Best TWAS P=1.1e-13 · Best GWAS P=6.77e-13 conditioned to 0.00802
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RALGPS1 | 0.08 | 0.07 | enet | 27 | 0.09 | 3.8e-11 | -7.2 | -7.4 | 1.1e-13 | 0.90 | 0.02 | 0.98 | TRUE |
2 | GTEx | Artery Coronary | RALGPS1 | 0.26 | 0.00 | enet | 26 | 0.07 | 2.9e-03 | 6.4 | 6.2 | 6.9e-10 | -0.38 | 0.10 | 0.20 | FALSE |
3 | GTEx | Brain Cerebellum | RALGPS1 | 0.28 | 0.17 | lasso | 7 | 0.19 | 2.8e-06 | -5.0 | -5.2 | 2.5e-07 | 0.89 | 0.14 | 0.85 | TRUE |
4 | GTEx | Esophagus Mucosa | RALGPS1 | 0.05 | 0.01 | lasso | 6 | 0.02 | 2.7e-02 | 6.3 | 6.4 | 1.6e-10 | -0.57 | 0.24 | 0.40 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | RALGPS1 | 0.06 | 0.02 | lasso | 6 | 0.01 | 2.5e-02 | 6.3 | 6.4 | 1.5e-10 | -0.74 | 0.32 | 0.55 | FALSE |
6 | GTEx | Thyroid | RALGPS1 | 0.09 | 0.04 | enet | 12 | 0.01 | 2.7e-02 | 6.1 | -6.2 | 5.3e-10 | 0.45 | 0.26 | 0.62 | FALSE |
7 | METSIM | Adipose | RALGPS1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 2.8e-06 | 6.6 | 6.4 | 1.4e-10 | -0.57 | 0.27 | 0.73 | FALSE |
8 | YFS | Blood | RALGPS1 | 0.08 | 0.13 | lasso | 18 | 0.15 | 1.1e-45 | 6.4 | 6.3 | 2.7e-10 | -0.75 | 0.38 | 0.62 | FALSE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ANGPTL2 | 0.10 | 0.08 | blup | 38 | 0.09 | 2.8e-04 | -5.2 | -5.6 | 1.9e-08 | 0.84 | 0.09 | 0.63 | FALSE |