TWAS
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Usage
Models
Genes
Traits
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Traits
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Impedance of arm (right)
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chr10:71,736,472-73,345,380
Best TWAS P=6.8e-17 · Best GWAS P=7.84e-22 conditioned to 0.927
71.8M
72M
72.2M
72.4M
72.6M
72.8M
73M
73.2M
73.4M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
ADAMTS14
0.38
0.35
bslmm
710
0.47
3.9e-67
9.6
8.4
6.8e-17
0.87
0.00
1.00
TRUE
2
GTEx
Artery Tibial
PCBD1
0.19
0.01
lasso
6
0.01
3.0e-02
-6.0
5.4
8.0e-08
0.44
0.11
0.18
TRUE
1
CommonMind
Brain Pre-frontal Cortex
ADAMTS14
0.28
0.24
bslmm
733
0.35
7.9e-44
-3.5
7.8
4.5e-15
0.81
0.10
0.90
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
ADAMTS14
0.05
0.03
enet
17
0.03
3.4e-07
-4.0
6.4
1.3e-10
0.72
0.07
0.93
FALSE