Best TWAS P=3.97e-08 · Best GWAS P=2.64e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Esophagus Mucosa | GATM | 0.10 | 0.04 | enet | 20 | 0.10 | 5.7e-07 | -4.5 | 5.2 | 2.4e-07 | -0.89 | 0.06 | 0.94 | FALSE |
2 | GTEx | Nerve Tibial | GATM | 0.07 | 0.04 | lasso | 2 | 0.08 | 1.9e-06 | 2.7 | 5.2 | 1.7e-07 | -0.49 | 0.26 | 0.45 | FALSE |
3 | GTEx | Thyroid | GATM | 0.14 | 0.13 | lasso | 5 | 0.17 | 8.4e-13 | -4.6 | 5.3 | 1.1e-07 | -0.91 | 0.05 | 0.95 | FALSE |
4 | YFS | Blood | GATM | 0.03 | 0.05 | lasso | 19 | 0.06 | 4.1e-19 | -5.4 | 5.5 | 4.7e-08 | -0.94 | 0.02 | 0.98 | FALSE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | GATM | 0.35 | 0.18 | blup | 41 | 0.18 | 2.4e-10 | -5.4 | 5.2 | 2.0e-07 | -0.95 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GATM | 0.02 | 0.01 | blup | 41 | 0.01 | 1.0e-02 | -4.5 | 5.2 | 2.2e-07 | -0.88 | 0.04 | 0.76 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | GATM | 0.04 | 0.01 | blup | 41 | 0.02 | 1.8e-03 | -5.3 | 5.5 | 4.0e-08 | -0.97 | 0.01 | 0.86 | TRUE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GATM | 0.02 | 0.01 | blup | 41 | 0.02 | 5.1e-03 | -4.6 | 5.3 | 1.2e-07 | -0.88 | 0.03 | 0.72 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GATM | 0.03 | 0.03 | blup | 41 | 0.04 | 7.3e-05 | -4.7 | 5.3 | 1.4e-07 | -0.86 | 0.08 | 0.91 | FALSE |