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chr11:61,627,881-63,284,510

Best TWAS P=9.52e-17 · Best GWAS P=7.76e-16 conditioned to 0.0125

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ROM1	0.25	0.17	lasso	3	0.18	1.5e-14	-7.4	7.6	2.5e-14	-0.78	0.48	0.52	FALSE
2	GTEx	Adipose Visceral Omentum	ROM1	0.29	0.16	lasso	8	0.23	3.7e-12	-7.0	8.0	1.4e-15	-0.81	0.21	0.79	FALSE
3	GTEx	Artery Aorta	ROM1	0.18	0.17	lasso	7	0.16	3.3e-09	-6.8	6.9	4.5e-12	-0.71	0.68	0.32	FALSE
4	GTEx	Artery Tibial	ROM1	0.14	0.05	lasso	6	0.03	2.5e-03	-6.9	7.0	2.6e-12	-0.74	0.24	0.63	FALSE
5	GTEx	Breast Mammary Tissue	ROM1	0.10	0.09	lasso	5	0.06	5.4e-04	-6.8	7.0	2.6e-12	-0.72	0.38	0.53	FALSE
6	GTEx	Breast Mammary Tissue (Male)	ROM1	0.17	0.00	enet	18	0.01	2.2e-01	-6.9	5.8	8.2e-09	-0.55	0.04	0.24	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ROM1	0.16	0.02	lasso	4	0.04	2.9e-02	-7.0	7.0	2.6e-12	-0.69	0.08	0.42	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	EML3	0.33	0.22	lasso	8	0.21	1.6e-07	-6.9	-6.5	6.3e-11	0.65	0.67	0.28	FALSE
9	GTEx	Cells Transformed fibroblasts	MTA2	0.06	0.09	lasso	1	0.07	3.0e-06	-7.3	-7.3	2.3e-13	0.82	0.43	0.51	FALSE
10	GTEx	Cells Transformed fibroblasts	EML3	0.19	0.16	lasso	9	0.18	7.3e-14	-7.3	-7.5	6.2e-14	0.81	0.65	0.35	FALSE
11	GTEx	Cells Transformed fibroblasts	HNRNPUL2	0.11	0.04	enet	14	0.05	9.8e-05	-3.2	6.0	2.1e-09	-0.84	0.03	0.97	FALSE
12	GTEx	Esophagus Mucosa	MTA2	0.29	0.34	lasso	5	0.33	6.9e-23	-6.9	-7.0	3.1e-12	0.71	0.95	0.05	FALSE
13	GTEx	Esophagus Mucosa	EML3	0.40	0.43	lasso	8	0.46	1.8e-33	-6.8	-7.1	1.3e-12	0.72	0.95	0.05	FALSE
14	GTEx	Lung	ROM1	0.25	0.18	enet	13	0.20	2.2e-15	-6.9	7.6	3.3e-14	-0.78	0.87	0.13	FALSE
15	GTEx	Lung	EML3	0.07	0.04	lasso	3	0.01	2.5e-02	-6.9	-6.9	5.0e-12	0.71	0.24	0.39	FALSE
16	GTEx	Nerve Tibial	ROM1	0.15	0.06	lasso	7	0.06	2.9e-05	-7.4	5.9	3.2e-09	-0.64	0.10	0.88	FALSE
17	GTEx	Nerve Tibial	EML3	0.17	0.10	lasso	4	0.09	3.9e-07	-6.9	-7.5	4.9e-14	0.77	0.14	0.86	FALSE
18	GTEx	Nerve Tibial	B3GAT3	0.18	0.11	lasso	3	0.09	4.7e-07	-8.0	-7.9	2.0e-15	0.97	0.00	1.00	FALSE
19	GTEx	Ovary	ROM1	0.25	0.00	lasso	5	0.00	3.3e-01	-7.3	7.8	6.4e-15	-0.81	0.07	0.28	FALSE
20	GTEx	Pituitary	STX5	0.22	0.11	lasso	3	0.11	9.7e-04	-2.5	6.5	6.5e-11	-0.55	0.05	0.44	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	ROM1	0.15	0.08	lasso	1	0.06	2.8e-04	-8.1	8.1	7.8e-16	-1.00	0.01	0.96	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	EML3	0.20	0.19	lasso	3	0.24	2.7e-13	-6.9	-7.6	3.7e-14	0.78	0.14	0.86	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	B3GAT3	0.18	0.11	lasso	3	0.11	9.8e-07	-8.0	-8.1	4.1e-16	0.96	0.00	1.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	MTA2	0.14	0.04	enet	21	0.05	3.1e-05	-7.4	-5.9	3.2e-09	0.73	0.08	0.89	FALSE
25	GTEx	Skin Sun Exposed Lower leg	ROM1	0.13	0.11	lasso	4	0.10	9.7e-09	-6.9	6.7	1.6e-11	-0.70	0.63	0.37	FALSE
26	GTEx	Skin Sun Exposed Lower leg	EML3	0.32	0.25	enet	19	0.26	8.0e-22	-6.9	-7.7	1.4e-14	0.71	0.92	0.08	FALSE
27	GTEx	Spleen	GANAB	0.35	-0.01	lasso	9	0.01	1.3e-01	-6.9	-6.4	1.4e-10	0.71	0.05	0.42	FALSE
28	GTEx	Spleen	MTA2	0.26	0.07	enet	19	0.07	8.7e-03	-7.0	-6.5	9.5e-11	0.68	0.05	0.76	FALSE
29	GTEx	Stomach	EML3	0.11	0.04	enet	5	0.03	2.1e-02	-7.3	-7.3	2.8e-13	0.79	0.08	0.44	FALSE
30	GTEx	Testis	EML3	0.27	0.22	enet	15	0.29	2.7e-13	-6.9	-7.5	6.6e-14	0.82	0.38	0.62	FALSE
31	GTEx	Thyroid	ROM1	0.17	0.16	lasso	8	0.16	3.6e-12	-6.9	7.2	7.8e-13	-0.72	0.72	0.28	FALSE
32	GTEx	Thyroid	EML3	0.10	0.11	lasso	4	0.10	5.9e-08	-6.9	-6.9	6.8e-12	0.70	0.36	0.63	FALSE
33	GTEx	Thyroid	B3GAT3	0.18	0.09	lasso	5	0.12	1.4e-09	-8.0	-7.9	2.1e-15	0.90	0.00	1.00	FALSE
34	GTEx	Whole Blood	EML3	0.17	0.09	lasso	7	0.08	6.3e-08	-6.8	-7.1	1.7e-12	0.74	0.78	0.22	FALSE
35	METSIM	Adipose	B3GAT3	0.08	0.06	enet	16	0.07	5.4e-11	-7.7	-7.4	2.0e-13	0.82	0.02	0.98	FALSE
36	METSIM	Adipose	EEF1G	0.08	0.05	bslmm	375	0.06	4.5e-09	-7.4	6.4	1.6e-10	-0.66	0.61	0.39	FALSE
37	METSIM	Adipose	EML3	0.15	0.14	bslmm	376	0.14	1.9e-20	-6.8	-6.5	6.9e-11	0.68	0.94	0.06	FALSE
38	METSIM	Adipose	ROM1	0.05	0.02	enet	17	0.02	9.9e-05	-6.9	6.2	4.9e-10	-0.57	0.48	0.48	FALSE
39	METSIM	Adipose	TTC9C	0.07	0.07	enet	25	0.08	1.4e-12	-3.3	-5.3	1.2e-07	0.71	0.73	0.27	FALSE
40	YFS	Blood	EEF1G	0.30	0.45	lasso	6	0.45	3.6e-166	-6.8	6.8	7.7e-12	-0.71	0.97	0.03	FALSE
41	YFS	Blood	EML3	0.20	0.31	lasso	12	0.33	1.3e-110	-7.4	-7.5	7.9e-14	0.76	0.61	0.39	FALSE
42	YFS	Blood	INTS5	0.09	0.12	lasso	4	0.12	1.9e-38	-8.0	-8.3	1.3e-16	0.97	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEF1G	0.04	0.05	lasso	1	0.04	1.1e-04	-7.4	7.4	1.3e-13	-0.73	0.05	0.90	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf83	0.01	0.00	blup	23	0.01	4.2e-03	-7.7	6.9	6.3e-12	-0.86	0.01	0.62	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	EEF1G	0.02	0.04	lasso	2	0.03	6.3e-07	-6.8	6.9	6.8e-12	-0.71	0.24	0.76	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	EML3	0.02	0.02	lasso	4	0.02	2.5e-05	-7.4	-7.3	2.0e-13	0.73	0.28	0.70	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROM1	0.01	0.02	enet	4	0.02	2.4e-04	-7.4	7.6	3.2e-14	-0.74	0.09	0.75	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	EEF1G	0.07	0.11	lasso	1	0.11	9.2e-07	-6.9	6.9	5.2e-12	-0.69	0.11	0.89	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	EML3	0.07	0.03	blup	29	0.05	6.5e-04	-7.3	-6.7	2.8e-11	0.69	0.10	0.33	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EEF1G	0.10	0.09	blup	26	0.09	9.8e-11	-6.9	6.1	9.6e-10	-0.61	0.30	0.70	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EML3	0.06	0.05	blup	27	0.06	7.6e-07	-7.7	-7.2	8.3e-13	0.77	0.03	0.97	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ROM1	0.04	0.02	blup	22	0.02	6.2e-03	-7.3	6.1	1.1e-09	-0.68	0.04	0.28	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EEF1G	0.11	0.12	blup	27	0.13	5.5e-14	-6.9	7.2	7.9e-13	-0.73	0.31	0.69	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML3	0.04	0.06	lasso	3	0.06	1.7e-07	-6.9	-6.9	5.9e-12	0.70	0.60	0.40	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EEF1G	0.07	0.04	blup	28	0.07	9.8e-05	-7.3	7.3	2.8e-13	-0.74	0.05	0.80	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EML3	0.06	0.09	lasso	2	0.08	1.6e-05	-7.7	-7.8	8.9e-15	0.79	0.02	0.97	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf83	0.02	0.01	blup	24	0.01	1.5e-02	-7.7	7.4	1.2e-13	-0.86	0.01	0.84	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEF1G	0.06	0.07	blup	27	0.07	8.1e-09	-6.8	6.8	1.0e-11	-0.75	0.04	0.96	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	EML3	0.03	0.04	blup	28	0.03	7.6e-05	-7.4	-7.1	1.0e-12	0.74	0.18	0.78	FALSE
60	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EEF1G	0.06	0.03	blup	27	0.04	4.5e-03	-7.7	7.7	1.0e-14	-0.78	0.01	0.79	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	EEF1G	0.06	0.08	lasso	8	0.08	5.9e-10	-6.8	7.3	3.4e-13	-0.78	0.11	0.89	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	EML3	0.03	0.03	blup	28	0.03	8.4e-05	-6.8	-7.7	1.8e-14	0.76	0.29	0.69	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	ROM1	0.04	0.04	blup	23	0.04	9.5e-06	-6.8	7.4	1.6e-13	-0.80	0.23	0.76	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf83	0.07	0.01	blup	24	0.01	1.0e-02	-8.0	7.5	6.1e-14	-0.80	0.00	0.90	FALSE
65	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EEF1G	0.08	0.13	lasso	4	0.12	3.1e-13	-6.8	6.8	7.5e-12	-0.71	0.35	0.65	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EML3	0.04	0.05	blup	27	0.05	3.5e-06	-7.4	-6.7	2.0e-11	0.75	0.10	0.89	FALSE
67	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML3	0.03	0.02	blup	27	0.03	3.5e-03	-7.4	-7.8	7.4e-15	0.81	0.02	0.73	FALSE
68	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EEF1G	0.08	0.08	blup	27	0.05	3.6e-03	-6.8	6.6	5.1e-11	-0.68	0.10	0.63	FALSE
69	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EEF1G	0.08	0.00	blup	27	0.04	1.3e-02	-6.8	6.5	6.7e-11	-0.68	0.03	0.65	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf83	0.03	0.03	blup	24	0.02	5.5e-03	-8.0	7.4	1.8e-13	-0.94	0.00	0.99	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	EEF1G	0.08	0.13	lasso	2	0.12	1.8e-12	-6.8	6.8	7.4e-12	-0.71	0.35	0.65	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	EML3	0.09	0.14	lasso	1	0.14	3.4e-14	-7.4	-7.4	1.3e-13	0.73	0.16	0.84	FALSE
73	The Cancer Genome Atlas	Rectum Adenocarcinoma	EML3	0.36	0.08	blup	27	0.19	3.7e-05	-7.4	-5.4	6.7e-08	0.55	0.05	0.31	FALSE
74	The Cancer Genome Atlas	Soft Tissue Sarcoma	ROM1	0.06	0.05	blup	24	0.03	8.1e-03	-6.8	7.3	2.1e-13	-0.73	0.06	0.27	FALSE
75	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EML3	0.32	0.03	lasso	2	0.07	4.9e-03	-7.3	-5.4	8.0e-08	0.77	0.02	0.36	FALSE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	EEF1G	0.05	0.07	blup	27	0.07	1.7e-05	-6.9	6.9	4.4e-12	-0.72	0.11	0.89	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	ROM1	0.05	0.08	lasso	3	0.08	3.1e-06	-6.9	7.1	1.1e-12	-0.74	0.23	0.75	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	EEF1G	0.15	0.27	blup	27	0.28	3.6e-27	-6.9	6.2	7.1e-10	-0.66	0.28	0.72	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	EML3	0.11	0.10	blup	28	0.12	2.3e-11	-7.4	-8.3	9.5e-17	0.78	0.03	0.97	TRUE
80	The Cancer Genome Atlas	Thyroid Carcinoma	ROM1	0.03	0.02	blup	23	0.02	1.1e-02	-6.9	7.3	3.4e-13	-0.77	0.05	0.62	FALSE