[Hub]/) : Traits : Impedance of leg (left) : ← →

chr2:197,560,575-200,117,777

Best TWAS P=1.26e-18 · Best GWAS P=2.97e-20 conditioned to 0.00133

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	8.7	-8.8	1.3e-18	-0.86	0.12	0.88	TRUE
15	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	8.8	8.8	2.0e-18	0.92	0.08	0.92	FALSE
8	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	8.9	8.6	7.3e-18	0.86	0.10	0.89	FALSE
14	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	8.6	8.4	3.7e-17	0.80	0.12	0.63	FALSE
10	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	8.6	8.4	4.8e-17	0.84	0.08	0.43	FALSE
2	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	8.7	8.3	9.8e-17	0.86	0.11	0.89	FALSE
11	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	8.6	-8.2	2.7e-16	-0.82	0.07	0.34	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	MARS2	0.05	0.03	enet	14	0.05	2.2e-07	-6.1	-7.6	4.1e-14	-0.75	0.16	0.83	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCL1	0.04	0.00	blup	130	0.02	4.0e-03	-1.0	7.5	4.5e-14	0.65	0.05	0.39	FALSE
13	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	8.5	7.5	6.0e-14	0.76	0.21	0.47	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	HSPD1	0.15	0.04	lasso	7	0.04	2.0e-02	5.9	-7.4	1.5e-13	-0.64	0.10	0.61	FALSE
19	YFS	Blood	PLCL1	0.10	0.10	lasso	9	0.14	1.5e-43	8.8	7.4	1.7e-13	0.83	0.13	0.87	FALSE
16	METSIM	Adipose	PLCL1	0.06	0.01	blup	517	0.05	3.6e-08	-2.7	7.3	2.3e-13	0.73	0.15	0.85	FALSE
17	NTR	Blood	PLCL1	0.02	0.01	enet	14	0.02	1.9e-06	8.8	6.7	2.4e-11	0.72	0.07	0.91	FALSE
12	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	4.4	6.5	1.0e-10	0.72	0.08	0.85	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MOBKL3	0.03	0.01	blup	32	0.02	6.3e-03	6.9	6.5	1.1e-10	0.63	0.01	0.53	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	3.5	6.3	2.2e-10	0.70	0.04	0.36	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	MARS2	0.15	0.14	lasso	4	0.07	2.6e-03	-6.4	-6.0	2.5e-09	-0.63	0.09	0.54	FALSE
7	GTEx	Colon Transverse	MARS2	0.17	0.12	lasso	4	0.13	7.4e-07	-6.4	-5.9	2.8e-09	-0.59	0.28	0.33	FALSE
4	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	3.4	5.8	7.5e-09	0.65	0.05	0.09	FALSE
3	GTEx	Brain Frontal Cortex BA9	MARS2	0.18	0.12	lasso	2	0.07	5.1e-03	5.5	-5.5	4.6e-08	-0.47	0.14	0.07	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HSPD1	0.08	0.09	lasso	7	0.09	2.2e-11	5.6	5.4	5.4e-08	0.45	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFTN2	0.02	0.02	lasso	2	0.01	1.1e-03	5.6	5.4	5.5e-08	0.45	0.22	0.22	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	RFTN2	0.15	0.10	lasso	1	0.08	2.3e-03	5.3	5.3	9.4e-08	0.44	0.04	0.34	FALSE