Best TWAS P=6.85e-11 · Best GWAS P=3.44e-13 conditioned to 4.14e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ORAOV1 | 0.13 | 0.07 | lasso | 3 | 0.04 | 2.0e-03 | -4.81 | -5.5 | 3.6e-08 | -0.10 | 0.14 | 0.44 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | IGHMBP2 | 0.49 | 0.47 | enet | 28 | 0.50 | 8.1e-29 | -4.46 | -5.4 | 5.5e-08 | -0.23 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Muscularis | IGHMBP2 | 0.12 | 0.06 | enet | 17 | 0.06 | 9.4e-05 | -4.53 | -5.2 | 1.5e-07 | -0.34 | 0.68 | 0.22 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | IGHMBP2 | 0.26 | 0.27 | lasso | 4 | 0.26 | 3.9e-12 | -5.12 | -5.2 | 1.6e-07 | -0.19 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Nerve Tibial | IGHMBP2 | 0.45 | 0.47 | enet | 44 | 0.48 | 2.0e-38 | -4.46 | -5.3 | 1.0e-07 | -0.25 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Vagina | C11orf24 | 0.24 | 0.04 | lasso | 9 | 0.08 | 5.8e-03 | 0.14 | -5.1 | 2.6e-07 | -0.65 | 0.04 | 0.50 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PPP6R3 | 0.04 | 0.01 | blup | 421 | 0.02 | 3.2e-04 | 7.24 | -5.6 | 1.7e-08 | -0.86 | 0.03 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAPS3 | 0.04 | 0.02 | blup | 84 | 0.04 | 2.5e-05 | 5.93 | -6.5 | 6.8e-11 | -0.86 | 0.12 | 0.87 | TRUE |