Best TWAS P=1.05e-20 · Best GWAS P=1.09e-17 conditioned to 0.539
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABO | 0.08 | 0.01 | blup | 43 | 0.07 | 7.9e-07 | 7.8 | 7.8 | 4.3e-15 | 0.77 | 0.01 | 0.99 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | 7.8 | 7.7 | 1.0e-14 | 0.93 | 0.30 | 0.70 | FALSE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ABO | 0.11 | 0.05 | blup | 43 | 0.12 | 1.2e-06 | -4.5 | 8.0 | 8.6e-16 | 0.77 | 0.03 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABO | 0.27 | 0.31 | blup | 43 | 0.33 | 2.1e-19 | 7.7 | 8.8 | 1.0e-18 | 0.87 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | 7.7 | 7.8 | 8.3e-15 | 0.93 | 0.02 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | ABO | 0.18 | 0.01 | blup | 42 | 0.07 | 3.0e-03 | 7.7 | 8.0 | 9.8e-16 | 0.83 | 0.00 | 0.75 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABO | 0.11 | 0.08 | blup | 43 | 0.12 | 2.5e-13 | 7.7 | 8.5 | 1.9e-17 | 0.78 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABO | 0.20 | 0.19 | blup | 43 | 0.33 | 3.0e-38 | -4.6 | 7.2 | 7.7e-13 | 0.79 | 0.61 | 0.39 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | 8.6 | 8.3 | 1.1e-16 | 0.97 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | 7.8 | 8.4 | 6.2e-17 | 0.87 | 0.47 | 0.53 | FALSE |
| 11 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | 8.6 | 8.5 | 1.3e-17 | 1.00 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | 7.8 | 8.1 | 4.5e-16 | 0.97 | 0.01 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ABO | 0.08 | 0.06 | blup | 43 | 0.09 | 1.7e-10 | 7.8 | 7.5 | 5.5e-14 | 0.88 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | 7.8 | 7.9 | 3.0e-15 | 0.94 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ABO | 0.23 | 0.21 | lasso | 5 | 0.20 | 6.7e-09 | 8.6 | 9.0 | 1.7e-19 | 0.96 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | 7.7 | 8.1 | 4.2e-16 | 0.95 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABO | 0.18 | 0.15 | blup | 43 | 0.21 | 3.4e-21 | 8.6 | 7.7 | 1.4e-14 | 0.84 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | 8.4 | 9.3 | 1.0e-20 | 0.89 | 0.00 | 0.98 | TRUE |
| 19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ABO | 0.32 | 0.18 | enet | 10 | 0.20 | 2.3e-12 | 7.8 | 8.0 | 9.9e-16 | 0.85 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | ABO | 0.38 | 0.11 | blup | 43 | 0.15 | 9.6e-05 | 6.3 | 7.9 | 3.8e-15 | 0.76 | 0.02 | 0.85 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ABO | 0.20 | 0.10 | blup | 42 | 0.18 | 5.8e-13 | 7.8 | 8.1 | 5.3e-16 | 0.83 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ABO | 0.41 | 0.17 | enet | 12 | 0.25 | 3.0e-09 | -3.4 | 6.1 | 9.9e-10 | 0.87 | 0.04 | 0.96 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | ABO | 0.44 | 0.57 | enet | 18 | 0.60 | 1.9e-73 | 7.8 | 8.7 | 3.8e-18 | 0.97 | 0.00 | 1.00 | FALSE |