TWAS hub - TMX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0115	0.0078	0.0020	0.014	0.008	0.010	NA	0.009	0.00045	0.0071	0.0033	NA	0.0041
2	TCGA	Colon Adenocarcinoma	0.0670	0.0440	0.0028	0.059	0.041	0.036	NA	0.053	0.00025	0.0020	0.0039	NA	0.0005
3	TCGA	Prostate Adenocarcinoma	0.0253	0.0163	0.0018	0.021	0.019	0.004	NA	0.016	0.00260	0.0037	0.1000	NA	0.0081

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Average weekly red wine intake	19.0	28.1	29.5	-5.0	-5.4	-5.4
Worry too long after embarrassment	17.5	29.4	39.1	4.8	6.3	5.1
Major Depression (MDD)	15.0	18.3	20.2	3.9	4.4	4.5
Neuroticism score	14.5	30.2	42.1	4.7	6.5	5.1
Neuroticism	14.4	34.6	46.6	5.2	6.8	5.5
Frequency of tiredness / lethargy in last 2 weeks	14.4	23.4	24.7	4.6	5.0	5.0
Frequency of unenthusiasm / disinterest in last 2 weeks	13.6	18.1	20.7	4.0	4.5	4.2
Alcohol usually taken with meals	13.5	21.8	22.6	-4.6	-4.7	-4.8
Depression (Nagel 2018)	13.4	20.2	25.2	4.1	5.0	4.3
Schizophrenia vs Biploar Disorder	12.8	16.9	21.3	4.6	2.9	4.5
Frequency of depressed mood in last 2 weeks	12.5	17.5	19.4	3.9	4.4	4.3
Neuroticism (Nagel 2018)	12.2	28.7	39.3	4.7	6.3	5.0
Worrier / anxious feelings	11.6	21.9	28.3	4.1	5.3	4.5
Guilty feelings	11.4	17.2	27.3	3.4	5.2	3.6
Fed-up feelings	10.7	19.4	23.3	4.0	4.8	4.4
Townsend deprivation index at recruitment	9.9	13.9	15.1	3.6	3.6	3.9
Schizophrenia (2018)	8.3	17.3	19.6	3.9	4.4	4.1
Financial difficulties in last 2 years	8.1	10.8	12.4	3.5	2.8	3.5
Overall health rating	8.1	17.4	20.1	4.4	3.6	4.5
Qualifications: nursing, teaching	8.1	12.7	14.6	-3.8	-3.0	-3.8
Schizophrenia (2014)	8.0	17.7	20.5	3.8	4.5	4.2
Alcohol intake frequency.	8.0	18.6	20.5	4.1	4.5	4.3
Qualifications: None of the above	7.9	17.0	20.2	4.2	3.6	4.5
Loneliness, isolation	7.9	11.0	13.4	3.0	3.7	3.2
Sensitivity / hurt feelings	7.6	13.1	19.0	3.2	4.4	3.2
Hair/balding pattern: Pattern 2	7.5	9.5	13.2	-3.6	-1.9	-3.5
Pulse rate, automated reading	7.3	23.5	23.6	4.9	4.9	4.8
Qualifications: CSEs or equivalent	7.0	9.3	9.7	3.0	3.0	3.1
Unable to work because of sickness or disability	6.8	8.8	11.9	2.5	3.5	2.9
Lung FEV1/FVC ratio	6.6	33.3	40.4	-6.4	-4.7	-6.1
Alcohol drinker status: Previous	6.6	7.5	13.0	2.0	3.6	2.3
Chronotype (morning person)	6.5	15.1	16.8	-4.0	-3.6	-4.1
Systolic Blood Pressure	6.1	30.7	64.0	-3.2	-8.0	-4.2
Tense / ‘highly strung’	6.1	10.1	12.5	2.9	3.5	3.1
Medication: Seretide 50 evohaler	6.1	7.0	9.1	2.3	3.0	2.6
Mineral and other dietary supplements	6.1	8.2	10.5	3.0	2.3	3.2
Blood Platelet Count	6.0	69.1	89.9	7.3	9.5	8.0
Prospective memory result	6.0	7.3	8.2	2.8	2.4	2.9
Wears glasses or contact lenses	5.8	6.7	7.9	-2.8	-2.1	-2.8
Depression (self-reported)	5.6	6.7	7.1	2.5	2.6	2.7
Eye problems/disorders: Glaucoma	5.6	6.7	8.2	-2.7	-2.1	-2.9
Peak expiratory flow (PEF)	5.3	12.4	14.7	-3.8	-2.8	-3.8
Headache pain in last month	5.3	9.2	19.7	1.6	4.4	2.3
Qualifications: College or University degree	5.3	16.6	18.1	-4.1	-3.9	-4.3
Pain all over the body in last month	5.0	5.3	5.9	2.1	2.4	2.4
Pain experienced in last month	5.0	8.4	11.5	-2.5	-3.4	-2.7
Pack years adult smoking proportion	4.9	7.5	10.0	2.3	3.2	2.7
Forced expiratory volume in 1-second (FEV1)	4.9	16.5	19.2	-4.4	-3.6	-4.2
Worry (Nagel 2018)	4.7	9.9	14.8	2.6	3.9	2.9
Irritability	4.7	8.0	14.9	1.8	3.9	2.4
Depressed Affect (Nagel 2018)	4.6	9.7	14.9	2.5	3.9	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	4.6	7.0	10.6	2.1	3.2	2.5
Supplements: Fish oil (including cod liver oil)	4.6	6.0	6.8	-2.3	-2.4	-2.6
Pack years of smoking	4.6	6.8	8.6	2.3	2.9	2.6
Intelligence (Savage-Jansen 2018)	4.4	13.6	16.6	-3.3	-4.1	-3.6
Neuroticism (2016)	4.4	6.4	9.1	2.0	3.0	2.4
Hand grip strength (left)	4.4	11.7	13.5	-3.5	-3.0	-3.7
Systolic blood pressure, automated reading	4.3	12.4	27.1	-1.9	-5.2	-2.5
Glaucoma (self-reported)	4.3	5.1	5.7	-2.2	-2.1	-2.4
Ever unenthusiastic/disinterested for a whole week	4.2	5.1	5.8	2.1	2.2	2.4
Verbal and Numeric Reasoning (VNR)	4.1	10.0	13.5	-2.7	-3.7	-3.0
Sitting height	4.1	28.8	32.1	-5.4	-5.1	-5.7
Happiness	4.1	5.0	7.0	2.5	1.3	2.6
Arm fat percentage (right)	4.0	15.6	22.4	3.2	4.7	3.7
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.9	16.0	-4.0	-2.9	-3.8
Smoking status: Current	4.0	6.3	9.7	1.9	3.1	2.3
Current tobacco smoking	3.9	6.3	9.9	1.9	3.1	2.3
Commuting to job workplace: Cycle	3.9	4.7	7.8	-1.6	-2.8	-2.0
Breast Cancer	3.8	9.1	11.3	-3.1	-2.6	-3.4
Mouth/teeth dental problems	3.8	5.9	6.5	-2.3	-2.5	-2.5
Prostate Cancer	3.7	5.1	7.4	-1.9	-2.7	-2.1
Hearing difficulty/problems: Yes	3.7	5.7	7.3	2.1	2.7	2.3
Fluid intelligence score	3.7	7.7	9.7	-2.4	-3.1	-2.7
Heel T-Score	3.5	27.8	32.5	5.3	4.8	5.7
Hand grip strength (right)	3.5	9.6	11.2	-3.2	-2.7	-3.3
Qualifications: A levels/AS levels or equivalent	3.5	7.8	8.6	-2.7	-2.7	-2.9
Heart disease (mother)	3.5	4.3	8.2	-1.3	-2.9	-1.7
Leg pain on walking	3.5	4.4	5.7	-2.4	-1.5	-2.2
Arm fat percentage (left)	3.5	14.1	19.6	3.1	4.4	3.6
Medication: Paracetamol	3.4	5.2	10.7	1.4	3.3	1.7
Trunk fat percentage	3.3	13.2	19.4	2.9	4.4	3.4
Mood swings	3.3	6.0	11.6	1.5	3.4	2.1
Hearing aid user	3.3	3.8	4.3	-1.7	-2.0	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.1	6.3	1.6	2.5	1.8
Body fat percentage	3.1	12.3	17.0	2.9	4.1	3.4
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	7.6	1.6	2.8	2.0
Medication: Paracetamol	3.0	4.9	11.0	1.3	3.3	1.5
Bipolar Disorder or Schizophrenia	2.9	7.1	11.3	2.0	3.4	2.4
Impedance of arm (right)	2.9	13.7	27.4	2.3	5.2	3.0
Exposure to tobacco smoke at home	2.9	3.2	4.6	2.1	1.2	1.9
Mouth/teeth dental problems: Loose teeth	2.9	3.4	4.2	2.0	1.6	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.1	6.8	-2.6	-2.3	-2.5
Ever taken oral contraceptive pill	2.9	3.2	3.8	-1.8	-1.6	-2.0
Commuting to job workplace: Public transport	2.9	3.5	4.3	-2.1	-1.6	-1.9
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	5.5	-2.0	-2.0	-2.4
Primary Biliary Cirrhosis	2.7	3.9	6.2	2.5	0.7	2.2
Mean time to correctly identify matches	2.7	5.2	6.0	2.5	1.9	2.4
Trunk fat-free mass	2.5	14.6	18.3	-4.2	-2.8	-4.3
Trunk predicted mass	2.5	14.5	18.1	-4.2	-2.8	-4.3
Financial situation satisfaction	2.5	3.1	3.4	1.7	1.8	1.8
Ever had prostate specific antigen (PSA) test	2.5	2.9	3.1	-1.8	-1.6	-1.8
Commuting to job workplace: Car/motor vehicle	2.4	2.8	3.9	1.4	2.0	1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	7.5	-2.6	-0.9	-2.7
Alcohol drinker status: Never	2.4	2.9	5.1	1.3	2.3	1.4
Number of operations (self-reported)	2.4	3.6	4.7	-2.2	-1.2	-2.2
Height	2.3	44.3	65.3	-8.1	-2.7	-7.8
Smoking Status	2.3	5.4	5.8	2.3	2.4	2.3
Supplements: Glucosamine	2.3	3.0	3.7	-1.7	-1.6	-1.9
Impedance of arm (left)	2.3	10.7	21.7	1.9	4.7	2.6
Standing height	2.3	22.8	32.7	-5.7	-2.2	-5.6
Age at last live birth	2.3	3.3	3.7	1.8	1.9	1.8
Ever had hysterectomy (womb removed)	2.2	2.5	4.7	-1.2	-2.2	-1.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	3.7	1.2	1.9	1.4
Arm fat-free mass (right)	2.0	10.2	11.7	-3.3	-2.9	-3.4
Ever depressed for a whole week	2.0	2.4	3.2	1.6	1.2	1.8
Body Mass Index (BMI) (2010)	1.9	2.6	4.3	1.3	2.1	1.3
Blood Red Count	1.9	18.4	35.3	2.9	5.9	3.4
Number of full brothers	1.9	2.3	4.6	-1.1	-2.1	-1.1
Ulcerative Colitis	1.8	2.6	3.7	-1.9	-1.0	-1.8
Blood Eosinophil Count	1.8	13.7	23.7	2.7	4.9	3.2
Medication: Ramipril	1.8	2.3	3.2	-1.2	-1.8	-1.4
Reaction Time	1.7	3.2	3.6	1.8	1.7	1.9
Father’s age at death	1.7	2.3	3.2	-1.8	-0.6	-1.8
Shortness of breath walking on level ground	1.7	2.0	5.4	0.4	2.3	0.7
Miserableness	1.7	3.0	4.6	1.5	2.1	1.5
Cholesterol lowering medication	1.7	2.5	4.0	2.0	0.4	1.9
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.2	-1.3	-1.5	-1.2
Medication: Atenolol	1.6	2.0	2.9	1.7	0.9	1.5
High blood pressure (mother)	1.6	2.3	3.5	-1.1	-1.9	-1.4
Birth weight of first child	1.6	2.9	4.8	-2.2	-0.2	-1.9
Leg fat percentage (right)	1.6	5.8	7.0	2.2	2.6	2.4
Arm predicted mass (right)	1.6	8.4	9.7	-3.0	-2.6	-3.1
Leg fat percentage (left)	1.6	5.6	7.1	2.1	2.7	2.4
Mean Putamen Volume	1.5	1.7	2.9	-0.9	-1.7	-1.1
Ever used hormone-replacement therapy (HRT)	1.5	2.0	2.9	1.7	0.5	1.7
Medication: Co-codamol	1.5	1.8	2.7	1.0	1.6	1.2
Mouth/teeth dental problems: Dentures	1.5	2.6	3.6	1.8	1.0	1.9
Whole body fat-free mass	1.5	8.6	11.0	-3.3	-2.0	-3.3
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.4	1.5	1.0	1.4
Angina	1.4	1.8	3.2	-0.9	-1.8	-1.2
Hearing difficulty/problems with background noise	1.4	2.3	3.2	1.4	1.2	1.8
Forced vital capacity (FVC)	1.4	5.5	7.3	-2.7	-1.7	-2.5
Arm fat mass (right)	1.4	5.6	10.0	1.7	3.2	2.0
Exposure to tobacco smoke outside home	1.4	1.8	2.3	-1.5	-1.1	-1.4
Angina (self-reported)	1.4	1.8	3.2	-0.9	-1.8	-1.1
Commuting to job workplace: Walk	1.4	1.5	1.7	-1.1	-1.3	-1.3
Arm fat-free mass (left)	1.4	7.0	8.5	-2.8	-2.1	-2.9
Fractured/broken bones in last 5 years	1.4	1.8	2.5	-1.1	-1.6	-1.3
Age started oral contraceptive pill	1.4	1.8	2.5	-1.6	-0.6	-1.6
Triglycerides	1.3	2.1	3.1	1.8	0.4	1.7
Lung cancer (father)	1.3	1.5	2.7	0.8	1.6	1.1
Blood clot in the leg (DVT)	1.3	1.7	2.6	1.1	1.6	1.2
Whole body water mass	1.3	7.5	9.6	-3.1	-1.9	-3.1
Coronary Artery Disease (CAD)	1.2	1.4	2.4	1.3	-0.5	1.6
Trunk fat mass	1.2	5.3	10.0	1.5	3.2	1.9
Number of children fathered	1.2	1.3	1.8	-1.1	-1.4	-1.0
Arm fat mass (left)	1.2	5.1	9.0	1.6	3.0	1.9
Alcohol intake versus 10 years previously	1.1	1.6	2.3	1.3	1.0	1.5
Hair/balding pattern: Pattern 3	1.1	1.6	1.8	-1.3	-1.2	-1.3
Suffer from ‘nerves’	1.1	1.7	3.0	0.9	1.7	1.1
Ever smoked	1.1	1.9	2.5	1.3	1.6	1.3
Arm predicted mass (left)	1.1	5.7	6.9	-2.5	-2.0	-2.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	1.8	1.4	0.8	1.3
Medication: Lansoprazole	1.0	1.1	1.5	0.8	1.2	1.1
Hair/balding pattern: Pattern 4	1.0	2.4	3.6	1.9	-0.9	1.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.2	0.4	1.8	0.7
Forced vital capacity (FVC), Best measure	1.0	3.7	5.2	-2.3	-1.3	-2.1
Comparative body size at age 10	1.0	2.7	4.2	1.4	2.1	1.4
Medication for pain relief, constipation, heartburn	1.0	1.8	4.6	-0.5	-2.1	-0.7
Migraine (self-reported)	1.0	1.2	3.1	0.4	1.8	0.7
Average weekly beer plus cider intake	1.0	1.5	3.6	-0.6	-1.9	-0.7
Crohns Disease (2012)	0.9	1.4	2.2	-1.0	-1.5	-1.0
BMI	0.9	5.4	6.8	2.1	2.6	2.3
Vitamin and mineral supplements	0.9	1.2	1.3	-1.1	-1.1	-1.1
Age when periods started (menarche)	0.9	2.2	3.7	-1.9	0.7	-1.6
Multivitamins +/- minerals	0.9	1.2	1.8	1.4	0.6	1.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.0	-0.8	-1.4	-1.0
Medication: Cholesterol lowering	0.9	1.5	1.7	-1.2	-1.3	-1.1
Pulse wave Arterial Stiffness index	0.9	1.0	1.4	-1.2	-0.8	-1.0
Whole body fat mass	0.9	3.8	7.1	1.3	2.7	1.6
Breast cancer (self-reported)	0.9	1.0	1.5	0.8	1.2	1.0
Basal metabolic rate	0.9	4.8	6.8	-2.6	-1.1	-2.5
Bipolar Disorder (2018)	0.8	1.3	2.4	-1.6	-0.1	-1.2
Alzheimer’s Disease (including proxy)	0.8	1.1	1.3	1.0	1.0	1.2
Chronic bronchitis/emphysema (father)	0.8	1.0	1.7	-1.3	0.6	-1.0
Body mass index (BMI)	0.8	3.6	3.8	1.8	1.9	1.9
Illnesses of siblings	0.8	1.2	1.9	-1.4	0.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.2	-1.0	-0.7	-1.1
Medication: Amlodipine	0.8	1.1	2.9	0.6	-1.7	0.3
Age at first live birth	0.8	1.5	2.1	-1.4	-0.5	-1.5
Emphysema/chronic bronchitis	0.8	1.0	1.2	-1.0	-0.8	-1.1
Ever had bowel cancer screening	0.8	0.9	2.4	-0.1	-1.5	-0.5
Medication: Bendroflumethiazide	0.8	1.2	1.9	-0.8	-1.4	-1.0
Illnesses of father: High blood pressure	0.8	0.9	2.4	-0.4	-1.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.9	0.7	1.4	0.8
Impedance of whole body	0.8	4.2	8.6	1.2	2.9	1.6
Ovarian Cancer	0.7	0.9	2.2	-0.2	-1.5	-0.7
Fasting Glucose	0.7	0.8	1.4	-1.2	-0.1	-1.1
HDL Cholesterol	0.7	1.2	2.4	0.7	1.6	0.8
Respiratory disease	0.7	1.6	4.5	0.4	2.1	0.4
Tanning	0.7	8.1	9.5	-2.7	-3.1	-2.8
Taking other prescription medications	0.7	1.0	2.7	0.3	1.6	0.6
Falls in the last year	0.7	0.9	1.9	0.6	1.4	0.7
Illnesses of mother	0.7	0.9	1.8	0.5	1.4	0.7
Chest pain or discomfort	0.7	1.0	1.2	-1.0	-1.1	-0.9
Supplements: Vitamin C	0.7	0.8	2.1	0.1	1.5	0.5
Asthma (self-reported)	0.7	1.3	3.6	0.5	1.9	0.4
Medication: Blood pressure	0.7	1.4	4.2	0.3	-2.0	-0.2
Alzheimer’s Disease (in father)	0.6	0.6	1.0	0.6	1.0	0.7
Lupus	0.6	0.8	1.3	1.1	0.1	1.1
Cardiovascular Disease	0.6	1.9	3.2	1.8	-0.3	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.2	-1.1	0.5	-0.8
Past tobacco smoking	0.6	1.1	1.8	-1.3	-0.5	-1.1
Diabetes (self-reported)	0.6	0.9	1.9	-0.5	-1.4	-0.7
Asthma	0.6	1.2	3.3	0.3	1.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.0	0.4	1.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.1	0.3	-1.8	0.2
High blood pressure (siblings)	0.6	0.8	2.0	-0.4	-1.4	-0.6
Neck or shoulder pain in last month	0.6	0.9	1.2	1.0	0.8	1.1
Leg fat mass (right)	0.6	2.4	4.3	1.0	2.1	1.3
Family relationship satisfaction	0.6	0.7	1.2	1.1	0.2	1.0
Medication for cholesterol	0.6	0.9	1.7	-0.8	1.3	-0.5
High cholesterol (Self-reported)	0.6	1.0	1.6	1.2	0.1	1.2
Risk taking	0.6	0.9	1.5	-1.2	0.1	-1.2
Leg fat mass (left)	0.6	2.2	4.2	0.9	2.1	1.2
Hypothyroidism (self reported)	0.5	1.2	2.7	0.8	-1.6	0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.0	-0.4	-1.0	-0.7
Severe depression (siblings)	0.5	0.6	1.4	0.4	1.2	0.3
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-0.9	-0.0	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.4	0.5	1.6	0.9
Gout (self-reported)	0.5	0.7	1.2	-1.1	-0.5	-0.9
Comparative height size at age 10	0.5	2.7	3.7	-1.9	-0.9	-1.9
Leg fat-free mass (right)	0.5	2.5	3.8	-1.9	-0.5	-1.8
Diabetes diagnosed by doctor	0.5	0.7	1.1	1.1	0.1	1.0
Leg predicted mass (right)	0.5	2.5	3.9	-2.0	-0.4	-1.8
Diastolic blood pressure, automated reading	0.5	1.4	3.1	0.9	-1.8	0.6
Heart disease (siblings)	0.5	0.6	0.7	0.8	-0.8	0.6
Leg fat-free mass (left)	0.4	2.1	3.3	-1.8	-0.3	-1.7
Medication: Levothyroxine sodium	0.4	0.6	0.7	0.8	-0.9	0.7
Leg predicted mass (left)	0.4	2.0	3.1	-1.8	-0.3	-1.7
Nervous feelings	0.4	0.8	0.9	0.8	1.0	0.9
Had menopause	0.4	0.5	0.9	0.6	-0.9	0.3
Noisy workplace	0.4	0.5	0.5	-0.7	-0.7	-0.6
Length of working week for main job	0.4	0.4	0.7	-0.9	0.3	-0.7
Breastfed as a baby	0.4	0.4	0.7	-0.4	-0.8	-0.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	-0.3	1.2	0.2
Loud music exposure frequency	0.4	0.5	1.4	-0.1	1.2	0.2
Birth weight	0.4	1.0	1.6	-1.3	0.2	-1.1
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	-0.3	1.5	0.0
Pulse wave peak to peak time	0.4	0.4	0.5	0.7	0.6	0.6
Medication: Ibuprofen	0.4	0.4	1.0	0.3	1.0	0.4
Number of full sisters	0.4	0.5	1.1	-0.4	-1.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.4	1.1	0.4
Irritable Bowel Disease (IBD)	0.3	0.6	0.7	-0.8	-0.8	-0.7
Age at First Birth	0.3	0.4	0.7	-0.5	0.9	-0.3
Bipolar Disorder (2011)	0.3	0.3	0.7	0.3	0.8	0.3
HbA1C	0.3	0.4	0.5	-0.7	-0.4	-0.7
LDL Cholesterol	0.3	0.5	0.8	0.9	-0.5	0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.8	-0.3	-0.6
Diabetes (father)	0.3	0.4	0.6	-0.7	-0.1	-0.7
Diabetes (mother)	0.3	0.4	0.8	-0.9	0.0	-0.7
Maternal smoking around birth	0.3	0.4	0.7	0.8	0.2	0.7
High blood pressure	0.3	0.9	1.5	1.2	-0.4	0.9
Had other major operations	0.3	0.4	0.5	-0.7	-0.5	-0.6
Medication: Simvastatin	0.3	0.4	1.1	0.0	-1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.4	0.6	0.7	0.5
Eye problems/disorders: None of the above	0.3	0.4	0.8	0.3	0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.4	-0.5	-0.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-0.1	-1.0	-0.3
Illnesses of father: Heart disease	0.3	0.4	1.3	0.3	-1.1	0.0
Smoking status: Previous	0.3	0.5	0.9	1.0	-0.4	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	0.6	0.6	0.4
Friendships satisfaction	0.3	0.3	0.5	0.7	0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	-0.4	1.1	-0.0
Back pain experienced in last month	0.3	0.4	1.1	0.2	1.0	0.4
Mother’s age at death	0.3	0.3	0.6	-0.8	0.4	-0.5
Medication: Atorvastatin	0.3	0.3	0.9	0.2	-1.0	0.3
Myopia	0.3	0.4	0.4	0.6	0.6	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.1	-1.0	0.8	-0.8
Crohns Disease (2017)	0.2	0.4	0.7	-0.4	-0.8	-0.5
Waist Hip Ratio (WHR)	0.2	1.1	1.4	-1.2	0.9	-1.0
Relative age of first facial hair	0.2	0.3	0.7	-0.8	-0.2	-0.5
Medication: Metformin	0.2	0.3	0.5	0.7	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.3	1.1	0.0
Waist circumference	0.2	0.7	2.1	-0.4	1.4	-0.1
Allergy	0.2	0.5	1.4	0.1	-1.2	0.3
Hip circumference	0.2	1.0	1.6	-1.3	0.5	-1.0
Number of live births	0.2	0.3	0.3	0.6	0.5	0.6
Pulse rate	0.2	0.3	0.8	0.1	0.9	-0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.3	-0.5	-0.4	-0.4
Medication: Blood pressure	0.2	0.4	0.9	0.4	0.9	0.5
Medication: Allopurinol	0.2	0.3	0.8	0.0	0.9	0.2
Medication: Omeprazole	0.2	0.2	0.5	0.1	0.7	0.1
Had major operations	0.2	0.2	0.3	-0.5	0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.6	0.4	0.4
Hypertension (Self-reported)	0.2	0.6	0.8	0.9	-0.9	0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.4	0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.6	0.1	-0.5
Osteoporosis (self-reported)	0.2	0.3	0.3	0.6	-0.4	0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	0.2	0.9	0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.5	-0.5	-0.6
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.2	0.6	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.6	-0.1	-0.4
Blood White Count	0.1	1.0	2.9	-0.1	1.7	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.1	-0.8	-0.1
Number of treatments/medications taken	0.1	0.2	0.4	0.1	0.6	0.2
Average weekly spirits intake	0.1	0.1	0.4	0.0	0.7	0.0
Medication for hormone replacement therapy	0.1	0.1	0.2	0.3	0.1	0.4
Impedance of leg (right)	0.1	0.3	0.8	-0.0	0.9	0.2
Average weekly fortified wine intake	0.1	0.1	0.2	0.5	-0.2	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.4	-0.3	-0.7
Stomach or abdominal pain in last month	0.1	0.2	0.3	0.2	0.6	0.3
Impedance of leg (left)	0.1	0.4	1.3	-0.1	1.1	0.2
Number of incorrect matches in round	0.1	0.2	0.3	0.5	-0.3	0.3
Weight	0.1	0.6	0.9	-0.8	0.9	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.4	0.1	0.3
Medication: Aspirin	0.1	0.2	0.4	0.4	0.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.5	0.2	-0.3
Medication: Gliclazide	0.1	0.1	0.2	0.4	-0.1	0.3
Number of self-reported non-cancer illnesses	0.1	0.3	0.7	0.2	-0.9	0.0
Medication: Lisinopril	0.1	0.1	0.1	-0.2	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.1	0.5	0.3
Supplements: Calcium	0.1	0.1	0.2	-0.2	-0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.2	-0.4	0.2
Rheumatoid Arthritis	0.0	0.1	0.2	-0.4	0.0	-0.0
Allergy or Eczema	0.0	0.1	0.2	0.4	0.3	0.2
Lung FVC	0.0	0.1	0.4	-0.1	-0.6	0.2
Hair Pigment	0.0	0.8	1.3	1.2	-0.0	1.0
Supplements: Zinc	0.0	0.0	0.1	-0.0	-0.3	-0.1
Relative age voice broke	0.0	0.0	0.0	0.2	-0.2	0.2
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.0	0.2	-0.1
Heart attack	0.0	0.1	0.2	0.0	-0.4	0.1
Time employed in main current job	0.0	0.0	0.0	-0.2	-0.0	0.0
Pulse wave reflection index	0.0	0.0	0.1	0.1	-0.3	0.1
Health satisfaction	0.0	0.0	0.0	0.0	0.1	0.2
Knee pain experienced in last month	0.0	0.0	0.1	0.1	0.3	0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.3	-0.0	0.1
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.2	-0.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.3	0.0	0.2
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.1	0.2	0.0
Medication: Aspirin	0.0	0.1	0.2	-0.1	-0.4	0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	-0.2	0.2

Hub : Genes

TMX2

Models

Trait associations