[Hub]/) : Traits : Impedance of arm (right) : ← →

chr12:47,671,905-52,022,819

Best TWAS P=1.8e-18 · Best GWAS P=1.25e-20 conditioned to 4.55e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
71	GTEx	Skin Sun Exposed Lower leg	RP1-228P16.1	0.29	0.24	enet	28	0.26	2.0e-21	8.0	-8.8	1.8e-18	-0.76	0.35	0.65	TRUE
1	CommonMind	Brain Pre-frontal Cortex	DIP2B	0.11	0.10	enet	16	0.13	2.6e-15	6.8	7.1	1.3e-12	0.01	0.01	0.99	TRUE
33	GTEx	Breast Mammary Tissue (Female)	CERS5	0.09	0.03	lasso	3	0.05	1.8e-02	-4.5	6.8	9.2e-12	-0.01	0.06	0.08	TRUE
90	METSIM	Adipose	LMBR1L	0.05	0.03	blup	303	0.03	5.2e-06	-5.0	5.6	1.7e-08	-0.06	0.01	0.98	TRUE
23	GTEx	Brain Cortex	ASB8	0.28	0.19	lasso	7	0.20	3.3e-06	8.1	8.6	5.2e-18	0.74	0.39	0.45	FALSE
4	GTEx	Adipose Subcutaneous	RP1-228P16.1	0.20	0.20	lasso	8	0.22	4.7e-18	7.8	-8.6	7.9e-18	-0.83	0.26	0.74	FALSE
24	GTEx	Brain Frontal Cortex BA9	TMEM106C	0.35	0.01	lasso	8	-0.01	6.8e-01	-3.8	8.6	8.2e-18	0.72	0.03	0.74	FALSE
79	GTEx	Testis	ASB8	0.17	0.15	lasso	3	0.13	1.8e-06	8.9	8.5	2.2e-17	0.84	0.04	0.95	FALSE
35	GTEx	Cells EBV-transformed lymphocytes	RP1-228P16.1	0.33	0.20	lasso	9	0.29	6.3e-10	7.4	-8.5	2.3e-17	-0.88	0.01	0.99	FALSE
103	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB8	0.04	0.03	blup	69	0.03	4.1e-04	7.2	8.3	1.1e-16	0.66	0.02	0.92	FALSE
25	GTEx	Brain Frontal Cortex BA9	ASB8	0.24	0.16	lasso	6	0.07	7.1e-03	8.1	8.2	2.2e-16	0.69	0.25	0.34	FALSE
73	GTEx	Spleen	RP1-228P16.1	0.35	0.23	lasso	7	0.19	1.6e-05	7.8	-8.1	4.7e-16	-0.76	0.03	0.96	FALSE
61	GTEx	Nerve Tibial	ASB8	0.09	0.08	lasso	4	0.07	1.8e-05	8.1	8.1	7.2e-16	0.73	0.25	0.70	FALSE
58	GTEx	Muscle Skeletal	RP1-228P16.1	0.12	0.10	lasso	9	0.09	7.4e-09	8.0	-8.0	9.4e-16	-0.75	0.11	0.89	FALSE
18	GTEx	Brain Caudate basal ganglia	RP1-228P16.1	0.14	0.12	lasso	4	0.11	5.7e-04	8.0	-8.0	1.5e-15	-0.72	0.08	0.72	FALSE
45	GTEx	Esophagus Mucosa	ZNF641	0.08	0.00	enet	23	0.01	1.0e-01	6.7	8.0	1.7e-15	0.56	0.10	0.80	FALSE
19	GTEx	Brain Cerebellar Hemisphere	RP1-228P16.1	0.30	0.21	lasso	7	0.28	6.5e-08	7.8	-7.9	2.0e-15	-0.73	0.50	0.48	FALSE
6	GTEx	Adipose Visceral Omentum	ASB8	0.10	0.00	lasso	6	0.00	6.8e-01	9.3	7.9	2.2e-15	0.86	0.02	0.95	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	ASB8	0.20	0.04	lasso	4	0.02	7.7e-02	7.4	7.9	3.5e-15	0.65	0.11	0.30	FALSE
9	GTEx	Adrenal Gland	RP1-228P16.1	0.19	0.20	lasso	5	0.15	4.4e-06	8.0	-7.9	4.0e-15	-0.72	0.15	0.84	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	ASB8	0.04	0.03	lasso	3	0.03	2.3e-04	8.1	7.9	4.1e-15	0.68	0.01	0.98	FALSE
12	GTEx	Artery Coronary	RP1-228P16.1	0.12	0.06	lasso	2	0.03	2.6e-02	8.1	-7.8	5.4e-15	-0.74	0.17	0.68	FALSE
75	GTEx	Stomach	RP1-228P16.1	0.12	0.03	lasso	7	0.05	1.9e-03	8.0	-7.8	6.5e-15	-0.76	0.03	0.96	FALSE
65	GTEx	Pituitary	RP1-228P16.1	0.20	0.15	lasso	6	0.16	1.1e-04	8.0	-7.7	1.1e-14	-0.73	0.20	0.54	FALSE
84	GTEx	Uterus	RP1-228P16.1	0.32	0.09	lasso	15	0.01	2.1e-01	7.4	-7.7	1.3e-14	-0.65	0.09	0.36	FALSE
5	GTEx	Adipose Visceral Omentum	ZNF641	0.14	0.09	lasso	4	0.08	3.7e-05	6.7	7.7	1.9e-14	0.62	0.33	0.52	FALSE
43	GTEx	Esophagus Gastroesophageal Junction	RP1-228P16.1	0.23	0.25	enet	17	0.23	6.8e-09	8.0	-7.6	2.2e-14	-0.73	0.62	0.37	FALSE
46	GTEx	Esophagus Mucosa	RP1-228P16.1	0.19	0.18	lasso	4	0.21	8.7e-14	8.0	-7.6	2.2e-14	-0.68	0.98	0.02	FALSE
41	GTEx	Colon Transverse	RP1-228P16.1	0.24	0.18	lasso	5	0.18	4.9e-09	8.0	-7.6	3.5e-14	-0.67	0.70	0.30	FALSE
55	GTEx	Lung	RP1-228P16.1	0.18	0.20	enet	21	0.21	7.0e-16	7.4	-7.5	4.8e-14	-0.71	0.97	0.03	FALSE
89	METSIM	Adipose	ASB8	0.03	0.00	bslmm	526	0.01	3.8e-02	7.8	7.5	5.2e-14	0.70	0.09	0.54	FALSE
8	GTEx	Adrenal Gland	ZNF641	0.31	0.18	lasso	3	0.21	4.2e-08	5.8	7.5	9.2e-14	0.65	0.17	0.78	FALSE
62	GTEx	Nerve Tibial	RP1-228P16.1	0.18	0.21	enet	22	0.21	4.9e-15	7.8	-7.4	1.0e-13	-0.72	0.26	0.74	FALSE
106	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB8	0.08	0.01	blup	69	0.04	3.9e-05	8.1	7.3	2.2e-13	0.56	0.02	0.96	FALSE
14	GTEx	Artery Tibial	RP1-228P16.1	0.16	0.14	lasso	14	0.15	5.9e-12	8.1	-7.3	3.4e-13	-0.71	0.91	0.09	FALSE
51	GTEx	Heart Left Ventricle	RP1-228P16.1	0.26	0.14	lasso	16	0.17	1.9e-09	8.0	-7.3	3.6e-13	-0.83	0.02	0.98	FALSE
52	GTEx	Liver	RP1-228P16.1	0.19	0.08	lasso	7	0.06	7.1e-03	6.4	-7.2	4.7e-13	-0.77	0.05	0.80	FALSE
67	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	6.7	7.2	5.3e-13	0.72	0.31	0.68	FALSE
7	GTEx	Adipose Visceral Omentum	RP1-228P16.1	0.18	0.13	lasso	4	0.15	2.3e-08	8.0	-7.2	5.8e-13	-0.65	0.34	0.66	FALSE
34	GTEx	Breast Mammary Tissue (Female)	RP1-228P16.1	0.07	-0.01	enet	2	-0.01	5.9e-01	7.8	-7.2	7.9e-13	-0.66	0.05	0.32	FALSE
13	GTEx	Artery Tibial	ZNF641	0.19	0.16	lasso	5	0.16	1.6e-12	6.7	7.1	9.0e-13	0.71	0.97	0.03	FALSE
29	GTEx	Brain Putamen basal ganglia	RP1-228P16.1	0.21	0.24	lasso	6	0.24	2.1e-06	6.7	-7.1	1.1e-12	-0.65	0.16	0.70	FALSE
22	GTEx	Brain Cortex	TMEM106C	0.21	0.04	enet	20	0.10	1.0e-03	7.8	7.1	1.3e-12	0.64	0.04	0.79	FALSE
82	GTEx	Thyroid	ZNF641	0.16	0.06	enet	26	0.13	2.0e-10	-4.1	7.1	1.3e-12	0.59	0.69	0.31	FALSE
54	GTEx	Lung	ZNF641	0.08	0.10	lasso	2	0.08	8.0e-07	7.0	6.9	5.2e-12	0.69	0.97	0.03	FALSE
93	YFS	Blood	ATF1	0.05	0.07	lasso	9	0.07	2.0e-21	6.5	6.9	5.6e-12	0.04	0.04	0.96	FALSE
70	GTEx	Skin Sun Exposed Lower leg	ZNF641	0.21	0.03	enet	17	0.08	6.5e-07	-3.2	6.9	6.5e-12	0.57	0.50	0.48	FALSE
87	GTEx	Whole Blood	RP1-228P16.1	0.10	0.06	enet	20	0.09	4.7e-09	9.0	-6.9	6.7e-12	-0.78	0.01	0.99	FALSE
91	METSIM	Adipose	ZNF641	0.07	0.03	blup	487	0.06	7.0e-09	-3.7	6.8	9.3e-12	0.58	0.98	0.02	FALSE
64	GTEx	Pancreas	RP1-228P16.1	0.12	0.05	enet	10	0.05	5.0e-03	5.0	-6.8	9.6e-12	-0.76	0.08	0.80	FALSE
17	GTEx	Brain Caudate basal ganglia	ASB8	0.18	0.02	lasso	4	0.04	2.1e-02	8.1	6.8	1.3e-11	0.67	0.09	0.31	FALSE
3	GTEx	Adipose Subcutaneous	ZNF641	0.10	0.10	lasso	4	0.10	2.8e-08	6.6	6.7	2.2e-11	0.69	0.99	0.01	FALSE
48	GTEx	Esophagus Muscularis	RP1-228P16.1	0.20	0.17	enet	14	0.17	1.2e-10	8.0	-6.7	2.2e-11	-0.67	0.23	0.77	FALSE
78	GTEx	Testis	CERS5	0.12	0.06	lasso	6	0.07	4.0e-04	6.5	6.7	2.8e-11	0.04	0.06	0.69	FALSE
60	GTEx	Nerve Tibial	ZNF641	0.14	0.11	lasso	4	0.08	2.3e-06	6.7	6.6	3.4e-11	0.69	0.89	0.10	FALSE
100	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMARCD1	0.02	0.03	lasso	1	0.03	3.7e-06	6.5	-6.5	5.9e-11	-0.03	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIMA1	0.08	0.10	blup	59	0.10	1.8e-11	6.3	-6.5	6.3e-11	-0.05	0.02	0.98	FALSE
59	GTEx	Nerve Tibial	CERS5	0.31	0.28	enet	20	0.36	2.2e-26	6.5	6.5	6.7e-11	0.00	0.06	0.94	FALSE
66	GTEx	Prostate	CERS5	0.19	0.08	lasso	4	0.02	1.2e-01	6.3	6.5	6.7e-11	0.02	0.06	0.36	FALSE
80	GTEx	Testis	RP1-228P16.1	0.38	0.28	lasso	6	0.31	4.0e-14	7.8	-6.5	9.3e-11	-0.69	0.49	0.51	FALSE
88	GTEx	Whole Blood	RP4-605O3.4	0.04	0.04	lasso	4	0.01	1.5e-02	6.3	6.5	1.1e-10	0.02	0.05	0.82	FALSE
50	GTEx	Heart Atrial Appendage	RP1-228P16.1	0.16	0.02	enet	14	0.02	3.2e-02	4.1	-6.4	1.3e-10	-0.64	0.18	0.44	FALSE
69	GTEx	Skin Not Sun Exposed Suprapubic	RP1-228P16.1	0.17	0.10	enet	23	0.16	4.1e-09	7.2	-6.4	1.3e-10	-0.71	0.04	0.96	FALSE
112	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM106C	0.27	0.10	lasso	3	0.09	1.7e-04	-4.5	6.4	1.4e-10	0.39	0.07	0.60	FALSE
95	YFS	Blood	LIMA1	0.04	0.06	enet	31	0.06	3.5e-19	-4.7	-6.4	1.5e-10	0.00	1.00	0.00	FALSE
107	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATF1	0.03	0.04	lasso	1	0.04	6.3e-05	6.4	-6.4	1.7e-10	-0.04	0.01	0.98	FALSE
38	GTEx	Cells Transformed fibroblasts	SMARCD1	0.08	0.07	enet	5	0.07	9.3e-06	6.0	-6.4	1.9e-10	-0.02	0.07	0.93	FALSE
28	GTEx	Brain Putamen basal ganglia	CERS5	0.29	0.12	enet	36	0.21	1.2e-05	6.5	6.3	3.0e-10	0.00	0.15	0.71	FALSE
83	GTEx	Thyroid	RP1-228P16.1	0.30	0.30	enet	41	0.33	1.4e-25	8.0	-6.3	3.0e-10	-0.65	0.99	0.01	FALSE
49	GTEx	Heart Atrial Appendage	CERS5	0.14	0.03	lasso	6	0.02	4.2e-02	6.5	6.3	3.5e-10	-0.02	0.16	0.72	FALSE
39	GTEx	Cells Transformed fibroblasts	RP1-228P16.1	0.09	0.03	lasso	3	0.04	8.1e-04	7.4	-6.2	4.3e-10	-0.63	0.26	0.64	FALSE
15	GTEx	Artery Tibial	RP4-605O3.4	0.04	0.01	lasso	4	0.00	3.2e-01	6.2	6.2	4.8e-10	0.02	0.06	0.77	FALSE
76	GTEx	Testis	SMARCD1	0.22	0.10	enet	22	0.10	2.6e-05	6.3	-6.2	6.6e-10	-0.03	0.04	0.94	FALSE
10	GTEx	Artery Aorta	ZNF641	0.22	0.13	enet	30	0.18	4.9e-10	7.2	6.2	7.4e-10	0.63	0.96	0.04	FALSE
109	The Cancer Genome Atlas	Lung Adenocarcinoma	DIP2B	0.09	0.02	enet	9	0.05	1.3e-06	-5.4	-6.1	9.2e-10	-0.01	0.19	0.64	FALSE
31	GTEx	Breast Mammary Tissue	RP1-228P16.1	0.22	0.14	lasso	8	0.20	1.3e-10	4.5	-6.1	1.1e-09	-0.61	0.80	0.19	FALSE
11	GTEx	Artery Aorta	RP1-228P16.1	0.16	0.05	enet	28	0.11	1.7e-06	7.2	-6.1	1.2e-09	-0.59	0.74	0.24	FALSE
16	GTEx	Brain Caudate basal ganglia	LIMA1	0.18	0.12	lasso	5	0.07	3.9e-03	6.5	6.1	1.2e-09	0.01	0.07	0.58	FALSE
72	GTEx	Spleen	ZNF641	0.42	0.21	lasso	11	0.28	5.4e-08	-4.1	6.1	1.2e-09	0.57	0.18	0.74	FALSE
94	YFS	Blood	DIP2B	0.36	0.27	bslmm	385	0.28	2.8e-90	-5.3	6.0	2.6e-09	-0.02	0.99	0.01	FALSE
105	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf62	0.08	0.01	blup	47	0.06	3.2e-04	-4.4	-6.0	2.6e-09	0.02	0.10	0.83	FALSE
116	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF641	0.11	0.12	enet	10	0.12	5.2e-12	5.8	5.9	2.9e-09	0.62	0.08	0.92	FALSE
99	The Cancer Genome Atlas	Breast Invasive Carcinoma	SENP1	0.01	0.00	blup	87	0.01	1.8e-02	-4.2	-5.9	3.5e-09	-0.63	0.04	0.36	FALSE
111	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SENP1	0.09	0.02	enet	10	0.06	1.1e-04	-4.2	-5.9	3.6e-09	-0.65	0.04	0.74	FALSE
36	GTEx	Cells Transformed fibroblasts	LIMA1	0.17	0.01	lasso	6	0.02	8.8e-03	-3.0	-5.8	8.0e-09	-0.01	0.15	0.05	FALSE
81	GTEx	Thyroid	CERS5	0.09	0.04	lasso	9	0.04	3.7e-04	-4.5	5.8	8.4e-09	-0.03	0.33	0.65	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM106C	0.07	0.01	enet	11	0.05	2.4e-05	-3.8	5.8	8.4e-09	0.32	0.08	0.10	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM106C	0.13	0.06	enet	21	0.11	3.2e-13	7.3	5.7	1.0e-08	0.58	0.86	0.14	FALSE
102	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf62	0.02	0.01	blup	47	0.01	1.7e-02	-3.9	-5.7	1.0e-08	0.02	0.03	0.43	FALSE
32	GTEx	Breast Mammary Tissue (Male)	RP1-228P16.1	0.13	0.00	lasso	6	0.01	1.8e-01	4.1	-5.6	1.9e-08	-0.59	0.06	0.38	FALSE
68	GTEx	Skin Not Sun Exposed Suprapubic	COX14	0.17	0.04	lasso	5	0.03	5.4e-03	-4.4	-5.6	2.0e-08	0.04	0.26	0.10	FALSE
57	GTEx	Muscle Skeletal	COX14	0.05	0.03	lasso	11	0.02	5.7e-03	-4.5	-5.6	2.1e-08	0.04	0.43	0.51	FALSE
92	NTR	Blood	ATF1	0.06	0.07	enet	35	0.07	4.0e-21	6.5	5.6	2.1e-08	0.07	0.04	0.96	FALSE
37	GTEx	Cells Transformed fibroblasts	DIP2B	0.16	0.08	lasso	3	0.08	6.2e-07	-5.3	-5.6	2.3e-08	0.03	0.93	0.02	FALSE
47	GTEx	Esophagus Muscularis	CERS5	0.15	0.07	enet	18	0.09	2.7e-06	-4.8	5.5	4.1e-08	-0.03	0.56	0.43	FALSE
101	The Cancer Genome Atlas	Colon Adenocarcinoma	DIP2B	0.13	0.14	lasso	2	0.12	1.3e-07	-5.4	-5.5	4.8e-08	0.01	0.88	0.07	FALSE
98	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf62	0.01	0.00	blup	47	0.00	4.6e-02	-4.4	-5.5	4.9e-08	0.03	0.03	0.35	FALSE
113	The Cancer Genome Atlas	Prostate Adenocarcinoma	COL2A1	0.03	0.01	blup	91	0.03	2.7e-04	4.2	-5.4	6.0e-08	-0.67	0.05	0.53	FALSE
108	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM186A	0.03	0.03	lasso	6	0.02	2.2e-03	-5.4	5.4	6.5e-08	-0.01	0.07	0.13	FALSE
30	GTEx	Breast Mammary Tissue	ATF1	0.07	0.07	lasso	5	0.04	2.9e-03	-4.5	-5.4	7.0e-08	0.01	0.16	0.13	FALSE
40	GTEx	Colon Sigmoid	RP1-228P16.1	0.16	0.18	lasso	6	0.13	2.6e-05	4.5	-5.4	7.1e-08	-0.53	0.43	0.21	FALSE
77	GTEx	Testis	SENP1	0.20	0.13	lasso	5	0.10	2.7e-05	4.5	5.4	7.8e-08	0.51	0.50	0.38	FALSE
20	GTEx	Brain Cerebellar Hemisphere	RP4-605O3.4	0.18	0.12	enet	14	0.10	1.5e-03	6.5	5.3	9.0e-08	0.01	0.04	0.71	FALSE
44	GTEx	Esophagus Mucosa	LMBR1L	0.07	0.03	lasso	5	0.04	1.8e-03	-4.8	5.3	9.7e-08	-0.03	0.03	0.89	FALSE
86	GTEx	Whole Blood	DIP2B	0.12	0.08	lasso	4	0.08	5.7e-08	-5.3	-5.3	1.0e-07	0.02	0.96	0.02	FALSE
85	GTEx	Vagina	ZNF641	0.23	-0.01	enet	39	0.01	2.2e-01	-3.7	5.3	1.1e-07	0.45	0.04	0.62	FALSE
96	YFS	Blood	METTL7A	0.09	0.08	lasso	12	0.08	1.8e-25	-5.6	5.3	1.1e-07	-0.04	0.93	0.07	FALSE
110	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ACCN2	0.04	0.03	enet	7	0.02	9.8e-03	-4.4	5.3	1.2e-07	-0.01	0.02	0.48	FALSE
74	GTEx	Stomach	DIP2B	0.09	0.09	lasso	5	0.07	4.1e-04	-5.3	-5.3	1.5e-07	0.03	0.18	0.10	FALSE
21	GTEx	Brain Cerebellum	RP1-228P16.1	0.16	0.05	enet	16	0.10	6.0e-04	4.9	-5.2	1.8e-07	-0.57	0.27	0.26	FALSE
53	GTEx	Lung	LMBR1L	0.05	0.02	lasso	2	0.00	1.5e-01	-4.8	5.2	1.8e-07	-0.02	0.03	0.81	FALSE
56	GTEx	Muscle Skeletal	ATF1	0.09	0.06	lasso	5	0.07	5.0e-07	-4.4	-5.2	2.2e-07	0.01	0.75	0.24	FALSE
26	GTEx	Brain Hippocampus	CERS5	0.31	0.21	lasso	4	0.22	5.9e-06	-4.5	5.2	2.3e-07	-0.04	0.32	0.10	FALSE
97	YFS	Blood	ZNF641	0.43	0.53	bslmm	482	0.58	3.1e-241	-4.1	5.1	2.7e-07	0.39	1.00	0.00	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	ATF1	0.15	0.15	lasso	4	0.14	7.8e-06	-4.8	-5.1	2.8e-07	0.02	0.61	0.13	FALSE
63	GTEx	Nerve Tibial	RP4-605O3.4	0.11	0.00	lasso	3	0.00	1.7e-01	6.2	5.1	3.1e-07	0.03	0.07	0.60	FALSE