Best TWAS P=8.89e-14 · Best GWAS P=2.09e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BTBD7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.8e-04 | 5.6 | -5.8 | 7.4e-09 | -0.02 | 0.60 | 0.36 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | BTBD7 | 0.16 | 0.01 | lasso | 8 | 0.04 | 3.6e-04 | 6.1 | -5.8 | 5.6e-09 | -0.02 | 0.09 | 0.90 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | 7.0 | -7.3 | 3.9e-13 | -0.95 | 0.01 | 0.99 | TRUE |
4 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | -7.3 | 7.5 | 8.9e-14 | 0.02 | 0.00 | 0.99 | TRUE |
5 | GTEx | Colon Sigmoid | RPS6KA5 | 0.16 | 0.09 | lasso | 5 | 0.08 | 7.1e-04 | 6.6 | 6.7 | 1.8e-11 | 0.79 | 0.07 | 0.82 | FALSE |
6 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | -5.5 | 6.2 | 4.9e-10 | -0.03 | 0.05 | 0.80 | FALSE |
7 | GTEx | Heart Left Ventricle | RPS6KA5 | 0.13 | 0.00 | enet | 38 | 0.02 | 2.2e-02 | 3.6 | 5.4 | 5.7e-08 | 0.55 | 0.03 | 0.75 | FALSE |
8 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | 5.7 | -6.4 | 1.9e-10 | -0.79 | 0.10 | 0.26 | FALSE |
9 | METSIM | Adipose | C14orf159 | 0.04 | 0.00 | blup | 464 | 0.01 | 4.0e-03 | 4.3 | -5.3 | 1.1e-07 | -0.70 | 0.08 | 0.73 | FALSE |
10 | NTR | Blood | BTBD7 | 0.02 | 0.03 | lasso | 2 | 0.02 | 6.1e-08 | 5.6 | -5.6 | 2.4e-08 | -0.02 | 0.76 | 0.24 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | 3.8 | 6.2 | 6.8e-10 | -0.04 | 0.03 | 0.04 | TRUE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BTBD7 | 0.02 | 0.01 | blup | 72 | 0.02 | 6.8e-03 | 6.3 | -6.2 | 4.2e-10 | 0.01 | 0.01 | 0.90 | TRUE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BTBD7 | 0.11 | 0.03 | blup | 72 | 0.02 | 8.0e-02 | 6.1 | -6.1 | 1.2e-09 | 0.01 | 0.02 | 0.72 | FALSE |