Best TWAS P=2.82e-09 · Best GWAS P=3.93e-08 conditioned to 0.898
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Breast Mammary Tissue | MED24 | 0.18 | 0.08 | enet | 16 | 0.16 | 8.1e-09 | 4.8 | -5.2 | 1.8e-07 | -0.72 | 0.04 | 0.94 | FALSE |
2 | GTEx | Breast Mammary Tissue (Female) | MED24 | 0.11 | 0.05 | lasso | 6 | 0.08 | 3.0e-03 | 4.9 | -5.6 | 2.1e-08 | -0.81 | 0.03 | 0.59 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | MED24 | 0.20 | 0.12 | enet | 18 | 0.11 | 1.4e-08 | 4.9 | -5.2 | 2.1e-07 | -0.81 | 0.05 | 0.95 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | MED24 | 0.26 | 0.16 | lasso | 11 | 0.20 | 1.1e-07 | 4.9 | -5.9 | 2.8e-09 | -0.92 | 0.01 | 0.99 | TRUE |
5 | GTEx | Esophagus Mucosa | GSDMB | 0.06 | 0.04 | lasso | 3 | 0.03 | 4.7e-03 | 5.2 | 5.2 | 1.6e-07 | 0.43 | 0.03 | 0.87 | FALSE |
6 | GTEx | Pituitary | MED24 | 0.37 | 0.28 | lasso | 3 | 0.21 | 6.1e-06 | 5.5 | -5.3 | 9.2e-08 | -1.00 | 0.00 | 0.99 | FALSE |
7 | GTEx | Spleen | MED24 | 0.35 | 0.21 | lasso | 6 | 0.24 | 6.5e-07 | 4.9 | -5.9 | 4.8e-09 | -0.89 | 0.01 | 0.98 | FALSE |
8 | METSIM | Adipose | GSDMA | 0.14 | 0.16 | lasso | 7 | 0.17 | 2.6e-24 | 5.2 | -5.1 | 2.6e-07 | -0.54 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | GSDMA | 0.23 | 0.16 | blup | 47 | 0.18 | 1.3e-05 | 4.1 | -5.4 | 7.2e-08 | -0.76 | 0.02 | 0.88 | FALSE |