Best TWAS P=6.56e-23 · Best GWAS P=8.88e-23 conditioned to 0.577
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C10orf11 | 0.24 | 0.21 | lasso | 9 | 0.20 | 3.3e-16 | -8.6 | 9.4 | 4.0e-21 | -0.87 | 0.08 | 0.92 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C10orf11 | 0.40 | 0.32 | enet | 11 | 0.27 | 2.2e-14 | -8.6 | 9.9 | 6.6e-23 | -0.89 | 0.04 | 0.96 | TRUE |
| 3 | GTEx | Adrenal Gland | C10orf11 | 0.24 | 0.22 | enet | 21 | 0.18 | 5.8e-07 | -8.6 | 8.9 | 6.6e-19 | -0.83 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Muscularis | C10orf11 | 0.45 | 0.39 | enet | 42 | 0.38 | 5.1e-24 | -8.6 | 9.8 | 6.9e-23 | -0.84 | 0.31 | 0.69 | FALSE |
| 5 | GTEx | Lung | C10orf11 | 0.30 | 0.26 | lasso | 5 | 0.24 | 2.0e-18 | -8.6 | 9.4 | 8.6e-21 | -0.87 | 0.07 | 0.93 | FALSE |
| 6 | GTEx | Testis | ZNF503-AS2 | 0.16 | 0.02 | lasso | 4 | 0.06 | 1.3e-03 | -6.9 | -6.2 | 7.7e-10 | 0.50 | 0.09 | 0.37 | FALSE |
| 7 | GTEx | Thyroid | C10orf11 | 0.38 | 0.21 | lasso | 9 | 0.25 | 6.7e-19 | -8.1 | 9.5 | 1.5e-21 | -0.80 | 0.17 | 0.83 | FALSE |
| 8 | METSIM | Adipose | C10orf11 | 0.11 | 0.10 | enet | 14 | 0.10 | 1.1e-14 | -8.1 | 8.0 | 9.6e-16 | -0.78 | 0.61 | 0.39 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | ZNF503 | 0.05 | 0.04 | bslmm | 342 | 0.04 | 2.2e-06 | -4.8 | -5.2 | 1.7e-07 | 0.15 | 0.96 | 0.00 | TRUE |