TWAS hub - ORAOV1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1350	0.0540	9.3e-03	0.072	NA	0.028	NA	0.043	8.5e-05	NA	1.1e-02	NA	2.0e-03
2	NTR	Blood	0.0433	0.0121	2.2e-05	0.023	0.017	0.015	0.019	0.021	4.1e-08	2.8e-06	7.6e-06	6e-07	2.3e-07
3	TCGA	Thyroid Carcinoma	0.0360	0.0190	5.7e-03	0.001	0.026	0.007	NA	0.001	2.7e-01	1.2e-03	5.8e-02	NA	2.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Impedance of leg (left)	14.3	69.6	76.4	-8.2	-8.7	-8.1
Impedance of leg (right)	13.9	67.2	73.9	-8.1	-8.6	-7.9
Impedance of whole body	9.7	49.5	61.4	-7.8	-6.9	-6.3
Comparative body size at age 10	8.7	23.9	39.9	2.4	6.3	5.1
Leg fat-free mass (left)	7.2	38.2	47.1	5.2	6.9	6.3
Leg predicted mass (left)	7.2	38.1	46.8	5.3	6.8	6.3
Birth weight	7.2	15.6	26.3	3.2	5.1	3.2
Leg fat-free mass (right)	7.2	38.2	46.2	5.3	6.8	6.3
Leg predicted mass (right)	7.1	37.8	45.8	5.2	6.8	6.3
BMI	6.6	38.4	40.8	6.1	6.4	6.1
Bilateral oophorectomy (both ovaries removed)	6.0	7.0	11.3	3.4	2.0	2.4
Whole body water mass	5.5	31.4	33.9	5.6	5.8	5.3
Whole body fat-free mass	5.4	31.1	34.1	5.5	5.8	5.3
Eye problems/disorders: None of the above	5.3	6.1	8.4	2.1	2.3	2.9
Basal metabolic rate	5.3	29.2	32.4	5.2	5.7	5.3
Breast Cancer	5.1	12.2	20.2	-1.4	-3.8	-4.5
Knee pain experienced in last month	5.0	7.7	12.2	3.5	1.8	2.8
Prostate Cancer	4.7	6.7	14.1	3.7	-1.4	-2.0
Body mass index (BMI)	4.7	20.0	24.5	3.8	5.0	4.6
Impedance of arm (left)	4.6	21.2	36.2	-6.0	-4.0	-3.4
Arm fat mass (right)	4.6	18.8	25.6	3.0	5.1	4.7
Average weekly red wine intake	4.6	6.9	11.4	-0.4	-3.0	-3.4
Mouth/teeth dental problems: Loose teeth	4.5	5.4	14.1	3.8	1.0	1.0
Waist Hip Ratio (WHR)	4.4	19.7	28.1	-2.4	-5.3	-5.1
Trunk fat-free mass	4.4	25.3	29.8	5.5	5.1	4.5
Body Mass Index (BMI) (2010)	4.3	5.9	8.5	2.1	2.9	2.2
Weight	4.3	21.0	25.7	3.9	5.1	4.7
Trunk predicted mass	4.3	24.6	29.2	5.4	5.0	4.5
Arm predicted mass (left)	4.2	21.3	23.3	4.8	4.7	4.3
Arm fat-free mass (left)	4.0	20.1	23.5	4.8	4.4	4.1
Medication: Gliclazide	3.9	4.4	9.4	0.6	1.8	3.1
Hip circumference	3.8	16.5	24.6	1.6	5.0	4.7
Arm fat mass (left)	3.8	15.5	20.2	2.9	4.5	4.3
Age at last live birth	3.6	5.2	10.5	-0.7	-2.2	-3.2
Blood White Count	3.5	25.6	40.2	-2.6	-6.3	-5.5
Arm fat-free mass (right)	3.5	17.8	22.2	4.7	4.1	3.8
Impedance of arm (right)	3.4	15.9	30.4	-5.5	-3.2	-2.7
Ever depressed for a whole week	3.4	4.2	7.6	1.0	2.0	2.8
Diabetes (father)	3.3	4.1	6.7	0.2	2.4	2.6
Age when periods started (menarche)	3.2	7.8	15.8	-0.9	-2.6	-4.0
Arm predicted mass (right)	3.1	16.0	20.9	4.6	4.0	3.3
Alcohol drinker status: Never	3.1	3.7	4.3	1.9	2.1	1.8
Arm fat percentage (right)	2.9	11.4	17.4	1.5	4.2	3.8
Breast cancer (self-reported)	2.9	3.4	5.1	1.0	2.0	2.3
Diverticular disease/diverticulitis (self-reported)	2.8	3.3	5.6	0.6	2.0	2.4
Mouth/teeth dental problems	2.8	4.3	6.5	-0.1	-2.5	-2.5
Ever highly irritable/argumentative for 2 days	2.6	3.1	4.8	1.4	2.2	1.6
Type 2 Diabetes (T2D) (2012)	2.5	2.9	4.8	1.9	2.2	0.0
Illnesses of siblings: Diabetes	2.5	3.1	5.4	1.5	1.2	2.3
Alzheimer’s Disease (in father)	2.4	2.5	5.9	-2.4	-0.8	-1.0
Falls in the last year	2.4	3.2	3.5	1.9	1.6	1.9
Medication: Aspirin	2.4	3.1	4.9	2.2	-2.0	-0.4
Arm fat percentage (left)	2.4	9.7	14.7	1.2	3.8	3.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	3.9	-1.4	-2.0	-1.5
Heart disease (mother)	2.2	2.7	7.8	2.8	-0.4	-0.5
Crohns Disease (2017)	2.1	4.6	10.4	-0.2	-3.2	-1.9
Whole body fat mass	2.1	8.9	12.2	1.7	3.5	3.4
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.0	-0.1	2.2	1.5
Medication: Aspirin	2.1	2.7	4.5	1.9	-2.1	-0.3
Irritable Bowel Disease (IBD)	2.0	4.8	9.9	-0.5	-3.1	-2.1
Chronic bronchitis/emphysema (father)	2.0	2.3	6.2	2.5	0.9	0.0
Leg fat mass (left)	2.0	7.9	12.0	1.5	3.5	3.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.8	2.2	0.9	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.5	7.2	2.7	-0.3	-0.2
Leg fat mass (right)	1.8	7.0	10.4	1.4	3.2	2.9
Ever had bowel cancer screening	1.8	2.1	5.3	0.6	2.3	0.7
Basal cell carcinoma (self-reported)	1.8	2.2	4.7	-2.2	-0.7	-1.2
Supplements: Zinc	1.7	1.8	3.6	1.9	1.3	0.3
Multivitamins +/- minerals	1.7	2.2	4.5	-1.3	2.1	0.7
Trunk fat mass	1.7	7.4	10.6	1.3	3.3	3.1
Prospective memory result	1.7	2.1	3.3	-0.7	-1.8	-1.6
High blood pressure (siblings)	1.7	2.5	4.2	-0.4	-1.8	-2.1
Alcohol intake frequency.	1.7	3.9	6.8	0.9	2.6	2.0
Pain experienced in last month	1.7	2.9	7.3	-2.7	-0.5	-1.0
Crohns Disease (2012)	1.5	2.4	7.1	0.1	-2.7	0.0
Systolic Blood Pressure	1.5	7.5	12.8	0.1	-3.6	-3.1
Vitamin and mineral supplements	1.5	2.0	4.2	1.2	-2.0	-0.7
Medication: Co-codamol	1.5	1.7	2.3	1.5	0.9	1.5
Had other major operations	1.5	1.8	4.6	-0.6	0.8	2.1
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.8	-0.1	1.9	1.9
Number of children fathered	1.5	1.7	4.8	2.2	-0.4	-0.3
Age at first live birth	1.5	2.6	4.5	-1.5	-1.1	-2.1
Suffer from ‘nerves’	1.5	2.3	4.5	2.1	1.4	0.5
Depression (Nagel 2018)	1.4	2.1	5.8	2.4	-0.2	-0.7
Age at First Birth	1.4	2.1	3.1	-0.8	-1.6	-1.8
Relative age of first facial hair	1.4	2.8	4.0	1.4	1.6	2.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.7	2.2	-0.4	0.8
Waist circumference	1.4	5.2	8.0	1.3	2.8	2.4
Mouth/teeth dental problems: Dentures	1.4	2.4	5.1	0.1	1.4	2.2
Commuting to job workplace: Walk	1.4	1.5	4.6	-2.1	-0.2	0.2
Ovarian Cancer	1.3	1.8	3.8	1.9	-0.7	-1.0
Heel T-Score	1.3	10.1	15.1	3.9	3.0	2.5
Relative age voice broke	1.3	1.9	4.0	1.1	0.8	2.0
Serious illness, injury or assault to yourself	1.3	1.6	3.2	1.8	0.6	1.0
Illnesses of father: Heart disease	1.3	1.7	4.7	-2.2	0.2	0.7
Irritability	1.3	2.2	6.2	-2.5	-0.7	-0.0
Fasting Glucose	1.2	1.4	1.9	1.4	1.2	1.0
Time employed in main current job	1.2	1.4	2.4	0.1	-1.6	-1.3
Length of working week for main job	1.2	1.3	2.0	-1.2	1.4	0.7
Birth weight of first child	1.2	2.3	3.6	1.7	1.9	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.0	-1.7	-0.8	-0.8
Long-standing illness, disability or infirmity	1.2	1.9	5.2	2.3	-0.0	0.6
Blood Platelet Count	1.1	12.7	23.1	-0.7	-4.8	-3.8
Average weekly spirits intake	1.1	1.4	4.1	2.0	-0.4	0.0
Severe depression (siblings)	1.1	1.2	2.2	-1.5	0.6	0.9
Father’s age at death	1.1	1.5	2.8	-1.0	-0.9	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.9	2.2	0.1	0.6
Hair/balding pattern: Pattern 3	1.1	1.7	2.1	1.4	1.1	1.3
Medication: Ventolin 100micrograms inhaler	1.1	1.5	2.8	-1.7	1.0	0.7
Medication: Blood pressure	1.1	2.0	3.1	0.3	-1.8	-1.6
Leg pain on walking	1.1	1.4	4.2	2.0	-0.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.4	1.8	-0.7	-0.2
Illnesses of father: High blood pressure	1.1	1.3	2.1	-1.4	0.7	1.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.1	1.8	-0.8	-0.4
Ulcerative Colitis (UC)	1.0	1.9	2.9	-0.9	-1.7	-1.4
LDL Cholesterol	1.0	1.6	3.4	-1.1	-0.4	1.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.8	-1.2	-1.3	-0.1
Pain all over the body in last month	1.0	1.1	2.1	1.5	0.5	0.9
Medication: Cholesterol lowering	1.0	1.6	2.7	-0.1	-1.6	-1.5
Friendships satisfaction	1.0	1.2	2.5	1.6	0.2	1.1
Ever smoked	1.0	1.8	3.5	0.3	-1.3	-1.9
Risk taking	1.0	1.4	2.4	0.8	-1.6	-1.0
HbA1C	0.9	1.0	1.9	-0.4	0.9	1.4
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	1.3	1.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.6	-0.3	1.1	-1.3
Qualifications: None of the above	0.9	1.9	4.3	1.0	0.7	2.1
Medication: Lansoprazole	0.9	1.0	1.7	-0.5	-1.1	-1.3
Tense / ‘highly strung’	0.9	1.4	2.8	1.2	-1.7	0.3
Osteoporosis (self-reported)	0.9	1.1	1.3	-1.0	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	6.0	2.4	0.1	-0.1
Bipolar Disorder (2011)	0.8	0.8	2.3	1.5	0.1	0.0
Qualifications: CSEs or equivalent	0.8	1.1	2.6	-1.6	-0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.6	0.1	-1.0	-1.6
Had menopause	0.8	1.0	2.6	1.6	-0.3	0.5
Allergy	0.8	1.9	4.5	2.1	1.1	0.4
Alcohol intake versus 10 years previously	0.8	1.2	2.7	0.4	1.7	0.9
Illnesses of mother	0.8	1.0	2.9	-1.7	0.4	-0.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.5	-0.2	-1.6	-1.5
Overall health rating	0.8	1.7	3.1	1.1	0.8	1.8
Qualifications: nursing, teaching	0.8	1.2	3.5	1.9	0.0	-0.2
Average weekly champagne plus white wine intake	0.8	1.1	1.8	-0.8	-1.3	-1.0
Guilty feelings	0.8	1.2	2.6	0.9	-1.6	-0.4
Myopia	0.8	1.2	1.9	-0.3	-1.3	-1.4
Reaction Time	0.7	1.2	2.5	-1.6	0.4	1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.2	1.8	1.3	0.3
Hearing difficulty/problems: Yes	0.7	1.1	2.0	1.4	1.2	0.1
Diabetes (mother)	0.7	0.9	2.3	-0.1	0.7	1.5
Trunk fat percentage	0.7	2.8	4.4	-0.2	2.0	2.1
High blood pressure (mother)	0.7	1.0	3.0	1.7	-0.0	0.2
Alcohol usually taken with meals	0.7	1.2	3.3	-1.8	0.2	0.3
Hearing difficulty/problems with background noise	0.7	1.2	1.5	1.2	0.9	1.1
Financial difficulties in last 2 years	0.7	0.9	1.3	-1.2	-0.7	-0.9
Heart attack	0.7	0.8	1.1	-0.8	-0.9	-1.0
Medication: Simvastatin	0.7	1.0	2.9	1.7	-0.4	0.1
Illnesses of siblings	0.7	0.9	2.0	-1.4	0.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.0	0.8	-0.8	-1.0
Medication: Paracetamol	0.7	1.2	3.1	-1.8	-0.3	0.7
Body fat percentage	0.7	2.6	4.1	-0.0	1.9	2.0
Emphysema/chronic bronchitis	0.7	0.8	2.5	-1.6	0.1	-0.0
Medication for pain relief, constipation, heartburn	0.7	1.2	3.4	-0.5	1.8	0.3
Angina (self-reported)	0.7	1.0	1.7	-0.4	-1.3	-1.0
Chest pain or discomfort	0.7	1.0	1.7	-0.7	-1.3	-0.8
Family relationship satisfaction	0.7	0.8	1.5	0.6	-0.7	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.8	-1.9	-0.5	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	1.1	0.8	0.5
Eye problems/disorders: Cataract	0.7	0.9	1.2	-1.1	-1.0	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	2.2	-1.5	-0.7	-0.0
Alzheimer’s Disease (including proxy)	0.6	0.8	2.2	-1.5	-0.4	-0.4
Mean Putamen Volume	0.6	0.7	2.1	-0.0	-1.5	0.3
Neuroticism (2016)	0.6	0.9	2.6	1.6	0.2	0.4
Pack years adult smoking proportion	0.6	0.9	1.4	-1.2	0.9	0.8
Supplements: Glucosamine	0.6	0.8	2.1	0.1	1.5	0.6
Depression (self-reported)	0.6	0.7	1.4	-0.1	1.2	0.8
Hair/balding pattern: Pattern 4	0.6	1.4	2.3	0.6	1.5	1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.6	-0.5	1.3	0.7
Headache pain in last month	0.6	1.0	1.9	-1.4	0.4	0.9
Gout (self-reported)	0.6	0.8	1.4	0.7	1.2	0.9
Qualifications: College or University degree	0.6	1.8	4.6	0.1	-0.9	-2.1
Medication: Omeprazole	0.6	0.7	1.1	1.0	-0.8	-0.6
Mean time to correctly identify matches	0.6	1.1	1.6	-1.3	1.0	0.8
Comparative height size at age 10	0.6	3.0	3.9	2.0	1.3	1.9
Medication for cholesterol	0.6	0.9	1.0	-0.9	1.0	-0.9
Financial situation satisfaction	0.6	0.7	1.6	-0.0	-0.7	-1.3
Medication: Blood pressure	0.6	1.2	2.0	1.2	-1.4	0.4
Medication: Bendroflumethiazide	0.6	0.9	2.2	0.7	-0.1	1.5
Medication: Paracetamol	0.6	0.9	1.5	-1.2	-0.5	1.0
Age started oral contraceptive pill	0.6	0.7	1.0	0.9	1.0	0.6
Unable to work because of sickness or disability	0.6	0.8	0.9	1.0	-0.7	-0.9
Pack years of smoking	0.6	0.9	1.2	-1.1	0.8	0.8
Primary Biliary Cirrhosis	0.5	0.7	1.5	-0.4	0.7	1.2
Triglycerides	0.5	0.9	1.9	-1.4	-0.8	0.3
Hand grip strength (left)	0.5	1.2	2.2	1.2	-0.1	-1.5
Number of treatments/medications taken	0.5	0.8	2.0	-0.7	-1.4	-0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	1.2	-0.5	-0.4
Systolic blood pressure, automated reading	0.5	1.4	4.2	2.1	0.0	-0.1
Angina	0.5	0.6	1.3	-0.4	-1.1	-0.6
Medication for hormone replacement therapy	0.5	0.6	1.1	0.5	-1.0	-0.5
Medication: Atenolol	0.5	0.7	0.8	0.9	0.7	0.9
Nervous feelings	0.5	1.0	1.5	-0.4	1.2	1.2
Happiness	0.5	0.7	1.6	1.3	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.6	1.6	-0.3	-0.6
Medication: Allopurinol	0.5	0.7	1.1	1.0	0.9	0.4
Illnesses of father: None of the above (group 1)	0.5	0.7	1.9	1.4	-0.1	0.3
Wears glasses or contact lenses	0.5	0.6	0.9	0.9	-0.9	0.2
Ever taken oral contraceptive pill	0.5	0.6	1.5	-1.2	0.4	0.4
Mother’s age at death	0.5	0.7	1.1	-0.9	0.4	1.0
High cholesterol (Self-reported)	0.5	0.9	2.7	0.1	-1.6	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.0	-1.4	1.4	0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.8	-0.7	-0.8	-0.9
Coronary Artery Disease (CAD)	0.4	0.4	1.1	-1.0	-0.5	0.0
HDL Cholesterol	0.4	0.7	1.2	0.4	-0.9	-1.1
Hypothyroidism (self reported)	0.4	0.9	2.0	-0.1	-1.4	-0.7
Hair Pigment	0.4	12.1	24.1	4.9	2.5	2.5
Medication: Metformin	0.4	0.6	0.7	0.8	0.7	0.8
Current tobacco smoking	0.4	0.6	1.8	-0.2	1.4	0.1
Maternal smoking around birth	0.4	0.6	1.0	0.2	-0.8	-1.0
Fed-up feelings	0.4	0.7	1.1	0.3	1.0	1.0
High blood pressure	0.4	1.0	1.5	1.2	-1.2	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.0	-1.4	-0.6	-0.0
Sitting height	0.4	2.6	5.7	1.2	0.8	2.4
Asthma	0.4	0.7	1.5	-0.8	-1.2	0.2
Breastfed as a baby	0.4	0.5	0.7	0.8	0.8	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	1.1	0.2	0.1
Neck or shoulder pain in last month	0.4	0.5	1.5	1.2	0.2	0.2
Hypertension (Self-reported)	0.4	1.0	1.6	1.2	-1.3	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-0.3	1.2	0.5
Asthma (self-reported)	0.4	0.8	1.3	-1.0	-1.1	0.3
Smoking status: Current	0.4	0.6	1.8	-0.3	1.3	0.2
Medication: Lisinopril	0.4	0.5	0.8	0.9	-0.8	-0.0
Leg fat percentage (left)	0.4	1.5	2.3	-0.4	1.5	1.4
Number of operations (self-reported)	0.4	0.7	1.5	0.2	-1.2	-0.7
Bipolar Disorder (2018)	0.3	0.4	1.1	-0.5	-1.0	0.0
Blood Eosinophil Count	0.3	2.6	4.1	-0.4	-1.9	-2.0
Cardiovascular Disease	0.3	1.1	3.3	0.2	-1.8	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.7	-0.8	0.6	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.8	0.7	-0.1
Average weekly fortified wine intake	0.3	0.4	0.6	0.5	0.8	0.5
Taking other prescription medications	0.3	0.5	0.7	-0.1	-0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	0.9	0.9	0.7	1.0
Worrier / anxious feelings	0.3	0.5	0.8	-0.9	-0.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	-0.7	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.4	1.6	-0.1	-0.1
Exposure to tobacco smoke at home	0.3	0.3	0.4	-0.6	-0.4	-0.7
Peak expiratory flow (PEF)	0.3	0.8	1.8	0.7	-0.2	-1.3
Glaucoma (self-reported)	0.3	0.4	1.1	0.2	-1.0	-0.3
Medication: Amlodipine	0.3	0.4	0.9	1.0	-0.1	0.6
Leg fat percentage (right)	0.3	1.1	1.7	-0.5	1.3	1.2
Number of full brothers	0.3	0.4	0.6	-0.2	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	0.7	-0.6	-0.3
Supplements: Vitamin C	0.3	0.4	0.9	-0.5	0.9	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	0.4	-0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.7	-0.8	-0.1
Mineral and other dietary supplements	0.3	0.4	1.2	0.2	-1.1	-0.1
Miserableness	0.3	0.6	0.9	0.0	-1.0	-0.9
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	1.0	0.4	-0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	0.1	-0.9	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.8	-0.7	-0.2
Diastolic blood pressure, automated reading	0.3	1.1	2.9	1.7	0.6	-0.0
Supplements: Calcium	0.3	0.4	0.7	-0.4	-0.4	-0.9
Heart disease (siblings)	0.3	0.4	1.0	1.0	0.2	0.5
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	0.9	0.5	0.3
Neuroticism (Nagel 2018)	0.2	0.4	0.5	0.7	0.5	0.6
Worry (Nagel 2018)	0.2	0.4	1.0	1.0	0.1	0.3
Ulcerative Colitis	0.2	0.3	0.7	-0.4	-0.8	0.0
Respiratory disease	0.2	0.4	0.8	-0.7	0.2	0.9
Lung FEV1/FVC ratio	0.2	1.1	1.3	1.1	0.9	-1.1
Townsend deprivation index at recruitment	0.2	0.2	0.5	0.2	0.7	0.3
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.2	-0.7	-0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.7	-0.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.0	0.5	0.8
Medication: Ramipril	0.2	0.3	0.6	0.5	-0.8	-0.4
Fluid intelligence score	0.2	0.3	1.0	1.0	0.2	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	1.1	-0.4	-0.5
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.2	-0.6	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.3	-0.4	0.5	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.8	0.5	0.2
Blood clot in the leg (DVT)	0.2	0.2	0.3	0.5	-0.4	-0.6
Exposure to tobacco smoke outside home	0.2	0.2	0.3	0.2	0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.4	0.7	0.5
Pulse wave peak to peak time	0.2	0.3	0.4	0.4	0.4	0.7
Health satisfaction	0.2	0.2	0.5	0.1	-0.7	-0.2
Had major operations	0.2	0.2	0.4	0.6	-0.3	-0.2
Mood swings	0.2	0.3	0.4	0.2	0.7	0.6
Loneliness, isolation	0.2	0.3	0.5	-0.6	-0.3	-0.7
Back pain experienced in last month	0.2	0.3	0.8	-0.0	-0.9	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.6	-0.3	-0.5
Hearing aid user	0.2	0.2	0.4	0.7	-0.1	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.8	-0.2	-0.1
Average weekly beer plus cider intake	0.2	0.3	0.8	0.2	-0.9	-0.0
Commuting to job workplace: Cycle	0.2	0.2	0.4	-0.5	-0.2	-0.6
Cholesterol lowering medication	0.2	0.2	0.4	0.7	-0.3	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.6	-0.1	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.1	0.2	-0.3	-0.5	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	0.6	0.3	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.5	0.0	0.0
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.1	-0.5	-0.1
Major Depression (MDD)	0.1	0.1	0.3	0.6	0.4	0.0
Lupus	0.1	0.2	0.6	0.2	0.2	0.8
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	0.5	-0.1
Schizophrenia (2014)	0.1	0.3	0.4	-0.7	-0.2	-0.5
Height	0.1	1.3	3.2	1.8	-0.5	-0.5
Smoking Status	0.1	0.3	0.7	0.1	0.8	-0.4
Allergy or Eczema	0.1	0.2	0.5	-0.1	0.2	0.7
Lung FVC	0.1	0.3	0.8	0.9	0.4	0.4
Neuroticism	0.1	0.2	0.3	0.3	-0.5	0.4
Chronotype (morning person)	0.1	0.2	0.6	0.2	0.8	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	0.2	0.3
Hand grip strength (right)	0.1	0.4	0.8	0.9	-0.1	-0.7
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	-0.2	0.4
Number of incorrect matches in round	0.1	0.1	0.2	-0.5	0.3	0.1
Forced vital capacity (FVC)	0.1	0.4	0.8	0.9	-0.4	-0.5
Noisy workplace	0.1	0.1	0.2	-0.1	-0.4	0.4
Lung cancer (father)	0.1	0.1	0.1	-0.2	-0.3	-0.3
Pulse wave reflection index	0.1	0.1	0.3	0.0	0.5	-0.3
Loud music exposure frequency	0.1	0.1	0.3	-0.0	-0.2	0.6
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	0.9	-0.2	-0.3
Worry too long after embarrassment	0.1	0.2	0.5	-0.5	0.7	0.1
Shortness of breath walking on level ground	0.1	0.2	0.5	0.7	0.0	0.0
Migraine (self-reported)	0.1	0.1	0.2	-0.1	-0.3	-0.4
Medication: Ibuprofen	0.1	0.1	0.3	0.0	-0.2	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.1	-0.2	0.6
Pulse rate, automated reading	0.1	0.3	0.7	-0.8	-0.2	0.5
Number of full sisters	0.1	0.1	0.2	-0.5	0.3	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.6	0.0	0.4
Smoking status: Previous	0.1	0.2	0.3	0.3	-0.5	-0.5
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.6	0.3	0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.2	-0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.7	-0.1	-0.2
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	-0.0	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	0.5	0.2	0.3
Schizophrenia (2018)	0.0	0.0	0.0	-0.0	0.2	-0.0
Blood Red Count	0.0	0.4	1.0	-0.2	1.0	0.3
Tanning	0.0	0.5	1.0	-0.1	-1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.3	0.0	0.2
Past tobacco smoking	0.0	0.0	0.0	-0.2	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.0	0.3	0.3
Diabetes (self-reported)	0.0	0.0	0.1	0.2	0.3	0.1
Neuroticism score	0.0	0.1	0.2	0.2	-0.1	0.4
Number of live births	0.0	0.1	0.1	-0.1	-0.4	0.1
Pulse rate	0.0	0.0	0.0	-0.2	-0.2	0.1
Standing height	0.0	0.3	0.3	0.4	0.6	0.5
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	0.0	-0.4	-0.1

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Trait associations