Best TWAS P=1.06e-11 · Best GWAS P=2.4e-12 conditioned to 0.00411
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HN1L | 0.08 | 0.01 | blup | 487 | 0.04 | 2.4e-05 | -3.7 | 5.7 | 1.1e-08 | -0.47 | 0.32 | 0.44 | FALSE |
2 | GTEx | Artery Tibial | LA16c-316G12.2 | 0.13 | 0.05 | enet | 18 | 0.06 | 1.1e-05 | -7.0 | -6.8 | 1.1e-11 | 0.70 | 0.01 | 0.98 | TRUE |
3 | GTEx | Breast Mammary Tissue | TELO2 | 0.16 | 0.03 | lasso | 4 | 0.06 | 3.4e-04 | -4.6 | 5.7 | 1.0e-08 | -0.68 | 0.03 | 0.82 | FALSE |
4 | GTEx | Esophagus Muscularis | LA16c-361A3.3 | 0.12 | 0.04 | enet | 7 | 0.05 | 5.1e-04 | -4.8 | -5.8 | 5.7e-09 | 0.82 | 0.34 | 0.50 | FALSE |
5 | METSIM | Adipose | TMEM204 | 0.08 | 0.01 | blup | 498 | 0.02 | 2.5e-04 | -4.9 | -5.8 | 8.3e-09 | 0.74 | 0.02 | 0.98 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | 5.7 | -5.2 | 1.9e-07 | 0.06 | 0.91 | 0.09 | FALSE |
7 | YFS | Blood | CRAMP1L | 0.02 | 0.01 | lasso | 5 | 0.01 | 1.6e-04 | -4.6 | -5.7 | 1.2e-08 | 0.77 | 0.76 | 0.21 | FALSE |
8 | YFS | Blood | MLST8 | 0.12 | 0.06 | bslmm | 326 | 0.06 | 4.3e-20 | 4.7 | -6.0 | 2.5e-09 | 0.04 | 0.72 | 0.28 | TRUE |
9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MAPK8IP3 | 0.18 | 0.06 | blup | 77 | 0.10 | 8.7e-06 | -4.8 | -6.0 | 1.7e-09 | 0.75 | 0.09 | 0.83 | FALSE |
10 | The Cancer Genome Atlas | Esophageal Carcinoma | CRAMP1L | 0.11 | 0.08 | blup | 60 | 0.07 | 2.2e-03 | -5.3 | -6.4 | 1.6e-10 | 0.87 | 0.02 | 0.84 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C16orf79 | 0.05 | 0.01 | lasso | 4 | 0.02 | 1.5e-03 | -4.1 | 5.1 | 2.7e-07 | 0.04 | 0.02 | 0.64 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IFT140 | 0.05 | 0.02 | blup | 94 | 0.04 | 6.1e-05 | -4.9 | 5.2 | 2.7e-07 | -0.77 | 0.04 | 0.91 | FALSE |