Best TWAS P=4.34e-08 · Best GWAS P=1.68e-07 conditioned to 0.491
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | 5.2 | -5.2 | 1.9e-07 | -0.97 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | 5.2 | -5.2 | 1.8e-07 | -0.99 | 0.02 | 0.88 | FALSE |
| 3 | GTEx | Stomach | MED19 | 0.10 | 0.04 | lasso | 7 | 0.09 | 6.8e-05 | 5.1 | -5.5 | 4.3e-08 | -0.90 | 0.02 | 0.89 | TRUE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | 5.2 | 5.2 | 1.7e-07 | 1.00 | 0.00 | 0.90 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | 5.2 | -5.2 | 2.1e-07 | -0.99 | 0.00 | 0.83 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED19 | 0.03 | 0.01 | lasso | 2 | 0.02 | 1.9e-03 | 5.1 | -5.3 | 9.5e-08 | -0.82 | 0.00 | 0.62 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | 5.2 | -5.2 | 1.9e-07 | -0.97 | 0.00 | 0.84 | FALSE |