TWAS hub - COL5A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1440	0.0350	4.2e-13	0.127	0.124	0.121	0.126	0.125	3.7e-15	8.1e-15	1.8e-14	4.3e-15	6.3e-15
2	GTEx	Brain Putamen basal ganglia	0.3370	0.1080	7.8e-03	-0.013	NA	0.005	NA	-0.011	9.2e-01	NA	2.4e-01	NA	7.6e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.4010	0.1670	5.3e-03	0.042	NA	0.108	NA	0.007	1.7e-02	NA	2.2e-04	NA	1.8e-01
4	GTEx	Cells Transformed fibroblasts	0.1760	0.0450	7.0e-09	0.106	NA	0.178	NA	0.159	2.3e-08	NA	2.5e-13	NA	5.9e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.0582	0.0223	8.7e-05	0.060	0.021	0.047	0.030	0.055	3.8e-08	9.2e-04	9.9e-07	8.9e-05	1.2e-07
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0397	0.0215	1.4e-03	-0.001	0.016	-0.001	NA	0.001	5.2e-01	5.9e-03	4.4e-01	NA	2.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6
Bipolar Disorder (2011)	3.4	3.3	8.1	-2.6	-0.0	-1.9	-2.9	1.2
Breast Cancer	2.9	6.9	20.3	2.2	0.8	3.0	2.5	-4.5
Ever had prostate specific antigen (PSA) test	2.9	3.4	6.7	2.4	0.1	2.6	1.9	-2.1
Mother’s age at death	2.8	3.5	7.1	-2.7	-1.7	-2.4	-2.3	0.3
Prospective memory result	2.7	3.3	8.4	-2.1	1.4	-2.2	-2.9	-0.0
Qualifications: CSEs or equivalent	2.6	3.4	13.0	-0.8	1.1	-1.7	-1.6	3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.5	12.8	-3.6	-1.5	-1.9	-3.6	1.3
Alzheimer’s Disease (in father)	2.5	2.7	5.7	-2.1	-0.8	-2.4	-1.9	1.3
Noisy workplace	2.4	2.9	5.7	-0.7	2.2	-1.7	-1.9	2.4
Coronary Artery Disease (CAD)	2.2	2.6	5.2	1.8	-2.3	0.7	1.8	-1.8
Fluid intelligence score	2.1	4.3	7.6	2.8	-2.7	1.7	2.5	-1.5
Impedance of whole body	2.1	10.9	46.6	-2.3	1.1	-2.1	-2.8	6.8
Had menopause	2.0	2.4	4.8	-2.0	0.5	-2.2	-2.2	0.9
Alcohol intake versus 10 years previously	2.0	3.0	7.6	2.2	0.6	2.8	1.5	-1.6
Impedance of arm (left)	2.0	9.1	35.0	-2.4	0.9	-2.3	-2.8	5.9
Supplements: Vitamin C	2.0	2.4	8.0	-2.0	0.2	-1.3	-2.8	0.7
Blood Red Count	1.9	18.0	37.1	-5.8	-3.8	-4.7	-6.1	0.9
Qualifications: nursing, teaching	1.9	2.9	9.7	3.1	-0.3	1.0	2.5	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	8.9	1.4	1.6	3.0	1.6	-1.1
Hearing difficulty/problems: Yes	1.7	2.5	4.6	-1.9	-1.7	-2.1	-1.7	1.2
Impedance of leg (right)	1.7	8.4	41.3	-1.4	1.0	-1.4	-2.0	6.4
Impedance of leg (left)	1.7	8.2	38.6	-1.7	0.9	-1.4	-2.1	6.2
Leg pain on walking	1.7	2.1	3.4	-1.7	1.8	-0.9	-1.5	1.7
Hearing aid user	1.7	1.9	6.5	-1.1	-2.5	-1.4	-0.6	1.2
Illnesses of father: High blood pressure	1.7	2.1	5.8	2.4	1.0	1.7	1.7	0.0
Average weekly beer plus cider intake	1.7	2.5	4.4	-1.1	2.0	-1.2	-1.8	2.1
Impedance of arm (right)	1.6	7.4	34.0	-1.4	1.5	-1.7	-1.9	5.8
Breastfed as a baby	1.6	2.0	7.2	-0.6	-2.0	-0.4	-0.4	-2.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.0	-1.7	0.1	-1.2	-1.9	2.0
Number of self-reported non-cancer illnesses	1.6	2.7	5.7	1.8	0.7	2.4	1.8	-1.9
Hand grip strength (left)	1.5	3.8	7.7	2.8	0.2	1.4	2.8	-2.4
Vitamin and mineral supplements	1.5	2.0	5.0	2.0	0.0	1.3	2.2	-1.1
Illnesses of siblings: Diabetes	1.5	1.8	5.2	2.3	1.4	0.7	1.5	-1.0
Commuting to job workplace: Walk	1.5	1.6	4.0	-0.9	-2.0	0.2	-0.8	-2.0
Heart disease (siblings)	1.5	1.8	6.3	2.5	0.7	0.7	1.6	-1.0
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.8	-1.6	0.8	-0.5	-1.5	1.9
Trunk fat percentage	1.4	5.7	12.7	-3.4	1.1	-1.7	-3.6	2.4
Stomach or abdominal pain in last month	1.4	1.7	3.4	-1.5	-1.2	-1.2	-1.3	1.8
Allergy	1.4	3.2	10.4	-2.5	-0.9	-0.7	-3.2	1.0
Hair/balding pattern: Pattern 3	1.4	2.1	11.1	-0.8	-3.3	-0.2	-0.6	-0.9
Irritable Bowel Disease (IBD)	1.3	3.2	7.8	2.6	0.1	1.0	2.8	-1.8
Crohns Disease (2012)	1.3	2.1	6.1	2.5	0.8	0.9	2.1	-0.6
Systolic Blood Pressure	1.3	6.3	15.9	4.0	2.4	3.0	2.6	-0.7
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.4	-0.8	1.5	-1.8	-1.3	1.2
Ever had bowel cancer screening	1.3	1.6	3.3	-1.8	-1.1	-1.7	-1.1	-0.9
High cholesterol (Self-reported)	1.3	2.3	5.6	1.3	1.2	2.4	1.4	-1.8
Crohns Disease (2017)	1.2	2.7	7.4	2.7	0.3	0.9	2.5	-1.3
Systolic blood pressure, automated reading	1.2	3.5	7.9	2.8	1.2	2.2	2.2	-1.4
Illnesses of siblings	1.2	1.7	5.2	-2.3	-1.6	-0.4	-1.4	0.4
Length of working week for main job	1.2	1.3	2.5	1.4	1.4	1.2	1.6	-0.2
Average weekly red wine intake	1.2	1.8	5.3	1.0	-0.7	1.3	1.5	-2.3
Number of operations (self-reported)	1.2	1.8	3.1	1.4	0.3	1.8	1.7	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.9	1.6	2.0	0.3	1.5	-0.6
Ovarian Cancer	1.1	1.5	4.1	2.0	-1.0	0.4	1.6	-1.0
Maternal smoking around birth	1.1	1.5	4.8	1.1	2.2	0.6	1.3	1.2
Alcohol usually taken with meals	1.1	1.8	4.8	0.7	-2.2	0.6	1.3	-1.8
Forced vital capacity (FVC)	1.1	4.2	10.6	-1.8	-3.2	-2.7	-1.5	1.2
Medication: Cholesterol lowering	1.1	1.7	5.0	0.6	0.3	2.2	0.8	-2.1
Tense / ‘highly strung’	1.1	1.8	4.8	1.4	2.2	1.5	1.0	-1.0
Forced vital capacity (FVC), Best measure	1.1	4.1	8.6	-2.0	-2.9	-2.8	-1.7	1.0
Body fat percentage	1.1	4.3	10.5	-3.0	1.3	-1.2	-3.2	1.7
Shortness of breath walking on level ground	1.1	1.3	2.1	1.4	1.3	1.4	0.7	-1.2
Eye problems/disorders: Cataract	1.1	1.3	6.5	-0.8	2.5	0.1	-0.5	0.6
Eye problems/disorders: Glaucoma	1.1	1.3	6.3	0.5	0.1	0.3	0.9	-2.5
Diastolic blood pressure, automated reading	1.1	3.4	10.4	3.2	0.6	1.8	2.6	-0.1
Average weekly spirits intake	1.0	1.3	3.0	0.8	-1.3	1.7	0.9	-1.3
Severe depression (siblings)	1.0	1.2	3.8	-1.6	0.0	-0.8	-2.0	-0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.2	5.6	1.6	-2.4	1.1	1.4	-1.3
Depression (self-reported)	1.0	1.2	3.4	-1.9	-0.6	-0.8	-1.4	0.9
Blood clot in the leg (DVT)	1.0	1.3	3.2	1.5	1.8	0.3	1.4	-0.6
Number of full brothers	1.0	1.2	5.1	1.2	2.3	0.6	0.7	-0.0
Number of children fathered	1.0	1.1	3.8	0.7	-1.0	0.4	1.0	-1.9
Qualifications: College or University degree	1.0	3.0	7.3	2.4	-1.6	1.3	2.7	-0.8
Average weekly champagne plus white wine intake	1.0	1.4	2.5	-1.6	-1.4	-1.6	-1.0	0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.9	1.2	-0.9	2.0	1.1	-0.6
Alcohol drinker status: Previous	1.0	1.1	3.6	-1.2	0.8	-0.1	-1.0	1.9
Reaction Time	0.9	1.7	5.4	1.3	2.3	0.3	1.0	1.4
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.0	1.7	1.2	0.2	1.1	0.3
Lung FVC	0.9	4.5	10.3	-3.1	-1.5	-2.2	-3.2	-0.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.0	0.7	1.2	1.7	1.3	-1.0
Multivitamins +/- minerals	0.9	1.2	2.6	-1.0	1.3	-1.0	-0.8	1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	3.8	-2.0	0.0	-1.2	-0.9	1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	11.6	-1.0	-3.4	-1.9	-0.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.3	1.3	0.2	1.0	1.0	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	9.3	-1.3	-3.0	-2.1	-1.0	1.2
Medication: Amlodipine	0.9	1.2	3.2	-1.4	-0.3	-1.2	-1.8	0.9
Leg fat percentage (right)	0.9	3.1	7.8	-2.4	1.6	-0.7	-2.8	1.5
Worry too long after embarrassment	0.9	1.6	5.7	0.6	2.4	1.4	0.5	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.7	0.9	1.9	0.7	0.8	0.8
Alzheimer’s Disease (including proxy)	0.8	1.1	2.3	-0.9	0.6	-1.3	-1.1	1.5
Waist Hip Ratio (WHR)	0.8	3.6	10.6	1.1	0.6	3.2	1.7	-2.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.4	1.9	-0.9	-0.2	1.3	0.4
Hand grip strength (right)	0.8	2.3	5.8	1.9	0.3	0.6	2.4	-2.0
Current tobacco smoking	0.8	1.3	7.1	-0.3	2.7	0.6	-0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	7.0	1.7	0.3	0.7	2.6	0.1
Hearing difficulty/problems with background noise	0.8	1.3	3.2	-0.8	-1.8	-1.3	-0.9	1.1
Had other major operations	0.8	1.0	2.2	1.4	-0.1	1.2	1.5	-0.7
Medication: Ramipril	0.8	1.0	3.5	0.1	1.2	-0.9	-0.4	1.9
Trunk fat-free mass	0.8	4.4	13.0	1.7	-1.8	1.1	2.5	-3.6
Trunk predicted mass	0.8	4.5	13.2	1.8	-1.7	1.2	2.5	-3.6
Exposure to tobacco smoke outside home	0.8	1.1	2.5	-1.6	0.7	-0.8	-1.5	0.8
Pulse wave peak to peak time	0.8	1.0	3.5	0.2	-1.4	-0.6	-0.3	1.9
Medication: Blood pressure	0.8	1.4	3.1	-1.5	1.3	-0.5	-1.8	1.0
Medication: Seretide 50 evohaler	0.8	1.0	3.3	-0.1	-1.8	-0.9	-0.1	-1.3
Had major operations	0.8	0.9	3.5	-1.9	-0.5	-0.1	-1.1	-0.6
Family relationship satisfaction	0.8	1.0	3.1	1.8	1.0	0.3	1.3	0.3
Illnesses of father: Heart disease	0.8	1.1	2.7	-0.5	-1.6	-1.4	-1.1	-0.8
Medication: Gliclazide	0.8	0.9	2.6	-1.3	1.6	0.4	-0.6	0.8
Medication: Lisinopril	0.8	1.1	2.2	-1.0	1.5	0.6	-1.0	-1.3
Medication: Atorvastatin	0.8	1.0	2.1	0.5	-1.3	1.4	0.2	-1.4
Leg fat percentage (left)	0.8	3.1	8.0	-2.6	1.3	-0.7	-2.8	1.2
Fractured/broken bones in last 5 years	0.8	1.0	2.5	0.3	0.9	1.6	0.7	-1.5
Pain experienced in last month	0.8	1.3	2.3	-1.4	0.6	-1.5	-1.5	0.8
Intelligence (Savage-Jansen 2018)	0.7	2.2	10.4	1.0	-3.2	-0.1	0.5	-1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.4	0.9	-2.3	0.3	0.9	-1.6
LDL Cholesterol	0.7	1.1	2.3	1.5	1.1	1.2	1.1	-0.6
Neuroticism (2016)	0.7	1.1	3.4	1.9	1.4	-0.1	1.0	-0.1
Ulcerative Colitis	0.7	1.0	3.4	0.9	0.1	0.1	1.8	-1.3
Medication for hormone replacement therapy	0.7	0.8	3.1	-0.6	0.9	-0.2	-0.7	1.8
Trunk fat mass	0.7	2.8	7.4	-2.7	0.6	-1.1	-2.6	1.0
Qualifications: None of the above	0.7	1.5	4.5	-2.1	1.3	-0.6	-1.2	1.0
Pain all over the body in last month	0.7	0.8	2.2	-1.0	1.5	-0.5	-1.0	0.5
Medication: Simvastatin	0.7	1.0	2.9	0.3	1.4	1.7	0.7	-0.8
Pulse wave Arterial Stiffness index	0.7	0.9	3.8	-0.1	1.0	0.5	0.4	-1.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.5	1.3	-1.9	-0.4	0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.2	-1.0	-0.3	-0.7	-0.7	1.8
Eye problems/disorders: None of the above	0.7	0.8	3.6	0.5	-1.9	0.2	0.4	0.7
Number of full sisters	0.7	0.8	1.7	-0.0	1.3	0.3	-1.3	-1.2
Mood swings	0.7	1.2	3.0	1.7	1.1	1.3	1.0	-0.1
Loneliness, isolation	0.7	1.0	4.0	-0.2	2.0	0.2	-0.8	1.2
Long-standing illness, disability or infirmity	0.7	1.1	2.3	1.5	0.3	1.1	1.0	-1.4
Asthma (self-reported)	0.7	1.4	3.0	1.5	1.4	0.7	1.7	-0.9
Smoking status: Current	0.7	1.2	6.1	0.0	2.5	0.6	-0.2	-0.7
Wears glasses or contact lenses	0.7	0.8	2.4	0.5	1.5	0.6	0.9	-1.0
Medication: Bendroflumethiazide	0.7	1.1	3.2	1.8	-0.0	0.9	1.1	-1.2
Bipolar Disorder or Schizophrenia	0.6	1.5	3.3	-1.7	0.2	-1.0	-1.4	1.8
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	1.0	0.8	0.9	1.4	-0.8
Alzheimer’s Disease (in mother)	0.6	0.7	2.1	-0.0	1.5	0.4	-0.5	1.3
Mean Putamen Volume	0.6	0.7	1.3	-0.7	-0.7	-1.2	-1.1	0.7
Smoking Status	0.6	1.4	7.2	0.5	2.7	0.8	0.0	-0.3
Sensitivity / hurt feelings	0.6	1.0	3.1	1.1	1.8	0.5	1.2	0.1
Supplements: Zinc	0.6	0.6	2.0	-1.4	0.4	-0.6	-0.9	0.6
Diabetes (mother)	0.6	0.8	1.9	-0.6	-0.1	-1.0	-1.2	1.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.3	-0.3	1.0	1.5	0.5	-0.3
Supplements: Glucosamine	0.6	0.8	1.8	-0.8	-1.0	-1.4	-1.0	0.5
Number of incorrect matches in round	0.6	1.0	2.1	-0.8	1.4	-0.9	-0.6	1.4
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	-0.8	-0.4	-1.3	-0.4	1.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	1.1	0.1	0.9	1.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.3	-1.5	0.2	-1.1	-1.3	0.8
Birth weight	0.6	1.4	4.2	1.8	-0.5	0.7	2.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.9	1.2	0.2	-0.1	1.7	0.0
Age at first live birth	0.6	1.1	2.0	1.2	1.1	1.2	1.4	-0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.6	1.6	-0.3	0.1	1.3	-0.4
Emphysema/chronic bronchitis	0.6	0.6	1.3	1.0	1.1	-1.1	-0.3	0.6
Neck or shoulder pain in last month	0.6	0.8	2.8	0.3	-1.7	0.5	0.0	-1.3
Heart disease (mother)	0.6	0.8	1.4	1.2	-1.1	-0.9	0.9	-0.4
Age at last live birth	0.6	0.8	2.0	1.4	0.7	0.9	1.2	-0.4
Arm fat percentage (left)	0.6	2.5	6.8	-2.4	1.2	-0.8	-2.6	0.7
Medication: Aspirin	0.6	0.8	1.7	0.8	0.9	1.1	0.7	-1.3
Whole body water mass	0.6	3.1	11.3	1.0	-1.6	0.8	1.8	-3.4
Basal cell carcinoma (self-reported)	0.6	0.7	2.8	1.7	0.4	0.2	0.5	-0.9
Depression (Nagel 2018)	0.5	0.7	1.5	0.6	0.9	0.7	1.0	-1.2
Schizophrenia (2018)	0.5	1.0	3.3	-1.1	0.1	-0.8	-0.7	1.8
Lupus	0.5	0.8	1.8	1.2	-0.8	0.7	0.6	-1.3
Primary Biliary Cirrhosis	0.5	0.7	1.9	1.4	-0.2	0.9	1.3	-0.1
Allergy or Eczema	0.5	1.4	5.1	1.4	1.1	0.3	2.2	0.1
Cardiovascular Disease	0.5	1.8	4.8	1.7	0.8	2.2	1.2	-0.9
Medication: Metformin	0.5	0.7	2.9	0.1	1.7	1.1	0.0	-0.5
Townsend deprivation index at recruitment	0.5	0.7	3.3	-0.4	0.2	1.8	-0.2	-0.6
Fed-up feelings	0.5	0.9	1.6	1.0	1.2	1.3	0.9	0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	0.1	1.4	-0.7	-0.6	1.0
Neuroticism score	0.5	1.0	4.7	0.9	2.2	0.6	0.3	0.3
Arm fat percentage (right)	0.5	2.1	5.0	-2.1	1.6	-0.6	-2.2	0.6
Asthma	0.5	1.0	2.1	1.2	1.3	0.3	1.4	-0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	0.0	-1.5	-1.4	0.1	0.8
Arm predicted mass (right)	0.5	2.4	9.2	0.4	-1.9	0.3	1.1	-3.0
Whole body fat-free mass	0.5	3.0	11.0	1.0	-1.6	0.7	1.7	-3.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.3	0.9	-1.5	-0.7	-0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.9	1.0	-0.5	0.4	1.4	-0.2
Friendships satisfaction	0.5	0.7	2.1	1.4	-0.2	0.4	1.2	0.5
Alcohol drinker status: Never	0.5	0.6	1.3	-0.9	-1.1	-0.5	-0.7	-1.0
Age started oral contraceptive pill	0.5	0.7	2.0	-1.4	0.5	-1.0	-0.6	0.7
Commuting to job workplace: Cycle	0.5	0.6	2.1	0.9	-1.4	-0.0	0.9	0.1
Cholesterol lowering medication	0.5	0.8	1.8	0.9	0.9	1.3	1.0	-0.4
Pack years of smoking	0.5	0.7	2.5	-0.6	-0.1	-0.2	-1.6	1.1
Bipolar Disorder (2018)	0.4	0.7	1.9	-1.3	0.3	-0.5	-1.4	0.7
Ulcerative Colitis (UC)	0.4	0.7	1.9	0.9	-0.3	0.3	1.4	-1.2
Schizophrenia (2014)	0.4	0.8	2.0	-0.7	1.0	-0.9	-0.6	1.4
Blood White Count	0.4	3.0	9.6	-3.1	0.1	-0.2	-2.9	0.6
Respiratory disease	0.4	0.8	2.2	1.5	0.6	0.4	1.4	-0.2
Chronotype (morning person)	0.4	0.9	2.1	1.2	-0.1	0.7	1.4	-1.2
Number of treatments/medications taken	0.4	0.7	2.3	1.0	0.1	1.5	0.9	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.3	-0.4	0.7	-0.3	-0.5	1.5
Angina	0.4	0.5	1.7	-0.0	-1.0	0.5	-0.0	-1.3
Pack years adult smoking proportion	0.4	0.7	2.4	-0.5	-0.0	-0.4	-1.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	-0.7	1.4	0.6	-0.4	0.1
High blood pressure	0.4	1.1	2.6	0.7	1.4	1.6	0.5	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.5	-1.2	0.2	-0.8	-0.7	-0.1
High blood pressure (mother)	0.4	0.6	2.1	1.4	0.6	-0.0	1.1	-0.2
Nervous feelings	0.4	0.7	1.9	1.4	0.6	1.1	0.6	-0.7
Diabetes (self-reported)	0.4	0.6	1.8	-0.1	1.3	1.3	-0.4	-0.4
Time employed in main current job	0.4	0.5	1.6	0.2	-1.3	-1.0	0.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.2	1.0	1.0	1.1	0.5	0.7
Medication: Lansoprazole	0.4	0.4	1.2	-0.1	0.8	-0.4	-0.7	1.1
Lung cancer (father)	0.4	0.4	1.3	-1.1	0.2	-0.7	-0.9	0.2
Hair/balding pattern: Pattern 4	0.4	0.9	2.9	-1.7	-0.1	-0.8	-1.4	0.1
Loud music exposure frequency	0.4	0.5	2.4	-0.2	1.6	-0.2	-0.6	0.3
Medication: Paracetamol	0.4	0.6	2.3	-0.3	0.4	-0.2	-1.0	1.5
Arm fat-free mass (right)	0.4	2.2	8.4	0.4	-1.8	0.4	1.0	-2.9
Comparative body size at age 10	0.4	1.1	4.5	-0.9	-1.1	0.2	-0.1	-2.1
Mean time to correctly identify matches	0.4	0.8	4.0	0.7	2.0	0.4	0.7	0.2
Whole body fat mass	0.4	1.5	4.1	-2.0	0.7	-0.6	-2.0	0.4
Alcohol intake frequency.	0.4	1.0	2.3	-1.2	1.5	0.7	-1.2	0.6
Leg fat-free mass (right)	0.4	2.0	8.9	0.2	-1.4	0.4	0.8	-3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.7	0.5	1.6	0.4	0.0	-0.1
Breast cancer (self-reported)	0.4	0.5	1.5	0.8	0.4	1.2	0.5	0.8
Osteoarthritis (self-reported)	0.4	0.5	2.6	0.4	-1.6	-0.2	0.1	-0.4
Leg predicted mass (right)	0.4	2.0	8.9	0.3	-1.4	0.4	0.9	-3.0
Miserableness	0.4	0.8	3.7	0.1	1.9	0.9	-0.3	-0.0
Ever taken oral contraceptive pill	0.4	0.4	2.5	-0.0	-1.6	-0.2	-0.2	-0.2
Medication: Blood pressure	0.4	0.8	1.5	1.2	-0.4	1.2	1.0	-0.8
Arm fat-free mass (left)	0.4	2.2	7.6	1.0	-1.4	0.7	1.6	-2.8
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.3	-0.9	-1.0	-1.8	-0.6	1.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.8	-1.0	0.1	1.1	-0.0
Arm predicted mass (left)	0.4	2.0	6.6	0.8	-1.6	0.6	1.3	-2.6
Neuroticism (Nagel 2018)	0.3	0.6	2.5	1.0	1.6	-0.0	0.4	0.5
Age at First Birth	0.3	0.5	1.7	-0.7	0.9	-1.3	-0.1	0.0
Hypothyroidism (self reported)	0.3	0.6	2.5	0.7	-1.6	-0.8	0.0	-0.4
Lung FEV1/FVC ratio	0.3	1.7	9.9	0.1	-3.1	0.4	0.1	-0.7
Neuroticism	0.3	0.8	3.2	1.3	1.8	-0.1	0.1	-0.4
Medication: Co-codamol	0.3	0.3	0.9	0.9	0.8	-0.0	0.7	0.1
Leg fat-free mass (left)	0.3	1.5	6.8	0.1	-1.4	0.4	0.6	-2.6
Relative age voice broke	0.3	0.4	0.9	0.9	-0.1	-0.9	0.7	0.4
Taking other prescription medications	0.3	0.4	1.5	1.2	-0.3	0.3	0.5	0.9
Leg predicted mass (left)	0.3	1.6	7.2	0.1	-1.4	0.4	0.7	-2.7
Waist circumference	0.3	1.0	4.5	-0.9	-0.4	0.8	-0.3	-2.1
Past tobacco smoking	0.3	0.5	2.3	-0.4	-1.5	0.4	-0.4	-0.6
Hip circumference	0.3	1.2	2.9	-1.7	-0.7	-0.8	-1.7	-0.4
Falls in the last year	0.3	0.4	1.5	0.3	-0.1	1.2	-0.1	-0.9
Pulse rate	0.3	0.5	1.2	0.9	0.3	-1.1	0.6	0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	1.5	-0.1	0.9	-0.2	-0.4	1.2
Illnesses of mother	0.3	0.4	1.2	-1.1	-0.0	0.0	-1.0	0.4
Birth weight of first child	0.3	0.5	1.0	-1.0	0.3	-0.9	-0.5	0.8
Peak expiratory flow (PEF)	0.3	0.7	3.2	0.3	-1.8	0.2	0.7	-0.5
Pulse wave reflection index	0.3	0.3	0.9	0.3	0.9	0.9	0.4	-0.3
Headache pain in last month	0.3	0.5	1.4	0.1	-0.5	1.2	-0.4	-1.0
Glaucoma (self-reported)	0.3	0.4	1.8	0.2	-0.1	0.1	0.7	-1.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	0.7	-1.1	-0.4	0.6	-0.2
High blood pressure (siblings)	0.3	0.4	1.3	1.1	0.9	-0.4	0.4	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	0.6	-0.5	-0.4	0.7	-1.4
Angina (self-reported)	0.3	0.4	1.5	-0.1	-0.4	0.7	-0.0	-1.2
Leg fat mass (right)	0.3	1.0	3.0	-1.6	0.7	-0.3	-1.7	-0.1
Suffer from ‘nerves’	0.3	0.5	1.2	0.5	-0.5	-1.1	-0.3	1.0
Overall health rating	0.3	0.6	1.8	0.4	0.9	0.9	0.3	1.3
Medication: Aspirin	0.3	0.4	1.0	0.4	0.3	0.9	0.3	-1.0
Hypertension (Self-reported)	0.3	0.8	2.0	0.5	1.1	1.4	0.2	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	-0.2	-0.3	-0.8	-0.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	0.6	-1.1	-0.8	0.7	1.1
Diabetes diagnosed by doctor	0.3	0.4	1.2	-0.5	1.1	0.7	-0.8	0.2
Mineral and other dietary supplements	0.3	0.4	0.7	0.7	0.6	0.8	0.8	-0.4
Guilty feelings	0.3	0.4	1.3	0.8	0.2	0.7	1.2	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	-0.7	-0.6	-1.1	-0.6	0.4
Ever smoked	0.3	0.5	1.6	-0.4	0.6	-0.8	-0.2	1.3
Basal metabolic rate	0.3	1.9	7.4	0.6	-1.4	0.5	1.2	-2.7
Risk taking	0.3	0.4	1.1	0.9	0.3	0.1	0.8	-1.0
Leg fat mass (left)	0.3	1.0	2.9	-1.7	0.6	-0.3	-1.7	-0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.4	0.9	1.2	-0.3	0.2	0.5
Prostate Cancer	0.2	0.3	0.9	-0.8	0.2	-0.9	-0.4	-0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	-0.7	-0.1	-0.3	-0.8	-0.3
Fasting Glucose	0.2	0.3	0.6	-0.5	-0.6	-0.4	-0.6	-0.8
Rheumatoid Arthritis	0.2	0.3	1.1	0.3	-1.0	0.1	-0.2	-0.8
Triglycerides	0.2	0.2	1.3	0.2	1.2	0.2	-0.1	-0.0
BMI	0.2	1.1	3.5	-0.7	0.8	0.5	-1.2	-1.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.6	0.7	0.4	0.3	-0.1
Average weekly fortified wine intake	0.2	0.3	1.1	-1.1	-0.3	-0.5	-0.2	-0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	-0.4	0.9	0.3	-0.1	-0.2
Medication: Levothyroxine sodium	0.2	0.4	1.1	0.8	-1.0	0.6	0.2	-0.6
Sitting height	0.2	1.7	8.5	-0.3	-2.9	-1.3	0.4	-0.2
Body mass index (BMI)	0.2	0.8	2.6	-0.9	0.6	0.1	-1.1	-1.6
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.3	-0.9	0.8	0.0	0.1
Mouth/teeth dental problems	0.2	0.3	0.8	-0.6	-0.3	-0.5	0.3	-0.9
Heart attack	0.2	0.3	0.9	0.6	-0.7	0.2	1.0	0.1
Father’s age at death	0.2	0.3	1.4	-0.3	0.1	-0.1	-0.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	-0.7	-0.5	0.1	-0.6	0.5
Standing height	0.2	1.8	6.9	0.3	-2.6	-0.9	1.4	1.0
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.3	0.4	0.4	0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	0.9	-1.2	0.0	0.0	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	1.1	0.2	1.0	-0.9	0.3	0.3
Health satisfaction	0.2	0.3	1.3	0.0	1.1	0.4	0.5	0.5
Migraine (self-reported)	0.2	0.3	0.9	-0.1	-0.8	0.1	1.0	0.1
Comparative height size at age 10	0.2	1.2	5.2	1.0	-2.3	-0.1	0.9	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.3	0.8	0.2	0.2	-0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.6	0.3	-0.3	-0.5	0.8
Smoking status: Previous	0.2	0.3	0.7	-0.1	0.8	-0.6	0.0	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.0	-0.8	0.4	-0.9	-0.1
Medication for cholesterol	0.2	0.4	1.2	-0.6	-0.6	-1.1	-0.5	0.1
Back pain experienced in last month	0.2	0.2	0.9	0.3	0.4	0.3	0.2	-1.0
Arm fat mass (left)	0.2	0.8	2.3	-1.4	0.5	-0.5	-1.5	-0.3
Financial situation satisfaction	0.2	0.3	0.9	-0.1	0.9	0.4	-0.2	0.7
Commuting to job workplace: Public transport	0.2	0.2	0.7	-0.4	-0.9	0.4	0.5	-0.0
Medication: Paracetamol	0.2	0.4	0.9	0.7	0.9	0.7	0.3	0.5
Irritability	0.2	0.4	1.4	-0.4	0.8	0.6	0.0	1.2
Ever depressed for a whole week	0.2	0.3	0.9	-0.7	0.3	-0.9	-0.2	0.5
Unable to work because of sickness or disability	0.2	0.3	0.7	-0.5	-0.8	0.8	0.3	-0.5
Myopia	0.2	0.3	1.3	0.3	-0.4	0.3	0.3	-1.1
Worry (Nagel 2018)	0.1	0.2	0.7	0.8	0.7	-0.4	0.0	-0.2
Major Depression (MDD)	0.1	0.1	0.3	0.4	0.3	-0.6	0.1	-0.1
HbA1C	0.1	0.1	0.4	-0.0	-0.1	0.6	0.1	0.3
HDL Cholesterol	0.1	0.2	0.4	-0.5	0.1	0.5	0.7	0.2
Blood Eosinophil Count	0.1	0.8	1.6	-1.3	0.5	-1.1	-1.0	0.9
Blood Platelet Count	0.1	0.6	2.9	0.5	0.6	0.2	-0.3	1.7
Heel T-Score	0.1	0.5	1.5	0.3	0.9	-0.7	0.1	-1.2
Height	0.1	1.8	6.9	0.3	-2.6	-1.6	1.0	0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.5	0.3	-0.3	-0.8	0.0
Hair Pigment	0.1	2.0	4.4	-2.1	-0.8	-1.5	-2.1	-0.2
Tanning	0.1	0.7	2.5	0.9	1.6	-0.4	0.6	-0.0
Relative age of first facial hair	0.1	0.1	0.5	-0.3	-0.7	-0.5	-0.1	0.1
Diabetes (father)	0.1	0.1	0.5	0.2	0.7	-0.1	-0.1	-0.1
Age when periods started (menarche)	0.1	0.3	0.5	-0.6	0.7	-0.7	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	-0.2	0.5	-0.3	-0.4	0.8
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.3	-0.1	-0.1	-0.0	0.6
Medication: Atenolol	0.1	0.1	0.5	-0.7	-0.3	-0.2	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.4	0.5	-0.3	-0.9	0.8
Weight	0.1	0.4	1.5	-0.7	-0.5	-0.3	-0.5	-1.2
Worrier / anxious feelings	0.1	0.2	0.7	0.5	-0.4	0.4	-0.1	-0.8
Number of live births	0.1	0.2	0.5	-0.5	-0.4	-0.4	-0.3	0.7
Happiness	0.1	0.1	0.2	0.5	-0.1	-0.2	0.1	0.4
Arm fat mass (right)	0.1	0.6	1.4	-1.1	0.9	-0.3	-1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.6	0.4	0.0	-0.1	-0.3
Gout (self-reported)	0.1	0.1	0.3	-0.1	0.6	-0.6	-0.0	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.0	0.6	0.1	0.0	0.4
Medication: Ibuprofen	0.1	0.1	0.2	-0.1	-0.4	0.4	0.2	0.1
Medication: Omeprazole	0.1	0.1	0.2	-0.0	0.3	-0.3	-0.2	0.4
Pulse rate, automated reading	0.1	0.3	1.3	1.1	0.5	-0.1	0.7	0.2
Chest pain or discomfort	0.1	0.1	0.6	0.3	0.1	-0.1	-0.2	-0.8
Knee pain experienced in last month	0.1	0.2	0.6	-0.2	0.6	-0.2	-0.0	0.8
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	-0.7	0.4	0.4	-0.6	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.8	-0.0	-0.2	0.1	0.2	0.9
Supplements: Calcium	0.1	0.1	0.3	0.5	0.0	0.2	-0.0	0.3
Medication: Allopurinol	0.0	0.1	0.2	-0.1	0.0	0.5	0.4	0.0
Osteoporosis (self-reported)	0.0	0.0	0.1	0.1	0.0	0.1	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.3	0.1	-0.3	-0.1	0.2

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COL5A2

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Trait associations