Best TWAS P=2.81e-15 · Best GWAS P=4.17e-13 conditioned to 0.0277
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAMTS17 | 0.14 | 0.00 | enet | 19 | 0.02 | 5.0e-03 | 6.2 | -6.1 | 1.3e-09 | -0.27 | 0.19 | 0.19 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | ADAMTS17 | 0.20 | 0.00 | enet | 20 | 0.05 | 2.2e-03 | -5.0 | -7.7 | 1.5e-14 | -0.55 | 0.10 | 0.27 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -6.1 | -7.9 | 2.8e-15 | -0.15 | 0.10 | 0.20 | TRUE |
| 4 | GTEx | Esophagus Mucosa | CTD-3076O17.1 | 0.28 | 0.10 | lasso | 6 | 0.11 | 4.7e-08 | -6.0 | -5.3 | 1.4e-07 | 0.09 | 0.91 | 0.08 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | ADAMTS17 | 0.22 | 0.00 | lasso | 4 | 0.09 | 9.6e-05 | -2.2 | -5.1 | 2.8e-07 | -0.19 | 0.10 | 0.19 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | CTD-3076O17.1 | 0.25 | 0.11 | enet | 24 | 0.17 | 3.8e-08 | -5.0 | -5.2 | 2.5e-07 | -0.06 | 0.67 | 0.07 | FALSE |
| 7 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -6.0 | -6.0 | 2.3e-09 | 0.06 | 0.90 | 0.09 | FALSE |
| 8 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -5.9 | -6.6 | 3.1e-11 | 0.06 | 0.50 | 0.07 | FALSE |
| 9 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -5.9 | -5.9 | 3.5e-09 | 0.06 | 0.92 | 0.08 | FALSE |
| 10 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -5.9 | -6.7 | 2.1e-11 | 0.05 | 0.84 | 0.08 | FALSE |