 0.0 -0.0 0.4 0.5
Schizophrenia (2018) 0.5 1.0 3.3 -1.1 0.1 0.0 -0.8 -0.7 1.8
Schizophrenia vs Biploar Disorder 0.6 0.8 2.0 1.0 0.8 0.0 0.9 1.4 -0.8
Worry (Nagel 2018) 0.1 0.2 0.7 0.8 0.7 0.0 -0.4 0.0 -0.2
Alzheimer’s Disease (in mother) 0.6 0.7 2.1 -0.0 1.5 0.0 0.4 -0.5 1.3
Alzheimer’s Disease (in father) 2.5 2.7 5.7 -2.1 -0.8 0.0 -2.4 -1.9 1.3
Alzheimer’s Disease (including proxy) 0.8 1.1 2.3 -0.9 0.6 0.0 -1.3 -1.1 1.5
Crohns Disease (2017) 1.2 2.7 7.4 2.7 0.3 0.0 0.9 2.5 -1.3
Irritable Bowel Disease (IBD) 1.3 3.2 7.8 2.6 0.1 0.0 1.0 2.8 -1.8
Ulcerative Colitis (UC) 0.4 0.7 1.9 0.9 -0.3 0.0 0.3 1.4 -1.2
Major Depression (MDD) 0.1 0.1 0.3 0.4 0.3 0.0 -0.6 0.1 -0.1
Reaction Time 0.9 1.7 5.4 1.3 2.3 0.0 0.3 1.0 1.4
Verbal and Numeric Reasoning (VNR) 0.7 1.6 5.4 0.9 -2.3 0.0 0.3 0.9 -1.6
Breast Cancer 2.9 6.9 20.3 2.2 0.8 0.0 3.0 2.5 -4.5
Ovarian Cancer 1.1 1.5 4.1 2.0 -1.0 0.0 0.4 1.6 -1.0
Prostate Cancer 0.2 0.3 0.9 -0.8 0.2 0.0 -0.9 -0.4 -0.3
Age at First Birth 0.3 0.5 1.7 -0.7 0.9 0.0 -1.3 -0.1 0.0
Bipolar Disorder (2011) 3.4 3.3 8.1 -2.6 -0.0 0.0 -1.9 -2.9 1.2
Body Mass Index (BMI) (2010) 0.2 0.2 0.7 -0.7 -0.1 0.0 -0.3 -0.8 -0.3
Coronary Artery Disease (CAD) 2.2 2.6 5.2 1.8 -2.3 0.0 0.7 1.8 -1.8
Crohns Disease (2012) 1.3 2.1 6.1 2.5 0.8 0.0 0.9 2.1 -0.6
Mean Putamen Volume 0.6 0.7 1.3 -0.7 -0.7 0.0 -1.2 -1.1 0.7
Fasting Glucose 0.2 0.3 0.6 -0.5 -0.6 0.0 -0.4 -0.6 -0.8
HbA1C 0.1 0.1 0.4 -0.0 -0.1 0.0 0.6 0.1 0.3
HDL Cholesterol 0.1 0.2 0.4 -0.5 0.1 0.0 0.5 0.7 0.2
LDL Cholesterol 0.7 1.1 2.3 1.5 1.1 0.0 1.2 1.1 -0.6
Lupus 0.5 0.8 1.8 1.2 -0.8 0.0 0.7 0.6 -1.3
Neuroticism (2016) 0.7 1.1 3.4 1.9 1.4 0.0 -0.1 1.0 -0.1
Primary Biliary Cirrhosis 0.5 0.7 1.9 1.4 -0.2 0.0 0.9 1.3 -0.1
Rheumatoid Arthritis 0.2 0.3 1.1 0.3 -1.0 0.0 0.1 -0.2 -0.8
Schizophrenia (2014) 0.4 0.8 2.0 -0.7 1.0 0.0 -0.9 -0.6 1.4
Triglycerides 0.2 0.2 1.3 0.2 1.2 0.0 0.2 -0.1 -0.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 3.0 1.7 1.2 0.0 0.2 1.1 0.3
Ulcerative Colitis 0.7 1.0 3.4 0.9 0.1 0.0 0.1 1.8 -1.3
Blood Eosinophil Count 0.1 0.8 1.6 -1.3 0.5 0.0 -1.1 -1.0 0.9
Blood Platelet Count 0.1 0.6 2.9 0.5 0.6 0.0 0.2 -0.3 1.7
Blood Red Count 1.9 18.0 37.1 -5.8 -3.8 0.0 -4.7 -6.1 0.9
Blood White Count 0.4 3.0 9.6 -3.1 0.1 0.0 -0.2 -2.9 0.6
Heel T-Score 0.1 0.5 1.5 0.3 0.9 0.0 -0.7 0.1 -1.2
BMI 0.2 1.1 3.5 -0.7 0.8 0.0 0.5 -1.2 -1.9
Height 0.1 1.8 6.9 0.3 -2.6 0.0 -1.6 1.0 0.8
Waist Hip Ratio (WHR) 0.8 3.6 10.6 1.1 0.6 0.0 3.2 1.7 -2.5
Systolic Blood Pressure 1.3 6.3 15.9 4.0 2.4 0.0 3.0 2.6 -0.7
Smoking Status 0.6 1.4 7.2 0.5 2.7 0.0 0.8 0.0 -0.3
Allergy or Eczema 0.5 1.4 5.1 1.4 1.1 0.0 0.3 2.2 0.1
Cardiovascular Disease 0.5 1.8 4.8 1.7 0.8 0.0 2.2 1.2 -0.9
Hypothyroidism (self reported) 0.3 0.6 2.5 0.7 -1.6 0.0 -0.8 0.0 -0.4
Respiratory disease 0.4 0.8 2.2 1.5 0.6 0.0 0.4 1.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.5 0.3 0.0 -0.3 -0.8 0.0
Lung FEV1/FVC ratio 0.3 1.7 9.9 0.1 -3.1 0.0 0.4 0.1 -0.7
Lung FVC 0.9 4.5 10.3 -3.1 -1.5 0.0 -2.2 -3.2 -0.2
Neuroticism 0.3 0.8 3.2 1.3 1.8 0.0 -0.1 0.1 -0.4
Chronotype (morning person) 0.4 0.9 2.1 1.2 -0.1 0.0 0.7 1.4 -1.2
Hair Pigment 0.1 2.0 4.4 -2.1 -0.8 0.0 -1.5 -2.1 -0.2
Tanning 0.1 0.7 2.5 0.9 1.6 0.0 -0.4 0.6 -0.0
Hand grip strength (left) 1.5 3.8 7.7 2.8 0.2 0.0 1.4 2.8 -2.4
Number of treatments/medications taken 0.4 0.7 2.3 1.0 0.1 0.0 1.5 0.9 0.4
Average weekly spirits intake 1.0 1.3 3.0 0.8 -1.3 0.0 1.7 0.9 -1.3
Sensitivity / hurt feelings 0.6 1.0 3.1 1.1 1.8 0.0 0.5 1.2 0.1
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.0 0.7 1.2 0.0 1.7 1.3 -1.0
Hearing difficulty/problems: Yes 1.7 2.5 4.6 -1.9 -1.7 0.0 -2.1 -1.7 1.2
Relative age of first facial hair 0.1 0.1 0.5 -0.3 -0.7 0.0 -0.5 -0.1 0.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 3.4 1.9 -0.9 0.0 -0.2 1.3 0.4
Ever used hormone-replacement therapy (HRT) 0.4 0.5 2.3 -0.4 0.7 0.0 -0.3 -0.5 1.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.5 0.6 0.7 0.0 0.4 0.3 -0.1
Systolic blood pressure, automated reading 1.2 3.5 7.9 2.8 1.2 0.0 2.2 2.2 -1.4
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 3.8 -1.6 0.8 0.0 -0.5 -1.5 1.9
Angina 0.4 0.5 1.7 -0.0 -1.0 0.0 0.5 -0.0 -1.3
Medication for hormone replacement therapy 0.7 0.8 3.1 -0.6 0.9 0.0 -0.2 -0.7 1.8
Vitamin and mineral supplements 1.5 2.0 5.0 2.0 0.0 0.0 1.3 2.2 -1.1
Supplements: Zinc 0.6 0.6 2.0 -1.4 0.4 0.0 -0.6 -0.9 0.6
Medication: Co-codamol 0.3 0.3 0.9 0.9 0.8 0.0 -0.0 0.7 0.1
Medication: Metformin 0.5 0.7 2.9 0.1 1.7 0.0 1.1 0.0 -0.5
Diabetes (father) 0.1 0.1 0.5 0.2 0.7 0.0 -0.1 -0.1 -0.1
Diabetes (mother) 0.6 0.8 1.9 -0.6 -0.1 0.0 -1.0 -1.2 1.4
Severe depression (siblings) 1.0 1.2 3.8 -1.6 0.0 0.0 -0.8 -2.0 -0.1
Pack years adult smoking proportion 0.4 0.7 2.4 -0.5 -0.0 0.0 -0.4 -1.6 1.1
Impedance of leg (right) 1.7 8.4 41.3 -1.4 1.0 0.0 -1.4 -2.0 6.4
Leg fat-free mass (left) 0.3 1.5 6.8 0.1 -1.4 0.0 0.4 0.6 -2.6
Trunk fat percentage 1.4 5.7 12.7 -3.4 1.1 0.0 -1.7 -3.6 2.4
Hand grip strength (right) 0.8 2.3 5.8 1.9 0.3 0.0 0.6 2.4 -2.0
Townsend deprivation index at recruitment 0.5 0.7 3.3 -0.4 0.2 0.0 1.8 -0.2 -0.6
Current tobacco smoking 0.8 1.3 7.1 -0.3 2.7 0.0 0.6 -0.7 -0.2
Average weekly fortified wine intake 0.2 0.3 1.1 -1.1 -0.3 0.0 -0.5 -0.2 -0.5
Maternal smoking around birth 1.1 1.5 4.8 1.1 2.2 0.0 0.6 1.3 1.2
Fed-up feelings 0.5 0.9 1.6 1.0 1.2 0.0 1.3 0.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 2.0 -0.7 1.4 0.0 0.6 -0.4 0.1
Relative age voice broke 0.3 0.4 0.9 0.9 -0.1 0.0 -0.9 0.7 0.4
Taking other prescription medications 0.3 0.4 1.5 1.2 -0.3 0.0 0.3 0.5 0.9
Age when periods started (menarche) 0.1 0.3 0.5 -0.6 0.7 0.0 -0.7 -0.3 0.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 2.3 -0.3 1.0 0.0 1.5 0.5 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.6 -0.2 0.5 0.0 -0.3 -0.4 0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.7 -0.4 0.9 0.0 0.3 -0.1 -0.2
Qualifications: CSEs or equivalent 2.6 3.4 13.0 -0.8 1.1 0.0 -1.7 -1.6 3.6
Serious illness, injury or assault to yourself 0.1 0.1 0.3 -0.3 -0.1 0.0 -0.1 -0.0 0.6
High blood pressure 0.4 1.1 2.6 0.7 1.4 0.0 1.6 0.5 -1.2
Hayfever, allergic rhinitis or eczema 0.8 1.7 7.0 1.7 0.3 0.0 0.7 2.6 0.1
Multivitamins +/- minerals 0.9 1.2 2.6 -1.0 1.3 0.0 -1.0 -0.8 1.6
Stomach or abdominal pain in last month 1.4 1.7 3.4 -1.5 -1.2 0.0 -1.2 -1.3 1.8
Supplements: Glucosamine 0.6 0.8 1.8 -0.8 -1.0 0.0 -1.4 -1.0 0.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.0 0.1 1.4 0.0 -0.7 -0.6 1.0
Medication: Atenolol 0.1 0.1 0.5 -0.7 -0.3 0.0 -0.2 -0.2 0.4
Medication: Levothyroxine sodium 0.2 0.4 1.1 0.8 -1.0 0.0 0.6 0.2 -0.6
Sitting height 0.2 1.7 8.5 -0.3 -2.9 0.0 -1.3 0.4 -0.2
Chronic bronchitis/emphysema (father) 0.4 0.4 1.5 -1.2 0.2 0.0 -0.8 -0.7 -0.1
High blood pressure (mother) 0.4 0.6 2.1 1.4 0.6 0.0 -0.0 1.1 -0.2
Body mass index (BMI) 0.2 0.8 2.6 -0.9 0.6 0.0 0.1 -1.1 -1.6
Impedance of leg (left) 1.7 8.2 38.6 -1.7 0.9 0.0 -1.4 -2.1 6.2
Leg predicted mass (left) 0.3 1.6 7.2 0.1 -1.4 0.0 0.4 0.7 -2.7
Trunk fat mass 0.7 2.8 7.4 -2.7 0.6 0.0 -1.1 -2.6 1.0
Waist circumference 0.3 1.0 4.5 -0.9 -0.4 0.0 0.8 -0.3 -2.1
Number of incorrect matches in round 0.6 1.0 2.1 -0.8 1.4 0.0 -0.9 -0.6 1.4
Past tobacco smoking 0.3 0.5 2.3 -0.4 -1.5 0.0 0.4 -0.4 -0.6
Alcohol usually taken with meals 1.1 1.8 4.8 0.7 -2.2 0.0 0.6 1.3 -1.8
Nervous feelings 0.4 0.7 1.9 1.4 0.6 0.0 1.1 0.6 -0.7
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.8 8.9 1.4 1.6 0.0 3.0 1.6 -1.1
Hearing difficulty/problems with background noise 0.8 1.3 3.2 -0.8 -1.8 0.0 -1.3 -0.9 1.1
Hair/balding pattern: Pattern 2 0.6 0.8 1.9 -0.8 -0.4 0.0 -1.3 -0.4 1.4
Had menopause 2.0 2.4 4.8 -2.0 0.5 0.0 -2.2 -2.2 0.9
Had other major operations 0.8 1.0 2.2 1.4 -0.1 0.0 1.2 1.5 -0.7
Forced vital capacity (FVC) 1.1 4.2 10.6 -1.8 -3.2 0.0 -2.7 -1.5 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 -0.4 0.5 0.0 -0.3 -0.9 0.8
Ever unenthusiastic/disinterested for a whole week 0.9 1.2 3.8 -2.0 0.0 0.0 -1.2 -0.9 1.0
Qualifications: None of the above 0.7 1.5 4.5 -2.1 1.3 0.0 -0.6 -1.2 1.0
Financial difficulties in last 2 years 0.2 0.3 0.9 -0.3 -0.9 0.0 0.8 0.0 0.1
Mouth/teeth dental problems 0.2 0.3 0.8 -0.6 -0.3 0.0 -0.5 0.3 -0.9
Heart attack 0.2 0.3 0.9 0.6 -0.7 0.0 0.2 1.0 0.1
Allergy 1.4 3.2 10.4 -2.5 -0.9 0.0 -0.7 -3.2 1.0
Pain all over the body in last month 0.7 0.8 2.2 -1.0 1.5 0.0 -0.5 -1.0 0.5
Diabetes (self-reported) 0.4 0.6 1.8 -0.1 1.3 0.0 1.3 -0.4 -0.4
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.6 1.1 0.1 0.0 0.9 1.3 -1.1
Medication: Ramipril 0.8 1.0 3.5 0.1 1.2 0.0 -0.9 -0.4 1.9
Medication: Simvastatin 0.7 1.0 2.9 0.3 1.4 0.0 1.7 0.7 -0.8
Fluid intelligence score 2.1 4.3 7.6 2.8 -2.7 0.0 1.7 2.5 -1.5
Illnesses of siblings 1.2 1.7 5.2 -2.3 -1.6 0.0 -0.4 -1.4 0.4
Neuroticism score 0.5 1.0 4.7 0.9 2.2 0.0 0.6 0.3 0.3
Weight 0.1 0.4 1.5 -0.7 -0.5 0.0 -0.3 -0.5 -1.2
Impedance of arm (right) 1.6 7.4 34.0 -1.4 1.5 0.0 -1.7 -1.9 5.8
Arm fat percentage (right) 0.5 2.1 5.0 -2.1 1.6 0.0 -0.6 -2.2 0.6
Trunk fat-free mass 0.8 4.4 13.0 1.7 -1.8 0.0 1.1 2.5 -3.6
Hip circumference 0.3 1.2 2.9 -1.7 -0.7 0.0 -0.8 -1.7 -0.4
Time employed in main current job 0.4 0.5 1.6 0.2 -1.3 0.0 -1.0 0.4 -0.1
Alcohol intake versus 10 years previously 2.0 3.0 7.6 2.2 0.6 0.0 2.8 1.5 -1.6
Father’s age at death 0.2 0.3 1.4 -0.3 0.1 0.0 -0.1 -0.1 -1.2
Worrier / anxious feelings 0.1 0.2 0.7 0.5 -0.4 0.0 0.4 -0.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.2 1.0 1.0 0.0 1.1 0.5 0.7
Falls in the last year 0.3 0.4 1.5 0.3 -0.1 0.0 1.2 -0.1 -0.9
Hair/balding pattern: Pattern 3 1.4 2.1 11.1 -0.8 -3.3 0.0 -0.2 -0.6 -0.9
Number of live births 0.1 0.2 0.5 -0.5 -0.4 0.0 -0.4 -0.3 0.7
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 11.6 -1.0 -3.4 0.0 -1.9 -0.9 1.1
Pulse rate 0.3 0.5 1.2 0.9 0.3 0.0 -1.1 0.6 0.5
Happiness 0.1 0.1 0.2 0.5 -0.1 0.0 -0.2 0.1 0.4
Noisy workplace 2.4 2.9 5.7 -0.7 2.2 0.0 -1.7 -1.9 2.4
Qualifications: A levels/AS levels or equivalent 1.0 2.2 5.6 1.6 -2.4 0.0 1.1 1.4 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.3 1.3 0.2 0.0 1.0 1.0 -1.5
Mouth/teeth dental problems: Dentures 0.3 0.4 1.5 -0.1 0.9 0.0 -0.2 -0.4 1.2
Asthma 0.5 1.0 2.1 1.2 1.3 0.0 0.3 1.4 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 -0.7 -0.5 0.0 0.1 -0.6 0.5
Medication: Cholesterol lowering 1.1 1.7 5.0 0.6 0.3 0.0 2.2 0.8 -2.1
Depression (self-reported) 1.0 1.2 3.4 -1.9 -0.6 0.0 -0.8 -1.4 0.9
Medication: Lansoprazole 0.4 0.4 1.2 -0.1 0.8 0.0 -0.4 -0.7 1.1
Prospective memory result 2.7 3.3 8.4 -2.1 1.4 0.0 -2.2 -2.9 -0.0
Lung cancer (father) 0.4 0.4 1.3 -1.1 0.2 0.0 -0.7 -0.9 0.2
Illnesses of mother 0.3 0.4 1.2 -1.1 -0.0 0.0 0.0 -1.0 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 9.3 -1.3 -3.0 0.0 -2.1 -1.0 1.2
Pulse wave Arterial Stiffness index 0.7 0.9 3.8 -0.1 1.0 0.0 0.5 0.4 -1.9
Impedance of arm (left) 2.0 9.1 35.0 -2.4 0.9 0.0 -2.3 -2.8 5.9
Arm fat mass (right) 0.1 0.6 1.4 -1.1 0.9 0.0 -0.3 -1.2 -0.5
Trunk predicted mass 0.8 4.5 13.2 1.8 -1.7 0.0 1.2 2.5 -3.6
Standing height 0.2 1.8 6.9 0.3 -2.6 0.0 -0.9 1.4 1.0
Length of working week for main job 1.2 1.3 2.5 1.4 1.4 0.0 1.2 1.6 -0.2
Exposure to tobacco smoke at home 0.2 0.2 0.6 0.3 0.4 0.0 0.4 0.6 0.8
Breastfed as a baby 1.6 2.0 7.2 -0.6 -2.0 0.0 -0.4 -0.4 -2.7
Tense / ‘highly strung’ 1.1 1.8 4.8 1.4 2.2 0.0 1.5 1.0 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.3 -1.5 0.2 0.0 -1.1 -1.3 0.8
Hair/balding pattern: Pattern 4 0.4 0.9 2.9 -1.7 -0.1 0.0 -0.8 -1.4 0.1
Birth weight of first child 0.3 0.5 1.0 -1.0 0.3 0.0 -0.9 -0.5 0.8
Peak expiratory flow (PEF) 0.3 0.7 3.2 0.3 -1.8 0.0 0.2 0.7 -0.5
Pulse wave reflection index 0.3 0.3 0.9 0.3 0.9 0.0 0.9 0.4 -0.3
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.4 -0.8 1.5 0.0 -1.8 -1.3 1.2
Loud music exposure frequency 0.4 0.5 2.4 -0.2 1.6 0.0 -0.2 -0.6 0.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.5 1.3 -1.9 0.0 -0.4 0.5 -0.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 0.6 0.4 0.0 0.0 -0.1 -0.3
Blood clot in the leg (DVT) 1.0 1.3 3.2 1.5 1.8 0.0 0.3 1.4 -0.6
Medication: Paracetamol 0.4 0.6 2.3 -0.3 0.4 0.0 -0.2 -1.0 1.5
Headache pain in last month 0.3 0.5 1.4 0.1 -0.5 0.0 1.2 -0.4 -1.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.3 0.0 -1.5 0.0 -1.4 0.1 0.8
Glaucoma (self-reported) 0.3 0.4 1.8 0.2 -0.1 0.0 0.1 0.7 -1.3
Gout (self-reported) 0.1 0.1 0.3 -0.1 0.6 0.0 -0.6 -0.0 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.4 0.9 -1.2 0.0 0.0 0.0 -0.4
Medication: Amlodipine 0.9 1.2 3.2 -1.4 -0.3 0.0 -1.2 -1.8 0.9
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 0.0 0.6 0.0 0.1 0.0 0.4
Birth weight 0.6 1.4 4.2 1.8 -0.5 0.0 0.7 2.0 -0.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.1 0.7 -1.1 0.0 -0.4 0.6 -0.2
High blood pressure (siblings) 0.3 0.4 1.3 1.1 0.9 0.0 -0.4 0.4 -0.4
Forced vital capacity (FVC), Best measure 1.1 4.1 8.6 -2.0 -2.9 0.0 -2.8 -1.7 1.0
Body fat percentage 1.1 4.3 10.5 -3.0 1.3 0.0 -1.2 -3.2 1.7
Leg fat percentage (right) 0.9 3.1 7.8 -2.4 1.6 0.0 -0.7 -2.8 1.5
Arm fat-free mass (right) 0.4 2.2 8.4 0.4 -1.8 0.0 0.4 1.0 -2.9
Exposure to tobacco smoke outside home 0.8 1.1 2.5 -1.6 0.7 0.0 -0.8 -1.5 0.8
Comparative body size at age 10 0.4 1.1 4.5 -0.9 -1.1 0.0 0.2 -0.1 -2.1
Number of full brothers 1.0 1.2 5.1 1.2 2.3 0.0 0.6 0.7 -0.0
Worry too long after embarrassment 0.9 1.6 5.7 0.6 2.4 0.0 1.4 0.5 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.2 -1.0 -0.3 0.0 -0.7 -0.7 1.8
Wheeze or whistling in the chest in last year 0.2 0.3 1.1 0.2 1.0 0.0 -0.9 0.3 0.3
Number of children fathered 1.0 1.1 3.8 0.7 -1.0 0.0 0.4 1.0 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.9 1.2 0.2 0.0 -0.1 1.7 0.0
Age at first live birth 0.6 1.1 2.0 1.2 1.1 0.0 1.2 1.4 -0.9
Pulse wave peak to peak time 0.8 1.0 3.5 0.2 -1.4 0.0 -0.6 -0.3 1.9
Health satisfaction 0.2 0.3 1.3 0.0 1.1 0.0 0.4 0.5 0.5
Shortness of breath walking on level ground 1.1 1.3 2.1 1.4 1.3 0.0 1.4 0.7 -1.2
Qualifications: College or University degree 1.0 3.0 7.3 2.4 -1.6 0.0 1.3 2.7 -0.8
Eye problems/disorders: None of the above 0.7 0.8 3.6 0.5 -1.9 0.0 0.2 0.4 0.7
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.6 1.6 -0.3 0.0 0.1 1.3 -0.4
Emphysema/chronic bronchitis 0.6 0.6 1.3 1.0 1.1 0.0 -1.1 -0.3 0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 1.9 0.6 -0.5 0.0 -0.4 0.7 -1.4
Neck or shoulder pain in last month 0.6 0.8 2.8 0.3 -1.7 0.0 0.5 0.0 -1.3
Medication: Blood pressure 0.8 1.4 3.1 -1.5 1.3 0.0 -0.5 -1.8 1.0
Angina (self-reported) 0.3 0.4 1.5 -0.1 -0.4 0.0 0.7 -0.0 -1.2
Migraine (self-reported) 0.2 0.3 0.9 -0.1 -0.8 0.0 0.1 1.0 0.1
Medication: Ibuprofen 0.1 0.1 0.2 -0.1 -0.4 0.0 0.4 0.2 0.1
Medication: Allopurinol 0.0 0.1 0.2 -0.1 0.0 0.0 0.5 0.4 0.0
Medication: Omeprazole 0.1 0.1 0.2 -0.0 0.3 0.0 -0.3 -0.2 0.4
Medication: Seretide 50 evohaler 0.8 1.0 3.3 -0.1 -1.8 0.0 -0.9 -0.1 -1.3
Mean time to correctly identify matches 0.4 0.8 4.0 0.7 2.0 0.0 0.4 0.7 0.2
Heart disease (mother) 0.6 0.8 1.4 1.2 -1.1 0.0 -0.9 0.9 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 3.7 0.9 1.9 0.0 0.7 0.8 0.8
Whole body fat mass 0.4 1.5 4.1 -2.0 0.7 0.0 -0.6 -2.0 0.4
Leg fat mass (right) 0.3 1.0 3.0 -1.6 0.7 0.0 -0.3 -1.7 -0.1
Arm predicted mass (right) 0.5 2.4 9.2 0.4 -1.9 0.0 0.3 1.1 -3.0
Pulse rate, automated reading 0.1 0.3 1.3 1.1 0.5 0.0 -0.1 0.7 0.2
Alcohol intake frequency. 0.4 1.0 2.3 -1.2 1.5 0.0 0.7 -1.2 0.6
Comparative height size at age 10 0.2 1.2 5.2 1.0 -2.3 0.0 -0.1 0.9 -0.4
Number of full sisters 0.7 0.8 1.7 -0.0 1.3 0.0 0.3 -1.3 -1.2
Suffer from ‘nerves’ 0.3 0.5 1.2 0.5 -0.5 0.0 -1.1 -0.3 1.0
Overall health rating 0.3 0.6 1.8 0.4 0.9 0.0 0.9 0.3 1.3
Chest pain or discomfort 0.1 0.1 0.6 0.3 0.1 0.0 -0.1 -0.2 -0.8
Had major operations 0.8 0.9 3.5 -1.9 -0.5 0.0 -0.1 -1.1 -0.6
Age at last live birth 0.6 0.8 2.0 1.4 0.7 0.0 0.9 1.2 -0.4
Family relationship satisfaction 0.8 1.0 3.1 1.8 1.0 0.0 0.3 1.3 0.3
Leg pain on walking 1.7 2.1 3.4 -1.7 1.8 0.0 -0.9 -1.5 1.7
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 4.0 -1.7 0.1 0.0 -1.2 -1.9 2.0
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.7 0.3 0.8 0.0 0.2 0.2 -0.8
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.6 -0.6 0.3 0.0 -0.3 -0.5 0.8
Medication: Aspirin 0.3 0.4 1.0 0.4 0.3 0.0 0.9 0.3 -1.0
Supplements: Vitamin C 2.0 2.4 8.0 -2.0 0.2 0.0 -1.3 -2.8 0.7
Knee pain experienced in last month 0.1 0.2 0.6 -0.2 0.6 0.0 -0.2 -0.0 0.8
Hypertension (Self-reported) 0.3 0.8 2.0 0.5 1.1 0.0 1.4 0.2 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.2 -0.2 -0.3 0.0 -0.8 -0.3 1.1
Illnesses of father: Heart disease 0.8 1.1 2.7 -0.5 -1.6 0.0 -1.4 -1.1 -0.8
Illnesses of siblings: Diabetes 1.5 1.8 5.2 2.3 1.4 0.0 0.7 1.5 -1.0
Smoking status: Previous 0.2 0.3 0.7 -0.1 0.8 0.0 -0.6 0.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.2 0.6 -1.1 0.0 -0.8 0.7 1.1
Whole body fat-free mass 0.5 3.0 11.0 1.0 -1.6 0.0 0.7 1.7 -3.3
Leg fat-free mass (right) 0.4 2.0 8.9 0.2 -1.4 0.0 0.4 0.8 -3.0
Arm fat percentage (left) 0.6 2.5 6.8 -2.4 1.2 0.0 -0.8 -2.6 0.7
Average weekly red wine intake 1.2 1.8 5.3 1.0 -0.7 0.0 1.3 1.5 -2.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.3 0.9 -1.5 0.0 -0.7 -0.2 0.3
Mood swings 0.7 1.2 3.0 1.7 1.1 0.0 1.3 1.0 -0.1
Loneliness, isolation 0.7 1.0 4.0 -0.2 2.0 0.0 0.2 -0.8 1.2
Long-standing illness, disability or infirmity 0.7 1.1 2.3 1.5 0.3 0.0 1.1 1.0 -1.4
Ever had bowel cancer screening 1.3 1.6 3.3 -1.8 -1.1 0.0 -1.7 -1.1 -0.9
Diabetes diagnosed by doctor 0.3 0.4 1.2 -0.5 1.1 0.0 0.7 -0.8 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.9 1.0 -0.5 0.0 0.4 1.4 -0.2
Friendships satisfaction 0.5 0.7 2.1 1.4 -0.2 0.0 0.4 1.2 0.5
Qualifications: nursing, teaching 1.9 2.9 9.7 3.1 -0.3 0.0 1.0 2.5 -1.0
Commuting to job workplace: Walk 1.5 1.6 4.0 -0.9 -2.0 0.0 0.2 -0.8 -2.0
Eye problems/disorders: Cataract 1.1 1.3 6.5 -0.8 2.5 0.0 0.1 -0.5 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 -0.0 -0.8 0.0 0.4 -0.9 -0.1
Medication for cholesterol 0.2 0.4 1.2 -0.6 -0.6 0.0 -1.1 -0.5 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 2.7 0.5 1.6 0.0 0.4 0.0 -0.1
Back pain experienced in last month 0.2 0.2 0.9 0.3 0.4 0.0 0.3 0.2 -1.0
Mineral and other dietary supplements 0.3 0.4 0.7 0.7 0.6 0.0 0.8 0.8 -0.4
Breast cancer (self-reported) 0.4 0.5 1.5 0.8 0.4 0.0 1.2 0.5 0.8
Asthma (self-reported) 0.7 1.4 3.0 1.5 1.4 0.0 0.7 1.7 -0.9
Osteoporosis (self-reported) 0.0 0.0 0.1 0.1 0.0 0.0 0.1 -0.2 -0.3
Osteoarthritis (self-reported) 0.4 0.5 2.6 0.4 -1.6 0.0 -0.2 0.1 -0.4
Medication: Aspirin 0.6 0.8 1.7 0.8 0.9 0.0 1.1 0.7 -1.3
Medication: Gliclazide 0.8 0.9 2.6 -1.3 1.6 0.0 0.4 -0.6 0.8
Illnesses of father: None of the above (group 1) 0.1 0.2 0.4 -0.7 0.4 0.0 0.4 -0.6 -0.0
Smoking status: Current 0.7 1.2 6.1 0.0 2.5 0.0 0.6 -0.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.5 12.8 -3.6 -1.5 0.0 -1.9 -3.6 1.3
Whole body water mass 0.6 3.1 11.3 1.0 -1.6 0.0 0.8 1.8 -3.4
Leg predicted mass (right) 0.4 2.0 8.9 0.3 -1.4 0.0 0.4 0.9 -3.0
Arm fat mass (left) 0.2 0.8 2.3 -1.4 0.5 0.0 -0.5 -1.5 -0.3
Number of self-reported non-cancer illnesses 1.6 2.7 5.7 1.8 0.7 0.0 2.4 1.8 -1.9
Average weekly champagne plus white wine intake 1.0 1.4 2.5 -1.6 -1.4 0.0 -1.6 -1.0 0.3
Miserableness 0.4 0.8 3.7 0.1 1.9 0.0 0.9 -0.3 -0.0
Guilty feelings 0.3 0.4 1.3 0.8 0.2 0.0 0.7 1.2 0.0
Wears glasses or contact lenses 0.7 0.8 2.4 0.5 1.5 0.0 0.6 0.9 -1.0
Ever taken oral contraceptive pill 0.4 0.4 2.5 -0.0 -1.6 0.0 -0.2 -0.2 -0.2
Hearing aid user 1.7 1.9 6.5 -1.1 -2.5 0.0 -1.4 -0.6 1.2
Mother’s age at death 2.8 3.5 7.1 -2.7 -1.7 0.0 -2.4 -2.3 0.3
Financial situation satisfaction 0.2 0.3 0.9 -0.1 0.9 0.0 0.4 -0.2 0.7
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.1 0.3 0.1 0.0 -0.3 -0.1 0.2
Commuting to job workplace: Public transport 0.2 0.2 0.7 -0.4 -0.9 0.0 0.4 0.5 -0.0
Eye problems/disorders: Glaucoma 1.1 1.3 6.3 0.5 0.1 0.0 0.3 0.9 -2.5
Medication: Blood pressure 0.4 0.8 1.5 1.2 -0.4 0.0 1.2 1.0 -0.8
Pain type(s) experienced in last month: Hip pain 1.0 1.3 3.9 1.2 -0.9 0.0 2.0 1.1 -0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.2 -0.7 -0.6 0.0 -1.1 -0.6 0.4
High cholesterol (Self-reported) 1.3 2.3 5.6 1.3 1.2 0.0 2.4 1.4 -1.8
Medication: Bendroflumethiazide 0.7 1.1 3.2 1.8 -0.0 0.0 0.9 1.1 -1.2
Medication: Paracetamol 0.2 0.4 0.9 0.7 0.9 0.0 0.7 0.3 0.5
Medication: Lisinopril 0.8 1.1 2.2 -1.0 1.5 0.0 0.6 -1.0 -1.3
Medication: Atorvastatin 0.8 1.0 2.1 0.5 -1.3 0.0 1.4 0.2 -1.4
Illnesses of father: High blood pressure 1.7 2.1 5.8 2.4 1.0 0.0 1.7 1.7 0.0
Alcohol drinker status: Never 0.5 0.6 1.3 -0.9 -1.1 0.0 -0.5 -0.7 -1.0
Ever smoked 0.3 0.5 1.6 -0.4 0.6 0.0 -0.8 -0.2 1.3
Basal metabolic rate 0.3 1.9 7.4 0.6 -1.4 0.0 0.5 1.2 -2.7
Leg fat percentage (left) 0.8 3.1 8.0 -2.6 1.3 0.0 -0.7 -2.8 1.2
Arm fat-free mass (left) 0.4 2.2 7.6 1.0 -1.4 0.0 0.7 1.6 -2.8
Number of operations (self-reported) 1.2 1.8 3.1 1.4 0.3 0.0 1.8 1.7 -1.7
Average weekly beer plus cider intake 1.7 2.5 4.4 -1.1 2.0 0.0 -1.2 -1.8 2.1
Irritability 0.2 0.4 1.4 -0.4 0.8 0.0 0.6 0.0 1.2
Risk taking 0.3 0.4 1.1 0.9 0.3 0.0 0.1 0.8 -1.0
Ever had prostate specific antigen (PSA) test 2.9 3.4 6.7 2.4 0.1 0.0 2.6 1.9 -2.1
Fractured/broken bones in last 5 years 0.8 1.0 2.5 0.3 0.9 0.0 1.6 0.7 -1.5
Age started oral contraceptive pill 0.5 0.7 2.0 -1.4 0.5 0.0 -1.0 -0.6 0.7
Diastolic blood pressure, automated reading 1.1 3.4 10.4 3.2 0.6 0.0 1.8 2.6 -0.1
Ever depressed for a whole week 0.2 0.3 0.9 -0.7 0.3 0.0 -0.9 -0.2 0.5
Unable to work because of sickness or disability 0.2 0.3 0.7 -0.5 -0.8 0.0 0.8 0.3 -0.5
Commuting to job workplace: Cycle 0.5 0.6 2.1 0.9 -1.4 0.0 -0.0 0.9 0.1
Myopia 0.2 0.3 1.3 0.3 -0.4 0.0 0.3 0.3 -1.1
Vascular/heart problems diagnosed by doctor 0.4 1.2 3.3 -0.9 -1.0 0.0 -1.8 -0.6 1.3
Cholesterol lowering medication 0.5 0.8 1.8 0.9 0.9 0.0 1.3 1.0 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.8 -0.0 -0.2 0.0 0.1 0.2 0.9
Pain experienced in last month 0.8 1.3 2.3 -1.4 0.6 0.0 -1.5 -1.5 0.8
Supplements: Calcium 0.1 0.1 0.3 0.5 0.0 0.0 0.2 -0.0 0.3
Basal cell carcinoma (self-reported) 0.6 0.7 2.8 1.7 0.4 0.0 0.2 0.5 -0.9
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.3 0.8 -1.0 0.0 0.1 1.1 -0.0
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 3.9 1.6 2.0 0.0 0.3 1.5 -0.6
Heart disease (siblings) 1.5 1.8 6.3 2.5 0.7 0.0 0.7 1.6 -1.0
Alcohol drinker status: Previous 1.0 1.1 3.6 -1.2 0.8 0.0 -0.1 -1.0 1.9
Pack years of smoking 0.5 0.7 2.5 -0.6 -0.1 0.0 -0.2 -1.6 1.1
Impedance of whole body 2.1 10.9 46.6 -2.3 1.1 0.0 -2.1 -2.8 6.8
Leg fat mass (left) 0.3 1.0 2.9 -1.7 0.6 0.0 -0.3 -1.7 -0.2
Arm predicted mass (left) 0.4 2.0 6.6 0.8 -1.6 0.0 0.6 1.3 -2.6