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chr11:75,678,647-78,979,645

Best TWAS P=2.09e-19 · Best GWAS P=3.93e-19 conditioned to 0.548

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	The Cancer Genome Atlas	Glioblastoma Multiforme	GAB2	0.10	0.07	blup	100	0.09	8.8e-04	8.59	-9.0	2.1e-19	-0.92	0.04	0.67	TRUE
4	GTEx	Adipose Visceral Omentum	LRRC32	0.21	0.00	enet	15	0.01	1.5e-01	4.27	5.3	1.0e-07	0.07	0.00	0.21	TRUE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	GAB2	0.04	0.04	blup	100	0.04	1.4e-03	8.83	-8.9	5.2e-19	-0.95	0.03	0.93	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAB2	0.06	0.06	blup	100	0.07	7.8e-08	8.44	-8.7	2.3e-18	-0.91	0.18	0.82	FALSE
12	GTEx	Brain Cerebellar Hemisphere	USP35	0.19	0.07	enet	13	0.09	2.5e-03	8.83	8.7	2.7e-18	0.95	0.06	0.79	FALSE
27	GTEx	Testis	USP35	0.07	0.06	lasso	2	0.07	6.4e-04	8.66	8.7	4.3e-18	0.95	0.05	0.91	FALSE
30	METSIM	Adipose	USP35	0.05	0.05	lasso	11	0.04	3.0e-06	8.45	8.6	8.2e-18	0.96	0.04	0.96	FALSE
10	GTEx	Artery Tibial	GAB2	0.06	0.00	lasso	2	0.01	2.4e-02	8.45	-8.5	2.5e-17	-0.94	0.09	0.68	FALSE
17	GTEx	Esophagus Muscularis	GAB2	0.05	0.04	lasso	7	0.04	1.8e-03	7.81	-8.4	3.3e-17	-0.77	0.13	0.79	FALSE
13	GTEx	Brain Cerebellar Hemisphere	NARS2	0.17	0.10	lasso	6	0.10	1.5e-03	7.37	-8.1	5.3e-16	-0.73	0.10	0.73	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	RP11-7I15.3	0.07	0.01	lasso	3	0.02	3.5e-02	8.54	7.8	4.7e-15	0.82	0.08	0.67	FALSE
2	CommonMind	Brain Pre-frontal Cortex	USP35	0.06	0.05	blup	363	0.04	1.6e-05	7.37	7.7	1.0e-14	0.77	0.03	0.96	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	GAB2	0.05	0.00	blup	435	0.02	8.0e-04	7.58	-7.6	2.0e-14	-0.75	0.22	0.68	FALSE
3	GTEx	Adipose Subcutaneous	NARS2	0.19	0.12	lasso	5	0.09	3.6e-08	7.34	-7.6	3.4e-14	-0.66	0.98	0.02	FALSE
34	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NARS2	0.09	0.04	blup	60	0.04	5.9e-03	7.43	-7.6	3.6e-14	-0.65	0.10	0.17	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	NARS2	0.30	0.19	lasso	2	0.17	2.6e-17	7.44	-7.5	7.9e-14	-0.65	0.98	0.02	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD21	0.03	0.00	blup	51	0.01	7.2e-02	8.85	-7.5	8.4e-14	-0.86	0.01	0.65	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	NARS2	0.15	0.22	lasso	5	0.20	9.6e-08	7.44	-7.4	1.0e-13	-0.65	0.98	0.01	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NARS2	0.14	0.06	lasso	2	0.06	2.9e-07	7.44	-7.4	1.0e-13	-0.66	0.98	0.02	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	NARS2	0.24	0.13	lasso	2	0.13	3.1e-14	7.43	-7.4	1.1e-13	-0.65	0.99	0.01	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	RP11-452H21.1	0.19	0.19	lasso	5	0.20	7.7e-08	7.40	-7.4	1.2e-13	-0.64	0.78	0.10	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NARS2	0.11	0.04	lasso	3	0.04	9.9e-06	7.40	-7.4	1.2e-13	-0.65	0.83	0.06	FALSE
28	GTEx	Thyroid	NARS2	0.30	0.30	lasso	4	0.32	1.4e-24	7.44	-7.4	1.3e-13	-0.65	1.00	0.00	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	NARS2	0.17	0.17	lasso	2	0.17	1.8e-21	7.34	-7.4	1.3e-13	-0.66	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	NARS2	0.27	0.27	lasso	4	0.27	1.9e-26	7.28	-7.4	1.3e-13	-0.66	0.99	0.01	FALSE
19	GTEx	Esophagus Muscularis	RP11-452H21.1	0.10	0.08	lasso	6	0.07	2.6e-05	7.37	-7.4	1.4e-13	-0.65	0.71	0.18	FALSE
23	GTEx	Nerve Tibial	NARS2	0.20	0.18	lasso	3	0.18	2.0e-12	7.34	-7.4	1.5e-13	-0.66	1.00	0.00	FALSE
8	GTEx	Artery Aorta	NARS2	0.26	0.29	lasso	2	0.28	1.7e-15	7.34	-7.4	1.6e-13	-0.66	1.00	0.00	FALSE
9	GTEx	Artery Coronary	NARS2	0.19	0.20	lasso	2	0.17	2.7e-06	7.34	-7.4	1.7e-13	-0.66	0.74	0.17	FALSE
11	GTEx	Artery Tibial	NARS2	0.18	0.20	lasso	2	0.19	5.9e-15	7.34	-7.4	1.7e-13	-0.66	1.00	0.00	FALSE
21	GTEx	Lung	NARS2	0.21	0.20	lasso	3	0.21	3.5e-16	7.34	-7.4	1.7e-13	-0.66	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	NARS2	0.25	0.19	lasso	3	0.17	8.7e-11	7.34	-7.4	1.8e-13	-0.66	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	NARS2	0.19	0.05	lasso	2	0.04	1.1e-04	7.34	-7.3	2.1e-13	-0.65	0.29	0.03	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	NARS2	0.12	0.05	lasso	2	0.05	2.0e-10	7.28	-7.3	2.6e-13	-0.65	0.99	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NARS2	0.44	0.57	bslmm	502	0.56	2.1e-81	7.34	-7.3	2.9e-13	-0.65	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NARS2	0.20	0.21	lasso	9	0.20	5.6e-09	7.28	-7.3	2.9e-13	-0.65	0.66	0.34	FALSE
29	GTEx	Thyroid	RP11-452H21.1	0.13	0.06	lasso	4	0.03	3.6e-03	7.42	-7.3	3.2e-13	-0.65	0.79	0.03	FALSE
5	GTEx	Adipose Visceral Omentum	ALG8	0.11	0.01	enet	8	0.02	3.7e-02	8.83	7.3	3.4e-13	0.90	0.01	0.95	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	NARS2	0.19	0.14	lasso	2	0.13	9.8e-05	7.44	-7.2	8.6e-13	-0.64	0.10	0.50	FALSE
20	GTEx	Liver	GAB2	0.17	-0.01	enet	20	-0.01	5.6e-01	8.19	7.1	1.0e-12	0.71	0.06	0.35	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	NARS2	0.17	0.09	enet	10	0.10	1.6e-11	7.44	-7.1	1.4e-12	-0.58	0.99	0.01	FALSE
7	GTEx	Artery Aorta	GAB2	0.10	0.02	lasso	4	0.02	1.7e-02	8.48	-7.0	2.3e-12	-0.80	0.07	0.64	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NARS2	0.11	0.01	enet	10	0.04	1.2e-03	7.40	-7.0	3.3e-12	-0.56	0.03	0.22	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	KCTD21	0.05	0.03	blup	51	0.03	1.2e-03	1.10	-6.4	1.6e-10	-0.68	0.05	0.42	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	NARS2	0.11	0.05	enet	7	0.06	2.0e-04	7.44	-6.1	1.3e-09	-0.59	0.13	0.52	FALSE
25	GTEx	Skin Sun Exposed Lower leg	GAB2	0.06	0.01	enet	26	0.03	2.2e-03	8.48	-6.0	2.3e-09	-0.67	0.11	0.84	FALSE
26	GTEx	Stomach	NARS2	0.27	0.05	lasso	8	0.06	6.1e-04	7.40	-5.8	6.5e-09	-0.52	0.21	0.04	FALSE
14	GTEx	Breast Mammary Tissue (Male)	INTS4	0.11	0.03	lasso	3	0.01	1.6e-01	0.43	-5.7	1.3e-08	-0.48	0.04	0.10	FALSE
6	GTEx	Adrenal Gland	NARS2	0.43	0.09	enet	47	0.22	2.6e-08	7.31	-5.1	2.9e-07	-0.42	0.58	0.20	FALSE