Best TWAS P=6.8e-17 · Best GWAS P=7.84e-22 conditioned to 0.927
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADAMTS14 | 0.28 | 0.24 | bslmm | 733 | 0.35 | 7.9e-44 | -3.5 | 7.8 | 4.5e-15 | 0.81 | 0.10 | 0.90 | FALSE |
| 2 | GTEx | Artery Tibial | PCBD1 | 0.19 | 0.01 | lasso | 6 | 0.01 | 3.0e-02 | -6.0 | 5.4 | 8.0e-08 | 0.44 | 0.11 | 0.18 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | ADAMTS14 | 0.38 | 0.35 | bslmm | 710 | 0.47 | 3.9e-67 | 9.6 | 8.4 | 6.8e-17 | 0.87 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADAMTS14 | 0.05 | 0.03 | enet | 17 | 0.03 | 3.4e-07 | -4.0 | 6.4 | 1.3e-10 | 0.72 | 0.07 | 0.93 | FALSE |