Best TWAS P=1.39e-13 · Best GWAS P=1.71e-11 conditioned to 0.918
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | RP11-834C11.4 | 0.09 | 0.03 | bslmm | 430 | 0.05 | 2.5e-08 | 6.0 | 5.3 | 1.5e-07 | 0.44 | 0.47 | 0.45 | FALSE |
2 | YFS | Blood | CBX5 | 0.02 | 0.01 | lasso | 3 | 0.02 | 2.0e-07 | 5.9 | 5.8 | 5.3e-09 | 0.09 | 0.51 | 0.47 | TRUE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC400043 | 0.02 | 0.01 | blup | 31 | 0.01 | 1.8e-03 | 6.0 | 5.4 | 7.7e-08 | 0.22 | 0.00 | 0.93 | FALSE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HOXC5 | 0.02 | 0.00 | blup | 51 | 0.01 | 2.4e-02 | 6.4 | 7.4 | 1.4e-13 | 0.67 | 0.01 | 0.58 | TRUE |
5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LOC400043 | 0.05 | 0.02 | blup | 31 | 0.03 | 4.6e-04 | 6.0 | 5.7 | 1.3e-08 | 0.27 | 0.00 | 0.96 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SMUG1 | 0.06 | 0.02 | blup | 42 | 0.05 | 1.9e-06 | 6.0 | -5.2 | 1.6e-07 | -0.23 | 0.00 | 1.00 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC6 | 0.03 | 0.02 | blup | 50 | 0.03 | 3.9e-04 | 6.6 | -7.3 | 3.3e-13 | -0.82 | 0.01 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HOXC8 | 0.03 | 0.05 | enet | 5 | 0.04 | 2.4e-05 | 6.6 | -7.1 | 1.0e-12 | -0.85 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | LOC400043 | 0.19 | 0.02 | blup | 31 | 0.04 | 8.6e-03 | -1.5 | 5.7 | 1.2e-08 | 0.21 | 0.01 | 0.26 | TRUE |
10 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SMUG1 | 0.09 | 0.06 | blup | 42 | 0.07 | 4.9e-04 | -2.1 | -5.2 | 1.7e-07 | -0.24 | 0.03 | 0.78 | FALSE |
11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LOC400043 | 0.26 | 0.07 | blup | 31 | 0.13 | 4.9e-04 | 6.0 | 6.1 | 9.6e-10 | 0.29 | 0.00 | 0.78 | FALSE |
12 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FLJ12825 | 0.15 | 0.02 | lasso | 5 | 0.06 | 8.9e-03 | 6.7 | 6.3 | 2.4e-10 | 0.66 | 0.01 | 0.62 | FALSE |