Best TWAS P=5.09e-11 · Best GWAS P=5.98e-13 conditioned to 0.00492
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | WDR20 | 0.14 | 0.18 | lasso | 3 | 0.18 | 9.0e-21 | -6.3 | -6.1 | 1.1e-09 | 0.90 | 0.43 | 0.57 | FALSE |
2 | GTEx | Adipose Subcutaneous | MARK3 | 0.12 | 0.05 | lasso | 3 | 0.06 | 2.5e-05 | 4.8 | 5.2 | 1.7e-07 | 0.05 | 0.02 | 0.97 | FALSE |
3 | GTEx | Brain Cerebellum | ZNF839 | 0.22 | 0.04 | lasso | 4 | 0.07 | 5.2e-03 | -5.1 | -6.3 | 3.4e-10 | 0.54 | 0.07 | 0.43 | TRUE |
4 | GTEx | Esophagus Muscularis | MOK | 0.13 | 0.02 | lasso | 5 | 0.01 | 4.1e-02 | -6.5 | 5.3 | 1.3e-07 | -0.76 | 0.08 | 0.49 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | MARK3 | 0.16 | 0.10 | lasso | 3 | 0.10 | 6.7e-06 | 4.8 | 5.1 | 2.8e-07 | 0.02 | 0.02 | 0.98 | FALSE |
6 | GTEx | Thyroid | ZNF839 | 0.10 | 0.08 | enet | 9 | 0.13 | 5.6e-10 | -6.2 | -6.5 | 8.4e-11 | 0.64 | 0.48 | 0.52 | FALSE |
7 | METSIM | Adipose | WDR20 | 0.03 | 0.04 | lasso | 8 | 0.04 | 1.6e-06 | -6.9 | 6.6 | 5.1e-11 | -0.92 | 0.03 | 0.97 | TRUE |
8 | YFS | Blood | HSP90AA1 | 0.02 | 0.02 | lasso | 2 | 0.02 | 3.2e-07 | -5.8 | 5.7 | 1.3e-08 | -0.67 | 0.80 | 0.18 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | RAGE | 0.08 | 0.09 | blup | 60 | 0.09 | 7.3e-06 | -6.6 | 6.2 | 7.6e-10 | -0.82 | 0.06 | 0.93 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HSP90AA1 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.4e-02 | -6.3 | 5.6 | 2.1e-08 | -0.60 | 0.04 | 0.30 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAGE | 0.04 | 0.01 | blup | 60 | 0.03 | 2.5e-04 | -6.8 | 5.6 | 2.0e-08 | -0.75 | 0.03 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TRMT61A | 0.02 | 0.00 | blup | 34 | 0.01 | 6.2e-02 | -3.9 | 5.2 | 1.7e-07 | 0.05 | 0.01 | 0.48 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRMT61A | 0.03 | 0.01 | blup | 32 | 0.01 | 1.4e-02 | 4.7 | 5.3 | 1.3e-07 | 0.03 | 0.00 | 0.41 | TRUE |